Impact of transporters and enzymes from blood–cerebrospinal fluid barrier and brain parenchyma on CNS drug uptake

Molecular anatomy and functions of the choroidal blood-cerebrospinal fluid barrier in health and disease

(2018) Jean-François Ghersi-Egea et al.   ACTA NEUROPATHOLOGICA

The role of brain barriers in fluid movement in the CNS: is there a ‘glymphatic’ system?

(2018) N. Joan Abbott et al.   ACTA NEUROPATHOLOGICA

Mouse models of SLC4-linked disorders of HCO3−-transporter dysfunction

(2018) Mark D. Parker   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

The affinity of transthyretin for T 3 or T 4 does not determine which form of the hormone accumulates in the choroid plexus

(2018) Samantha J. Richardson et al.   GENERAL AND COMPARATIVE ENDOCRINOLOGY

Strategies for Enhancing the Permeation of CNS-Active Drugs through the Blood-Brain Barrier: A Review

(2018) Isra’ Zeiadeh et al.   MOLECULES

The choroid plexus as a sex hormone target: Functional implications

(2017) Cecília R.A. Santos et al.   FRONTIERS IN NEUROENDOCRINOLOGY

Role of LRP1 in the pathogenesis of Alzheimer’s disease: evidence from clinical and preclinical studies

(2017) Mitsuru Shinohara et al.   JOURNAL OF LIPID RESEARCH

Multiple blood-brain barrier transport mechanisms limit bumetanide accumulation, and therapeutic potential, in the mammalian brain

(2017) Kerstin Römermann et al.   NEUROPHARMACOLOGY

Gender-specific expression of ATP-binding cassette ( Abc ) transporters and cytoprotective genes in mouse choroid plexus

(2017) Katiria Flores et al.   TOXICOLOGY

Glial Cells and Their Function in the Adult Brain: A Journey through the History of Their Ablation

(2017) Sarah Jäkel et al.   Frontiers in Cellular Neuroscience

Potential Pathways for CNS Drug Delivery Across the Blood-Cerebrospinal Fluid Barrier

(2016) Nathalie Strazielle et al.   CURRENT PHARMACEUTICAL DESIGN

Glucose Transporters at the Blood-Brain Barrier: Function, Regulation and Gateways for Drug Delivery

(2016) Simon G. Patching   MOLECULAR NEUROBIOLOGY

The astrocytic transporter SLC7A10 (Asc-1) mediates glycinergic inhibition of spinal cord motor neurons

(2016) Jeffrey T. Ehmsen et al.   Scientific Reports

The alanine-serine-cysteine-1 (Asc-1) transporter controls glycine levels in the brain and is required for glycinergic inhibitory transmission

(2015) H. Safory et al.   EMBO REPORTS

A balanced view of choroid plexus structure and function: Focus on adult humans

(2015) Reynold Spector et al.   EXPERIMENTAL NEUROLOGY

Immunohistochemical analysis of transporters related to clearance of amyloid-β peptides through blood–cerebrospinal fluid barrier in human brain

(2015) Koichi Matsumoto et al.   HISTOCHEMISTRY AND CELL BIOLOGY

Quantitative targeted absolute proteomics of rat blood-cerebrospinal fluid barrier transporters: comparison with a human specimen

(2015) Yasuo Uchida et al.   JOURNAL OF NEUROCHEMISTRY

Neuroprotective effects of levetiracetam target xCT in astrocytes in parkinsonian mice

(2015) Ikuko Miyazaki et al.   JOURNAL OF NEUROCHEMISTRY

Choroid plexus–CSF system

(2015) Eduardo E. Benarroch   NEUROLOGY

Acute hypoglycemia results in reduced cortical neuronal injury in the developing IUGR rat

(2015) Anne M. Maliszewski-Hall et al.   PEDIATRIC RESEARCH

Disruption of Slc4a10 augments neuronal excitability and modulates synaptic short-term plasticity

(2015) Anne Sinning et al.   Frontiers in Cellular Neuroscience

Transport of thyroid hormones via the choroid plexus into the brain: the roles of transthyretin and thyroid hormone transmembrane transporters

(2015) Samantha J. Richardson et al.   Frontiers in Neuroscience

Insulin Regulates the Activity of the High-Affinity Choline Transporter CHT

(2015) Katherine J. Fishwick et al.   PLoS One

Expression and Function of Organic Cation and Anion Transporters (SLC22 Family) in the CNS

(2014) Christine Farthing et al.   CURRENT PHARMACEUTICAL DESIGN

Transporters at CNS Barrier Sites: Obstacles or Opportunities for Drug Delivery?

(2014) Lucy Sanchez-Covarrubias et al.   CURRENT PHARMACEUTICAL DESIGN

Distribution of the creatine transporter throughout the human brain reveals a spectrum of creatine transporter immunoreactivity

(2014) Matthew T.J. Lowe et al.   JOURNAL OF COMPARATIVE NEUROLOGY

Metabolism and functions of copper in brain

(2014) Ivo F. Scheiber et al.   PROGRESS IN NEUROBIOLOGY

Glucose transporter 3 is a rab11-dependent trafficking cargo and its transport to the cell surface is reduced in neurons of CAG140 Huntington’s disease mice

(2014) Hollis McClory et al.   Acta Neuropathologica Communications

Upregulation of zinc transporter 2 in the blood–CSF barrier following lead exposure

(2013) Xue Fu et al.   EXPERIMENTAL BIOLOGY AND MEDICINE

Blood–brain barrier structure and function and the challenges for CNS drug delivery

(2013) N. Joan Abbott   JOURNAL OF INHERITED METABOLIC DISEASE

Transporters of the blood–brain and blood–CSF interfaces in development and in the adult

(2013) Norman R. Saunders et al.   MOLECULAR ASPECTS OF MEDICINE

Physiology of Blood–Brain Interfaces in Relation to Brain Disposition of Small Compounds and Macromolecules

(2013) N. Strazielle et al.   MOLECULAR PHARMACEUTICS

The Pro-inflammatory Cytokine TNF-α Regulates the Activity and Expression of the Serotonin Transporter (SERT) in Astrocytes

(2013) Sandra Malynn et al.   NEUROCHEMICAL RESEARCH

Overview and introduction: The blood-brain barrier in health and disease

(2012) N. Joan Abbott et al.   EPILEPSIA

Role of the blood-cerebrospinal fluid barrier transporter as a cerebral clearance system for prostaglandin E2produced in the brain

(2012) Masanori Tachikawa et al.   JOURNAL OF NEUROCHEMISTRY

The Acetylcholinesterase Inhibitors Competitively Inhibited an Acetyl l-Carnitine Transport Through the Blood–Brain Barrier

(2012) Na-Young Lee et al.   NEUROCHEMICAL RESEARCH

Organic anion transport pathways in antiviral handling in choroid plexus in Oat1 (Slc22a6) and Oat3 (Slc22a8) deficient tissue

(2012) Megha A. Nagle et al.   NEUROSCIENCE LETTERS

Roles of organic anion/cation transporters at the blood–brain and blood–cerebrospinal fluid barriers involving uremic toxins

(2011) Ken-ichi Hosoya et al.   Clinical and Experimental Nephrology

Organic Anion Transporter 3 Mediates the Efflux Transport of an Amphipathic Organic Anion, Dehydroepiandrosterone Sulfate, across the Blood-Brain Barrier in Mice

(2011) M. Miyajima et al.   DRUG METABOLISM AND DISPOSITION

Amyloid-β peptide(1-40) elimination from cerebrospinal fluid involves low-density lipoprotein receptor-related protein 1 at the blood-cerebrospinal fluid barrier

(2011) Masachika Fujiyoshi et al.   JOURNAL OF NEUROCHEMISTRY

Quantitative targeted absolute proteomics of human blood-brain barrier transporters and receptors

(2011) Yasuo Uchida et al.   JOURNAL OF NEUROCHEMISTRY

Transcriptomic and Quantitative Proteomic Analysis of Transporters and Drug Metabolizing Enzymes in Freshly Isolated Human Brain Microvessels

(2011) Ramzi Shawahna et al.   MOLECULAR PHARMACEUTICS

Distribution of Glycylsarcosine and Cefadroxil among Cerebrospinal Fluid, Choroid Plexus, and Brain Parenchyma after Intracerebroventricular Injection is Markedly Different between Wild-Type and Pept2 Null Mice

(2010) David E Smith et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Developmental Expression of GLUT1 and GLUT3 Glucose Transporters in Rat Brain

(2010) Susan J. Vannucci   JOURNAL OF NEUROCHEMISTRY

Localization of Drug-Metabolizing Enzyme Activities to Blood-Brain Interfaces and Circumventricular Organs

(2010) J. F. Ghersi-Egea et al.   JOURNAL OF NEUROCHEMISTRY

Functional and immunocytochemical characterization of the creatine transporter in rat hippocampal neurons

(2010) Joanna R. Dodd et al.   JOURNAL OF NEUROCHEMISTRY

Blood−brain barrier transporters and response to CNS-active drugs

(2009) Bradley L. Urquhart et al.   EUROPEAN JOURNAL OF CLINICAL PHARMACOLOGY

Localization of zip1 and zip4 mRNA in the adult rat brain

(2009) Luisa Belloni-Olivi et al.   JOURNAL OF NEUROSCIENCE RESEARCH

Structure and function of the blood–brain barrier

(2009) N. Joan Abbott et al.   NEUROBIOLOGY OF DISEASE

ABC Transporter (P-gp/ABCB1, MRP1/ABCC1, BCRP/ABCG2) Expression in the Developing Human CNS

(2009) M. Daood et al.   NEUROPEDIATRICS

Disruption of Sodium Bicarbonate Transporter SLC4A10 in a Patient With Complex Partial Epilepsy and Mental Retardation

(2008) Christina A. Gurnett et al.   ARCHIVES OF NEUROLOGY

Role and Relevance of PEPT2 in Drug Disposition, Dynamics, and Toxicity

(2008) Mohamed A. Kamal et al.   Drug Metabolism and Pharmacokinetics

Differential expression of the multidrug resistance-related proteins ABCb1 and ABCc1 between blood-brain interfaces

(2008) Silvia Gazzin et al.   JOURNAL OF COMPARATIVE NEUROLOGY

The blood-cerebrospinal fluid barrier is a major pathway of cerebral creatinine clearance: involvement of transporter-mediated process

(2008) Masanori Tachikawa et al.   JOURNAL OF NEUROCHEMISTRY

Polymorphisms in the Drug Transporter Gene ABCB1 Predict Antidepressant Treatment Response in Depression

(2008) Manfred Uhr et al.   NEURON

Characterization of Copper Interactions with Alzheimer Amyloid β Peptides

(2003) Craig S. Atwood et al.   JOURNAL OF NEUROCHEMISTRY