The evolution of allergen and non-specific immunotherapy: past achievements, current applications and future outlook

Lack of Inflammatory Cells in the Oral Mucosa of Subjects Undergoing Sublingual Immunotherapy

(2017) F. Marcucci et al.   INTERNATIONAL JOURNAL OF IMMUNOPATHOLOGY AND PHARMACOLOGY

Heightened response of eosinophilic asthmatic patients to the CRTH2 antagonist OC000459

(2014) R. Pettipher et al.   ALLERGY

Recommendations for the standardization of clinical outcomes used in allergen immunotherapy trials for allergic rhinoconjunctivitis: an EAACI Position Paper

(2014) O. Pfaar et al.   ALLERGY

Efficacy of allergen-specific immunotherapy for peanut allergy: A meta-analysis of randomized controlled trials

(2014) Jinqiao Sun et al.   ALLERGY AND ASTHMA PROCEEDINGS

Setipiprant, a selective CRTH2 antagonist, reduces allergen-induced airway responses in allergic asthmatics

(2014) Z. Diamant et al.   CLINICAL AND EXPERIMENTAL ALLERGY

Regulatory T cells and their roles in immune dysregulation and allergy

(2014) Laurence Pellerin et al.   IMMUNOLOGIC RESEARCH

Allergens and the airway epithelium response: Gateway to allergic sensitization

(2014) Bart N. Lambrecht et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Peanut oral immunotherapy results in increased antigen-induced regulatory T-cell function and hypomethylation of forkhead box protein 3 (FOXP3)

(2014) Aleena Syed et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Mechanisms of allergen-specific immunotherapy: Multiple suppressor factors at work in immune tolerance to allergens

(2014) Mübeccel Akdis et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Efficacy and safety of an anti–IL-13 mAb in patients with severe asthma: A randomized trial

(2014) Erika H. De Boever et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Subsets of regulatory T cells and their roles in allergy

(2014) Huiyun Zhang et al.   Journal of Translational Medicine

Effects of an Anti-TSLP Antibody on Allergen-Induced Asthmatic Responses

(2014) Gail M. Gauvreau et al.   NEW ENGLAND JOURNAL OF MEDICINE

Immunotherapy - risk/benefit in food allergy

(2014) Atanaska I. Kostadinova et al.   PEDIATRIC ALLERGY AND IMMUNOLOGY

Sublingual immunotherapy: World Allergy Organization position paper 2013 update

(2014) Giorgio Walter Canonica et al.   World Allergy Organization Journal

Anti-eosinophil activity and clinical efficacy of the CRTH2 antagonist OC000459 in eosinophilic esophagitis

(2013) A. Straumann et al.   ALLERGY

Changing the route of immunotherapy administration: An 18-year survey in pediatric patients with allergic rhinitis and asthma

(2013) Giovanni B. Pajno et al.   ALLERGY AND ASTHMA PROCEEDINGS

Oral immunotherapy for peanut allergy in clinical practice is ready

(2013) Lyndon E. Mansfield   ALLERGY AND ASTHMA PROCEEDINGS

Allergy training and immunotherapy in Latin America: results of a regional overview

(2013) Carlos E. Baena-Cagnani et al.   ANNALS OF ALLERGY ASTHMA & IMMUNOLOGY

Sublingual immunotherapy

(2013) Harold S. Nelson   Current Opinion in Allergy and Clinical Immunology

From phenotypes to endotypes to asthma treatment

(2013) Ioana O. Agache   Current Opinion in Allergy and Clinical Immunology

The use of single versus multiple antigens in specific allergen immunotherapy for allergic rhinitis

(2013) Giovanni Passalacqua   Current Opinion in Allergy and Clinical Immunology

Development and function of group 2 innate lymphoid cells

(2013) Jennifer A Walker et al.   CURRENT OPINION IN IMMUNOLOGY

Immunopathogenesis of allergic disorders: current concepts

(2013) Yashwant Kumar et al.   Expert Review of Clinical Immunology

Recent advances in immunotherapy: the active treatment of food allergy on the horizon

(2013) Giovanni B Pajno et al.   Expert Review of Clinical Immunology

Update on allergy immunotherapy: American Academy of Allergy, Asthma & Immunology/European Academy of Allergy and Clinical Immunology/PRACTALL consensus report

(2013) A. Wesley Burks et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Effects of benralizumab on airway eosinophils in asthmatic patients with sputum eosinophilia

(2013) Michel Laviolette et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Grading local side effects of sublingual immunotherapy for respiratory allergy: Speaking the same language

(2013) Giovanni Passalacqua et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

The novel TLR-9 agonist QbG10 shows clinical efficacy in persistent allergic asthma

(2013) Kai-Michael Beeh et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Efficacy of a short course of specific immunotherapy in patients with allergic rhinoconjunctivitis to ragweed pollen

(2013) Piyush Patel et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Specific immunotherapy in asthma: a comprehensive review

(2013) Giovanni Passalacqua   JOURNAL OF ASTHMA

TH2, allergy and group 2 innate lymphoid cells

(2013) Paula Licona-Limón et al.   NATURE IMMUNOLOGY

Dupilumab in Persistent Asthma with Elevated Eosinophil Levels

(2013) Sally Wenzel et al.   NEW ENGLAND JOURNAL OF MEDICINE

Efficacy and safety of AZD1981, a CRTH2 receptor antagonist, in patients with moderate to severe COPD

(2013) Noel Snell et al.   RESPIRATORY MEDICINE

Innate immune cells in asthma

(2013) Julie Deckers et al.   TRENDS IN IMMUNOLOGY

Pollinex Quattro: An innovative four injections immunotherapy In allergic rhinitis

(2013) Martin Rosewich et al.   Human Vaccines & Immunotherapeutics

A WAO - ARIA - GA²LEN consensus document on molecular-based allergy diagnostics

(2013) Giorgio Walter Canonica et al.   World Allergy Organization Journal

Oral immunotherapy for food allergy: Clinical and preclinical studies

(2012) Mike Kulis et al.   ADVANCED DRUG DELIVERY REVIEWS

Mechanisms of peripheral tolerance to allergens

(2012) O. U. Soyer et al.   ALLERGY

Adherence to pharmacological treatment and specific immunotherapy in allergic rhinitis

(2012) G. Passalacqua et al.   CLINICAL AND EXPERIMENTAL ALLERGY

Biologic Agents in the Treatment of Urticaria

(2012) Allen P. Kaplan   CURRENT ALLERGY AND ASTHMA REPORTS

Oral immunotherapy for cowʼs milk allergy

(2012) Giovanni Passalacqua et al.   Current Opinion in Allergy and Clinical Immunology

A phase II placebo-controlled study of tralokinumab in moderate-to-severe asthma

(2012) Edward Piper et al.   EUROPEAN RESPIRATORY JOURNAL

Intralymphatic immunotherapy for cat allergy induces tolerance after only 3 injections

(2012) Gabriela Senti et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Urinary levels of triclosan and parabens are associated with aeroallergen and food sensitization

(2012) Jessica H. Savage et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Safety and efficacy of the prostaglandin D2 receptor antagonist AMG 853 in asthmatic patients

(2012) William W. Busse et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Mepolizumab for severe eosinophilic asthma (DREAM): a multicentre, double-blind, placebo-controlled trial

(2012) Ian D Pavord et al.   LANCET

Changes in antigen-specific T-cell number and function during oral desensitization in cow's milk allergy enabled with omalizumab

(2012) D Bedoret et al.   Mucosal Immunology

Innate and adaptive immune responses in asthma

(2012) Stephen T Holgate   NATURE MEDICINE

Asthma phenotypes: the evolution from clinical to molecular approaches

(2012) Sally E Wenzel   NATURE MEDICINE

Perspectives on allergen-specific immunotherapy in childhood: An EAACI position statement

(2012) M. A. Calderon et al.   PEDIATRIC ALLERGY AND IMMUNOLOGY

Oral Immunotherapy for Food Allergy: Towards a New Horizon

(2012) Evelyne Khoriaty et al.   Allergy Asthma & Immunology Research

Adjuvants for allergy vaccines

(2012) Philippe Moingeon   Human Vaccines & Immunotherapeutics

Systematic reviews of sublingual immunotherapy (SLIT)

(2011) S. Radulovic et al.   ALLERGY

Ultrashort-specific immunotherapy successfully treats seasonal allergic rhinoconjunctivitis to grass pollen

(2011) Lawrence M. DuBuske et al.   ALLERGY AND ASTHMA PROCEEDINGS

Reslizumab for Poorly Controlled, Eosinophilic Asthma

(2011) Mario Castro et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Specific immunotherapy and turning off the T cell: how does it work?

(2011) Cevdet Ozdemir et al.   ANNALS OF ALLERGY ASTHMA & IMMUNOLOGY

Biological characterization of a novel class of toll-like receptor 7 agonists designed to have reduced systemic activity

(2011) M Biffen et al.   BRITISH JOURNAL OF PHARMACOLOGY

Immunotherapy for allergic rhinitis

(2011) S. M. Walker et al.   CLINICAL AND EXPERIMENTAL ALLERGY

Sublingual immunotherapy for allergic conjunctivitis: Cochrane systematic review and meta-analysis

(2011) M. A. Calderon et al.   CLINICAL AND EXPERIMENTAL ALLERGY

Assessment of clinical efficacy of CYT003-QbG10 in patients with allergic rhinoconjunctivitis: a phase IIb study

(2011) L. Klimek et al.   CLINICAL AND EXPERIMENTAL ALLERGY

An evidence-based appraisal of the surrogate markers of efficacy of allergen immunotherapy

(2011) Gianenrico Senna et al.   Current Opinion in Allergy and Clinical Immunology

Anti-interleukin-5 antibody therapy in asthma and allerges

(2011) Jonathan Corren   Current Opinion in Allergy and Clinical Immunology

Novel Administration Routes for Allergen-Specific Immunotherapy: A Review of Intralymphatic and Epicutaneous Allergen-Specific Immunotherapy

