Targeting classical IL-6 signalling or IL-6trans-signalling in depression?
Published 2014 View Full Article
- Home
- Publications
- Publication Search
- Publication Details
Title
Targeting classical IL-6 signalling or IL-6trans-signalling in depression?
Authors
Keywords
-
Journal
EXPERT OPINION ON THERAPEUTIC TARGETS
Volume 18, Issue 5, Pages 495-512
Publisher
Informa Healthcare
Online
2014-02-19
DOI
10.1517/14728222.2014.888417
References
Ask authors/readers for more resources
Related references
Note: Only part of the references are listed.- So depression is an inflammatory disease, but where does the inflammation come from?
- (2016) Michael Berk et al. BMC Medicine
- Tocilizumab: A novel humanized anti-interleukin 6 (IL-6) receptor antibody for the treatment of patients with non-RA systemic, inflammatory rheumatic diseases
- (2013) Rieke Alten et al. ANNALS OF MEDICINE
- Zinc in Depression: A Meta-Analysis
- (2013) Walter Swardfager et al. BIOLOGICAL PSYCHIATRY
- Biologic therapy for autoimmune diseases: an update
- (2013) Ziv Rosman et al. BMC Medicine
- Lower CSF interleukin-6 predicts future depression in a population-based sample of older women followed for 17 years
- (2013) Silke Kern et al. BRAIN BEHAVIOR AND IMMUNITY
- Depression, anxiety-like behavior and memory impairment are associated with increased oxidative stress and inflammation in a rat model of social stress
- (2013) Gaurav Patki et al. BRAIN RESEARCH
- Interplay between the pro-oxidant and antioxidant systems and proinflammatory cytokine levels, in relation to iron metabolism and the erythron in depression
- (2013) Joanna Rybka et al. FREE RADICAL BIOLOGY AND MEDICINE
- Plasma levels of interleukin-6 and selective serotonin reuptake inhibitor response in patients with major depressive disorder
- (2013) Reiji Yoshimura et al. HUMAN PSYCHOPHARMACOLOGY-CLINICAL AND EXPERIMENTAL
- Sertraline decreases serum level of interleukin-6 (IL-6) in hemodialysis patients with depression: Results of a randomized double-blind, placebo-controlled clinical trial
- (2013) Mohammad Taraz et al. INTERNATIONAL IMMUNOPHARMACOLOGY
- CRP, IL-6 and depression: A systematic review and meta-analysis of longitudinal studies
- (2013) Vyara Valkanova et al. JOURNAL OF AFFECTIVE DISORDERS
- A functional IL-6 receptor (IL6R) variant is a risk factor for persistent atopic dermatitis
- (2013) Jorge Esparza-Gordillo et al. JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY
- Maternal Immune Activation during Gestation Interacts with Disc1 Point Mutation to Exacerbate Schizophrenia-Related Behaviors in Mice
- (2013) T. V. Lipina et al. JOURNAL OF NEUROSCIENCE
- Increased cerebrospinal fluid interleukin-6 levels in patients with schizophrenia and those with major depressive disorder
- (2013) Daimei Sasayama et al. JOURNAL OF PSYCHIATRIC RESEARCH
- Brain IL-6 and autism
- (2013) H. Wei et al. NEUROSCIENCE
- Prolonged Restraint Stress Increases IL-6, Reduces IL-10, and Causes Persistent Depressive-Like Behavior That Is Reversed by Recombinant IL-10
- (2013) Jeffrey L. Voorhees et al. PLoS One
- Impact of inflammation on neurotransmitter changes in major depression: An insight into the action of antidepressants
- (2013) Brian E. Leonard PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY
- Serotonin and interleukin-6: The role of genetic polymorphisms in IFN-induced neuropsychiatric symptoms
- (2013) Marc Udina et al. PSYCHONEUROENDOCRINOLOGY
- Anti–IL-6 Antibody Treatment but Not IL-6 Knockout Improves Intestinal Barrier Function and Reduces Inflammation After Binge Ethanol Exposure and Burn Injury
- (2013) Anita Zahs et al. SHOCK
- In depression, bacterial translocation may drive inflammatory responses, oxidative and nitrosative stress (O&NS), and autoimmune responses directed against O&NS-damaged neoepitopes
- (2012) M. Maes et al. ACTA PSYCHIATRICA SCANDINAVICA
- Depression and sickness behavior are Janus-faced responses to shared inflammatory pathways
- (2012) Michael Maes et al. BMC Medicine
- A meta-analysis of differences in IL-6 and IL-10 between people with and without depression: Exploring the causes of heterogeneity
- (2012) Sarah A. Hiles et al. BRAIN BEHAVIOR AND IMMUNITY
- The role of immune genes in the association between depression and inflammation: A review of recent clinical studies
- (2012) Chiara Bufalino et al. BRAIN BEHAVIOR AND IMMUNITY
- Hitting a complex target: an update on interleukin-6 trans-signalling
- (2012) Georg H Waetzig et al. EXPERT OPINION ON THERAPEUTIC TARGETS
- Targeting IL-1 in depression
- (2012) Michael Maes et al. EXPERT OPINION ON THERAPEUTIC TARGETS
- Interleukin-6, a Major Cytokine in the Central Nervous System
- (2012) María Erta et al. International Journal of Biological Sciences
- Targeting Interleukin-6: All the Way to Treat Autoimmune and Inflammatory Diseases
- (2012) Toshio Tanaka et al. International Journal of Biological Sciences
- Effect of celecoxib add-on treatment on symptoms and serum IL-6 concentrations in patients with major depressive disorder: Randomized double-blind placebo-controlled study
- (2012) Seyed-Hesameddin Abbasi et al. JOURNAL OF AFFECTIVE DISORDERS
- Increased autoimmune responses against auto-epitopes modified by oxidative and nitrosative damage in depression: Implications for the pathways to chronic depression and neuroprogression
- (2012) Michael Maes et al. JOURNAL OF AFFECTIVE DISORDERS
- The IL6R variation Asp358Ala is a potential modifier of lung function in subjects with asthma
- (2012) Gregory A. Hawkins et al. JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY
- Brain indoleamine 2,3-dioxygenase contributes to the comorbidity of pain and depression
- (2012) Hyangin Kim et al. JOURNAL OF CLINICAL INVESTIGATION
- Tocilizumab Treatment Decreases Circulating Myeloid Dendritic Cells and Monocytes, 2 Components of the Myeloid Lineage
- (2012) C. RICHEZ et al. JOURNAL OF RHEUMATOLOGY
- Effects of fluoxetine, tianeptine and olanzapine on unpredictable chronic mild stress-induced depression-like behavior in mice
- (2012) Oguz Mutlu et al. LIFE SCIENCES
- Evidence for a differential role of HPA-axis function, inflammation and metabolic syndrome in melancholic versus atypical depression
- (2012) F Lamers et al. MOLECULAR PSYCHIATRY
- Phenelzine (Monoamine Oxidase Inhibitor) Increases Production of Nitric Oxide and Proinflammatory Cytokines via the NF-κB Pathway in Lipopolysaccharide-Activated Microglia Cells
- (2012) Hwan-Suck Chung et al. NEUROCHEMICAL RESEARCH
- Dopamine Agonists Upregulate IL-6 and IL-8 Production in Human Keratinocytes
- (2012) Andrea Cecilia Parrado et al. NEUROIMMUNOMODULATION
- Candidate Genes Expression Profile Associated with Antidepressants Response in the GENDEP Study: Differentiating between Baseline ‘Predictors’ and Longitudinal ‘Targets’
- (2012) Annamaria Cattaneo et al. NEUROPSYCHOPHARMACOLOGY
- Soluble Interleukin-6 Receptor Induces Motor Stereotypies and Co-Localizes with Gp130 in Regions Linked to Cortico-Striato-Thalamo-Cortical Circuits
- (2012) Ankur Patel et al. PLoS One
- CD4+CD25+ Regulatory T Cell Depletion Modulates Anxiety and Depression-Like Behaviors in Mice
- (2012) Soo-Jeong Kim et al. PLoS One
- Putative neuroprotective agents in neuropsychiatric disorders
- (2012) Seetal Dodd et al. PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY
- Serum concentrations of CRP, IL-6, TNF-α and cortisol in major depressive disorder with melancholic or atypical features
- (2012) Dalibor Karlović et al. PSYCHIATRY RESEARCH
- Interleukin-6, C-reactive protein and interleukin-10 after antidepressant treatment in people with depression: a meta-analysis
- (2012) S. A. Hiles et al. PSYCHOLOGICAL MEDICINE
- Influence of hypothalamic IL-6/gp130 receptor signaling on the HPA axis response to chronic stress
- (2012) Milena Girotti et al. PSYCHONEUROENDOCRINOLOGY
- Association of depressive disorders, depression characteristics and antidepressant medication with inflammation
- (2012) N Vogelzangs et al. Translational Psychiatry
- Evidence for sustained elevation of IL-6 in the CNS as a key contributor of depressive-like phenotypes
- (2012) S J Sukoff Rizzo et al. Translational Psychiatry
