Impaired Notch-MKP-1 signalling in hidradenitis suppurativa: an approach to pathogenesis by evidence from translational biology

Cigarette Smoke-Induced Pulmonary Inflammation Is TLR4/MyD88 and IL-1R1/MyD88 Signaling Dependent

(2014) E. Doz et al.   JOURNAL OF IMMUNOLOGY

Acne Inversa: Evaluating Antimicrobial Peptides and Proteins

(2012) Falk G. Bechara et al.   Annals of Dermatology

A clinical-pathological review of hidradenitis suppurativa: using immunohistochemistry one disease becomes two

(2012) SILJE FISMEN et al.   APMIS

A novel splice site mutation inNCSTNunderlies a Japanese family with hidradenitis suppurativa

(2012) Y. Nomura et al.   BRITISH JOURNAL OF DERMATOLOGY

Impact of Toll-like receptor-4 and tumour necrosis factor gene polymorphisms in patients with hidradenitis suppurativa

(2012) A. Savva et al.   BRITISH JOURNAL OF DERMATOLOGY

Regulation of TH17 cell differentiation by innate immune signals

(2012) Gonghua Huang et al.   Cellular & Molecular Immunology

Tumor Necrosis Factor-α Signaling in Macrophages

(2012) Narayanan Parameswaran et al.   CRITICAL REVIEWS IN EUKARYOTIC GENE EXPRESSION

Hidradenitis suppurativa: viewpoint on clinical phenotyping, pathogenesis and novel treatments

(2012) Hessel H. van der Zee et al.   EXPERIMENTAL DERMATOLOGY

Is mechanical stress an important pathogenic factor in hidradenitis suppurativa?

(2012) Kim de Winter et al.   EXPERIMENTAL DERMATOLOGY

Notch Activation by the Metalloproteinase ADAM17 Regulates Myeloproliferation and Atopic Barrier Immunity by Suppressing Epithelial Cytokine Synthesis

(2012) Aditya Murthy et al.   IMMUNITY

Interleukin-1β Interferes with Epidermal Homeostasis through Induction of Insulin Resistance: Implications for Psoriasis Pathogenesis

(2012) Claudia Buerger et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

Nicastrin Mutations in French Families with Hidradenitis Suppurativa

(2012) Snaigune Miskinyte et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

Mutations in the γ-Secretase Genes NCSTN , PSENEN , and PSEN1 Underlie Rare Forms of Hidradenitis Suppurativa (Acne Inversa)

(2012) Andrew E. Pink et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

Saturated fatty acids activate TLR-mediated proinflammatory signaling pathways

(2012) Shurong Huang et al.   JOURNAL OF LIPID RESEARCH

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(2012) Fernando Souza-Fonseca-Guimaraes et al.   MOLECULAR MEDICINE

Signaling via the kinase p38α programs dendritic cells to drive TH17 differentiation and autoimmune inflammation

(2012) Gonghua Huang et al.   NATURE IMMUNOLOGY

Increased Prevalence of Metabolic Syndrome in Patients with Acne Inversa

(2012) Robert Sabat et al.   PLoS One

Etanercept attenuates short-term cigarette-smoke-exposure-induced pulmonary arterial remodelling in rats by suppressing the activation of TNF-α/NF-κB signal and the activities of MMP-2 and MMP-9

(2012) Hong Xue et al.   PULMONARY PHARMACOLOGY & THERAPEUTICS

Cigarette smoke induces the release of CXCL-8 from human bronchial epithelial cells via TLRs and induction of the inflammasome

(2011) E. Mortaz et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Th17 responses and host defense against microorganisms: an overview

(2011) Frank L. Van De Veerdonk et al.   BMB Reports

Two novel mutations of the nicastrin gene in Chinese patients with acne inversa

(2011) C.-R. Li et al.   BRITISH JOURNAL OF DERMATOLOGY

Hidradenitis suppurativa: a disease of the absent sebaceous gland? Sebaceous gland number and volume are significantly reduced in uninvolved hair follicles from patients with hidradenitis suppurativa

(2011) S. Kamp et al.   BRITISH JOURNAL OF DERMATOLOGY

Elevated levels of tumour necrosis factor (TNF)-α, interleukin (IL)-1β and IL-10 in hidradenitis suppurativa skin: a rationale for targeting TNF-α and IL-1β

