Correction of cognitive deficits in mouse models of Down syndrome by a pharmacological inhibitor of DYRK1A

Dual-specificity tyrosine phosphorylation-regulated kinase 1A (DYRK1A) inhibitors: a survey of recent patent literature

(2017) Thu Lan Nguyen et al.   EXPERT OPINION ON THERAPEUTIC PATENTS

The connectomics of brain demyelination: Functional and structural patterns in the cuprizone mouse model

(2017) Neele S. Hübner et al.   NEUROIMAGE

Prenatal neurogenesis induction therapy normalizes brain structure and function in Down syndrome mice

(2017) Akiko Nakano-Kobayashi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A chemical with proven clinical safety rescues Down-syndrome-related phenotypes in through DYRK1A inhibition

(2016) Hyeongki Kim et al.   Disease Models & Mechanisms

Longitudinal measures of cognition in the Ts65Dn mouse: Refining windows and defining modalities for therapeutic intervention in Down syndrome

(2016) J. Luis Olmos-Serrano et al.   EXPERIMENTAL NEUROLOGY

DYRK1A inhibition as potential treatment for Alzheimer’s disease

(2016) Silvia Stotani et al.   Future Medicinal Chemistry

Safety and efficacy of cognitive training plus epigallocatechin-3-gallate in young adults with Down's syndrome (TESDAD): a double-blind, randomised, placebo-controlled, phase 2 trial

(2016) Rafael de la Torre et al.   LANCET NEUROLOGY

Dementia in Down's syndrome

(2016) Clive Ballard et al.   LANCET NEUROLOGY

Mouse models of Down syndrome: gene content and consequences

(2016) Meenal Gupta et al.   MAMMALIAN GENOME

Phosphorylation of β-Tubulin by the Down Syndrome Kinase, Minibrain/DYRK1a, Regulates Microtubule Dynamics and Dendrite Morphogenesis

(2016) Kassandra M. Ori-McKenney et al.   NEURON

DYRK1A, a Dosage-Sensitive Gene Involved in Neurodevelopmental Disorders, Is a Target for Drug Development in Down Syndrome

(2016) Arnaud Duchon et al.   Frontiers in Behavioral Neuroscience

Fully-Automated μMRI Morphometric Phenotyping of the Tc1 Mouse Model of Down Syndrome

(2016) Nick M. Powell et al.   PLoS One

The Brain's Default Mode Network

(2015) Marcus E. Raichle   Annual Review of Neuroscience

Anomalous brain functional connectivity contributing to poor adaptive behavior in Down syndrome

(2015) Jesus Pujol et al.   CORTEX

Leucettine L41, a DYRK1A-preferential DYRKs/CLKs inhibitor, prevents memory impairments and neurotoxicity induced by oligomeric Aβ25–35 peptide administration in mice

(2015) Gaëlle Naert et al.   EUROPEAN NEUROPSYCHOPHARMACOLOGY

Genetic dissection of the Down syndrome critical region

(2015) Xiaoling Jiang et al.   HUMAN MOLECULAR GENETICS

Truncation and Activation of Dual Specificity Tyrosine Phosphorylation-regulated Kinase 1A by Calpain I

(2015) Nana Jin et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

A novel DYRK1A (Dual specificity tyrosine phosphorylation-regulated kinase 1A) inhibitor for the treatment of Alzheimer's disease: effect on Tau and amyloid pathologiesin vitro

(2015) Séverine Coutadeur et al.   JOURNAL OF NEUROCHEMISTRY

Evidence of altered age-related brain cytoarchitecture in mouse models of down syndrome: a diffusional kurtosis imaging study

(2015) Xingju Nie et al.   MAGNETIC RESONANCE IMAGING

Chromatin-wide Profiling of DYRK1A Reveals a Role as a Gene-Specific RNA Polymerase II CTD Kinase

(2015) Chiara Di Vona et al.   MOLECULAR CELL

Loss of PCLO function underlies pontocerebellar hypoplasia type III

(2015) M. Y. Ahmed et al.   NEUROLOGY

Applying the ARRIVE Guidelines to an In Vivo Database

(2015) Natasha A. Karp et al.   PLOS BIOLOGY

The Down syndrome-related protein kinase DYRK1A phosphorylates p27Kip1and Cyclin D1 and induces cell cycle exit and neuronal differentiation

(2014) Ulf Soppa et al.   CELL CYCLE

Molecular Rescue of DYRK1A Overexpression in Cystathionine Beta Synthase-Deficient Mouse Brain by Enriched Environment Combined with Voluntary Exercise

(2014) Benoit Souchet et al.   JOURNAL OF MOLECULAR NEUROSCIENCE

Prefrontal Deficits in a Murine Model Overexpressing the Down Syndrome Candidate Gene Dyrk1a

(2014) A. Thomazeau et al.   JOURNAL OF NEUROSCIENCE

Excitation/inhibition balance and learning are modified by Dyrk1a gene dosage

(2014) Benoit Souchet et al.   NEUROBIOLOGY OF DISEASE

Overexpression of Dyrk1A Is Implicated in Several Cognitive, Electrophysiological and Neuromorphological Alterations Found in a Mouse Model of Down Syndrome

(2014) Susana García-Cerro et al.   PLoS One

Large-scale topology and the default mode network in the mouse connectome

(2014) James M. Stafford et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

DYRK1A-mediated phosphorylation of GluN2A at Ser1048 regulates the surface expression and channel activity of GluN1/GluN2A receptors

(2014) Cristina Grau et al.   Frontiers in Cellular Neuroscience

Activity-dependent facilitation of Synaptojanin and synaptic vesicle recycling by the Minibrain kinase

(2014) Chun-Kan Chen et al.   Nature Communications

Mechanism of dual specificity kinase activity of DYRK1A

(2013) Agnes Walte et al.   FEBS Journal

Epigallocatechin-3-gallate, a DYRK1A inhibitor, rescues cognitive deficits in Down syndrome mouse models and in humans

(2013) Rafael De la Torre et al.   MOLECULAR NUTRITION & FOOD RESEARCH

Environmental enrichment rescues DYRK1A activity and hippocampal adult neurogenesis in TgDyrk1A

(2013) Meritxell Pons-Espinal et al.   NEUROBIOLOGY OF DISEASE

Distributed BOLD and CBV-weighted resting-state networks in the mouse brain

(2013) Francesco Sforazzini et al.   NEUROIMAGE

Abnormal brain synchrony in Down Syndrome

(2013) Jeffrey S. Anderson et al.   NeuroImage-Clinical

Recent Advances in the Design, Synthesis, and Biological Evaluation of Selective DYRK1A Inhibitors: A New Avenue for a Disease Modifying Treatment of Alzheimer’s?

(2012) Breland Smith et al.   ACS Chemical Neuroscience

Molecular cytogenetic characterization of an interstitial deletion of chromosome 21 (21q22.13q22.3) in a patient with dysmorphic features, intellectual disability and severe generalized epilepsy

(2012) Angelo Valetto et al.   European Journal of Medical Genetics

Dual-specificity Tyrosine Phosphorylation-regulated Kinase 1A (Dyrk1A) Modulates Serine/Arginine-rich Protein 55 (SRp55)-promoted Tau Exon 10 Inclusion

(2012) Xiaomin Yin et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

TheDYRK1Agene is a cause of syndromic intellectual disability with severe microcephaly and epilepsy

(2012) Jean-Benoît Courcet et al.   JOURNAL OF MEDICAL GENETICS

Selectivity, Cocrystal Structures, and Neuroprotective Properties of Leucettines, a Family of Protein Kinase Inhibitors Derived from the Marine Sponge Alkaloid Leucettamine B

(2012) Tania Tahtouh et al.   JOURNAL OF MEDICINAL CHEMISTRY

DYRK1A: A master regulatory protein controlling brain growth

(2012) Fayçal Guedj et al.   NEUROBIOLOGY OF DISEASE

Normalization of Dyrk1A expression by AAV2/1-shDyrk1A attenuates hippocampal-dependent defects in the Ts65Dn mouse model of Down syndrome

(2012) Xavier Altafaj et al.   NEUROBIOLOGY OF DISEASE

Phosphorylation by Dyrk1A of Clathrin Coated Vesicle-Associated Proteins: Identification of the Substrate Proteins and the Effects of Phosphorylation

(2012) Noriko Murakami et al.   PLoS One

DYRK1A protein kinase promotes quiescence and senescence through DREAM complex assembly

(2011) L. Litovchick et al.   GENES & DEVELOPMENT

SYN1 loss-of-function mutations in autism and partial epilepsy cause impaired synaptic function

(2011) Anna Fassio et al.   HUMAN MOLECULAR GENETICS

Leucettines, a Class of Potent Inhibitors of cdc2-Like Kinases and Dual Specificity, Tyrosine Phosphorylation Regulated Kinases Derived from the Marine Sponge Leucettamine B: Modulation of Alternative Pre-RNA Splicing

(2011) Mansour Debdab et al.   JOURNAL OF MEDICINAL CHEMISTRY

Piccolo Regulates the Dynamic Assembly of Presynaptic F-Actin

(2011) C. L. Waites et al.   JOURNAL OF NEUROSCIENCE

Identification of the translocation breakpoints in the Ts65Dn and Ts1Cje mouse lines: relevance for modeling down syndrome

(2011) Arnaud Duchon et al.   MAMMALIAN GENOME

Increased functional connectivity indicates the severity of cognitive impairment in multiple sclerosis

(2011) D. J. Hawellek et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Clinical manifestations of the deletion of Down syndrome critical region including DYRK1A and KCNJ6

(2010) Toshiyuki Yamamoto et al.   AMERICAN JOURNAL OF MEDICAL GENETICS PART A

High-content siRNA screening of the kinome identifies kinases involved in Alzheimer's disease-related tau hyperphosphorylation

(2010) David O Azorsa et al.   BMC GENOMICS

Effects of individual segmental trisomies of human chromosome 21 syntenic regions on hippocampal long-term potentiation and cognitive behaviors in mice

(2010) Tao Yu et al.   BRAIN RESEARCH

Dyrk1A-mediated phosphorylation of Presenilin 1: a functional link between Down syndrome and Alzheimer’s disease

(2010) Young Shin Ryu et al.   JOURNAL OF NEUROCHEMISTRY

Link Between DYRK1A Overexpression and Several-Fold Enhancement of Neurofibrillary Degeneration With 3-Repeat Tau Protein in Down Syndrome

(2010) Jerzy Wegiel et al.   JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY

The synapsins: Key actors of synapse function and plasticity

(2010) F. Cesca et al.   PROGRESS IN NEUROBIOLOGY

Improving Bioscience Research Reporting: The ARRIVE Guidelines for Reporting Animal Research

(2010) Carol Kilkenny et al.   PLOS BIOLOGY

Nonprimed and DYRK1A-primed GSK3 -phosphorylation sites on MAP1B regulate microtubule dynamics in growing axons

(2009) T. M. E. Scales et al.   JOURNAL OF CELL SCIENCE

Tea catechins’ affinity for human cannabinoid receptors

(2009) G. Korte et al.   PHYTOMEDICINE

Green Tea Polyphenols Rescue of Brain Defects Induced by Overexpression of DYRK1A

(2009) Fayçal Guedj et al.   PLoS One

Truncation of the Down Syndrome Candidate Gene DYRK1A in Two Unrelated Patients with Microcephaly

(2008) Rikke S. Møller et al.   AMERICAN JOURNAL OF HUMAN GENETICS

"Sighted C3H" mice - a tool for analysing the influence of vision on mouse behaviour?

(2008) Sabine et al.   Frontiers in Bioscience-Landmark

Increased Dosage of Dyrk1A Alters Alternative Splicing Factor (ASF)-regulated Alternative Splicing of Tau in Down Syndrome

(2008) Jianhua Shi et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Piccolo modulation of Synapsin1a dynamics regulates synaptic vesicle exocytosis

(2008) Sergio Leal-Ortiz et al.   JOURNAL OF CELL BIOLOGY

The down syndrome candidate dual-specificity tyrosine phosphorylation-regulated kinase 1A phosphorylates the neurodegeneration-related septin 4

(2008) J.H. Sitz et al.   NEUROSCIENCE

Dual-specificity tyrosine(Y)-phosphorylation regulated kinase 1A-mediated phosphorylation of amyloid precursor protein: evidence for a functional link between Down syndrome and Alzheimer’s disease

(2007) Soo-Ryoon Ryoo et al.   JOURNAL OF NEUROCHEMISTRY