Contributions of HIV-1 Nef to immune dysregulation in HIV-infected patients: a therapeutic target?

Nanobodies: Natural Single-Domain Antibodies

(2013) Serge Muyldermans   Annual Review of Biochemistry

Effector Kinase Coupling Enables High-Throughput Screens for Direct HIV-1 Nef Antagonists with Antiretroviral Activity

(2013) Lori A. Emert-Sedlak et al.   CHEMISTRY & BIOLOGY

Exosomes Derived from HIV-1-infected Cells Contain Trans-activation Response Element RNA

(2013) Aarthi Narayanan et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Comparative Proteomic Analysis of HIV-1 Particles Reveals a Role for Ezrin and EHD4 in the Nef-Dependent Increase of Virus Infectivity

(2013) C. Bregnard et al.   JOURNAL OF VIROLOGY

Talk of HIV cure goes viral

(2013) David Holmes   LANCET INFECTIOUS DISEASES

HIV Nef, Paxillin, and Pak1/2 Regulate Activation and Secretion of TACE/ADAM10 Proteases

(2013) Jung-Hyun Lee et al.   MOLECULAR CELL

Attenuation of multiple Nef functions in HIV-1 elite controllers

(2013) Philip Mwimanzi et al.   Retrovirology

Binding of HIV-1 gp120 to DC-SIGN Promotes ASK-1-Dependent Activation-Induced Apoptosis of Human Dendritic Cells

(2013) Yongxiong Chen et al.   PLoS Pathogens

Post-Treatment HIV-1 Controllers with a Long-Term Virological Remission after the Interruption of Early Initiated Antiretroviral Therapy ANRS VISCONTI Study

(2013) Asier Sáez-Cirión et al.   PLoS Pathogens

Overview of the Current State of the Epidemic

(2013) Catherine Hankins   Current HIV/AIDS Reports

Mucosal Transmission of Human Immunodeficiency Virus

(2012) Denis M. Tebit et al.   CURRENT HIV RESEARCH

DC-SIGN Antagonists, a Potential New Class of Anti-Infectives

(2012) M. Anderluh et al.   CURRENT MEDICINAL CHEMISTRY

HIV-1 Antiretroviral Resistance

(2012) Michele W. Tang et al.   DRUGS

Targets for Inhibition of HIV Replication: Entry, Enzyme Action, Release and Maturation

(2012) Saleta Sierra et al.   INTERVIROLOGY

Single-Domain Antibody-SH3 Fusions for Efficient Neutralization of HIV-1 Nef Functions

(2012) J. Bouchet et al.   JOURNAL OF VIROLOGY

Nef Alleles from All Major HIV-1 Clades Activate Src-Family Kinases and Enhance HIV-1 Replication in an Inhibitor-Sensitive Manner

(2012) Purushottam S. Narute et al.   PLoS One

Identification of a highly conserved valine-glycine-phenylalanine amino acid triplet required for HIV-1 Nef function

(2012) Pieter J Meuwissen et al.   Retrovirology

Siglec-1 Is a Novel Dendritic Cell Receptor That Mediates HIV-1 Trans-Infection Through Recognition of Viral Membrane Gangliosides

(2012) Nuria Izquierdo-Useros et al.   PLOS BIOLOGY

Projected life expectancy of people with HIV according to timing of diagnosis

(2011) Fumiyo Nakagawa et al.   AIDS

Immune reconstitution under antiretroviral therapy: the new challenge in HIV-1 infection

(2011) P. Corbeau et al.   BLOOD

HIV-1 Nef compensates for disorganization of the immunological synapse by inducing trans-Golgi network-associated Lck signaling

(2011) X. Pan et al.   BLOOD

Inhibition of the Nef regulatory protein of HIV-1 by a single-domain antibody

(2011) J. Bouchet et al.   BLOOD

Clinical Utility of Maraviroc

(2011) Jorge Parra et al.   CLINICAL DRUG INVESTIGATION

HIV-1 Nef Protein Visits B-Cells via Macrophage Nanotubes: A Mechanism for AIDS-Related Lymphoma Pathogenesis?

(2011) Susanna L. Lamers et al.   CURRENT HIV RESEARCH

Nef Surfaces: Where to Interfere with Function

(2011) Sebastian Lulf et al.   CURRENT HIV RESEARCH

One Protein to Rule them All: Modulation of Cell Surface Receptors and Molecules by HIV Nef

(2011) Alessia Landi et al.   CURRENT HIV RESEARCH

The Nef-Infectivity Enigma: Mechanisms of Enhanced Lentiviral Infection

(2011) Jolien Vermeire et al.   CURRENT HIV RESEARCH

HIV-1 Nef Disrupts Intracellular Trafficking of Major Histocompatibility Complex Class I, CD4, CD8, and CD28 by Distinct Pathways That Share Common Elements

(2011) J. A. Leonard et al.   JOURNAL OF VIROLOGY

Secretion Modification Region-Derived Peptide Disrupts HIV-1 Nef's Interaction with Mortalin and Blocks Virus and Nef Exosome Release

(2011) M. N. Shelton et al.   JOURNAL OF VIROLOGY

Molecular Design, Functional Characterization and Structural Basis of a Protein Inhibitor Against the HIV-1 Pathogenicity Factor Nef

(2011) Sebastian Breuer et al.   PLoS One

The Identification of a Small Molecule Compound That Reduces HIV-1 Nef-Mediated Viral Infectivity Enhancement

(2011) Nopporn Chutiwitoonchai et al.   PLoS One

HIV-mediated up-regulation of invariant chain (CD74) correlates with generalized immune activation in HIV+ subjects

(2011) Yanina Ghiglione et al.   VIRUS RESEARCH

How HIV Takes Advantage of the Cytoskeleton in Entry and Replication

(2011) Bettina Stolp et al.   Viruses-Basel

The Sydney Blood Bank Cohort: implications for viral fitness as a cause of elite control

(2011) John Zaunders et al.   Current Opinion in HIV and AIDS

Evidence for the cure of HIV infection by CCR5 32/ 32 stem cell transplantation

(2010) K. Allers et al.   BLOOD

Nef does not inhibit F-actin remodelling and HIV-1 cell–cell transmission at the T lymphocyte virological synapse

(2010) Claudia Haller et al.   EUROPEAN JOURNAL OF CELL BIOLOGY

HIV-1 Nef Triggers Macrophage Fusion in a p61Hck- and Protease-Dependent Manner

(2010) C. Verollet et al.   JOURNAL OF IMMUNOLOGY

Small Molecule Inhibition of HIV-1–Induced MHC-I Down-Regulation Identifies a Temporally Regulated Switch in Nef Action

(2010) Jimmy D. Dikeakos et al.   MOLECULAR BIOLOGY OF THE CELL

Chemical Library Screens Targeting an HIV-1 Accessory Factor/Host Cell Kinase Complex Identify Novel Antiretroviral Compounds

(2009) Lori Emert-Sedlak et al.   ACS Chemical Biology

Drug-induced lipotoxicity: Lipodystrophy associated with HIV-1 infection and antiretroviral treatment

(2009) Francesc Villarroya et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS

Massive Secretion by T Cells Is Caused by HIV Nef in Infected Cells and by Nef Transfer to Bystander Cells

(2009) Claudia Muratori et al.   Cell Host & Microbe

HIV-1 Nef Interferes with Host Cell Motility by Deregulation of Cofilin

(2009) Bettina Stolp et al.   Cell Host & Microbe

Dys-regulated activation of a Src tyroine kinase Hck at the Golgi disturbsN-glycosylation of a cytokine receptor Fms

(2009) Ranya Hassan et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Simultaneous Cell-to-Cell Transmission of Human Immunodeficiency Virus to Multiple Targets through Polysynapses

(2009) D. Rudnicka et al.   JOURNAL OF VIROLOGY

HIV-1 evades virus-specific IgG2 and IgA responses by targeting systemic and intestinal B cells via long-range intercellular conduits

(2009) Weifeng Xu et al.   NATURE IMMUNOLOGY

The nephrotoxic effects of HAART

(2009) Hassane Izzedine et al.   Nature Reviews Nephrology

HIV interactions with monocytes and dendritic cells: viral latency and reservoirs

(2009) Christopher M Coleman et al.   Retrovirology

HIV Nef is Secreted in Exosomes and Triggers Apoptosis in Bystander CD4+ T Cells

(2009) Metka Lenassi et al.   TRAFFIC

Cell Biology of HIV-1 Infection of Macrophages

(2008) Carol A. Carter et al.   Annual Review of Microbiology

Evidence for a Pathogenic Determinant in HIV-1 Nef Involved in B Cell Dysfunction in HIV/AIDS

(2008) Simon Swingler et al.   Cell Host & Microbe

HIV Nef: Role in Pathogenesis and Viral Fitness

(2008) Kevin Arien et al.   CURRENT HIV RESEARCH

Mechanisms of HIV non-progression; robust and sustained CD4+ T-cell proliferative responses to p24 antigen correlate with control of viraemia and lack of disease progression after long-term transfusion-acquired HIV-1 infection

(2008) Wayne B Dyer et al.   Retrovirology