Inhibition of a NEDD8 Cascade Restores Restriction of HIV by APOBEC3G

The Glomuvenous Malformation Protein Glomulin Binds Rbx1 and Regulates Cullin RING Ligase-Mediated Turnover of Fbw7

(2012) Adriana E. Tron et al.   MOLECULAR CELL

Endogenous Origins of HIV-1 G-to-A Hypermutation and Restriction in the Nonpermissive T Cell Line CEM2n

(2012) Eric W. Refsland et al.   PLoS Pathogens

An Allosteric Inhibitor of the Human Cdc34 Ubiquitin-Conjugating Enzyme

(2011) Derek F. Ceccarelli et al.   CELL

The Control of HIV Transcription: Keeping RNA Polymerase II on Track

(2011) Melanie Ott et al.   Cell Host & Microbe

Human and Rhesus APOBEC3D, APOBEC3F, APOBEC3G, and APOBEC3H Demonstrate a Conserved Capacity To Restrict Vif-Deficient HIV-1

(2011) J. F. Hultquist et al.   JOURNAL OF VIROLOGY

Vif Proteins of Human and Simian Immunodeficiency Viruses Require Cellular CBF  To Degrade APOBEC3 Restriction Factors

(2011) J. F. Hultquist et al.   JOURNAL OF VIROLOGY

A RING E3–substrate complex poised for ubiquitin-like protein transfer: structural insights into cullin-RING ligases

(2011) Matthew F Calabrese et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Interplay of transcription factors in T-cell differentiation and function: the role of Runx

(2010) Won Fen Wong et al.   IMMUNOLOGY

Atomic Force Microscopy Studies Provide Direct Evidence for Dimerization of the HIV Restriction Factor APOBEC3G

(2010) Luda S. Shlyakhtenko et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Small Molecular Compounds Inhibit HIV-1 Replication through Specifically Stabilizing APOBEC3G

(2010) Shan Cen et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Long-Term Restriction by APOBEC3F Selects Human Immunodeficiency Virus Type 1 Variants with Restored Vif Function

(2010) J. S. Albin et al.   JOURNAL OF VIROLOGY

A Dual E3 Mechanism for Rub1 Ligation to Cdc53

(2010) Daniel C. Scott et al.   MOLECULAR CELL

Substrate-Assisted Inhibition of Ubiquitin-like Protein-Activating Enzymes: The NEDD8 E1 Inhibitor MLN4924 Forms a NEDD8-AMP Mimetic In Situ

(2010) James E. Brownell et al.   MOLECULAR CELL

LEDGF Hybrids Efficiently Retarget Lentiviral Integration Into Heterochromatin

(2010) Rik Gijsbers et al.   MOLECULAR THERAPY

APOBEC3 proteins mediate the clearance of foreign DNA from human cells

(2010) Mark D Stenglein et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Quantitative profiling of the full APOBEC3 mRNA repertoire in lymphocytes and tissues: implications for HIV-1 restriction

(2010) Eric W. Refsland et al.   NUCLEIC ACIDS RESEARCH

Cellular Proteins and HIV-1 Rev Function

(2009) Modem Suhasini et al.   CURRENT HIV RESEARCH

E2-RING Expansion of the NEDD8 Cascade Confers Specificity to Cullin Modification

(2009) Danny T. Huang et al.   MOLECULAR CELL

An inhibitor of NEDD8-activating enzyme as a new approach to treat cancer

(2009) Teresa A. Soucy et al.   NATURE

Viral avoidance and exploitation of the ubiquitin system

(2009) Felix Randow et al.   NATURE CELL BIOLOGY

APOBEC3G induces a hypermutation gradient: purifying selection at multiple steps during HIV-1 replication results in levels of G-to-A mutations that are high in DNA, intermediate in cellular viral RNA, and low in virion RNA

(2009) Rebecca A Russell et al.   Retrovirology

Multiple ways of targeting APOBEC3–virion infectivity factor interactions for anti-HIV-1 drug development

(2009) Jessica L. Smith et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

Structural Insights into NEDD8 Activation of Cullin-RING Ligases: Conformational Control of Conjugation

(2008) David M. Duda et al.   CELL

HIV-1 Accessory Proteins—Ensuring Viral Survival in a Hostile Environment

(2008) Michael H. Malim et al.   Cell Host & Microbe

Structures of the cIAP2 RING Domain Reveal Conformational Changes Associated with Ubiquitin-conjugating Enzyme (E2) Recruitment

(2008) Peter D. Mace et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Human Immunodeficiency Virus Type 1 Vif Induces Cell Cycle Delay via Recruitment of the Same E3 Ubiquitin Ligase Complex That Targets APOBEC3 Proteins for Degradation

(2008) J. L. DeHart et al.   JOURNAL OF VIROLOGY

Dcn1 Functions as a Scaffold-Type E3 Ligase for Cullin Neddylation

(2008) Thimo Kurz et al.   MOLECULAR CELL

Multimodal Activation of the Ubiquitin Ligase SCF by Nedd8 Conjugation

(2008) Anjanabha Saha et al.   MOLECULAR CELL

Small-molecule inhibition of HIV-1 Vif

(2008) Robin Nathans et al.   NATURE BIOTECHNOLOGY

APOBEC proteins and intrinsic resistance to HIV-1 infection

(2008) M. H Malim   PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES