Pathogenic mechanisms of acute pancreatitis

Pharmacological and genetic inhibition of calcineurin protects against carbachol-induced pathological zymogen activation and acinar cell injury

(2012) Kamaldeen A. Muili et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

Fractalkine Upregulates Inflammation through CX3CR1 and the Jak–Stat Pathway in Severe Acute Pancreatitis Rat Model

(2012) Li-ya Huang et al.   INFLAMMATION

Impaired autophagy and organellar dysfunction in pancreatitis

(2012) Ilya Gukovsky et al.   JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY

Inflammasomes in health and disease

(2012) Till Strowig et al.   NATURE

Effects of Mitogen-Activated Protein Kinase Signaling Pathway Inhibition on the Development of Cerulein-Induced Acute Pancreatitis in Mice

(2012) Emanuela Mazzon et al.   PANCREAS

Protein Kinase D Regulates Cell Death Pathways in Experimental Pancreatitis

(2012) Jingzhen Yuan et al.   Frontiers in Physiology

Organellar Dysfunction in the Pathogenesis of Pancreatitis

(2011) Ilya Gukovsky et al.   ANTIOXIDANTS & REDOX SIGNALING

Drinking and driving pancreatitis

(2011) Aurelia Lugea et al.   Autophagy

The endo-lysosomal system as an NAADP-sensitive acidic Ca2+ store: Role for the two-pore channels

(2011) Sandip Patel et al.   CELL CALCIUM

Ca2+ signaling mechanisms of cell survival and cell death: An introduction

(2011) H. De Smedt et al.   CELL CALCIUM

Acidic Ca2+ stores come to the fore

(2011) Sandip Patel et al.   CELL CALCIUM

Aberrant Ca2+ signalling through acidic calcium stores in pancreatic acinar cells

(2011) O.H. Petersen et al.   CELL CALCIUM

A dual role for Ca2+ in autophagy regulation

(2011) Jean-Paul Decuypere et al.   CELL CALCIUM

Molecular mechanisms of pancreatic injury

(2011) Raghuwansh P. Sah et al.   CURRENT OPINION IN GASTROENTEROLOGY

Upregulation of PIAS1 protects against sodium taurocholate-induced severe acute pancreatitis associated with acute lung injury

(2011) Ping Chen et al.   CYTOKINE

Redox signaling and histone acetylation in acute pancreatitis

(2011) Javier Escobar et al.   FREE RADICAL BIOLOGY AND MEDICINE

Myeloid, but Not Pancreatic, RelA/p65 Is Required for Fibrosis in a Mouse Model of Chronic Pancreatitis

(2011) Matthias Treiber et al.   GASTROENTEROLOGY

Genetic and Pharmacologic Inhibition of the Ca2+ Influx Channel TRPC3 Protects Secretory Epithelia From Ca2+-Dependent Toxicity

(2011) Min Seuk Kim et al.   GASTROENTEROLOGY

Intra-acinar Trypsinogen Activation Mediates Early Stages of Pancreatic Injury but Not Inflammation in Mice With Acute Pancreatitis

(2011) Rajinder Dawra et al.   GASTROENTEROLOGY

Interferon Regulatory Factor-2 Regulates Exocytosis Mechanisms Mediated by SNAREs in Pancreatic Acinar Cells

(2011) Hirosato Mashima et al.   GASTROENTEROLOGY

TLR9 and the NLRP3 Inflammasome Link Acinar Cell Death With Inflammation in Acute Pancreatitis

(2011) Rafaz Hoque et al.   GASTROENTEROLOGY

Intracellular activation of trypsinogen in transgenic mice induces acute but not chronic pancreatitis

(2011) S. Gaiser et al.   GUT

Sensing damage by the NLRP3 inflammasome

(2011) Jaklien C. Leemans et al.   IMMUNOLOGICAL REVIEWS

Melittin inhibits cerulein-induced acute pancreatitis via inhibition of the JNK pathway

(2011) Seung-Won Yun et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Cyclic Adenosine Diphosphate Ribose Activates Ryanodine Receptors, whereas NAADP Activates Two-pore Domain Channels

(2011) Oluseye A. Ogunbayo et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Effects of c-Jun N-Terminal Kinase Signaling Pathway on Severe Acute Pancreatitis–Associated Lung Injury

(2011) Mingdong Liu et al.   PANCREAS

Calmodulin protects against alcohol-induced pancreatic trypsinogen activation elicited via Ca2+ release through IP3 receptors

(2011) J. V. Gerasimenko et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Essential Regulation of Cell Bioenergetics by Constitutive InsP3 Receptor Ca2+ Transfer to Mitochondria

(2010) César Cárdenas et al.   CELL

An intimate liaison: spatial organization of the endoplasmic reticulum–mitochondria relationship

(2010) Olga Martins de Brito et al.   EMBO JOURNAL

Adaptive Unfolded Protein Response Attenuates Alcohol-Induced Pancreatic Damage

(2010) Aurelia Lugea et al.   GASTROENTEROLOGY

Zymophagy, a Novel Selective Autophagy Pathway Mediated by VMP1-USP9x-p62, Prevents Pancreatic Cell Death

(2010) Daniel Grasso et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Acidic calcium stores open for business: expanding the potential for intracellular Ca2+ signaling

(2010) Sandip Patel et al.   TRENDS IN CELL BIOLOGY

Nelfinavir/ritonavir reduces acinar injury but not inflammation during mouse caerulein pancreatitis

(2009) Vijay P. Singh et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

The Inflammasomes: Guardians of the Body

(2009) Fabio Martinon et al.   Annual Review of Immunology

Regulation and Function of NF-κB Transcription Factors in the Immune System

(2009) Sivakumar Vallabhapurapu et al.   Annual Review of Immunology

STIM1 Clusters and Activates CRAC Channels via Direct Binding of a Cytosolic Domain to Orai1

(2009) Chan Young Park et al.   CELL

Roles of NF-κB in health and disease: mechanisms and therapeutic potential

(2009) Ee Tsin Wong et al.   CLINICAL SCIENCE

Cross-Talk between Oxidative Stress and Pro-Inflammatory Cytokines in Acute Pancreatitis: A Key Role for Protein Phosphatases

(2009) Javier Escobar et al.   CURRENT PHARMACEUTICAL DESIGN

An endoplasmic reticulum/plasma membrane junction: STIM1/Orai1/TRPCs

(2009) Kyu Pil Lee et al.   FEBS LETTERS

Impaired Autolysosome Formation Correlates With Lamp-2 Depletion: Role of Apoptosis, Autophagy, and Necrosis in Pancreatitis

(2009) Franco Fortunato et al.   GASTROENTEROLOGY

Deletion of TRPC3 in Mice Reduces Store-Operated Ca2+ Influx and the Severity of Acute Pancreatitis

(2009) Min Seuk Kim et al.   GASTROENTEROLOGY

New Insights Into the Mechanisms of Pancreatitis

(2009) Herbert Y. Gaisano et al.   GASTROENTEROLOGY

Biliary Acute Pancreatitis in Mice is Mediated by the G-Protein−Coupled Cell Surface Bile Acid Receptor Gpbar1

(2009) George Perides et al.   GASTROENTEROLOGY

Intracellular Trypsin Induces Pancreatic Acinar Cell Death but Not NF-κB Activation

(2009) Baoan Ji et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Pancreatic protease activation by alcohol metabolite depends on Ca2+ release via acid store IP3 receptors

(2009) J. V. Gerasimenko et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

MAM: more than just a housekeeper

(2009) Teruo Hayashi et al.   TRENDS IN CELL BIOLOGY

PAR2 exerts local protection against acute pancreatitis via modulation of MAP kinase and MAP kinase phosphatase signaling

(2008) Wan Namkung et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

Mitochondrial injury in pancreatitis

(2008) R MUKHERJEE et al.   CELL CALCIUM

Involvement of autophagy in trypsinogen activation within the pancreatic acinar cells

(2008) Daisuke Hashimoto et al.   JOURNAL OF CELL BIOLOGY

Calcium and apoptosis: ER-mitochondria Ca2+ transfer in the control of apoptosis

(2008) P Pinton et al.   ONCOGENE

Polarized Calcium Signaling in Exocrine Gland Cells

(2007) Ole H. Petersen et al.   Annual Review of Physiology