An evaluation of the latestin vitrotools for drug metabolism studies
Published 2013 View Full Article
- Home
- Publications
- Publication Search
- Publication Details
Title
An evaluation of the latestin vitrotools for drug metabolism studies
Authors
Keywords
-
Journal
Expert Opinion on Drug Metabolism & Toxicology
Volume 10, Issue 1, Pages 103-119
Publisher
Informa Healthcare
Online
2013-11-09
DOI
10.1517/17425255.2014.857402
References
Ask authors/readers for more resources
Related references
Note: Only part of the references are listed.- Human Precision-Cut Liver Slices as an ex Vivo Model to Study Idiosyncratic Drug-Induced Liver Injury
- (2013) Mackenzie Hadi et al. CHEMICAL RESEARCH IN TOXICOLOGY
- Preclinical Antitumor Activity of Cabazitaxel, a Semisynthetic Taxane Active in Taxane-Resistant Tumors
- (2013) P. Vrignaud et al. CLINICAL CANCER RESEARCH
- Sandwich-cultured hepatocytes: utility forin vitroexploration of hepatobiliary drug disposition and drug-induced hepatotoxicity
- (2013) Tom De Bruyn et al. Expert Opinion on Drug Metabolism & Toxicology
- Prediction of Total Hepatic Clearance by Combining Metabolism, Transport, and Permeability Data in the In Vitro–In Vivo Extrapolation Methods: Emphasis on an Apparent Fraction Unbound in Liver for Drugs
- (2013) Patrick Poulin JOURNAL OF PHARMACEUTICAL SCIENCES
- A long-term three dimensional liver co-culture system for improved prediction of clinically relevant drug-induced hepatotoxicity
- (2013) Radina Kostadinova et al. TOXICOLOGY AND APPLIED PHARMACOLOGY
- Spheroid culture as a tool for creating 3D complex tissues
- (2013) Eelco Fennema et al. TRENDS IN BIOTECHNOLOGY
- In-vitro maintenance and functionality of primary renal tubules and their application in the study of relative renal toxicity of nephrotoxic drugs
- (2013) Jinsheng Xu et al. JOURNAL OF PHARMACOLOGICAL AND TOXICOLOGICAL METHODS
- Influence of a three-dimensional, microarray environment on human Cell culture in drug screening systems
- (2012) Luciana Meli et al. BIOMATERIALS
- The prediction of drug metabolism using scaffold-mediated enhancement of the induced cytochrome P450 activities in fibroblasts by hepatic transcriptional regulators
- (2012) Tsai-Shin Chiang et al. BIOMATERIALS
- Application of IVIVE and PBPK modeling in prospective prediction of clinical pharmacokinetics: strategy and approach during the drug discovery phase with four case studies
- (2012) Yuan Chen et al. BIOPHARMACEUTICS & DRUG DISPOSITION
- In vitro 3D human small intestinal villous model for drug permeability determination
- (2012) Jiajie Yu et al. BIOTECHNOLOGY AND BIOENGINEERING
- Mouse Precision-Cut Liver Slices as an ex Vivo Model To Study Idiosyncratic Drug-Induced Liver Injury
- (2012) Mackenzie Hadi et al. CHEMICAL RESEARCH IN TOXICOLOGY
- In Vitro Methods to Study the Interplay of Drug Metabolism and Efflux in the Intestine
- (2012) Sanna Siissalo et al. CURRENT DRUG METABOLISM
- Precision-cut Intestinal Slices as In Vitro Tool for Studies on Drug Metabolism
- (2012) Geny M.M. Groothuis et al. CURRENT DRUG METABOLISM
- Application of PBPK modeling to predict human intestinal metabolism of CYP3A substrates – An evaluation and case study using GastroPlus™
- (2012) Aki T. Heikkinen et al. EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES
- Establishment of a triple co-culture in vitro cell models to study intestinal absorption of peptide drugs
- (2012) Filipa Antunes et al. EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS
- Computational Prediction of Metabolism: Sites, Products, SAR, P450 Enzyme Dynamics, and Mechanisms
- (2012) Johannes Kirchmair et al. Journal of Chemical Information and Modeling
- Generation of metabolically functioning hepatocytes from human pluripotent stem cells by FOXA2 and HNF1α transduction
- (2012) Kazuo Takayama et al. JOURNAL OF HEPATOLOGY
- Comparative Assessment of In Vitro–In Vivo Extrapolation Methods used for Predicting Hepatic Metabolic Clearance of Drugs
- (2012) Patrick Poulin et al. JOURNAL OF PHARMACEUTICAL SCIENCES
- A critical evaluation of in vitro cell culture models for high-throughput drug screening and toxicity
- (2012) Anna Astashkina et al. PHARMACOLOGY & THERAPEUTICS
- Hepatocyte-like cells differentiated from human induced pluripotent stem cells: Relevance to cellular therapies
- (2012) Yue Yu et al. Stem Cell Research