- New drug targets in depression: inflammatory, cell-mediated immune, oxidative and nitrosative stress, mitochondrial, antioxidant, and neuroprogressive pathways. And new drug candidates—Nrf2 activators and GSK-3 inhibitors
- (2012) Michael Maes et al. INFLAMMOPHARMACOLOGY
- The pro- and anti-inflammatory properties of the cytokine interleukin-6
- (2011) Jürgen Scheller et al. BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH
- An intermediate-risk multiple myeloma subgroup is defined by sIL-6r: levels synergistically increase with incidence of SNP rs2228145 and 1q21 amplification
- (2011) O. W. Stephens et al. BLOOD
- IL-6 signaling in autoimmunity, chronic inflammation and inflammation-associated cancer
- (2011) Markus F. Neurath et al. CYTOKINE & GROWTH FACTOR REVIEWS
- PROINFLAMMATORY AND “RESILIENCY” PROTEINS IN THE CSF OF PATIENTS WITH MAJOR DEPRESSION
- (2011) Jose M. Martinez et al. DEPRESSION AND ANXIETY
- Increased autoimmune activity against 5-HT: A key component of depression that is associated with inflammation and activation of cell-mediated immunity, and with severity and staging of depression
- (2011) Michael Maes et al. JOURNAL OF AFFECTIVE DISORDERS
- Interleukin (IL)-6, tumour necrosis factor alpha (TNF-α) and soluble interleukin-2 receptors (sIL-2R) are elevated in patients with major depressive disorder: A meta-analysis and meta-regression
- (2011) Yang Liu et al. JOURNAL OF AFFECTIVE DISORDERS
- Inhibition of Classic Signaling Is a Novel Function of Soluble Glycoprotein 130 (sgp130), Which Is Controlled by the Ratio of Interleukin 6 and Soluble Interleukin 6 Receptor
- (2011) Christoph Garbers et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Therapeutic strategies for the clinical blockade of IL-6/gp130 signaling
- (2011) Simon A. Jones et al. JOURNAL OF CLINICAL INVESTIGATION
- Constant Darkness Induces IL-6-Dependent Depression-Like Behavior through the NF- B Signaling Pathway
- (2011) F. J. Monje et al. JOURNAL OF NEUROSCIENCE
- Antidepressants and Neuroinflammation: Can Antidepressants Calm Glial Rage Down?
- (2011) S. Hashioka MINI-REVIEWS IN MEDICINAL CHEMISTRY
- The Effect of Antidepressant Medication Treatment on Serum Levels of Inflammatory Cytokines: A Meta-Analysis
- (2011) Jonas Hannestad et al. NEUROPSYCHOPHARMACOLOGY
- Mechanistic explanations how cell-mediated immune activation, inflammation and oxidative and nitrosative stress pathways and their sequels and concomitants play a role in the pathophysiology of unipolar depression
- (2011) Brian Leonard et al. NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS
- Role of cytokines in atypical depression
- (2011) Ho-Kyoung Yoon et al. NORDIC JOURNAL OF PSYCHIATRY
- Activation of cell-mediated immunity in depression: Association with inflammation, melancholia, clinical staging and the fatigue and somatic symptom cluster of depression
- (2011) Michael Maes et al. PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY
- Leptin and interleukin-6 alter the function of mesolimbic dopamine neurons in a rodent model of prenatal inflammation
- (2011) Argel Aguilar-Valles et al. PSYCHONEUROENDOCRINOLOGY
- Serum level of oxidative stress marker is dramatically low in patients with rheumatoid arthritis treated with tocilizumab
- (2011) Makoto Hirao et al. RHEUMATOLOGY INTERNATIONAL
- Increase in IL-6 levels among major depressive disorder patients after a 6-week treatment with duloxetine 60 mg/day: a preliminary observation
- (2011) Michele Fornaro et al. Neuropsychiatric Disease and Treatment
- Genome-Wide Pharmacogenetics of Antidepressant Response in the GENDEP Project
- (2010) Rudolf Uher et al. AMERICAN JOURNAL OF PSYCHIATRY
- Immune modulation of learning, memory, neural plasticity and neurogenesis
- (2010) Raz Yirmiya et al. BRAIN BEHAVIOR AND IMMUNITY
- Cytokine levels in the blood may distinguish suicide attempters from depressed patients
- (2010) Shorena Janelidze et al. BRAIN BEHAVIOR AND IMMUNITY
- Loss of CD4 + T Cell IL-6R Expression during Inflammation Underlines a Role for IL-6 Trans Signaling in the Local Maintenance of Th17 Cells
- (2010) Gareth W. Jones et al. JOURNAL OF IMMUNOLOGY
