Caspase-6 as a novel early target in the treatment of Alzheimer's disease

Caspase 6 Regulates B Cell Activation and Differentiation into Plasma Cells

(2014) C. Watanabe et al.   JOURNAL OF IMMUNOLOGY

Caspase-6 activity predicts lower episodic memory ability in aged individuals

(2013) Jasmine Ramcharitar et al.   NEUROBIOLOGY OF AGING

Biochemistry and Cell Biology of Tau Protein in Neurofibrillary Degeneration

(2013) E.-M. Mandelkow et al.   Cold Spring Harbor Perspectives in Medicine

An Optimized Activity-Based Probe for the Study of Caspase-6 Activation

(2012) Laura E. Edgington et al.   CHEMISTRY & BIOLOGY

Rescue from excitotoxicity and axonal degeneration accompanied by age-dependent behavioral and neuroanatomical alterations in caspase-6-deficient mice

(2012) Valeria Uribe et al.   HUMAN MOLECULAR GENETICS

Inhibitory Mechanism of Caspase-6 Phosphorylation Revealed by Crystal Structures, Molecular Dynamics Simulations, and Biochemical Assays

(2012) Qin Cao et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Zinc-mediated Allosteric Inhibition of Caspase-6

(2012) Elih M. Velázquez-Delgado et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Depletion of GGA1 and GGA3 Mediates Postinjury Elevation of BACE1

(2012) K. R. Walker et al.   JOURNAL OF NEUROSCIENCE

A Caspase Cascade Regulating Developmental Axon Degeneration

(2012) D. J. Simon et al.   JOURNAL OF NEUROSCIENCE

A mutation in APP protects against Alzheimer’s disease and age-related cognitive decline

(2012) Thorlakur Jonsson et al.   NATURE

Allosteric peptides bind a caspase zymogen and mediate caspase tetramerization

(2012) Karen Stanger et al.   Nature Chemical Biology

Two distinct types of dying back axonal degenerationin vitro

(2012) G. Öztürk et al.   NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY

A Whole Cell Assay to Measure Caspase-6 Activity by Detecting Cleavage of Lamin A/C

(2012) Robert Mintzer et al.   PLoS One

Mechanistic and Structural Understanding of Uncompetitive Inhibitors of Caspase-6

(2012) Christopher E. Heise et al.   PLoS One

Corticotropin-releasing factor receptor-dependent effects of repeated stress on tau phosphorylation, solubility, and aggregation

(2012) R. A. Rissman et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Phosphorylation Regulates Assembly of the Caspase-6 Substrate-Binding Groove

(2012) Elih M. Velázquez-Delgado et al.   STRUCTURE

Caspase-3 in the central nervous system: beyond apoptosis

(2012) Marcello D’Amelio et al.   TRENDS IN NEUROSCIENCES

Synapses and Alzheimer's Disease

(2012) M. Sheng et al.   Cold Spring Harbor Perspectives in Biology

Some evolutionary perspectives on Alzheimer’s disease pathogenesis and pathology

(2011) Daniel J. Glass et al.   Alzheimers & Dementia

Involvement of Caspase-6 and Caspase-8 in Neuronal Apoptosis and the Regenerative Failure of Injured Retinal Ganglion Cells

(2011) P. P. Monnier et al.   JOURNAL OF NEUROSCIENCE

Intranasal Delivery of Caspase-9 Inhibitor Reduces Caspase-6-Dependent Axon/Neuron Loss and Improves Neurological Function after Stroke

(2011) N. Akpan et al.   JOURNAL OF NEUROSCIENCE

Chronic Stress Exacerbates Tau Pathology, Neurodegeneration, and Cognitive Performance through a Corticotropin-Releasing Factor Receptor-Dependent Mechanism in a Transgenic Mouse Model of Tauopathy

(2011) J. C. Carroll et al.   JOURNAL OF NEUROSCIENCE

G303V tau mutation presenting with progressive supranuclear palsy-like features

(2011) Ariane Choumert et al.   MOVEMENT DISORDERS

The Many Faces of Tau

(2011) Meaghan Morris et al.   NEURON

A Quantitative Method for the Specific Assessment of Caspase-6 Activity in Cell Culture

(2011) Dagmar E. Ehrnhoefer et al.   PLoS One

Nicotinamide mononucleotide adenylyl transferase 1 protects against acute neurodegeneration in developing CNS by inhibiting excitotoxic-necrotic cell death

(2011) P. B. Verghese et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Activation of Specific Apoptotic Caspases with an Engineered Small-Molecule-Activated Protease

(2010) Daniel C. Gray et al.   CELL

Caspase-3 Activation via Mitochondria Is Required for Long-Term Depression and AMPA Receptor Internalization

(2010) Zheng Li et al.   CELL

Identification and Evaluation of Small Molecule Pan-Caspase Inhibitors in Huntington's Disease Models

(2010) Melissa J. Leyva et al.   CHEMISTRY & BIOLOGY

Crystal structures of human caspase 6 reveal a new mechanism for intramolecular cleavage self-activation

(2010) Xiao-Jun Wang et al.   EMBO REPORTS

MicroRNA profiling reveals new aspects of HIV neurodegeneration: caspase-6 regulates astrocyte survival

(2010) Farshid Noorbakhsh et al.   FASEB JOURNAL

Ubiquitin Regulates GGA3-mediated Degradation of BACE1

(2010) Eugene L. Kang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Alternatively Spliced Caspase-6B Isoform Inhibits the Activation of Caspase-6A

(2010) Andrea W. Lee et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Identification of Caspase-6-Mediated Processing of the Valosin Containing Protein (p97) in Alzheimer's Disease: A Novel Link to Dysfunction in Ubiquitin Proteasome System-Mediated Protein Degradation

(2010) D. Halawani et al.   JOURNAL OF NEUROSCIENCE

Many Neuronal and Behavioral Impairments in Transgenic Mouse Models of Alzheimer's Disease Are Independent of Caspase Cleavage of the Amyloid Precursor Protein

(2010) J. A. Harris et al.   JOURNAL OF NEUROSCIENCE

Amyloid Precursor Protein Cleavage-Dependent and -Independent Axonal Degeneration Programs Share a Common Nicotinamide Mononucleotide Adenylyltransferase 1-Sensitive Pathway

(2010) B. P. S. Vohra et al.   JOURNAL OF NEUROSCIENCE

Axonal Degeneration Is Regulated by the Apoptotic Machinery or a NAD+-Sensitive Pathway in Insects and Mammals

(2010) Z. Schoenmann et al.   JOURNAL OF NEUROSCIENCE

Semantic dementia associated with mutation V363I in the tau gene

(2010) Valentina Bessi et al.   JOURNAL OF THE NEUROLOGICAL SCIENCES

Caspase activation precedes and leads to tangles

(2010) Alix de Calignon et al.   NATURE

p75NTR-dependent, myelin-mediated axonal degeneration regulates neural connectivity in the adult brain

(2010) Katya J Park et al.   NATURE NEUROSCIENCE

Where Vascular Meets Neurodegenerative Disease

(2010) J. A. Schneider et al.   STROKE

Familial amyloid precursor protein mutants cause caspase-6-dependent but amyloid β-peptide-independent neuronal degeneration in primary human neuron cultures.

(2010) S N Sivananthan et al.   Cell Death & Disease

Classification and basic pathology of Alzheimer disease

(2009) Charles Duyckaerts et al.   ACTA NEUROPATHOLOGICA

Reversal of learning deficits in hAPP transgenic mice carrying a mutation at Asp664: A role for early experience

(2009) Junli Zhang et al.   BEHAVIOURAL BRAIN RESEARCH

Of Mice and Men

(2009) Hugo Geerts   CNS DRUGS

Synthesis and in Vitro Evaluation of Sulfonamide Isatin Michael Acceptors as Small Molecule Inhibitors of Caspase-6

(2009) Wenhua Chu et al.   JOURNAL OF MEDICINAL CHEMISTRY

Role of caspase-3 in tau truncation at D421 is restricted in transgenic mouse models for tauopathies

(2009) Qipeng Zhang et al.   JOURNAL OF NEUROCHEMISTRY

Caspase-6 Activation in Familial Alzheimer Disease Brains Carrying Amyloid Precursor Protein or Presenilin I or Presenilin II Mutations

(2009) Steffen Albrecht et al.   JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY

APP binds DR6 to trigger axon pruning and neuron death via distinct caspases

(2009) Anatoly Nikolaev et al.   NATURE

Long-term prevention of Alzheimer's disease-like behavioral deficits in PDAPP mice carrying a mutation in Asp664

(2008) Veronica Galvan et al.   BEHAVIOURAL BRAIN RESEARCH

Self-activation of Caspase-6 in vitro and in vivo: Caspase-6 activation does not induce cell death in HEK293T cells

(2008) Guy Klaiman et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

In Vivo Imaging Reveals Dissociation between Caspase Activation and Acute Neuronal Death in Tangle-Bearing Neurons

(2008) T. L. Spires-Jones et al.   JOURNAL OF NEUROSCIENCE

Long-term effects of Aβ42 immunisation in Alzheimer's disease: follow-up of a randomised, placebo-controlled phase I trial

(2008) Clive Holmes et al.   LANCET

Targets of Caspase-6 Activity in Human Neurons and Alzheimer Disease

(2008) Guy Klaiman et al.   MOLECULAR & CELLULAR PROTEOMICS