Depression and sickness behavior are Janus-faced responses to shared inflammatory pathways

Evolutionary medicine and chronic inflammatory state—known and new concepts in pathophysiology

(2012) Rainer H. Straub   JOURNAL OF MOLECULAR MEDICINE-JMM

Biological underpinnings of the commonalities in depression, somatization, and Chronic Fatigue Syndrome

(2012) George Anderson et al.   MEDICAL HYPOTHESES

New drug targets in depression: inflammatory, cell-mediated immune, oxidative and nitrosative stress, mitochondrial, antioxidant, and neuroprogressive pathways. And new drug candidates—Nrf2 activators and GSK-3 inhibitors

(2012) Michael Maes et al.   INFLAMMOPHARMACOLOGY

HIV infection and psychiatric illness

(2011) MB Owe-Larsson et al.   African Journal of Psychiatry

Seasonality patterns in postpartum depression

(2011) Sara M. Sylvén et al.   AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY

Calorie restriction attenuates LPS-induced sickness behavior and shifts hypothalamic signaling pathways to an anti-inflammatory bias

(2011) Leah MacDonald et al.   AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY

Proinflammatory activity and the sensitization of depressive-like behavior during maternal separation.

(2011) Michael B. Hennessy et al.   BEHAVIORAL NEUROSCIENCE

Does stage of illness impact treatment response in bipolar disorder? Empirical treatment data and their implication for the staging model and early intervention

(2011) Michael Berk et al.   BIPOLAR DISORDERS

Plasma kynurenine levels are elevated in suicide attempters with major depressive disorder

(2011) M. Elizabeth Sublette et al.   BRAIN BEHAVIOR AND IMMUNITY

Inflammatory and Neurodegenerative Pathways in Depression: A New Avenue for Antidepressant Development?

(2011) M. Catena-Dell'Osso et al.   CURRENT MEDICINAL CHEMISTRY

IgM-mediated autoimmune responses directed against multiple neoepitopes in depression: New pathways that underpin the inflammatory and neuroprogressive pathophysiology

(2011) Michael Maes et al.   JOURNAL OF AFFECTIVE DISORDERS

Increased autoimmune activity against 5-HT: A key component of depression that is associated with inflammation and activation of cell-mediated immunity, and with severity and staging of depression

(2011) Michael Maes et al.   JOURNAL OF AFFECTIVE DISORDERS

Interleukin (IL)-6, tumour necrosis factor alpha (TNF-α) and soluble interleukin-2 receptors (sIL-2R) are elevated in patients with major depressive disorder: A meta-analysis and meta-regression

(2011) Yang Liu et al.   JOURNAL OF AFFECTIVE DISORDERS

Inhibition of interleukin-6 trans-signaling in the brain facilitates recovery from lipopolysaccharide-induced sickness behavior

(2011) Michael D Burton et al.   Journal of Neuroinflammation

Severe depression is associated with increased microglial quinolinic acid in subregions of the anterior cingulate gyrus: Evidence for an immune-modulated glutamatergic neurotransmission?

(2011) Johann Steiner et al.   Journal of Neuroinflammation

Inflammation-Induced Lethargy Is Mediated by Suppression of Orexin Neuron Activity

(2011) A. J. Grossberg et al.   JOURNAL OF NEUROSCIENCE

 -Adrenergic Receptor Antagonism Prevents Anxiety-Like Behavior and Microglial Reactivity Induced by Repeated Social Defeat

(2011) E. S. Wohleb et al.   JOURNAL OF NEUROSCIENCE

The Effect of Antidepressant Medication Treatment on Serum Levels of Inflammatory Cytokines: A Meta-Analysis

(2011) Jonas Hannestad et al.   NEUROPSYCHOPHARMACOLOGY

Inflammatory stimuli reduce survival of serotonergic neurons and induce neuronal expression of indoleamine 2,3-dioxygenase in rat dorsal raphe nucleus organotypic brain slices

(2011) T. Hochstrasser et al.   NEUROSCIENCE

Mechanistic explanations how cell-mediated immune activation, inflammation and oxidative and nitrosative stress pathways and their sequels and concomitants play a role in the pathophysiology of unipolar depression

(2011) Brian Leonard et al.   NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS

Activation of cell-mediated immunity in depression: Association with inflammation, melancholia, clinical staging and the fatigue and somatic symptom cluster of depression

(2011) Michael Maes et al.   PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY

Linking the cytokine and neurocircuitry hypotheses of depression: A translational framework for discovery and development of novel anti-depressants

(2010) Timothy M. Piser   BRAIN BEHAVIOR AND IMMUNITY

Ascending caudal medullary catecholamine pathways drive sickness-induced deficits in exploratory behavior: Brain substrates for fatigue?

