Linking abnormal mitosis to the acquisition of DNA damage

Telomere-Driven Tetraploidization Occurs in Human Cells Undergoing Crisis and Promotes Transformation of Mouse Cells

(2012) Teresa Davoli et al.   CANCER CELL

GF-15, a Novel Inhibitor of Centrosomal Clustering, Suppresses Tumor Cell Growth In Vitro and In Vivo

(2012) M. S. Raab et al.   CANCER RESEARCH

Mechanisms for recurrent and complex human genomic rearrangements

(2012) Pengfei Liu et al.   CURRENT OPINION IN GENETICS & DEVELOPMENT

Losing balance: the origin and impact of aneuploidy in cancer

(2012) Andrew J Holland et al.   EMBO REPORTS

Global analysis of genome, transcriptome and proteome reveals the response to aneuploidy in human cells

(2012) Silvia Stingele et al.   Molecular Systems Biology

DNA breaks and chromosome pulverization from errors in mitosis

(2012) Karen Crasta et al.   NATURE

Causes and consequences of aneuploidy in cancer

(2012) David J. Gordon et al.   NATURE REVIEWS GENETICS

A telomere-dependent DNA damage checkpoint induced by prolonged mitotic arrest

(2012) Makoto T Hayashi et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

The Causes and Consequences of Polyploidy in Normal Development and Cancer

(2011) Teresa Davoli et al.   Annual Review of Cell and Developmental Biology

Navitoclax (ABT-263) Accelerates Apoptosis during Drug-Induced Mitotic Arrest by Antagonizing Bcl-xL

(2011) J. Shi et al.   CANCER RESEARCH

Massive Genomic Rearrangement Acquired in a Single Catastrophic Event during Cancer Development

(2011) Philip J. Stephens et al.   CELL

Chromosome Catastrophes Involve Replication Mechanisms Generating Complex Genomic Rearrangements

(2011) Pengfei Liu et al.   CELL

Identification of Aneuploidy-Selective Antiproliferation Compounds

(2011) Yun-Chi Tang et al.   CELL

Hallmarks of Cancer: The Next Generation

(2011) Douglas Hanahan et al.   CELL

Give me a break, but not in mitosis

(2011) Simona Giunta et al.   CELL CYCLE

Navitoclax Enhances the Efficacy of Taxanes in Non–Small Cell Lung Cancer Models

(2011) Nguyen Tan et al.   CLINICAL CANCER RESEARCH

Cohesion Fatigue Induces Chromatid Separation in Cells Delayed at Metaphase

(2011) John R. Daum et al.   CURRENT BIOLOGY

PICH and BLM limit histone association with anaphase centromeric DNA threads and promote their resolution

(2011) Yuwen Ke et al.   EMBO JOURNAL

MCL1 meets its end during mitotic arrest

(2011) Scott E Millman et al.   EMBO REPORTS

Repeated cleavage failure does not establish centrosome amplification in untransformed human cells

(2011) Anna Krzywicka-Racka et al.   JOURNAL OF CELL BIOLOGY

Prolonged mitotic arrest triggers partial activation of apoptosis, resulting in DNA damage and p53 induction

(2011) James D. Orth et al.   MOLECULAR BIOLOGY OF THE CELL

SCFFBW7 regulates cellular apoptosis by targeting MCL1 for ubiquitylation and destruction

(2011) Hiroyuki Inuzuka et al.   NATURE

Chromosome missegregation in human cells arises through specific types of kinetochore-microtubule attachment errors

(2011) S. L. Thompson et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Chromosome Segregation Errors as a Cause of DNA Damage and Structural Chromosome Aberrations

(2011) A. Janssen et al.   SCIENCE

Aneuploidy Drives Genomic Instability in Yeast

(2011) J. M. Sheltzer et al.   SCIENCE

New insights into the formation and resolution of ultra-fine anaphase bridges

(2011) Kok Lung Chan et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

Merotelic kinetochore attachment: causes and effects

(2011) Juraj Gregan et al.   TRENDS IN CELL BIOLOGY

Pharmacologic Inhibition of the Anaphase-Promoting Complex Induces A Spindle Checkpoint-Dependent Mitotic Arrest in the Absence of Spindle Damage

(2010) Xing Zeng et al.   CANCER CELL

DNA damage foci in mitosis are devoid of 53BP1

(2010) Glyn Nelson et al.   CELL CYCLE

Chromosome missegregation causes colon cancer byAPCloss of heterozygosity

(2010) Darren J. Baker et al.   CELL CYCLE

Caspase-3-mediated degradation of condensin Cap-H regulates mitotic cell death

(2010) S-K Lai et al.   CELL DEATH AND DIFFERENTIATION

Prolonged Prometaphase Blocks Daughter Cell Proliferation Despite Normal Completion of Mitosis

(2010) Yumi Uetake et al.   CURRENT BIOLOGY

Mad2 Prolongs DNA Damage Checkpoint Arrest Caused by a Double-Strand Break via a Centromere-Dependent Mechanism

(2010) Farokh Dotiwala et al.   CURRENT BIOLOGY

Mechanisms of aneuploidy

(2010) Duane A Compton   CURRENT OPINION IN CELL BIOLOGY

Phosphorylation of Mcl-1 by CDK1–cyclin B1 initiates its Cdc20-dependent destruction during mitotic arrest

(2010) Margaret E Harley et al.   EMBO JOURNAL

Mitotic chromosome condensation mediated by the retinoblastoma protein is tumor-suppressive

(2010) C. H. Coschi et al.   GENES & DEVELOPMENT

Loss of pRB causes centromere dysfunction and chromosomal instability

(2010) A. L. Manning et al.   GENES & DEVELOPMENT

DNA damage signaling in response to double-strand breaks during mitosis

(2010) Simona Giunta et al.   JOURNAL OF CELL BIOLOGY

Proliferation of aneuploid human cells is limited by a p53-dependent mechanism

(2010) Sarah L. Thompson et al.   JOURNAL OF CELL BIOLOGY

Centromere DNA decatenation depends on cohesin removal and is required for mammalian cell division

(2010) L. H.-C. Wang et al.   JOURNAL OF CELL SCIENCE

The DNA Damage Response: Making It Safe to Play with Knives

(2010) Alberto Ciccia et al.   MOLECULAR CELL

Genetic activities in micronuclei: Is the DNA entrapped in micronuclei lost for the cell?

(2010) Mariona Terradas et al.   MUTATION RESEARCH-REVIEWS IN MUTATION RESEARCH

The landscape of somatic copy-number alteration across human cancers

(2010) Rameen Beroukhim et al.   NATURE

Maintaining genome stability at the replication fork

(2010) Dana Branzei et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Genomic instability — an evolving hallmark of cancer

(2010) Simona Negrini et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Centromere-localized breaks indicate the generation of DNA damage by the mitotic spindle

(2010) A. A. Guerrero et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Caspase 3/caspase-activated DNase promote cell differentiation by inducing DNA strand breaks

(2010) B. D. Larsen et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Proteins Required for Centrosome Clustering in Cancer Cells

(2010) B. Leber et al.   Science Translational Medicine

The Nuclear Envelope

(2010) M. W. Hetzer   Cold Spring Harbor Perspectives in Biology

A Mitotic Phosphorylation Feedback Network Connects Cdk1, Plk1, 53BP1, and Chk2 to Inactivate the G2/M DNA Damage Checkpoint

(2010) Marcel A. T. M. van Vugt et al.   PLOS BIOLOGY

How the Fanconi Anemia Pathway Guards the Genome

(2009) George-Lucian Moldovan et al.   Annual Review of Genetics

No Way Out for Tumor Cells

(2009) Conly L. Rieder et al.   CANCER CELL

Whole Chromosome Instability Caused by Bub1 Insufficiency Drives Tumorigenesis through Tumor Suppressor Gene Loss of Heterozygosity

(2009) Darren J. Baker et al.   CANCER CELL

Evidence that Mitotic Exit Is a Better Cancer Therapeutic Target Than Spindle Assembly

(2009) Hsiao-Chun Huang et al.   CANCER CELL

Aurora B-Mediated Abscission Checkpoint Protects against Tetraploidization

(2009) Patrick Steigemann et al.   CELL

Mitotic arrest and JNK-induced proteasomal degradation of FLIP and Mcl-1 are key events in the sensitization of breast tumor cells to TRAIL by antimicrotubule agents

(2009) T Sánchez-Pérez et al.   CELL DEATH AND DIFFERENTIATION

A mechanism linking extra centrosomes to chromosomal instability

(2009) Neil J. Ganem et al.   NATURE

Replication stress induces sister-chromatid bridging at fragile site loci in mitosis

(2009) Kok Lung Chan et al.   NATURE CELL BIOLOGY

A mechanism for chromosome segregation sensing by the NoCut checkpoint

(2009) Manuel Mendoza et al.   NATURE CELL BIOLOGY

DNA Damage, Aging, and Cancer

(2009) Jan H.J. Hoeijmakers   NEW ENGLAND JOURNAL OF MEDICINE

Human Condensin Function Is Essential for Centromeric Chromatin Assembly and Proper Sister Kinetochore Orientation

(2009) Alexander Samoshkin et al.   PLoS One

The actin cytoskeleton in spindle assembly and positioning

(2009) Patricia Kunda et al.   TRENDS IN CELL BIOLOGY

Cancer Cells Display Profound Intra- and Interline Variation following Prolonged Exposure to Antimitotic Drugs

(2008) Karen E. Gascoigne et al.   CANCER CELL

Mechanisms to suppress multipolar divisions in cancer cells with extra centrosomes

(2008) M. Kwon et al.   GENES & DEVELOPMENT

RBF1 promotes chromatin condensation through a conserved interaction with the Condensin II protein dCAP-D3

(2008) M. S. Longworth et al.   GENES & DEVELOPMENT

Examining the link between chromosomal instability and aneuploidy in human cells

(2008) Sarah L. Thompson et al.   JOURNAL OF CELL BIOLOGY

Topoisomerase II Inactivation Prevents the Completion of DNA Replication in Budding Yeast

(2008) Jonathan Baxter et al.   MOLECULAR CELL

Extra centrosomes and/or chromosomes prolong mitosis in human cells

(2008) Zhenye Yang et al.   NATURE CELL BIOLOGY

Aneuploidy Affects Proliferation and Spontaneous Immortalization in Mammalian Cells

(2008) B. R. Williams et al.   SCIENCE