Inhibitory Mechanism of Caspase-6 Phosphorylation Revealed by Crystal Structures, Molecular Dynamics Simulations, and Biochemical Assays
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Title
Inhibitory Mechanism of Caspase-6 Phosphorylation Revealed by Crystal Structures, Molecular Dynamics Simulations, and Biochemical Assays
Authors
Keywords
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Journal
JOURNAL OF BIOLOGICAL CHEMISTRY
Volume 287, Issue 19, Pages 15371-15379
Publisher
American Society for Biochemistry & Molecular Biology (ASBMB)
Online
2012-03-22
DOI
10.1074/jbc.m112.351213
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- XDS
- (2010) Wolfgang Kabsch ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY
- PHENIX: a comprehensive Python-based system for macromolecular structure solution
- (2010) Paul D. Adams et al. ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY
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- Synthesis and in Vitro Evaluation of Sulfonamide Isatin Michael Acceptors as Small Molecule Inhibitors of Caspase-6
- (2009) Wenhua Chu et al. JOURNAL OF MEDICINAL CHEMISTRY
- APP binds DR6 to trigger axon pruning and neuron death via distinct caspases
- (2009) Anatoly Nikolaev et al. NATURE
- Self-activation of Caspase-6 in vitro and in vivo: Caspase-6 activation does not induce cell death in HEK293T cells
- (2008) Guy Klaiman et al. BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH
- Targets of Caspase-6 Activity in Human Neurons and Alzheimer Disease
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