(2010) Ronald P.A. Gaykema et al.   BRAIN BEHAVIOR AND IMMUNITY

Inflammation 2010: New Adventures of an Old Flame

(2010) Ruslan Medzhitov   CELL

The possible role of the kynurenine pathway in adolescent depression with melancholic features

(2010) Vilma Gabbay et al.   JOURNAL OF CHILD PSYCHOLOGY AND PSYCHIATRY

Pathways underlying neuroprogression in bipolar disorder: Focus on inflammation, oxidative stress and neurotrophic factors

(2010) M. Berk et al.   NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS

Evidence for a key role of the peripheral kynurenine pathway in the modulation of anxiety- and depression-like behaviours in mice: Focus on individual differences

(2010) Anthony Laugeray et al.   PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR

The association between serum levels of neopterin and number of depressive episodes of major depression

(2010) Cemil Celik et al.   PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY

Cytokines mediated inflammation and decreased neurogenesis in animal models of depression

(2010) Cai Song et al.   PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY

An intriguing and hitherto unexplained co-occurrence: Depression and chronic fatigue syndrome are manifestations of shared inflammatory, oxidative and nitrosative (IO&NS) pathways

(2010) Michael Maes   PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY

The new ‘5-HT’ hypothesis of depression: Cell-mediated immune activation induces indoleamine 2,3-dioxygenase, which leads to lower plasma tryptophan and an increased synthesis of detrimental tryptophan catabolites (TRYCATs), both of which contribute to the onset of depression

(2010) M. Maes et al.   PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY

A review on the oxidative and nitrosative stress (O&NS) pathways in major depression and their possible contribution to the (neuro)degenerative processes in that illness

(2010) Michael Maes et al.   PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY

In animal models, psychosocial stress-induced (neuro)inflammation, apoptosis and reduced neurogenesis are associated to the onset of depression

(2010) Marta Kubera et al.   PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY

Depression is an inflammatory disease, but cell-mediated immune activation is the key component of depression

(2010) Michael Maes   PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY

Differences in the relative involvement of peripherally released interleukin (IL)-6, brain IL-1β and prostanoids in mediating lipopolysaccharide-induced fever and sickness behavior

(2010) Lois M. Harden et al.   PSYCHONEUROENDOCRINOLOGY

Psychiatric Comorbidity and Other Psychological Factors in Patients with “Chronic Lyme Disease”

(2009) Afton L. Hassett et al.   AMERICAN JOURNAL OF MEDICINE

The functional neuroanatomy of depression: Distinct roles for ventromedial and dorsolateral prefrontal cortex

(2009) Michael Koenigs et al.   BEHAVIOURAL BRAIN RESEARCH

Inflammation Causes Mood Changes Through Alterations in Subgenual Cingulate Activity and Mesolimbic Connectivity

(2009) Neil A. Harrison et al.   BIOLOGICAL PSYCHIATRY

A Meta-Analysis of Cytokines in Major Depression

(2009) Yekta Dowlati et al.   BIOLOGICAL PSYCHIATRY

Resting energy expenditure in manic episode

(2009) Okan Caliyurt et al.   BIPOLAR DISORDERS

Lipopolysaccharide challenge-induced suppression of Fos in hypothalamic orexin neurons: Their potential role in sickness behavior

(2009) Ronald P.A. Gaykema et al.   BRAIN BEHAVIOR AND IMMUNITY

Cytokine Regulation of AMPK signalling

(2009) Gregory et al.   Frontiers in Bioscience-Landmark

Effect of short term calorie restriction on pro-inflammatory NF-kB and AP-1 in aged rat kidney

