Pancreatic beta-cell function and type 2 diabetes risk: quantify the causal effect using a Mendelian randomization approach based on meta-analyses

Genetics of Type 2 Diabetes

(2010) E. Ahlqvist et al.   CLINICAL CHEMISTRY

From Genetic Association to Molecular Mechanism

(2010) Martijn van de Bunt et al.   Current Diabetes Reports

Molecular Function of TCF7L2: Consequences of TCF7L2 Splicing for Molecular Function and Risk for Type 2 Diabetes

(2010) Ola Hansson et al.   Current Diabetes Reports

Detailed Physiologic Characterization Reveals Diverse Mechanisms for Novel Genetic Loci Regulating Glucose and Insulin Metabolism in Humans

(2010) E. Ingelsson et al.   DIABETES

A map of open chromatin in human pancreatic islets

(2010) Kyle J Gaulton et al.   NATURE GENETICS

Genetic variation in GIPR influences the glucose and insulin responses to an oral glucose challenge

(2010) Richa Saxena et al.   NATURE GENETICS

New genetic loci implicated in fasting glucose homeostasis and their impact on type 2 diabetes risk

(2010) Josée Dupuis et al.   NATURE GENETICS

Twelve type 2 diabetes susceptibility loci identified through large-scale association analysis

(2010) Benjamin F Voight et al.   NATURE GENETICS

Mendelian randomization analysis of case-control data using structural mean models

(2010) Jack Bowden et al.   STATISTICS IN MEDICINE

The emerging genetics of type 2 diabetes

(2010) Amélie Bonnefond et al.   TRENDS IN MOLECULAR MEDICINE

Association between TCF7L2gene polymorphisms and susceptibility to Type 2 Diabetes Mellitus: a large Human Genome Epidemiology (HuGE) review and meta-analysis

(2009) Yu Tong et al.   BMC Medical Genetics

Linking the Genetics of Type 2 Diabetes With Low Birth Weight: A Role for Prenatal Islet Maldevelopment?

(2009) J. J. Meier   DIABETES

TCF7L2 Variant rs7903146 Affects the Risk of Type 2 Diabetes by Modulating Incretin Action

(2009) D. T. Villareal et al.   DIABETES

The beta cell lesion in type 2 diabetes: there has to be a primary functional abnormality

(2009) S. E. Kahn et al.   DIABETOLOGIA

Decreased TCF7L2 protein levels in type 2 diabetes mellitus correlate with downregulation of GIP- and GLP-1 receptors and impaired beta-cell function

(2009) Luan Shu et al.   HUMAN MOLECULAR GENETICS

Strengthening causal inference in cardiovascular epidemiology through Mendelian randomization

(2008) George Davey Smith et al.   ANNALS OF MEDICINE

Meta-analysis of genome-wide association data and large-scale replication identifies additional susceptibility loci for type 2 diabetes

(2008) Eleftheria Zeggini et al.   NATURE GENETICS

Beta cells in type 2 diabetes – a crucial contribution to pathogenesis

(2007) Kathrin Maedler   DIABETES OBESITY & METABOLISM

Mendelian randomization: Using genes as instruments for making causal inferences in epidemiology

(2007) Debbie A. Lawlor et al.   STATISTICS IN MEDICINE