An endoplasmic reticulum/plasma membrane junction: STIM1/Orai1/TRPCs

The TRPC Class of Ion Channels: A Critical Review of Their Roles in Slow, Sustained Increases in Intracellular Ca2+ Concentrations

(2009) Lutz Birnbaumer   Annual Review of Pharmacology and Toxicology

A minimal regulatory domain in the C terminus of STIM1 binds to and activates ORAI1 CRAC channels

(2009) Takumi Kawasaki et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

STIM1 Clusters and Activates CRAC Channels via Direct Binding of a Cytosolic Domain to Orai1

(2009) Chan Young Park et al.   CELL

Recent progress on STIM1 domains controlling Orai activation

(2009) R. Schindl et al.   CELL CALCIUM

Deletion of TRPC3 in Mice Reduces Store-Operated Ca2+ Influx and the Severity of Acute Pancreatitis

(2009) Min Seuk Kim et al.   GASTROENTEROLOGY

A Cytosolic Homomerization and a Modulatory Domain within STIM1 C Terminus Determine Coupling to ORAI1 Channels

(2009) Martin Muik et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

A Ca2+Release-activated Ca2+(CRAC) Modulatory Domain (CMD) within STIM1 Mediates Fast Ca2+-dependent Inactivation of ORAI1 Channels

(2009) Isabella Derler et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Molecular Determinants of the Coupling between STIM1 and Orai Channels

(2009) Irene Frischauf et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The Short N-terminal Domains of STIM1 and STIM2 Control the Activation Kinetics of Orai1 Channels

(2009) Yandong Zhou et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Native Store-operated Ca2+Influx Requires the Channel Function of Orai1 and TRPC1

(2009) Min Seuk Kim et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Coupling of Ca2+Microdomains to Spatially and Temporally Distinct Cellular Responses by the Tyrosine Kinase Syk

(2009) Siaw-Wei Ng et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

TRPC channels function independently of STIM1 and Orai1

(2009) Wayne I. DeHaven et al.   JOURNAL OF PHYSIOLOGY-LONDON

Properties of Orai1 mediated store-operated current depend on the expression levels of STIM1 and Orai1 proteins

(2009) N. Scrimgeour et al.   JOURNAL OF PHYSIOLOGY-LONDON

SOAR and the polybasic STIM1 domains gate and regulate Orai channels

(2009) Joseph P. Yuan et al.   NATURE CELL BIOLOGY

Molecular determinants of fast Ca2+-dependent inactivation and gating of the Orai channels

(2009) K. P. Lee et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

STIM1 and calmodulin interact with Orai1 to induce Ca2+-dependent inactivation of CRAC channels

(2009) F. M. Mullins et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Calcium influx is sufficient to induce muscular dystrophy through a TRPC-dependent mechanism

(2009) Douglas P. Millay et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Orai1 internalization and STIM1 clustering inhibition modulate SOCE inactivation during meiosis

(2009) F. Yu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Activation of TRPC1 by STIM1 in ER-PM microdomains involves release of the channel from its scaffold caveolin-1

(2009) B. Pani et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Structural and Mechanistic Insights into STIM1-Mediated Initiation of Store-Operated Calcium Entry

(2008) Peter B. Stathopulos et al.   CELL

STIM1 converts TRPC1 from a receptor-operated to a store-operated channel: Moving TRPC1 in and out of lipid rafts

(2008) Sampieri Alicia et al.   CELL CALCIUM

Dynamic Coupling of the Putative Coiled-coil Domain of ORAI1 with STIM1 Mediates ORAI1 Channel Activation

(2008) Martin Muik et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Orai1 Mediates the Interaction between STIM1 and hTRPC1 and Regulates the Mode of Activation of hTRPC1-forming Ca2+Channels

(2008) Isaac Jardin et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Functional Requirement for Orai1 in Store-operated TRPC1-STIM1 Channels

(2008) Kwong Tai Cheng et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Lipid Rafts Determine Clustering of STIM1 in Endoplasmic Reticulum-Plasma Membrane Junctions and Regulation of Store-operated Ca2+Entry (SOCE)

(2008) Biswaranjan Pani et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

STIM1 Gates TRPC Channels, but Not Orai1, by Electrostatic Interaction

(2008) Weizhong Zeng et al.   MOLECULAR CELL

Oligomerization of STIM1 couples ER calcium depletion to CRAC channel activation

(2008) Riina M. Luik et al.   NATURE

Cardiac Plasticity

(2008) Joseph A. Hill et al.   NEW ENGLAND JOURNAL OF MEDICINE

Functional interactions among Orai1, TRPCs, and STIM1 suggest a STIM-regulated heteromeric Orai/TRPC model for SOCE/Icrac channels

(2008) Y. Liao et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA