Metabolic and thermal stimuli control K2P2.1 (TREK-1) through modular sensory and gating domains

Selective disruption of high sensitivity heat activation but not capsaicin activation of TRPV1 channels by pore turret mutations

(2012) Yuanyuan Cui et al.   JOURNAL OF GENERAL PHYSIOLOGY

Structure of a KirBac potassium channel with an open bundle crossing indicates a mechanism of channel gating

(2012) Vassiliy N Bavro et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

TWIK1, a unique background channel with variable ion selectivity

(2012) F. C. Chatelain et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Crystal Structure of the Human K2P TRAAK, a Lipid- and Mechano-Sensitive K+ Ion Channel

(2012) S. G. Brohawn et al.   SCIENCE

Crystal Structure of the Human Two-Pore Domain Potassium Channel K2P1

(2012) A. N. Miller et al.   SCIENCE

Thermosensory and Nonthermosensory Isoforms of Drosophila melanogaster TRPA1 Reveal Heat-Sensor Domains of a ThermoTRP Channel

(2012) Lixian Zhong et al.   Cell Reports

Structural correlates of selectivity and inactivation in potassium channels

(2011) Jason G. McCoy et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES

A Multipoint Hydrogen-Bond Network Underlying KcsA C-Type Inactivation

(2011) Julio F. Cordero-Morales et al.   BIOPHYSICAL JOURNAL

Crystal Structure of the Mammalian GIRK2 K+ Channel and Gating Regulation by G Proteins, PIP2, and Sodium

(2011) Matthew R. Whorton et al.   CELL

Molecular regulations governing TREK and TRAAK channel functions

(2011) Jacques Noël et al.   Channels

The pore structure and gating mechanism of K2P channels

(2011) Paula L Piechotta et al.   EMBO JOURNAL

Multiple modalities converge on a common gate to control K2Pchannel function

(2011) Sviatoslav N Bagriantsev et al.   EMBO JOURNAL

External Ba2+Block of the Two-pore Domain Potassium Channel TREK-1 Defines Conformational Transition in Its Selectivity Filter

(2011) Xiao-Yun Ma et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Ganglion-specific splicing of TRPV1 underlies infrared sensation in vampire bats

(2011) Elena O. Gracheva et al.   NATURE

Structural basis of PIP2 activation of the classical inward rectifier K+ channel Kir2.2

(2011) Scott B. Hansen et al.   NATURE

Mechanism for selectivity-inactivation coupling in KcsA potassium channels

(2011) W. W. L. Cheng et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Cytoplasmic ankyrin repeats of transient receptor potential A1 (TRPA1) dictate sensitivity to thermal and chemical stimuli

(2011) J. F. Cordero-Morales et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Modular thermal sensors in temperature-gated transient receptor potential (TRP) channels

(2011) J. Yao et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Optical probing of a dynamic membrane interaction that regulates the TREK1 channel

(2011) G. Sandoz et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Domain Reorientation and Rotation of an Intracellular Assembly Regulate Conduction in Kir Potassium Channels

(2010) Oliver B. Clarke et al.   CELL

Separate Gating Mechanisms Mediate the Regulation of K2PPotassium Channel TASK-2 by Intra- and Extracellular pH

(2010) María Isabel Niemeyer et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Structural mechanism of C-type inactivation in K+ channels

(2010) Luis G. Cuello et al.   NATURE

Structural basis for the coupling between activation and inactivation gates in K+ channels

(2010) Luis G. Cuello et al.   NATURE

Molecular basis of infrared detection by snakes

(2010) Elena O. Gracheva et al.   NATURE

Temperature-induced opening of TRPV1 ion channel is stabilized by the pore domain

(2010) Jörg Grandl et al.   NATURE NEUROSCIENCE

Molecular Background of Leak K+ Currents: Two-Pore Domain Potassium Channels

(2010) Péter Enyedi et al.   PHYSIOLOGICAL REVIEWS

Thermosensitive TRP channel pore turret is part of the temperature activation pathway

(2010) F. Yang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The mechano-activated K+ channels TRAAK and TREK-1 control both warm and cold perception

(2009) Jacques Noël et al.   EMBO JOURNAL

Disruption of the IS6-AID Linker Affects Voltage-gated Calcium Channel Inactivation and Facilitation

(2009) Felix Findeisen et al.   JOURNAL OF GENERAL PHYSIOLOGY

Molecular mechanisms underlying membrane-potential-mediated regulation of neuronal K2P2.1 channels

(2009) Yifat Segal-Hayoun et al.   MOLECULAR AND CELLULAR NEUROSCIENCE

Immunohistochemical colocalization of TREK-1, TREK-2 and TRAAK with TRP channels in the trigeminal ganglion cells

(2009) Yoshio Yamamoto et al.   NEUROSCIENCE LETTERS

Extracellular acidification exerts opposite actions on TREK1 and TREK2 potassium channels via a single conserved histidine residue

(2009) G. Sandoz et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Crystal structure of full-length KcsA in its closed conformation

(2009) S. Uysal et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Crystal Structure of the Eukaryotic Strong Inward-Rectifier K+ Channel Kir2.2 at 3.1 A Resolution

(2009) X. Tao et al.   SCIENCE

The M1P1 Loop of TASK3 K2P Channels Apposes the Selectivity Filter and Influences Channel Function

(2008) Catherine E. Clarke et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

A Novel Mechanism for Human K2P2.1 Channel Gating

(2008) Asi Cohen et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Origin of the Voltage Dependence of G-Protein Regulation of P/Q-type Ca2+ Channels

(2008) Y. Zhang et al.   JOURNAL OF NEUROSCIENCE

Mtap2 Is a Constituent of the Protein Network That Regulates Twik-Related K+ Channel Expression and Trafficking

(2008) G. Sandoz et al.   JOURNAL OF NEUROSCIENCE

An internal thermal sensor controlling temperature preference in Drosophila

(2008) Fumika N. Hamada et al.   NATURE

Pore region of TRPV3 ion channel is specifically required for heat activation

(2008) Jörg Grandl et al.   NATURE NEUROSCIENCE

Inverse coupling in leak and voltage-activated K+ channel gates underlies distinct roles in electrical signaling

(2008) Yuval Ben-Abu et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

A Yeast Genetic Screen Reveals a Critical Role for the Pore Helix Domain in TRP Channel Gating

(2008) Benjamin R. Myers et al.   NEURON