Mechanistic and Structural Understanding of Uncompetitive Inhibitors of Caspase-6

A Whole Cell Assay to Measure Caspase-6 Activity by Detecting Cleavage of Lamin A/C

(2012) Robert Mintzer et al.   PLoS One

Structural and Enzymatic Insights into Caspase-2 Protein Substrate Recognition and Catalysis

(2011) Yinyan Tang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Caspase-6 and neurodegeneration

(2011) Rona K. Graham et al.   TRENDS IN NEUROSCIENCES

PHENIX: a comprehensive Python-based system for macromolecular structure solution

(2010) Paul D. Adams et al.   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

Identification and Evaluation of Small Molecule Pan-Caspase Inhibitors in Huntington's Disease Models

(2010) Melissa J. Leyva et al.   CHEMISTRY & BIOLOGY

Crystal structures of human caspase 6 reveal a new mechanism for intramolecular cleavage self-activation

(2010) Xiao-Jun Wang et al.   EMBO REPORTS

SIRT1 Activation by Small Molecules

(2010) Han Dai et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

SRT1720, SRT2183, SRT1460, and Resveratrol Are Not Direct Activators of SIRT1

(2010) Michelle Pacholec et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Cleavage at the 586 Amino Acid Caspase-6 Site in Mutant huntingtin Influences Caspase-6 Activation In Vivo

(2010) R. K. Graham et al.   JOURNAL OF NEUROSCIENCE

Emerging principles in protease-based drug discovery

(2010) Marcin Drag et al.   NATURE REVIEWS DRUG DISCOVERY

Selective Identification of Cooperatively Binding Fragments in a High-Throughput Ligation Assay Enables Development of a Picomolar Caspase-3 Inhibitor

(2009) Marco F. Schmidt et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Resveratrol is Not a Direct Activator of SIRT1 Enzyme Activity

(2009) Dirk Beher et al.   Chemical Biology & Drug Design

APP binds DR6 to trigger axon pruning and neuron death via distinct caspases

(2009) Anatoly Nikolaev et al.   NATURE

Some commonly used caspase substrates and inhibitors lack the specificity required to monitor individual caspase activity

(2008) Natasha Ann Pereira et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Chemical Mechanism of a Cysteine Protease, Cathepsin C, As Revealed by Integration of both Steady-State and Pre-Steady-State Solvent Kinetic Isotope Effects

(2008) Jessica L. Schneck et al.   BIOCHEMISTRY

Enzyme Kinetics and Binding Studies on Inhibitors of MEK Protein Kinase

(2008) Wendy S. VanScyoc et al.   BIOCHEMISTRY

Self-activation of Caspase-6 in vitro and in vivo: Caspase-6 activation does not induce cell death in HEK293T cells

(2008) Guy Klaiman et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Global Sequencing of Proteolytic Cleavage Sites in Apoptosis by Specific Labeling of Protein N Termini

(2008) Sami Mahrus et al.   CELL

In search of negative allosteric modulators of biological targets

(2008) Duncan R. Groebe   DRUG DISCOVERY TODAY

Caspases in apoptosis and beyond

(2008) J Li et al.   ONCOGENE