Article
Chemistry, Multidisciplinary
Tian-tian Wang, Ling-ling Wu, Jie Wu, Li-sheng Zhang, Wan-jun Shen, Ying-hua Zhao, Jiao-na Liu, Bo Fu, Xu Wang, Qing-gang Li, Xue-yuan Bai, Li-qiang Wang, Xiang-mei Chen
Summary: Acute kidney injury (AKI) is a group of clinical syndromes that may lead to chronic kidney disease (CKD), and the transcriptional coactivator YAP, as well as its regulatory protein 14-3-3 zeta, play important roles in the AKI-CKD transition.
ACTA PHARMACOLOGICA SINICA
(2023)
Article
Oncology
Chao Gao, Si-wei Wang, Jia-cheng Lu, Xiao-qiang Chai, Yuan-cheng Li, Peng-fei Zhang, Xiao-yong Huang, Jia-bin Cai, Yi-min Zheng, Xiao-jun Guo, Guo-ming Shi, Ai-wu Ke, Jia Fan
Summary: This study reveals the important role of KSR2 in the occurrence and development of HCC, and high expression of KSR2 is associated with poor prognosis. Mechanistically, the interaction between KSR2 and 14-3-3ζ plays a key role in the activation of the MAPK signaling pathway and drug resistance in HCC cells. Therefore, the KSR2-14-3-3ζ interaction may be a therapeutic target to enhance the sensitivity of HCC to sorafenib.
BIOMARKER RESEARCH
(2022)
Article
Immunology
Hongwei Tan, Jinping Li, Chunsen Jia, Haozhong Huang, Lei Li, Bin Liao, Yang Long, Yongmei Nie, Fengxu Yu
Summary: This study investigated the role of 14-3-3 protein and the Hippo/YAP signaling pathway in lipopolysaccharide (LPS)-induced vascular inflammation. Human umbilical vein endothelial cells (HUVECs) and C57B6 mice were used as models, and various techniques were employed to measure inflammatory factors and the expression of 14-3-3 protein and YAP phosphorylation. The results showed that downregulation of 14-3-3 protein in chronic vascular inflammation promotes inflammation by increasing Hippo/YAP nuclear translocation, and the YAP inhibitor Verteporfin can alleviate LPS-induced vascular inflammation.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Andrea Eisenreichova, Evzen Boura
Summary: This article reports the crystal structure of the complex formed by SARS-CoV-2 nucleocapsid protein and 14-3-3 protein, revealing the details of the binding. The study found that the N protein forms a complex with 14-3-3 protein through phosphorylation, and the central binding groove of 14-3-3 protein plays a key role. These findings enhance our understanding of the viral infection mechanism.
JOURNAL OF STRUCTURAL BIOLOGY
(2022)
Article
Fisheries
Rui Xue, Dinglong Yang, Yijing Han, Qinyou Deng, Xin Wang, Xiangquan Liu, Jianmin Zhao
Summary: The 14-3-3 zeta and 14-3-3 epsilon proteins play important roles in innate immunity against V. harveyi infection in mollusks, with their differential expression leading to different immune responses.
DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY
(2021)
Article
Neurosciences
Cuixian Li, Shen Huang, Jin Peng, Tianguo Hong, Chun Zhou, Jie Tang
Summary: In this study, a new cellular protein, 14-3-3 zeta, was found to interact with the beta subunit of GABA(A)Rs and BIG1, and co-localize with them in hippocampal neurons. Overexpression of 14-3-3 zeta increased the surface expression of BIG1 and its binding with GABA(A)R. Depletion of 14-3-3 zeta or BIG1 significantly decreased GABA(A)R expression at the cell surface and inhibited GABA-gated influx of chloride ions.
MOLECULAR NEUROBIOLOGY
(2023)
Article
Oncology
S. Breedy, W. S. Ratnayake, L. Lajmi, R. Hill, M. Acevedo-Duncan
Summary: Neuroblastoma is a common cancer in children under the age of 1 and has varying prognosis based on age and cell differentiation. Our study identified two protein kinase inhibitors with potential therapeutic effects against NB cells. These inhibitors induced cell apoptosis and inhibited EMT. The Akt1/NF-κB and TGF-β pathways were found to be regulated by aPKCs, and their association with 14-3-3 and Smad2/3 could be diminished by aPKC inhibitors. Both inhibitors show promise as neuroblastoma therapeutics and require further research.
FRONTIERS IN ONCOLOGY
(2023)
Article
Oncology
Ting Wang, Xue-Ying Huang, Su-Jun Zheng, Ye-Ying Liu, Si-Si Chen, Feng Ren, Jun Lu, Zhong-Ping Duan, Mei Liu
Summary: This study identified novel proteins in AFP-negative HCC and evaluated using autoantibodies for predicting hepatocarcinogenesis.
FRONTIERS IN ONCOLOGY
(2021)
Article
Medicine, Research & Experimental
Wenyu Fu, Wenhuo Hu, Young-Su Yi, Aubryanna Hettinghouse, Guodong Sun, Yufei Bi, Wenjun He, Lei Zhang, Guanmin Gao, Jody Liu, Kazuhito Toyo-oka, Guozhi Xiao, David B. Solit, Png Loke, Chuan-ju Liu
Summary: This study identified 14-3-3c as a crucial component of the TNFR2 receptor complex, playing a key role in regulating macrophage polarization and anti-inflammatory effects. Deletion of 14-3-3c exacerbated inflammatory arthritis and counteracted the protective effects of TNFR2 activation against inflammation and autoimmunity. TNFR2/14-3-3c signaling pathway restricts NF-KB activation while stimulating C/EBPp activation, influencing macrophage plasticity.
JOURNAL OF CLINICAL INVESTIGATION
(2021)
Article
Oncology
Mingda Zhao, Yibing Zhang, Longfei Li, Xiaobin Liu, Wenping Zhou, Chunhui Wang, Yufu Tang
Summary: Our study found that KHDRBS3 is highly expressed in human HCC tissues and predicts poor prognosis. Knockdown of KHDRBS3 inhibits tumor growth, reduces glycolysis, enhances sensitivity to doxorubicin, and induces apoptosis in HCC cells. On the contrary, overexpression of KHDRBS3 promotes malignant behavior. KHDRBS3 interacts with YWHAZ, and the promotion of proliferation and glycolysis and the inhibition of apoptosis caused by KHDRBS3 overexpression can be reversed by silencing 14-3-3ζ.
CANCER CELL INTERNATIONAL
(2023)
Article
Geriatrics & Gerontology
Yuanyuan Lu, Alzheimer's Dis Neuroimaging Initiat
Summary: This study revealed the potential diagnostic and prognostic utility of CSF 14-3-3ζ in the AD continuum. High 14-3-3ζ predicted conversion from MCI to AD and was associated with related biomarkers.
FRONTIERS IN AGING NEUROSCIENCE
(2022)
Article
Biology
Pavel Pohl, Rohit Joshi, Olivia Petrvalska, Tomas Obsil, Veronika Obsilova
Summary: The study investigated the structural basis of Nedd4-2 regulation by 14-3-3 and identified phosphorylated Ser342 and Ser448 as key residues facilitating 14-3-3 binding. The Nedd4-2:14-3-3 complex induces a structural rearrangement of Nedd4-2 by inhibiting interactions between its structured domains.
COMMUNICATIONS BIOLOGY
(2021)
Article
Plant Sciences
Feiyan Chen, Lin Chen, Weifeng Liang, Zhengguang Zhang, Jiao Li, Wan Zheng, Zhu Zhu, Jiapeng Zhu, Yunan Zhao
Summary: The study identified a direct interaction between the ginsenoside metabolite PPD and the 14-3-3 zeta protein in brain tissues, with mutations in specific residues of the protein leading to decreased affinity with PPD. This finding could aid in the development of small-molecular compounds that bind to the 14-3-3 zeta protein based on dammarane-type triterpenoid structure.
JOURNAL OF GINSENG RESEARCH
(2021)
Article
Biochemistry & Molecular Biology
Nikolai N. Sluchanko, Anna A. Kapitonova, Mikhail A. Shulepko, Ilya D. Kukushkin, Dmitrii S. Kulbatskii, Kristina Tugaeva, Larisa A. Varfolomeeva, Mikhail E. Minyaev, Konstantin M. Boyko, Vladimir O. Popov, Mikhail P. Kirpichnikov, Ekaterina N. Lyukmanova
Summary: Nicotinic acetylcholine receptors (nAChRs) are ligand-gated ion channels composed of five homologous subunits. The α7-nAChR, abundantly expressed in the brain, undergoes phosphorylation by protein kinase A (PKA) and interacts with the human brain protein 14-3-3 zeta. The study reveals the molecular basis for the interaction between α7-nAChR and 14-3-3 zeta, providing insights into the regulation of nAChR activity.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2023)
Article
Biology
Kotaro Akaki, Kosuke Ogata, Yuhei Yamauchi, Noriki Iwai, Ka Man Tse, Fabian Hia, Atsushi Mochizuki, Yasushi Ishihama, Takashi Mino, Osamu Takeuchi
Summary: The study reveals a novel interaction between Regnase-1 and 14-3-3 in response to IL-1β or TLR stimulation, showing that 14-3-3 can protect Regnase-1 from degradation by beta TRCP, while simultaneously inhibiting Regnase-1-mediated mRNA decay.
Article
Materials Science, Paper & Wood
Su Jun Kim, Bo Min Hong, Won Ho Park
Article
Materials Science, Biomaterials
Hyeong Chan Nam, Won Ho Park
ACS BIOMATERIALS SCIENCE & ENGINEERING
(2020)
Article
Materials Science, Biomaterials
Min Hee Kim, Jee Na Lee, Jeehee Lee, Haeshin Lee, Won Ho Park
ACS BIOMATERIALS SCIENCE & ENGINEERING
(2020)
Article
Chemistry, Applied
Ji Youn Shin, Yong Ho Yeo, Jae Eun Jeong, Su A. Park, Won Ho Park
CARBOHYDRATE POLYMERS
(2020)
Article
Chemistry, Physical
Dong Su Im, Bo Min Hong, Min Hee Kim, Won Ho Park
COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS
(2020)
Article
Nanoscience & Nanotechnology
Jee Na Lee, Su Yeon Lee, Won Ho Park
Summary: A novel polymer hydrogel mimicking mussel foot proteins was designed in this study, with improved adhesive strength in wet conditions by introducing catechol moiety and simply synthesized through pH control. Additionally, the addition of laponite led to enhanced mechanical and self-healing properties of the hydrogel. PAA-based hydrogels have great potential for diverse applications beyond commercial adhesives.
ACS APPLIED MATERIALS & INTERFACES
(2021)
Article
Biochemistry & Molecular Biology
Eunu Kim, Ji Min Seok, Su Bin Bae, Su A. Park, Won Ho Park
Summary: The study synthesized alginate derivatives and silk fibroin to prepare bioinks, enhancing cell compatibility, and pregelated them by ionic cross-linking to increase viscosity for 3D printing. The results showed that the new bioink had improved cytocompatibility compared to traditional bioinks, making it a promising material for tissue engineering.
Article
Chemistry, Applied
Yong Ho Yeo, Won Ho Park
Summary: Self-healing, thermo-responsive hydrogels have been developed using methylcellulose (MC) and a water-soluble chitosan oligomer (CHI-O) through dual-crosslinking. The copolymer hydrogels exhibited superior gelation rate, mechanical properties, and self-healing capabilities compared to MC hydrogels, making them suitable for cosmetic applications. Release studies of model compounds from the DAMC/CHI-O copolymer hydrogel showed promise for future applications.
CARBOHYDRATE POLYMERS
(2021)
Article
Chemistry, Multidisciplinary
Jinho Kee, Hyungju Ahn, Hyeok Park, Young-Soo Seo, Yong Ho Yeo, Won Ho Park, Jaseung Koo
Summary: Soft electronics, such as the Ag-SAN elastomer, have gained attention for practical applications due to their appropriate electrical conductivity, excellent elastic properties, and self-healing capabilities provided by reversible coordination bonds.
Article
Environmental Sciences
Su Yeon Lee, Yu Jin Jeong, Won Ho Park
Summary: In this study, nanofibrous membranes (NFMs) were fabricated via green electrospinning of poly(vinyl alcohol) (PVA), and their water resistance was improved through simple heat treatment. Heavy metal adsorbents were prepared by dip-coating the NFMs in an aqueous solution of tannic acid (TA). The TA-coated PVA NFMs exhibited excellent selectivity for Pb(II) and retained over 70% of their initial adsorption capacity after multiple cycles of adsorption/desorption.
Article
Materials Science, Characterization & Testing
Chul Min Yang, Kiramage Chathuranga, Jong Soo Lee, Won Ho Park
Summary: This study investigated the effect of polyphenolic additives on the thermal decomposition of polymers and compared the influence of different numbers of phenolic hydroxyl groups on the properties of the composite films.
Article
Nanoscience & Nanotechnology
Su Yeon Lee, Jun Tae Kim, Kiramage Chathuranga, Jong Soo Lee, Se Won Park, Won Ho Park
Summary: Due to its ability to remove particulate matter without compromising air permeability, nanofibrous membranes (NFMs) have become increasingly important as filter layers in face masks. In this study, tannic-acid-enriched poly(vinyl alcohol) (PVA-TA) NFMs were successfully fabricated using electrospinning, achieving a uniform solution without coacervate formation. These NFMs exhibited excellent filtration performance, UV-blocking, and antibacterial properties.
ACS APPLIED MATERIALS & INTERFACES
(2023)
Article
Chemistry, Applied
Su Jin Lee, Min A. Gwak, Kiramage Chathuranga, Jong Soo Le, Jaseung Koo, Won Ho Park
Summary: In this study, multifunctional tannic acid (TA) was incorporated into pristine chitosan (CS) to prepare CS-TA composite films with excellent mechanical, antioxidant, and antibacterial properties. The composite films effectively reduced enzymatic browning and water loss from food, making them suitable for long-term food storage as active packaging materials.
FOOD HYDROCOLLOIDS
(2023)
Article
Food Science & Technology
Jeong Jin Park, Yun Hyeok Choi, Eun Jung Sim, Eunhye Lee, Ki Chull Yoon, Won Ho Park
Summary: In this study, eco-friendly food packaging films made of biodegradable polyester P3HB-4HB were prepared as an alternative to non-degradable packaging films. The films were prepared using hot-pressing and surface-modified to be hydrophilic via N2 plasma treatment. Coated with tannic acid (TA) by dip-coating, the films showed improved mechanical and thermal properties without affecting the visible-light transparency. In the banana storage experiment, the films demonstrated lower weight loss and browning compared to non-packaged bananas.
FOOD PACKAGING AND SHELF LIFE
(2023)
Article
Polymer Science
Chul Min Yang, Jeehee Lee, Su Yeon Lee, Haeshin Lee, Kiramage Chathuranga, Jongsoo Lee, Wonho Park
Summary: In this study, a modified silk fibroin (SF-BGE) soluble in water was prepared by introducing butyl glycidyl ether (BGE) into its side chain. A coordination bond between ZnO and tannic acid (TA) was formed to develop an SF-based nanocomposite hydrogel. The hydrogel showed superior hemostatic and cytocompatible activities.