- Altered expression of genes involved in inflammation and apoptosis in frontal cortex in major depression
- (2010) R C Shelton et al. MOLECULAR PSYCHIATRY
- Pathways underlying neuroprogression in bipolar disorder: Focus on inflammation, oxidative stress and neurotrophic factors
- (2010) M. Berk et al. NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS
- Interleukin-6 Receptor Gene Polymorphism Modulates Interleukin-6 Levels and the Metabolic Syndrome: GBCS-CVD
- (2010) Chao Qiang Jiang et al. Obesity
- Interleukin 6 in autoimmune and inflammatory diseases: a personal memoir
- (2010) Toshio HIRANO PROCEEDINGS OF THE JAPAN ACADEMY SERIES B-PHYSICAL AND BIOLOGICAL SCIENCES
- In animal models, psychosocial stress-induced (neuro)inflammation, apoptosis and reduced neurogenesis are associated to the onset of depression
- (2010) Marta Kubera et al. PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY
- Effects of eicosapentaenoic acid and fluoxetine on plasma cortisol, serum interleukin-1beta and interleukin-6 concentrations in patients with major depressive disorder
- (2010) Shima Jazayeri et al. PSYCHIATRY RESEARCH
- Overnight Changes of Immune Parameters and Catecholamines Are Associated With Mood and Stress
- (2010) Winfried Rief et al. PSYCHOSOMATIC MEDICINE
- Interleukin-6 Is Elevated in the Cerebrospinal Fluid of Suicide Attempters and Related to Symptom Severity
- (2009) Daniel Lindqvist et al. BIOLOGICAL PSYCHIATRY
- A Meta-Analysis of Cytokines in Major Depression
- (2009) Yekta Dowlati et al. BIOLOGICAL PSYCHIATRY
- Dynamics of macrophage polarization reveal new mechanism to inhibit IL-1β release through pyrophosphates
- (2009) Pablo Pelegrin et al. EMBO JOURNAL
- Higher plasma interleukin-6 (IL-6) level is associated with SSRI- or SNRI-refractory depression
- (2009) Reiji Yoshimura et al. PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY
- Risk of postpartum depression in association with serum leptin and interleukin-6 levels at delivery: A nested case–control study within the UPPSAT cohort
- (2009) Alkistis Skalkidou et al. PSYCHONEUROENDOCRINOLOGY
- Associations of Depression With C-Reactive Protein, IL-1, and IL-6: A Meta-Analysis
- (2009) M Bryant Howren et al. PSYCHOSOMATIC MEDICINE
- IL-6 mediated alterations on immobile behavior of rats in the forced swim test via ERK1/2 activation in specific brain regions
- (2008) Tung-Huan Wu et al. BEHAVIOURAL BRAIN RESEARCH
- Mechanisms and pathologic significances in increase in serum interleukin-6 (IL-6) and soluble IL-6 receptor after administration of an anti-IL-6 receptor antibody, tocilizumab, in patients with rheumatoid arthritis and Castleman disease
- (2008) N. Nishimoto et al. BLOOD
- CD4 T cells: fates, functions, and faults
- (2008) J. Zhu et al. BLOOD
- Structure-guided Optimization of the Interleukin-6 Trans-signaling Antagonist sgp130
- (2008) Stephanie Tenhumberg et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- IL-6 transsignalling modulates the early effector phase of EAE and targets the blood-brain barrier
- (2008) Ralf A. Linker et al. JOURNAL OF NEUROIMMUNOLOGY
- The inflammatory & neurodegenerative (I&ND) hypothesis of depression: leads for future research and new drug developments in depression
- (2008) Michael Maes et al. METABOLIC BRAIN DISEASE
- Functional polymorphisms in the interleukin-6 and serotonin transporter genes and depression and fatigue induced by interferon-α and ribavirin treatment
- (2008) S J Bull et al. MOLECULAR PSYCHIATRY
- Immune challenge induces differential corticosterone and interleukin-6 responsiveness in rats bred for extremes in anxiety-related behavior
- (2008) N. Salome et al. NEUROSCIENCE
- Common Genetic Contributions to Depressive Symptoms and Inflammatory Markers in Middle-Aged Men: The Twins Heart Study
- (2008) Shaoyong Su et al. PSYCHOSOMATIC MEDICINE
Find the ideal target journal for your manuscript
Explore over 38,000 international journals covering a vast array of academic fields.
SearchCreate your own webinar
Interested in hosting your own webinar? Check the schedule and propose your idea to the Peeref Content Team.
Create Now