Journal
JOURNAL OF NEUROIMMUNOLOGY
Volume 193, Issue 1-2, Pages 12-23Publisher
ELSEVIER
DOI: 10.1016/j.jneuroim.2007.07.025
Keywords
stem cells; experimental autoimmune encephalomyelitis; indoleamine 2,3-dioxygenase; immunomodulation
Categories
Funding
- NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE [T32NS007098, R01NS008952, P50NS011920, P01NS011920] Funding Source: NIH RePORTER
- NINDS NIH HHS [T32 NS007098, R01 NS008952-36, T32 NS007098-28, NS 07098, P50 NS011920-29, NS 08952, P50 NS011920, R01 NS008952, NS 11920] Funding Source: Medline
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Syngeneic, pluripotent Lin(-)Scal(+) bone marrow stem cells (SC), transferred to mice with experimental autoimmune encephalomyelitis, a model of multiple sclerosis, enhanced recovery, prevented relapses and promoted myelin repair. SC-treated mice showed elevated interferon-gamma production and induction of indoleamine 2,3 -dioxygenase (IDO) in CD11c(+) dendritic cells (DC). IDO induction was specific since in the presence of IDO-producing CD11c(+) DC, PLP stimulated T cell proliferation was inhibited and the IDO-inhibitor, 1-MT, abrogated the SC effect. Relapse prevention during chronic disease correlated with decreased responsiveness to PLP178-191 and MBP85-99. Thus, pluripotent SC induce IDO in DC leading to inhibition of antigen reactivity and spreading in EAE. (C) 206 Elsevier B.V. All rights reserved.
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