A chemical with proven clinical safety rescues Down-syndrome-related phenotypes in through DYRK1A inhibition
Published 2016 View Full Article
- Home
- Publications
- Publication Search
- Publication Details
Title
A chemical with proven clinical safety rescues Down-syndrome-related phenotypes in through DYRK1A inhibition
Authors
Keywords
-
Journal
Disease Models & Mechanisms
Volume 9, Issue 8, Pages 839-848
Publisher
The Company of Biologists
Online
2016-07-08
DOI
10.1242/dmm.025668
References
Ask authors/readers for more resources
Related references
Note: Only part of the references are listed.- A high-throughput chemical screen reveals that harmine-mediated inhibition of DYRK1A increases human pancreatic beta cell replication
- (2015) Peng Wang et al. NATURE MEDICINE
- Regulation of diacylglycerol acyltransferase 2 protein stability by gp78-associated endoplasmic-reticulum-associated degradation
- (2014) Kwangman Choi et al. FEBS Journal
- Identification of a Novel Function of CX-4945 as a Splicing Regulator
- (2014) Hyeongki Kim et al. PLoS One
- Epigallocatechin-3-gallate, a DYRK1A inhibitor, rescues cognitive deficits in Down syndrome mouse models and in humans
- (2013) Rafael De la Torre et al. MOLECULAR NUTRITION & FOOD RESEARCH
- Riquiqui and Minibrain are regulators of the Hippo pathway downstream of Dachsous
- (2013) Joffrey L. Degoutin et al. NATURE CELL BIOLOGY
- Recent Advances in the Design, Synthesis, and Biological Evaluation of Selective DYRK1A Inhibitors: A New Avenue for a Disease Modifying Treatment of Alzheimer’s?
- (2012) Breland Smith et al. ACS Chemical Neuroscience
- DYRK1A Kinase Inhibitors with Emphasis on Cancer
- (2012) A. Ionescu et al. MINI-REVIEWS IN MEDICINAL CHEMISTRY
- Minibrain/Dyrk1a Regulates Food Intake through the Sir2-FOXO-sNPF/NPY Pathway in Drosophila and Mammals
- (2012) Seung-Hyun Hong et al. PLoS Genetics
- Specific CLK Inhibitors from a Novel Chemotype for Regulation of Alternative Splicing
- (2011) Oleg Fedorov et al. CHEMISTRY & BIOLOGY
- Leucettines, a Class of Potent Inhibitors of cdc2-Like Kinases and Dual Specificity, Tyrosine Phosphorylation Regulated Kinases Derived from the Marine Sponge Leucettamine B: Modulation of Alternative Pre-RNA Splicing
- (2011) Mansour Debdab et al. JOURNAL OF MEDICINAL CHEMISTRY
- Harmine is an ATP-competitive inhibitor for dual-specificity tyrosine phosphorylation-regulated kinase 1A (Dyrk1A)
- (2010) Tatyana Adayev et al. ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS
- CX-4945, an Orally Bioavailable Selective Inhibitor of Protein Kinase CK2, Inhibits Prosurvival and Angiogenic Signaling and Exhibits Antitumor Efficacy
- (2010) A. Siddiqui-Jain et al. CANCER RESEARCH
- DYRK family of protein kinases: evolutionary relationships, biochemical properties, and functional roles
- (2010) Sergi Aranda et al. FASEB JOURNAL
- MNB/DYRK1A as a multiple regulator of neuronal development
- (2010) Francisco J. Tejedor et al. FEBS Journal
- The role of DYRK1A in neurodegenerative diseases
- (2010) Jerzy Wegiel et al. FEBS Journal
- Structural basis of CX-4945 binding to human protein kinase CK2
- (2010) Andrew D. Ferguson et al. FEBS LETTERS
- Dyrk1A-mediated phosphorylation of Presenilin 1: a functional link between Down syndrome and Alzheimer’s disease
- (2010) Young Shin Ryu et al. JOURNAL OF NEUROCHEMISTRY
- Development of a novel selective inhibitor of the Down syndrome-related kinase Dyrk1A
- (2010) Yasushi Ogawa et al. Nature Communications
- Evaluation of substituted 6-arylquinazolin-4-amines as potent and selective inhibitors of cdc2-like kinases (Clk)
- (2009) Bryan T. Mott et al. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
- Down syndrome--recent progress and future prospects
- (2009) F. K. Wiseman et al. HUMAN MOLECULAR GENETICS
- Drosophila short neuropeptide F signalling regulates growth by ERK-mediated insulin signalling
- (2008) Kyu-Sun Lee et al. NATURE CELL BIOLOGY
- Impaired Spatial Learning Strategies and Novel Object Recognition in Mice Haploinsufficient for the Dual Specificity Tyrosine-Regulated Kinase-1A (Dyrk1A)
- (2008) Glòria Arqué et al. PLoS One
- Dual-specificity tyrosine(Y)-phosphorylation regulated kinase 1A-mediated phosphorylation of amyloid precursor protein: evidence for a functional link between Down syndrome and Alzheimer’s disease
- (2007) Soo-Ryoon Ryoo et al. JOURNAL OF NEUROCHEMISTRY
Find the ideal target journal for your manuscript
Explore over 38,000 international journals covering a vast array of academic fields.
SearchAsk a Question. Answer a Question.
Quickly pose questions to the entire community. Debate answers and get clarity on the most important issues facing researchers.
Get Started