(2009) K. J. Jung et al.   INFLAMMATION RESEARCH

Predictors of mortality in beta-hemolytic streptococcal bacteremia: A population-based study

(2009) Sari Rantala et al.   JOURNAL OF INFECTION

Reductions of acetylcholine release and nerve growth factor expression are correlated with memory impairment induced by interleukin-1β administrations: effects of omega-3 fatty acid EPA treatment

(2009) Pornnarin Taepavarapruk et al.   JOURNAL OF NEUROCHEMISTRY

Interferon-  and Tumor Necrosis Factor-  Mediate the Upregulation of Indoleamine 2,3-Dioxygenase and the Induction of Depressive-Like Behavior in Mice in Response to Bacillus Calmette-Guerin

(2009) J. C. O'Connor et al.   JOURNAL OF NEUROSCIENCE

Viral Infection Leading to Brain Dysfunction: More Prevalent Than Appreciated?

(2009) Anthony N. van den Pol   NEURON

Associations of Depression With C-Reactive Protein, IL-1, and IL-6: A Meta-Analysis

(2009) M Bryant Howren et al.   PSYCHOSOMATIC MEDICINE

Toxic Effects of Depression on Brain Function: Impairment of Delayed Recall and the Cumulative Length of Depressive Disorder in a Large Sample of Depressed Outpatients

(2008) Philip Gorwood et al.   AMERICAN JOURNAL OF PSYCHIATRY

How does immune challenge inhibit ingestion of palatable food? Evidence that systemic lipopolysaccharide treatment modulates key nodal points of feeding neurocircuitry

(2008) Su-Mi Park et al.   BRAIN BEHAVIOR AND IMMUNITY

Brain structural and functional abnormalities in mood disorders: implications for neurocircuitry models of depression

(2008) Wayne C. Drevets et al.   Brain Structure & Function

Severity of depressive episodes during the course of depressive disorder

(2008) Lars Vedel Kessing   BRITISH JOURNAL OF PSYCHIATRY

Brain-derived neurotrophic factor and inflammatory markers in patients with early- vs. late-stage bipolar disorder

(2008) Marcia Kauer-Sant'Anna et al.   INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY

Calorie Restriction Modulates Inactivity-Induced Changes in the Inflammatory Markers C-Reactive Protein and Pentraxin-3

(2008) Alessandra Bosutti et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Cytokine Mechanisms of Central Sensitization: Distinct and Overlapping Role of Interleukin-1 , Interleukin-6, and Tumor Necrosis Factor-  in Regulating Synaptic and Neuronal Activity in the Superficial Spinal Cord

(2008) Y. Kawasaki et al.   JOURNAL OF NEUROSCIENCE

Medically unexplained symptoms, somatisation disorder and hypochondriasis: Course and prognosis. A systematic review

(2008) Tim C. olde Hartman et al.   JOURNAL OF PSYCHOSOMATIC RESEARCH

The inflammatory & neurodegenerative (I&ND) hypothesis of depression: leads for future research and new drug developments in depression

(2008) Michael Maes et al.   METABOLIC BRAIN DISEASE

Inhibition of peripheral TNF can block the malaise associated with CNS inflammatory diseases

(2008) Y. Jiang et al.   NEUROBIOLOGY OF DISEASE

Depression and Bone Metabolism

(2008) Lana J. Williams et al.   PSYCHOTHERAPY AND PSYCHOSOMATICS

From inflammation to sickness and depression: when the immune system subjugates the brain

(2007) Robert Dantzer et al.   NATURE REVIEWS NEUROSCIENCE

Exaggerated sickness behavior and brain proinflammatory cytokine expression in aged mice in response to intracerebroventricular lipopolysaccharide

(2007) Y. Huang et al.   NEUROBIOLOGY OF AGING

Lipopolysaccharide suppresses activation of the tuberomammillary histaminergic system concomitant with behavior: A novel target of immune-sensory pathways

(2007) R.P.A. Gaykema et al.   NEUROSCIENCE

Allostatic load in bipolar disorder: Implications for pathophysiology and treatment

(2007) Flavio Kapczinski et al.   NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS