Building and remodelling Cullin-RING E3 ubiquitin ligases

Following Ariadne's thread: a new perspective on RBR ubiquitin ligases

(2013) Dawn M Wenzel et al.   BMC BIOLOGY

Cand1 Promotes Assembly of New SCF Complexes through Dynamic Exchange of F Box Proteins

(2013) Nathan W. Pierce et al.   CELL

The emerging family of CULLIN3-RING ubiquitin ligases (CRL3s): cellular functions and disease implications

(2013) Pascal Genschik et al.   EMBO JOURNAL

Mechanisms and function of substrate recruitment by F-box proteins

(2013) Jeffrey R. Skaar et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Thalidomide-analogue biology: immunological, molecular and epigenetic targets in cancer therapy

(2013) J Shortt et al.   ONCOGENE

CSN- and CAND1-dependent remodelling of the budding yeast SCF complex

(2013) Aleksandra Zemla et al.   Nature Communications

CAND1 controls in vivo dynamics of the cullin 1-RING ubiquitin ligase repertoire

(2013) Shuangding Wu et al.   Nature Communications

Inhibition of a NEDD8 Cascade Restores Restriction of HIV by APOBEC3G

(2013) David J. Stanley et al.   PLoS Pathogens

Mechanism of ubiquitin ligation and lysine prioritization by a HECT E3

(2013) Hari B Kamadurai et al.   eLife

The Ubiquitin Code

(2012) David Komander et al.   Annual Review of Biochemistry

Deconjugation of Nedd8 from Cul1 Is Directly Regulated by Skp1-F-box and Substrate, and the COP9 Signalosome Inhibits Deneddylated SCF by a Noncatalytic Mechanism

(2012) Ethan D. Emberley et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Understanding Cullin-RING E3 Biology through Proteomics-based Substrate Identification

(2012) J. Wade Harper et al.   MOLECULAR & CELLULAR PROTEOMICS

Structure of a Glomulin-RBX1-CUL1 Complex: Inhibition of a RING E3 Ligase through Masking of Its E2-Binding Surface

(2012) David M. Duda et al.   MOLECULAR CELL

Molecular Model of the Human 26S Proteasome

(2012) Paula C.A. da Fonseca et al.   MOLECULAR CELL

EZH2 Generates a Methyl Degron that Is Recognized by the DCAF1/DDB1/CUL4 E3 Ubiquitin Ligase Complex

(2012) Ji Min Lee et al.   MOLECULAR CELL

The Glomuvenous Malformation Protein Glomulin Binds Rbx1 and Regulates Cullin RING Ligase-Mediated Turnover of Fbw7

(2012) Adriana E. Tron et al.   MOLECULAR CELL

Ubiquitin-dependent regulation of COPII coat size and function

(2012) Lingyan Jin et al.   NATURE

Structure of a RING E3 ligase and ubiquitin-loaded E2 primed for catalysis

(2012) Anna Plechanovová et al.   NATURE

Mutations in kelch-like 3 and cullin 3 cause hypertension and electrolyte abnormalities

(2012) Lynn M. Boyden et al.   NATURE

BIRC7–E2 ubiquitin conjugate structure reveals the mechanism of ubiquitin transfer by a RING dimer

(2012) Hao Dou et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Molecular architecture of the 26S proteasome holocomplex determined by an integrative approach

(2012) K. Lasker et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Structural Conservation of Distinctive N-terminal Acetylation-Dependent Interactions across a Family of Mammalian NEDD8 Ligation Enzymes

(2012) Julie K. Monda et al.   STRUCTURE

Structural Basis for a Reciprocal Regulation between SCF and CSN

(2012) Radoslav I. Enchev et al.   Cell Reports

Pathogenic Role of the CRL4 Ubiquitin Ligase in Human Disease

(2012) Jennifer Lee et al.   Frontiers in Oncology

The Cullin-RING Ubiquitin-Protein Ligases

(2011) Zhihua Hua et al.   Annual Review of Plant Biology

The Molecular Basis of CRL4DDB2/CSA Ubiquitin Ligase Architecture, Targeting, and Activation

(2011) Eric S. Fischer et al.   CELL

Global Identification of Modular Cullin-RING Ligase Substrates

(2011) Michael J. Emanuele et al.   CELL

An Allosteric Inhibitor of the Human Cdc34 Ubiquitin-Conjugating Enzyme

(2011) Derek F. Ceccarelli et al.   CELL

Autophagy: Renovation of Cells and Tissues

(2011) Noboru Mizushima et al.   CELL

Structural regulation of cullin-RING ubiquitin ligase complexes

(2011) David M Duda et al.   CURRENT OPINION IN STRUCTURAL BIOLOGY

Mechanism of CRL4Cdt2, a PCNA-dependent E3 ubiquitin ligase

(2011) C. G. Havens et al.   GENES & DEVELOPMENT

SCCRO (DCUN1D1) Promotes Nuclear Translocation and Assembly of the Neddylation E3 Complex

(2011) Guochang Huang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Quantitative Proteomic Analysis of Cellular Protein Modulation upon Inhibition of the NEDD8-Activating Enzyme by MLN4924

(2011) Hua Liao et al.   MOLECULAR & CELLULAR PROTEOMICS

Characterization of the role of COP9 signalosome in regulating cullin E3 ubiquitin ligase activity

(2011) Yin Yin Choo et al.   MOLECULAR BIOLOGY OF THE CELL

Systematic and Quantitative Assessment of the Ubiquitin-Modified Proteome

(2011) Woong Kim et al.   MOLECULAR CELL

A RING E3–substrate complex poised for ubiquitin-like protein transfer: structural insights into cullin-RING ligases

(2011) Matthew F Calabrese et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Twists and turns in ubiquitin-like protein conjugation cascades

(2011) Brenda A. Schulman   PROTEIN SCIENCE

N-Terminal Acetylation Acts as an Avidity Enhancer Within an Interconnected Multiprotein Complex

(2011) D. C. Scott et al.   SCIENCE

E2s: structurally economical and functionally replete

(2010) Dawn M. Wenzel et al.   BIOCHEMICAL JOURNAL

Dynamics of Cullin-RING Ubiquitin Ligase Network Revealed by Systematic Quantitative Proteomics

(2010) Eric J. Bennett et al.   CELL

C. elegans CAND-1 regulates cullin neddylation, cell proliferation and morphogenesis in specific tissues

(2010) Dimple R. Bosu et al.   DEVELOPMENTAL BIOLOGY

Building on bortezomib: second-generation proteasome inhibitors as anti-cancer therapy

(2010) Lawrence R. Dick et al.   DRUG DISCOVERY TODAY

Viral Exploitation of Host SOCS Protein Functions

(2010) L. N. Akhtar et al.   JOURNAL OF VIROLOGY

The Steady-State Repertoire of Human SCF Ubiquitin Ligase Complexes Does Not Require Ongoing Nedd8 Conjugation

(2010) J. Eugene Lee et al.   MOLECULAR & CELLULAR PROTEOMICS

A Dual E3 Mechanism for Rub1 Ligation to Cdc53

(2010) Daniel C. Scott et al.   MOLECULAR CELL

Substrate-Assisted Inhibition of Ubiquitin-like Protein-Activating Enzymes: The NEDD8 E1 Inhibitor MLN4924 Forms a NEDD8-AMP Mimetic In Situ

(2010) James E. Brownell et al.   MOLECULAR CELL

Priming and Extending: A UbcH5/Cdc34 E2 Handoff Mechanism for Polyubiquitination on a SCF Substrate

(2010) Kenneth Wu et al.   MOLECULAR CELL

Skp2 targeting suppresses tumorigenesis by Arf-p53-independent cellular senescence

(2010) Hui-Kuan Lin et al.   NATURE

An allosteric inhibitor of substrate recognition by the SCFCdc4 ubiquitin ligase

(2010) Stephen Orlicky et al.   NATURE BIOTECHNOLOGY

Chemical genetics screen for enhancers of rapamycin identifies a specific inhibitor of an SCF family E3 ubiquitin ligase

(2010) Mariam Aghajan et al.   NATURE BIOTECHNOLOGY

Ubiquitin-like protein conjugation and the ubiquitin–proteasome system as drug targets

(2010) Lynn Bedford et al.   NATURE REVIEWS DRUG DISCOVERY

Identification of a Primary Target of Thalidomide Teratogenicity

(2010) T. Ito et al.   SCIENCE

RING Domain E3 Ubiquitin Ligases

(2009) Raymond J. Deshaies et al.   Annual Review of Biochemistry

Rapid E2-E3 Assembly and Disassembly Enable Processive Ubiquitylation of Cullin-RING Ubiquitin Ligase Substrates

(2009) Gary Kleiger et al.   CELL

E2-RING Expansion of the NEDD8 Cascade Confers Specificity to Cullin Modification

(2009) Danny T. Huang et al.   MOLECULAR CELL

F-Box-Directed CRL Complex Assembly and Regulation by the CSN and CAND1

(2009) Michael W. Schmidt et al.   MOLECULAR CELL

Detection of sequential polyubiquitylation on a millisecond timescale

(2009) Nathan W. Pierce et al.   NATURE

An inhibitor of NEDD8-activating enzyme as a new approach to treat cancer

(2009) Teresa A. Soucy et al.   NATURE

Building ubiquitin chains: E2 enzymes at work

(2009) Yihong Ye et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Ubiquitin-like protein activation by E1 enzymes: the apex for downstream signalling pathways

(2009) Brenda A. Schulman et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

The human Dcn1-like protein DCNL3 promotes Cul3 neddylation at membranes

(2009) N. Meyer-Schaller et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Structural Basis of UV DNA-Damage Recognition by the DDB1–DDB2 Complex

(2008) Andrea Scrima et al.   CELL

Structural Insights into NEDD8 Activation of Cullin-RING Ligases: Conformational Control of Conjugation

(2008) David M. Duda et al.   CELL

SCCRO (DCUN1D1) Is an Essential Component of the E3 Complex for Neddylation

(2008) Alexander Y. Kim et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Dcn1 Functions as a Scaffold-Type E3 Ligase for Cullin Neddylation

(2008) Thimo Kurz et al.   MOLECULAR CELL

Multimodal Activation of the Ubiquitin Ligase SCF by Nedd8 Conjugation

(2008) Anjanabha Saha et al.   MOLECULAR CELL

Autoinhibitory regulation of SCF-mediated ubiquitination by human cullin 1's C-terminal tail

(2008) K. Yamoah et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Genetic analysis of CAND1-CUL1 interactions in Arabidopsis supports a role for CAND1-mediated cycling of the SCFTIR1 complex

(2008) W. Zhang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Identification of SCF Ubiquitin Ligase Substrates by Global Protein Stability Profiling

(2008) H.-C. S. Yen et al.   SCIENCE