(2011) Seraina von Moos et al.   IMMUNOLOGY AND ALLERGY CLINICS OF NORTH AMERICA

Mechanisms of immune tolerance relevant to food allergy

(2011) Brian P. Vickery et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Recombinant allergens for specific immunotherapy

(2011) Oliver Cromwell et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Rapid oral desensitization in combination with omalizumab therapy in patients with cow’s milk allergy

(2011) Kari C. Nadeau et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

The who, where, and when of IgE in allergic airway disease

(2011) Melissa Dullaers et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Epicutaneous allergen-specific immunotherapy ameliorates grass pollen–induced rhinoconjunctivitis: A double-blind, placebo-controlled dose escalation study

(2011) Gabriela Senti et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Reslizumab in children and adolescents with eosinophilic esophagitis: Results of a double-blind, randomized, placebo-controlled trial

(2011) Jonathan M. Spergel et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

MicroRNA-21 Limits In Vivo Immune Response-Mediated Activation of the IL-12/IFN-  Pathway, Th1 Polarization, and the Severity of Delayed-Type Hypersensitivity

(2011) T. X. Lu et al.   JOURNAL OF IMMUNOLOGY

Lebrikizumab Treatment in Adults with Asthma

(2011) Jonathan Corren et al.   NEW ENGLAND JOURNAL OF MEDICINE

A Randomized, Controlled, Phase 2 Study of AMG 317, an IL-4Rα Antagonist, in Patients with Asthma

(2010) Jonathan Corren et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

SUBLINGUAL IMMUNOTHERAPY FOR HAZELNUT FOOD ALLERGY: A FOLLOW-UP STUDY

(2010) Ernesto Enrique et al.   ANNALS OF ALLERGY ASTHMA & IMMUNOLOGY

Preventive effects of sublingual immunotherapy in childhood: an open randomized controlled study

(2010) Maurizio Marogna et al.   ANNALS OF ALLERGY ASTHMA & IMMUNOLOGY

Safety, tolerability, and immunologic effects of a food allergy herbal formula in food allergic individuals: a randomized, double-blinded, placebo-controlled, dose escalation, phase 1 study

(2010) Julie Wang et al.   ANNALS OF ALLERGY ASTHMA & IMMUNOLOGY

Basophil CD203c Levels Are Increased at Baseline and Can Be Used to Monitor Omalizumab Treatment in Subjects with Nut Allergy

(2010) Yael Gernez et al.   INTERNATIONAL ARCHIVES OF ALLERGY AND IMMUNOLOGY

Speaking the same language: The World Allergy Organization Subcutaneous Immunotherapy Systemic Reaction Grading System

(2010) Linda Cox et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

The Consolidated Standards of Reporting Trials (CONSORT) Statement applied to allergen-specific immunotherapy with inhalant allergens: A Global Allergy and Asthma European Network (GA2LEN) article

(2010) Philippe J. Bousquet et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Disease-modifying effect and economic implications of sublingual immunotherapy

(2010) Giorgio Walter Canonica et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Toll-like receptor 7 agonists are potent and rapid bronchodilators in guinea pigs

(2010) Elad H. Kaufman et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Allergen immunotherapy: A practice parameter third update

(2010) Linda Cox et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Update in the Mechanisms of Allergen-Specific Immunotheraphy

(2010) Tunc Akkoc et al.   Allergy Asthma & Immunology Research

Effects of omalizumab on markers of inflammation in patients with allergic asthma

(2009) S. Holgate et al.   ALLERGY

Randomized double-blind, placebo-controlled trial of sublingual immunotherapy with a Pru p 3 quantified peach extract

(2009) M. Fernández-Rivas et al.   ALLERGY

Specific immunotherapy with allergen mixes: what is the evidence?

(2009) Harold S Nelson   Current Opinion in Allergy and Clinical Immunology

Recommendations for appropriate sublingual immunotherapy clinical trials

(2009) Thomas B. Casale et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Early onset of action of a 5-grass-pollen 300-IR sublingual immunotherapy tablet evaluated in an allergen challenge chamber

(2009) Friedrich Horak et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Antagonism of microRNA-126 suppresses the effector function of TH2 cells and the development of allergic airways disease

(2009) J. Mattes et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Food Allergy: Recent Advances in Pathophysiology and Treatment

(2009) Julie Wang et al.   Allergy Asthma & Immunology Research

Allergic Rhinitis and its Impact on Asthma (ARIA) 2008*

(2008) J. Bousquet et al.   ALLERGY

An update on the safety of specific immunotherapy

(2008) Hugh H Windom et al.   Current Opinion in Allergy and Clinical Immunology

In vivo switch to IL-10–secreting T regulatory cells in high dose allergen exposure

(2008) Flurina Meiler et al.   JOURNAL OF EXPERIMENTAL MEDICINE

The development of allergic inflammation

(2008) Stephen J. Galli et al.   NATURE

Treatment of Patients with the Hypereosinophilic Syndrome with Mepolizumab

(2008) Marc E. Rothenberg et al.   NEW ENGLAND JOURNAL OF MEDICINE