(2011) H.H. van der Zee et al.   BRITISH JOURNAL OF DERMATOLOGY

Immunohistological pointers to a possible role for excessive cathelicidin (LL-37) expression by apocrine sweat glands in the pathogenesis of hidradenitis suppurativa/acne inversa

(2011) V.U. Emelianov et al.   BRITISH JOURNAL OF DERMATOLOGY

Unfolded Protein Response Signaling and MAP Kinase Pathways Underlie Pathogenesis of Arsenic-Induced Cutaneous Inflammation

(2011) C. Li et al.   Cancer Prevention Research

Cytokines present in smokers' serum interact with smoke components to enhance endothelial dysfunction

(2011) Silvia S. Barbieri et al.   CARDIOVASCULAR RESEARCH

A Role for the Primary Cilium in Notch Signaling and Epidermal Differentiation during Skin Development

(2011) Ellen J. Ezratty et al.   CELL

The disintegrin/metalloproteinase Adam10 is essential for epidermal integrity and Notch-mediated signaling

(2011) S. Weber et al.   DEVELOPMENT

Hedgehog pathway does not play a role in hidradenitis suppurativa pathogenesis

(2011) Elga Mozeika et al.   EXPERIMENTAL DERMATOLOGY

Tobacco smoke is related to Th17 generation with clinical implications for psoriasis patients

(2011) Kan Torii et al.   EXPERIMENTAL DERMATOLOGY

Toll-like receptor activation modulates antimicrobial peptide expression by ocular surface cells

(2011) Rachel L. Redfern et al.   EXPERIMENTAL EYE RESEARCH

Functional Specialization of Interleukin-17 Family Members

(2011) Yoichiro Iwakura et al.   IMMUNITY

Notch Signal Suppresses Toll-like Receptor-triggered Inflammatory Responses in Macrophages by Inhibiting Extracellular Signal-regulated Kinase 1/2-mediated Nuclear Factor κB Activation

(2011) Qinghua Zhang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

PSENEN and NCSTN Mutations in Familial Hidradenitis Suppurativa (Acne Inversa)

(2011) Andrew E. Pink et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

Confirmation by Exome Sequencing of the Pathogenic Role of NCSTN Mutations in Acne Inversa (Hidradenitis Suppurativa)

(2011) Yuan Liu et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

Expression of the IL-23/Th17 pathway in lesions of hidradenitis suppurativa

(2011) Christoph Schlapbach et al.   JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY

Expression of innate defense antimicrobial peptides in hidradenitis suppurativa

(2011) Silke C. Hofmann et al.   JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY

Notch3-mediated regulation of MKP-1 levels promotes survival of T acute lymphoblastic leukemia cells

(2011) M Masiero et al.   LEUKEMIA

Mitogen-activated protein kinase phosphatase (MKP)-1 in immunology, physiology, and disease

(2011) Lyn M. Wancket et al.   LIFE SCIENCES

Notch Signaling Regulates Late-Stage Epidermal Differentiation and Maintains Postnatal Hair Cycle Homeostasis

(2011) Hsien-Yi Lin et al.   PLoS One

Cigarette Smoke Synergizes Lipopolysaccharide-Induced InterIeukin-1β and Tumor Necrosis Factor–α Secretion from Macrophages via Substance P–Mediated Nuclear Factor–κB Activation

(2010) Junyang Xu et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

Functions of Notch Signaling in the Immune System: Consensus and Controversies

(2010) Julie S. Yuan et al.   Annual Review of Immunology

Emerging role of Notch signaling in epidermal differentiation and skin cancer

(2010) John Panelos et al.   CANCER BIOLOGY & THERAPY

Effects of active and passive smoking on Crohnʼs disease and ulcerative colitis in a cohort from a regional hospital

(2010) Frans van der Heide et al.   EUROPEAN JOURNAL OF GASTROENTEROLOGY & HEPATOLOGY

Up-regulation of TNF-alpha secretion by cigarette smoke is mediated by Egr-1 in HaCaT human keratinocytes

(2010) Sang Hoon Jeong et al.   EXPERIMENTAL DERMATOLOGY

Deficiency of IL-22 Contributes to a Chronic Inflammatory Disease: Pathogenetic Mechanisms in Acne Inversa

(2010) K. Wolk et al.   JOURNAL OF IMMUNOLOGY

Chronic exposure to nicotine and saquinavir decreases endothelial Notch-4 expression and disrupts blood-brain barrier integrity

(2010) Vamshi K. Manda et al.   JOURNAL OF NEUROCHEMISTRY

DAMPening Inflammation by Modulating TLR Signalling

(2010) A. M. Piccinini et al.   MEDIATORS OF INFLAMMATION

Release of Inflammatory Mediators by Human Adipose Tissue Is Enhanced in Obesity and Primarily by the Nonfat Cells: A Review

(2010) John N. Fain   MEDIATORS OF INFLAMMATION

Notch signaling drives IL-22 secretion in CD4+ T cells by stimulating the aryl hydrocarbon receptor

(2010) M. S. Alam et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

 -Secretase Gene Mutations in Familial Acne Inversa

(2010) B. Wang et al.   SCIENCE

Occlusion regulates epidermal cytokine production and inhibits scar formation

(2010) Corrie L. Gallant-Behm et al.   WOUND REPAIR AND REGENERATION

Regulation of JNK and p38 MAPK in the immune system: Signal integration, propagation and termination

(2009) Gonghua Huang et al.   CYTOKINE

Toll-like receptor signaling in cell proliferation and survival

(2009) Xinyan Li et al.   CYTOKINE

Notch signaling in bulge stem cells is not required for selection of hair follicle fate

(2009) S. Demehri et al.   DEVELOPMENT

Hidradenitis suppurativa (acne inversa): early inflammatory events at terminal follicles and at interfollicular epidermis*

(2009) Maximilian von Laffert et al.   EXPERIMENTAL DERMATOLOGY

Sebocytes, multifaceted epithelial cells: Lipid production and holocrine secretion

(2009) Marlon R. Schneider et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

Monocyte/macrophage androgen receptor suppresses cutaneous wound healing in mice by enhancing local TNF-α expression

(2009) Jiann-Jyh Lai et al.   JOURNAL OF CLINICAL INVESTIGATION

Increased Inflammation, Impaired Bacterial Clearance, and Metabolic Disruption after Gram-Negative Sepsis in Mkp-1-Deficient Mice

(2009) W. J. Frazier et al.   JOURNAL OF IMMUNOLOGY

Notch Activation Induces the Generation of Functional NK Cells from Human Cord Blood CD34-Positive Cells Devoid of IL-15

(2009) Kyoko Haraguchi et al.   JOURNAL OF IMMUNOLOGY

Hidradenitis suppurativa: A comprehensive review

(2009) Ali Alikhan et al.   JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY

Hidradenitis suppurativa and smoking

(2009) Thierry Simonart   JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY

Phosphorylation of IRS proteins, insulin action, and insulin resistance

(2008) Sigalit Boura-Halfon et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Down-regulation of the Notch Pathway in Human Airway Epithelium in Association with Smoking and Chronic Obstructive Pulmonary Disease

(2008) Ann E. Tilley et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Toll-like receptor 2 is highly expressed in lesions of acne inversa and colocalizes with C-type lectin receptor

(2008) R.E. Hunger et al.   BRITISH JOURNAL OF DERMATOLOGY

Epidermal Notch signalling: differentiation, cancer and adhesion

(2008) Fiona M Watt et al.   CURRENT OPINION IN CELL BIOLOGY

What causes hidradenitis suppurativa?

(2008) Lübeck Ralf Paus et al.   EXPERIMENTAL DERMATOLOGY

Arsenite Suppresses Notch1 Signaling in Human Keratinocytes

(2008) Tatiana V. Reznikova et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

Presenilins: Members of the γ-Secretase Quartets, But Part-Time Soloists Too

(2008) Tomoko Wakabayashi et al.   PHYSIOLOGY

Notch signaling: Its role in epidermal homeostasis and in the pathogenesis of skin diseases

(2007) Ryuhei Okuyama et al.   JOURNAL OF DERMATOLOGICAL SCIENCE