Article
Immunology
Ghulam Raza, Fakhar-un-Nisa Yunus, Hitesh Bhagavanbhai Mangukiya, Siva Bharath Merugu, Dhahiri Saidi Mashausi, Wang Zeling, Hema Negi, Bingjie Zhou, Debmalya Roy, Zhenghua Wu, Dawei Li
Summary: This study examines the effect of the monoclonal antibody mAb15D8 on lung cancer cells, revealing its potential to significantly reduce cell proliferation and migration, as well as inhibit tumor growth and metastasis in vivo. The results suggest mAb15D8 as a potential therapeutic agent for cancer therapy.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2021)
Article
Pharmacology & Pharmacy
Ruijia Liang, Cheng Wu, Shiming Liu, Wenyan Zhao
Summary: Despite limited treatment options for GBM, nanotechnology and functionalized nanocarriers show potential in delivering therapeutic agents to GBM tissues. IL13R alpha 2 serves as a potential target for GBM therapy due to its high expression and absence in surrounding normal tissues.
Article
Hematology
Julie Kanter, R. Clark Brown, Cynthia Norris, Santosh M. Nair, Abdullah Kutlar, Deepa Manwani, Nirmish Shah, Chiaki Tanaka, Shankaranand Bodla, Gessami Sanchez-Olle, Urs Albers, Darla Liles
Summary: This study analyzed the pharmacokinetics, pharmacodynamics, safety, and efficacy of crizanlizumab in patients with sickle cell disease. The results demonstrated the sustained efficacy and long-term safety of the drug in treating sickle cell disease.
Article
Pharmacology & Pharmacy
Sang-Hwan Ji, Ki Young Huh, Jaeseong Oh, Hee-Jeong Jeong, Young-Eun Jang, Eun-Hee Kim, Ji-Hyun Lee, Jin-Tae Kim, Hee-Soo Kim
Summary: This study investigated the pharmacokinetics and pharmacodynamics of sugammadex in Korean children. The results showed that the recommended dose of 2 mg/kg of sugammadex could be safely administered for reversing moderate neuromuscular blockade. Some differences in the pharmacokinetics of sugammadex were observed according to age.
FRONTIERS IN PHARMACOLOGY
(2023)
Article
Pharmacology & Pharmacy
Xue Zhao, Hongzhong Liu, Wei Tian, Ligang Fang, Mengyang Yu, Xiaofei Wu, Aijing Liu, Ruijie Wan, Li Li, Jinghui Luo, Yuqiong Li, Bo Liu, Yu He, Xiaowen Chen, Yuan Li, Donghong Xu, Hongyun Wang, Xiaohong Han
Summary: This study aimed to investigate the safety, tolerability, pharmacokinetics, and pharmacodynamics of aficamten in healthy Chinese adults. The results showed that aficamten was safe and well-tolerated in the Chinese population, with pharmacokinetics comparable to Western participants. These findings support future clinical studies of aficamten in Chinese patients.
FRONTIERS IN PHARMACOLOGY
(2023)
Review
Pharmacology & Pharmacy
Joseph A. Piscatelli, Jisun Ban, Andrew T. Lucas, William C. Zamboni
Summary: Major developments in nanomedicines, such as nanoparticles and conjugates, have revolutionized drug delivery capabilities, but there is considerable inter-patient variability seen in the systemic disposition, tumor delivery, and pharmacological effects of NP agents. Evaluating fundamental factors influencing NP disposition is crucial for clinical development.
Article
Endocrinology & Metabolism
Ki Young Huh, Jun Gi Hwang, Wonjung Shin, Seungjae Baek, JaeDuk Choi, Nora Lee, Young Min Cho, Howard Lee
Summary: HM15136, a novel long-acting glucagon analogue, was shown to be safe and well tolerated in doses ranging from 10-120 μg/kg in a randomized, double-blind, placebo-controlled study. It increased blood glucose levels and suppressed the secretion of endogenous glucagon.
DIABETES OBESITY & METABOLISM
(2022)
Review
Biochemistry & Molecular Biology
Marta Jaen, Angela Martin-Regalado, Ruben A. Bartolome, Javier Robles, J. Ignacio Casal
Summary: IL13R alpha 2 plays a significant role in cancer invasion and metastasis. The reasons for its highly expressed affinity for IL-13 in cancer cells remain unclear. Elevated expression of IL13R alpha 2 is associated with poor prognosis in cancer. The effects of inflammation, cancer type, and tumor degree on the expression of IL13R alpha 2 are still largely uncharacterized.
BIOCHIMICA ET BIOPHYSICA ACTA-REVIEWS ON CANCER
(2022)
Article
Endocrinology & Metabolism
Susanna Bianzano, Andrea Henrich, Lena Herich, Brigitte Kalsch, Donald Sarubbi, Friedeborg Seitz, Thomas Forst
Summary: Two Phase I studies showed that BI 1356225, a GOAT inhibitor, was well-tolerated in healthy males and subjects with overweight/obesity. However, treatment with BI 1356225 for 28 days did not lead to significant reduction in bodyweight or changes in appetite, eating control, or energy intake.
METABOLISM-CLINICAL AND EXPERIMENTAL
(2023)
Article
Pharmacology & Pharmacy
Brian Hess, William Townsend, Weiyun Ai, Anastasios Stathis, Melhem Solh, Juan Pablo Alderuccio, David Ungar, Sam Liao, Lori Liao, Lisa Khouri, Xiaoyan Zhang, Joseph Boni
Summary: An integrated population pharmacokinetic model was developed to investigate the pharmacokinetics and exposure-response relationships of loncastuximab tesirine in relapsed/refractory B cell non-Hodgkin lymphoma. The model utilized recommended dosing schedules and data from phase 1 and 2 studies, exploring associations between exposure, efficacy, and adverse events. The model supported the recommended dosing schedule and highlighted factors influencing drug exposure and response.
Review
Multidisciplinary Sciences
Basel Abdelazeem, Joseph Shehata, Kirellos Said Abbas, Nahla Ahmed El-Shahat, Bilal Malik, Pramod Savarapu, Mostafa Eltobgy, Arvind Kunadi
Summary: This meta-analysis evaluated the efficacy and safety of ROX in NDD-CKD patients with anemia. The results showed that ROX significantly increased Hb level and improved iron utilization parameters, but it was also associated with higher serious adverse effects, especially deep venous thrombosis and hypertension.
Article
Oncology
Aiqin Gu, Yue Bai, Can Zhang, Chang Xu, Zhijing An, Ying Zhang, Steven H. Zhong, Yi Hu, Xiaosong Zhong
Summary: In this study, three different third-generation CARs targeting IL13Ra2 were generated and their anti-tumor activity was investigated. The IL13-CD28TM-28.BB. CAR-T cells exhibited the best anti-tumor activity in xenograft mouse models.
CANCER IMMUNOLOGY IMMUNOTHERAPY
(2023)
Article
Endocrinology & Metabolism
Wonjung Shin, Marcus Hompesch, JinHee Byeon, Seohyun Kang, Jaehyuk Choi, Seungjae Baek
Summary: This study evaluated the safety, tolerability, pharmacokinetics and pharmacodynamics of a novel long-acting glucagon analogue HM15136 in overweight/obese patients with co-morbidities, with and without type 2 diabetes (T2D). The results showed that HM15136 had good safety and tolerability in patients with dyslipidaemia and/or hypertension, but its use in patients with T2D may cause hyperglycaemia.
DIABETES OBESITY & METABOLISM
(2023)
Article
Pharmacology & Pharmacy
Dominic Beale, Jeremy Dennison, Malcolm Boyce, Francesca Mazzo, Naoki Honda, Paul Smith, Mark Bruce
Summary: The study demonstrated that ONO-7684 was well-tolerated in healthy subjects at both single and multiple doses, with low incidence of adverse events. Pharmacokinetic data showed dose proportionality for ONO-7684. Pharmacodynamic results revealed a strong inhibition of FXI coagulation activity and an increase in aPTT at 250 mg ONO-7684 daily. These findings support the potential of ONO-7684 as an oral FXIa inhibitor for anticoagulation indications.
BRITISH JOURNAL OF CLINICAL PHARMACOLOGY
(2021)
Article
Pharmacology & Pharmacy
Gunavanthi D. Boorgula, Laxmi U. M. R. Jakkula, Tawanda Gumbo, Bockgie Jung, Shashikant Srivastava
Summary: The study compared microbial kill and resistance emergence of different rifamycins in the treatment of pulmonary MAC infection. Results showed no significant difference in efficacy and resistance suppression among the three rifamycins tested, and monotherapy with rifamycins was ineffective and led to drug resistance development.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Critical Care Medicine
Samuel Y. Ash, Gonzalo Vegas Sanchez-Ferrero, Mark L. Schiebler, Farbod N. Rahaghi, Ashish Rai, Carolyn E. Come, James C. Ross, Alysha G. Colon, Juan Carlos Cardet, Eugene R. Bleecker, Mario Castro, John Fahy, Sean B. Fain, Benjamin M. Gaston, Eric A. Hoffman, Nizar N. Jarjour, Jason K. Lempel, David T. Mauger, Matthew C. Tattersall, Sally E. Wenzel, Bruce D. Levy, George R. Washko, Elliot Israel, Raul San Jose Estepar, Bruce Levy, George Washko, Manuela Cernadas, Wanda Phipatanakul, Sally Wenzel, Merritt Fajt, Benjamin Gaston, James Chmiel, W. Gerald Teague, Anne-Marie Irani, Serpil Erzurum, Sumita Khatri, Suzy Comhair, Raed Dweik, Kristie Ross, Ross Myers, Wendy Moore, Deborah Meyers, Eugene Bleecker, Stephen Peters, Annette Hastie, Victor Ortega, Greg Hawkins, Xingan Li, Anne Fitzpatrick, Nazar Jarjour, Loren Denlinger, Sean Fain, Ronald Sorkness, Leonard Bacharier, David Gierada, Kenneth Schechtman, Jason Woods, John Fahy, Prescott Woodruff, Ngoc Ly, David Mauger
Article
Critical Care Medicine
Michael C. Peters, Satria Sajuthi, Peter Deford, Stephanie Christenson, Cydney L. Rios, Michael T. Montgomery, Prescott G. Woodruff, David T. Mauger, Serpil C. Erzurum, Mats W. Johansson, Loren C. Denlinger, Nizar N. Jarjour, Mario Castro, Annette T. Hastie, Wendy Moore, Victor E. Ortega, Eugene R. Bleecker, Sally E. Wenzel, Elliot Israel, Bruce D. Levy, Max A. Seibold, John Fahy
AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE
(2020)
Article
Allergy
Juliana Durack, Laura S. Christian, Snehal Nariya, Jeanmarie Gonzalez, Nirav R. Bhakta, K. Mark Ansel, Avraham Beigelman, Mario Castro, Anne-Marie Dyer, Elliot Israel, Monica Kraft, Richard J. Martin, David T. Mauger, Stephen P. Peters, Sharon R. Rosenberg, Christine A. Sorkness, Michael E. Wechsler, Sally E. Wenzel, Steven R. White, Susan Lynch, Homer A. Boushey, Yvonne J. Huang
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY
(2020)
Article
Allergy
Peter Bradding, Matthew Richardson, Timothy S. C. Hinks, Peter H. Howarth, David F. Choy, Joseph R. Arron, Sally E. Wenzel, Salman Siddiqui
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY
(2020)
Article
Multidisciplinary Sciences
Jinming Zhao, Haider H. Dar, Yanhan Deng, Claudette M. St Croix, Zhipeng Li, Yoshinori Minami, Indira H. Shrivastava, Yulia Y. Tyurina, Emily Etling, Joel C. Rosenbaum, Tadao Nagasaki, John B. Trudeau, Simon C. Watkins, Ivet Bahar, Hulya Bayir, Andy P. VanDemark, Valerian E. Kagan, Sally E. Wenzel
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2020)
Review
Critical Care Medicine
Sally E. Wenzel
Summary: Evaluation and management of severe asthma remains a core focus in pulmonary practice. Advances in clinical phenotyping and molecular tools have greatly enhanced our understanding and treatment of severe asthma. Challenges still exist, but conceptual understanding of the disease has evolved significantly in a relatively short period of time.
AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE
(2021)
Article
Physiology
Kaveh Moghbeli, Eleanor Valenzi, Rachel Naramore, John Charles Sembrat, Kong Chen, Mauricio M. Rojas, Sally E. Wenzel, Robert Lafyatis, Brian Modena, Nathaniel M. Weathington
Summary: The study analyzed BAL samples from Severe Asthma patients and found suppression of the BALcAMP gene module, influenced by various factors. The results showed that the BALcAMP gene network expression was suppressed in multiple cell populations, particularly significantly in macrophages.
AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY
(2021)
Article
Medicine, Research & Experimental
Matthew J. Camiolo, Xiuxia Zhou, Qi Wei, Humberto E. Trejo Bittar, Naftali Kaminski, Anuradha Ray, Sally E. Wenzel
Summary: Asthma is a common disease with highly variable natural history and patient morbidity. Previous studies have linked gene expression changes in severe asthma to specific clinical and physiological characteristics. Using bronchial epithelial cell gene expression data, a transcriptional signature was identified for participants with exacerbation-prone asthma and impaired lung function. This approach identified a set of 31 genes that classified patients accurately and highlighted IL-18 signaling in severe asthma pathogenesis.
Article
Critical Care Medicine
Alexander J. Schuyler, Sally E. Wenzel
Summary: This study aims to explore the impact of historical redlining on contemporary racial inequities in environmental quality and lung health. The findings suggest that individuals living in neighborhoods subjected to historical redlining, especially Black individuals, face higher levels of asthma-related outcomes and environmental burdens, indicating the long-term effects of systemic racism.
AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE
(2022)
Article
Allergy
Brandy M. Byrwa-Hill, Tricia L. Morphew, Albert A. Presto, James P. Fabisiak, Sally E. Wenzel
Summary: Living in an environmentally just tract increases the likelihood of severe and uncontrolled asthma, which is influenced by age at onset, disease duration, and traffic-related air pollution.
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY
(2023)
Review
Physiology
Hannah H. Covert, Firoz Abdoel Wahid, Sally E. Wenzel, Maureen Y. Lichtveld
Summary: Anthropogenic climate change has a negative impact on human health, particularly respiratory health. This article examines the effects of climate change on respiratory health risks, including heat, wildfires, pollen, extreme weather events, and viruses. The intersection of exposure and vulnerability, influenced by social determinants of health, determines the risk of adverse health outcomes. The authors call for a transdisciplinary approach to accelerate research, practice, and policy development for respiratory health in the context of climate change.
PHYSIOLOGICAL REVIEWS
(2023)
Article
Biochemical Research Methods
Matthew J. Camiolo, Sally E. Wenzel, Anuradha Ray
Summary: Bulk expression data from heterogeneous cell populations can be challenging for investigators, but ICLite, a tool for bulk RNA sequencing on mixed populations, helps construct correlated gene modules and identify their relationship to specific lineages.
Article
Allergy
Robert Naclerio, Fuad Baroody, Claus Bachert, Benjamin Bleier, Larry Borish, Erica Brittain, Geoffrey Chupp, Anat Fisher, Wytske Fokkens, Philippe Gevaert, David Kennedy, Jean Kim, Tanya M. Laidlaw, Jake J. Lee, Jay F. Piccirillo, Jayant M. Pinto, Lauren T. Roland, Robert P. Schleimer, Rodney J. Schlosser, Julie M. Schwaninger, Timothy L. Smith, Bruce K. Tan, Ming Tan, Elina Toskala, Sally Wenzel, Alkis Togias
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY-IN PRACTICE
(2020)
Correction
Radiology, Nuclear Medicine & Medical Imaging
Hyun Bin Cho, Kum Ju Chae, Gong Yong Jin, Jiwoong Choi, Ching-Long Lin, Eric A. Hoffman, Sally E. Wenzel, Mario Castro, Sean B. Fain, Nizar N. Jarjour, Mark L. Schiebler, R. Graham Barr, Nadia Hansel, Christopher B. Cooper, Eric C. Kleerup, MeiLan K. Han, Prescott G. Woodruff, Richard E. Kanner, Eugene R. Bleecker, Stephen P. Peters, Wendy C. Moore, Chang Hyun Lee, Sanghun Choi
KOREAN JOURNAL OF RADIOLOGY
(2020)
Review
Medicine, General & Internal
Michael C. Peters, Sally E. Wenzel