- The Adjuvant Use of Stromal Vascular Fraction and Platelet-Rich Fibrin for Autologous Adipose Tissue Transplantation
- (2012) Bin Liu et al. TISSUE ENGINEERING PART C-METHODS
- Inflammatory response modulation of airway epithelial cells exposed to formaldehyde
- (2012) Charles Persoz et al. TOXICOLOGY LETTERS
- Human induced pluripotent stem cells derived hepatocytes: rising promise for disease modeling, drug development and cell therapy
- (2012) Fei Yi et al. Protein & Cell
- In vitro models for liver toxicity testing
- (2012) Valerie Y. Soldatow et al. Toxicology Research
- Physiologically-Based Pharmacokinetics in Drug Development and Regulatory Science
- (2011) Malcolm Rowland et al. Annual Review of Pharmacology and Toxicology
- Rat Primary Hepatocytes Show Enhanced Performance and Sensitivity to Acetaminophen During Three-Dimensional Culture on a Polystyrene Scaffold Designed for Routine Use
- (2011) Maaike Schutte et al. ASSAY AND DRUG DEVELOPMENT TECHNOLOGIES
- Hydrogel embedding of precision-cut liver slices in a microfluidic device improves drug metabolic activity
- (2011) Paul M. van Midwoud et al. BIOTECHNOLOGY AND BIOENGINEERING
- PBPK Modeling of Intestinal and Liver Enzymes and Transporters in Drug Absorption and Sequential Metabolism
- (2011) Jianghong Fan et al. CURRENT DRUG METABOLISM
- Predicting Clearance in Humans from In Vitro Data
- (2011) R. Scott Obach CURRENT TOPICS IN MEDICINAL CHEMISTRY
- Effect of Culture Time on the Basal Expression Levels of Drug Transporters in Sandwich-Cultured Primary Rat Hepatocytes
- (2011) E. H. Tchaparian et al. DRUG METABOLISM AND DISPOSITION
- Culture Period-Dependent Changes in the Uptake of Transporter Substrates in Sandwich-Cultured Rat and Human Hepatocytes
- (2011) N. Kotani et al. DRUG METABOLISM AND DISPOSITION
- Time-course activities of Oct1, Mrp3, and cytochrome P450s in cultures of cryopreserved rat hepatocytes
- (2011) Jacob Kramer Jacobsen et al. EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES
- Human liver cell spheroids in extended perfusion bioreactor culture for repeated-dose drug testing
- (2011) Rui M. Tostões et al. HEPATOLOGY
- Effect of dispersants of multi-walled carbon nanotubes on cellular uptake and biological responses
- (2011) Hisao Haniu et al. International Journal of Nanomedicine
- Novel In Vitro-In Vivo Extrapolation (IVIVE) Method to Predict Hepatic Organ Clearance in Rat
- (2011) Ken-ichi Umehara et al. PHARMACEUTICAL RESEARCH
- Alginate: Properties and biomedical applications
- (2011) Kuen Yong Lee et al. PROGRESS IN POLYMER SCIENCE
- Alginate based 3D hydrogels as an in vitro co-culture model platform for the toxicity screening of new chemical entities
- (2011) Shih-Feng Lan et al. TOXICOLOGY AND APPLIED PHARMACOLOGY
- CYP1A1/1B1 and CYP2A6/2A13 activity is conserved in cultures of differentiated primary human tracheobronchial epithelial cells
- (2011) Nik Newland et al. TOXICOLOGY IN VITRO
- Merging bioreactor technology with 3D hepatocyte-fibroblast culturing approaches: Improved in vitro models for toxicological applications
- (2011) Sofia B. Leite et al. TOXICOLOGY IN VITRO
- In Silico Toxicology – Non-Testing Methods
- (2011) Hannu Raunio Frontiers in Pharmacology
- Therapeutic cell delivery and fate control in hydrogels and hydrogel hybrids☆
- (2010) Chunming Wang et al. ADVANCED DRUG DELIVERY REVIEWS
- Perfusion of 3D encapsulated hepatocytes-A synergistic effect enhancing long-term functionality in bioreactors
- (2010) Rui M. Tostões et al. BIOTECHNOLOGY AND BIOENGINEERING
- An in vitro triple cell co-culture model with primary cells mimicking the human alveolar epithelial barrier
- (2010) Andrea D. Lehmann et al. EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS
- Evaluation of drug toxicity with hepatocytes cultured in a micro-space cell culture system
- (2010) Kazuaki Nakamura et al. JOURNAL OF BIOSCIENCE AND BIOENGINEERING
- A microfluidic approach for in vitro assessment of interorgan interactions in drug metabolism using intestinal and liver slices
- (2010) Paul M. van Midwoud et al. LAB ON A CHIP
- Improved Extrapolation of Hepatobiliary Clearance fromin VitroSandwich Cultured Rat Hepatocytes through Absolute Quantification of Hepatobiliary Transporters
- (2010) Na Li et al. MOLECULAR PHARMACEUTICS
- Differentiation and Characterization of Metabolically Functioning Hepatocytes from Human Embryonic Stem Cells
- (2010) Yuyou Duan et al. STEM CELLS
- Tissue-Engineered Three-Dimensional In Vitro Models for Normal and Diseased Kidney
- (2010) Balajikarthick Subramanian et al. TISSUE ENGINEERING PART A
- Extending Hepatocyte Functionality for Drug-Testing Applications Using High-Viscosity Alginate–Encapsulated Three-Dimensional Cultures in Bioreactors
- (2010) Joana P. Miranda et al. TISSUE ENGINEERING PART C-METHODS
- Idiosyncratic Drug-Induced Liver Injury and the Role of Inflammatory Stress with an Emphasis on an Animal Model of Trovafloxacin Hepatotoxicity
- (2010) Patrick J. Shaw et al. TOXICOLOGICAL SCIENCES
- Mechanisms of Immune-Mediated Liver Injury
- (2010) David H. Adams et al. TOXICOLOGICAL SCIENCES
- Interference with Bile Salt Export Pump Function Is a Susceptibility Factor for Human Liver Injury in Drug Development
- (2010) Ryan E. Morgan et al. TOXICOLOGICAL SCIENCES
- Long-term cultivation of HepG2 liver cells encapsulated in alginate hydrogels: A study of cell viability, morphology and drug metabolism
- (2010) Shih-Feng Lan et al. TOXICOLOGY IN VITRO
- Chronic exposure to cigarette smoke condensate in vitro induces epithelial to mesenchymal transition-like changes in human bronchial epithelial cells, BEAS-2B
- (2010) Emilija Veljkovic et al. TOXICOLOGY IN VITRO
- Prediction of Hepatic Clearance in Human From In Vitro Data for Successful Drug Development
- (2009) Masato Chiba et al. AAPS Journal
- Modelling and PBPK Simulation in Drug Discovery
- (2009) Hannah M. Jones et al. AAPS Journal
- Hyaluronic acid-based hydrogels as 3D matrices for in vitro evaluation of chemotherapeutic drugs using poorly adherent prostate cancer cells
- (2009) Lisa A. Gurski et al. BIOMATERIALS
- Efficient generation of hepatocyte-like cells from human induced pluripotent stem cells
- (2009) Zhihua Song et al. CELL RESEARCH
- Serum-free collagen sandwich cultures of adult rat hepatocytes maintain liver-like properties long term: A valuable model for in vitro toxicity and drug–drug interaction studies
- (2009) Gregor Tuschl et al. CHEMICO-BIOLOGICAL INTERACTIONS
- Liver tissue engineering in the evaluation of drug safety
- (2009) Ajit Dash et al. Expert Opinion on Drug Metabolism & Toxicology
- A microfluidic 3D hepatocyte chip for drug toxicity testing
- (2009) Yi-Chin Toh et al. LAB ON A CHIP
- Study of the Crosstalk Between Hepatocytes and Endothelial Cells Using a Novel Multicompartmental Bioreactor: A Comparison Between Connected Cultures and Cocultures
- (2009) Maria Angela Guzzardi et al. TISSUE ENGINEERING PART A
- Recent advances in three-dimensional multicellular spheroid culture for biomedical research
- (2008) Ruei-Zhen Lin et al. Biotechnology Journal
- Biosimulation of drug metabolism—A yeast based model
- (2008) I. Pieper et al. EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES
- Intestinal efflux transporters and drug absorption
- (2008) Teruo Murakami et al. Expert Opinion on Drug Metabolism & Toxicology
- 3-D Tumor Model forIn VitroEvaluation of Anticancer Drugs
- (2008) Jayme L. Horning et al. MOLECULAR PHARMACEUTICS
- Highly efficient differentiation of hESCs to functional hepatic endoderm requires ActivinA and Wnt3a signaling
- (2008) D. C. Hay et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Efficient Differentiation of Functional Hepatocytes from Human Embryonic Stem Cells
- (2008) Sadhana Agarwal et al. STEM CELLS
- Efficient Differentiation of Hepatocytes from Human Embryonic Stem Cells Exhibiting Markers Recapitulating Liver Development In Vivo
- (2008) David C. Hay et al. STEM CELLS
- Mature Human Hepatocytes from Ex Vivo Differentiation of Alginate-Encapsulated Hepatoblasts
- (2008) Nancy Cheng et al. TISSUE ENGINEERING PART A
- Hyaluronan hydrogel: An appropriate three-dimensional model for evaluation of anticancer drug sensitivity
- (2007) Laurent David et al. Acta Biomaterialia
- Idiosyncratic Drug Reactions: Past, Present, and Future
- (2007) Jack Uetrecht CHEMICAL RESEARCH IN TOXICOLOGY
- Development and specification of physiologically based pharmacokinetic models for use in risk assessment
- (2007) Rebecca A. Clewell et al. REGULATORY TOXICOLOGY AND PHARMACOLOGY
Find Funding. Review Successful Grants.
Explore over 25,000 new funding opportunities and over 6,000,000 successful grants.
ExploreDiscover Peeref hubs
Discuss science. Find collaborators. Network.
Join a conversation