Molecular mechanisms of temperature adaptation

TREK2 Expressed Selectively in IB4-Binding C-Fiber Nociceptors Hyperpolarizes Their Membrane Potentials and Limits Spontaneous Pain

(2014) C. Acosta et al.   JOURNAL OF NEUROSCIENCE

Heat and Noxious Chemical Sensor, Chicken TRPA1, as a Target of Bird Repellents and Identification of Its Structural Determinants by Multispecies Functional Comparison

(2014) Shigeru Saito et al.   MOLECULAR BIOLOGY AND EVOLUTION

Directionality of Temperature Activation in Mouse TRPA1 Ion Channel Can Be Inverted by Single-Point Mutations in Ankyrin Repeat Six

(2014) Sairam Jabba et al.   NEURON

A gain-of-function voltage-gated sodium channel 1.8 mutation drives intense hyperexcitability of A- and C-fiber neurons

(2014) Sheldon R. Garrison et al.   PAIN

Heat and AITC activate green anole TRPA1 in a membrane-delimited manner

(2014) Erkin Kurganov et al.   PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY

Down regulation of sodium channels in the central nervous system of hibernating snails

(2014) T. Kiss et al.   PHYSIOLOGY & BEHAVIOR

Over-Expression of TRESK K+ Channels Reduces the Excitability of Trigeminal Ganglion Nociceptors

(2014) Zhaohua Guo et al.   PLoS One

Significant Determinants of Mouse Pain Behaviour

(2014) Michael S. Minett et al.   PLoS One

Human TRPA1 is intrinsically cold- and chemosensitive with and without its N-terminal ankyrin repeat domain

(2014) Lavanya Moparthi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Neuronal mechanism for acute mechanosensitivity in tactile-foraging waterfowl

(2014) E. R. Schneider et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Embryonic thermosensitive TRPA1 determines transgenerational diapause phenotype of the silkworm,Bombyx mori

(2014) Azusa Sato et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Ion Channel Profile of TRPM8 Cold Receptors Reveals a Role of TASK-3 Potassium Channels in Thermosensation

(2014) Cruz Morenilla-Palao et al.   Cell Reports

The Cellular Code for Mammalian Thermosensation

(2013) L. A. Pogorzala et al.   JOURNAL OF NEUROSCIENCE

A Sensory-Labeled Line for Cold: TRPM8-Expressing Sensory Neurons Define the Cellular Basis for Cold, Cold Pain, and Cooling-Mediated Analgesia

(2013) W. M. Knowlton et al.   JOURNAL OF NEUROSCIENCE

Dynamic and Permissive Roles of TRPV1 and TRPV4 Channels for Thermosensation in Mouse Supraoptic Magnocellular Neurosecretory Neurons

(2013) Jessica R. Sudbury et al.   JOURNAL OF NEUROSCIENCE

TRPV1 structures in distinct conformations reveal activation mechanisms

(2013) Erhu Cao et al.   NATURE

Structure of the TRPV1 ion channel determined by electron cryo-microscopy

(2013) Maofu Liao et al.   NATURE

TRPV1 Channels Are Intrinsically Heat Sensitive and Negatively Regulated by Phosphoinositide Lipids

(2013) Erhu Cao et al.   NEURON

The Star-Nosed Mole Reveals Clues to the Molecular Basis of Mammalian Touch

(2013) Kristin A. Gerhold et al.   PLoS One

Metabolic and thermal stimuli control K2P2.1 (TREK-1) through modular sensory and gating domains

(2012) Sviatoslav N Bagriantsev et al.   EMBO JOURNAL

Analysis of Transient Receptor Potential Ankyrin 1 (TRPA1) in Frogs and Lizards Illuminates Both Nociceptive Heat and Chemical Sensitivities and Coexpression with TRP Vanilloid 1 (TRPV1) in Ancestral Vertebrates

(2012) Shigeru Saito et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Pharmacological Blockade of the Cold Receptor TRPM8 Attenuates Autonomic and Behavioral Cold Defenses and Decreases Deep Body Temperature

(2012) M. C. Almeida et al.   JOURNAL OF NEUROSCIENCE

Residues in the pore region ofDrosophilatransient receptor potential A1 dictate sensitivity to thermal stimuli

(2012) Hong Wang et al.   JOURNAL OF PHYSIOLOGY-LONDON

Leak K+ channel mRNAs in dorsal root ganglia: Relation to inflammation and spontaneous pain behaviour

(2012) Barnaby Marsh et al.   MOLECULAR AND CELLULAR NEUROSCIENCE

Transient Receptor Potential Melastatin 8 (TRPM8) Channels are Involved in Body Temperature Regulation

(2012) Narender R Gavva et al.   Molecular Pain

Nav1.8 expression is not restricted to nociceptors in mouse peripheral nervous system

(2012) Shannon D. Shields et al.   PAIN

Deletion of TRAAK Potassium Channel Affects Brain Metabolism and Protects against Ischemia

(2012) Christophe Laigle et al.   PLoS One

Thermosensory and Nonthermosensory Isoforms of Drosophila melanogaster TRPA1 Reveal Heat-Sensor Domains of a ThermoTRP Channel

(2012) Lixian Zhong et al.   Cell Reports

Multiple modalities converge on a common gate to control K2Pchannel function

(2011) Sviatoslav N Bagriantsev et al.   EMBO JOURNAL

Oxaliplatin-induced cold hypersensitivity is due to remodelling of ion channel expression in nociceptors

(2011) Juliette Descoeur et al.   EMBO Molecular Medicine

Trpv1 Reporter Mice Reveal Highly Restricted Brain Distribution and Functional Expression in Arteriolar Smooth Muscle Cells

(2011) D. J. Cavanaugh et al.   JOURNAL OF NEUROSCIENCE

TRP Vanilloid 2 Knock-Out Mice Are Susceptible to Perinatal Lethality But Display Normal Thermal and Mechanical Nociception

(2011) U. Park et al.   JOURNAL OF NEUROSCIENCE

TRPV3 and TRPV4 Ion Channels are Not Major Contributors to Mouse Heat Sensation

(2011) Susan M Huang et al.   Molecular Pain

Modulation of TRPA1 thermal sensitivity enables sensory discrimination in Drosophila

(2011) Kyeongjin Kang et al.   NATURE

Ganglion-specific splicing of TRPV1 underlies infrared sensation in vampire bats

(2011) Elena O. Gracheva et al.   NATURE

TRPM3 Is a Nociceptor Channel Involved in the Detection of Noxious Heat

(2011) Joris Vriens et al.   NEURON

Cytoplasmic ankyrin repeats of transient receptor potential A1 (TRPA1) dictate sensitivity to thermal and chemical stimuli

(2011) J. F. Cordero-Morales et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Hypermorphic mutation of the voltage-gated sodium channel encoding gene Scn10a causes a dramatic stimulus-dependent neurobehavioral phenotype

(2011) A. L. Blasius et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

TRPV1-lineage neurons are required for thermal sensation

(2010) Santosh K Mishra et al.   EMBO JOURNAL

Osmotic and thermal control of magnocellular neurosecretory neurons - role of an N-terminal variant of trpv1

(2010) Jessica R. Sudbury et al.   EUROPEAN JOURNAL OF NEUROSCIENCE

TRPA1 Contributes to Cold Hypersensitivity

(2010) D. del Camino et al.   JOURNAL OF NEUROSCIENCE

Molecular basis of infrared detection by snakes

(2010) Elena O. Gracheva et al.   NATURE

Specific roles for DEG/ENaC and TRP channels in touch and thermosensation in C. elegans nociceptors

(2010) Marios Chatzigeorgiou et al.   NATURE NEUROSCIENCE

TRPM8, but not TRPA1, is required for neural and behavioral responses to acute noxious cold temperatures and cold-mimetics in vivo

(2010) Wendy M. Knowlton et al.   PAIN

The mechano-activated K+ channels TRAAK and TREK-1 control both warm and cold perception

(2009) Jacques Noël et al.   EMBO JOURNAL

Immunohistochemical colocalization of TREK-1, TREK-2 and TRAAK with TRP channels in the trigeminal ganglion cells

(2009) Yoshio Yamamoto et al.   NEUROSCIENCE LETTERS

Evolution of Thermal Response Properties in a Cold-Activated TRP Channel

(2009) Benjamin R. Myers et al.   PLoS One

TRPA1 acts as a cold sensor in vitro and in vivo

(2009) Y. Karashima et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

An internal thermal sensor controlling temperature preference in Drosophila

(2008) Fumika N. Hamada et al.   NATURE

Pungent agents from Szechuan peppers excite sensory neurons by inhibiting two-pore potassium channels

(2008) Diana M Bautista et al.   NATURE NEUROSCIENCE

TRPV1 Gene Required for Thermosensory Transduction and Anticipatory Secretion from Vasopressin Neurons during Hyperthermia

(2008) Reza Sharif-Naeini et al.   NEURON

The Cell and Molecular Basis of Mechanical, Cold, and Inflammatory Pain

(2008) B. Abrahamsen et al.   SCIENCE