Molecular mechanisms of pancreatic injury

The beneficial effect of resveratrol on severe acute pancreatitis

(2011) Qingyong Ma et al.   Annals of the New York Academy of Sciences

Lymphocyte function antigen-1 regulates neutrophil recruitment and tissue damage in acute pancreatitis

(2011) Darbaz Awla et al.   BRITISH JOURNAL OF PHARMACOLOGY

Mesenchymal Stem Cells: Therapeutic Potential for Acute Pancreatitis

(2011) Günter Schneider et al.   GASTROENTEROLOGY

Genetic and Pharmacologic Inhibition of the Ca2+ Influx Channel TRPC3 Protects Secretory Epithelia From Ca2+-Dependent Toxicity

(2011) Min Seuk Kim et al.   GASTROENTEROLOGY

Reactive Oxygen Species Induced by Bile Acid Induce Apoptosis and Protect Against Necrosis in Pancreatic Acinar Cells

(2011) David M. Booth et al.   GASTROENTEROLOGY

Cyclic Adenosine Diphosphate Ribose Activates Ryanodine Receptors, whereas NAADP Activates Two-pore Domain Channels

(2011) Oluseye A. Ogunbayo et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Pomalidomide suppresses cerulein-induced acute pancreatitis in mice

(2011) Ming Jen Tsai et al.   JOURNAL OF GASTROENTEROLOGY

Grp78 Heterozygosity Regulates Chaperone Balance in Exocrine Pancreas with Differential Response to Cerulein-Induced Acute Pancreatitis

(2010) Risheng Ye et al.   AMERICAN JOURNAL OF PATHOLOGY

Tauroursodeoxycholic acid reduces endoplasmic reticulum stress, trypsin activation, and acinar cell apoptosis while increasing secretion in rat pancreatic acini

(2010) A. Malo et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

Dantrolene mitigates caerulein-induced pancreatitis in vivo in mice

(2010) Abrahim I. Orabi et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

A novel protein kinase D inhibitor attenuates early events of experimental pancreatitis in isolated rat acini

(2010) Edwin C. Thrower et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

Nuclear factor kappa B–dependent gene transcription in cholecystokinin- and tumor necrosis factor-α–stimulated isolated acinar cells is regulated by p38 mitogen-activated protein kinase

(2010) Deborah E. Williard et al.   AMERICAN JOURNAL OF SURGERY

Genetic Aspects of Pancreatitis

(2010) David C. Whitcomb   Annual Review of Medicine

The Natural Flavonoid Quercetin Ameliorates Cerulein-Induced Acute Pancreatitis in Mice

(2010) Karine Maria Martins Bezerra Carvalho et al.   BIOLOGICAL & PHARMACEUTICAL BULLETIN

Flavocoxid, a dual inhibitor of cyclooxygenase-2 and 5-lipoxygenase, reduces pancreatic damage in an experimental model of acute pancreatitis

(2010) F Polito et al.   BRITISH JOURNAL OF PHARMACOLOGY

Rho-kinase signalling regulates trypsinogen activation and tissue damage in severe acute pancreatitis

(2010) D Awla et al.   BRITISH JOURNAL OF PHARMACOLOGY

TPCs: Endolysosomal channels for Ca2+ mobilization from acidic organelles triggered by NAADP

(2010) Michael X. Zhu et al.   FEBS LETTERS

Dynamic Changes in Cytosolic and Mitochondrial ATP Levels in Pancreatic Acinar Cells

(2010) Svetlana G. Voronina et al.   GASTROENTEROLOGY

Adaptive Unfolded Protein Response Attenuates Alcohol-Induced Pancreatic Damage

(2010) Aurelia Lugea et al.   GASTROENTEROLOGY

Human Bone Marrow–Derived Clonal Mesenchymal Stem Cells Inhibit Inflammation and Reduce Acute Pancreatitis in Rats

(2010) Kyung Hee Jung et al.   GASTROENTEROLOGY

Panhematin provides a therapeutic benefit in experimental pancreatitis

(2010) A. Habtezion et al.   GUT

Pathophysiological relevance of apical large-conductance Ca2+-activated potassium channels in pancreatic duct epithelial cells

(2010) V. Venglovecz et al.   GUT

Non-conjugated chenodeoxycholate induces severe mitochondrial damage and inhibits bicarbonate transport in pancreatic duct cells

(2010) J. Maleth et al.   GUT

The acinar-ductal tango in the pathogenesis of acute pancreatitis

(2010) P. Hegyi et al.   GUT

Low Extracellular pH Induces Damage in the Pancreatic Acinar Cell by Enhancing Calcium Signaling

(2010) Anamika M. Reed et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Zymophagy, a Novel Selective Autophagy Pathway Mediated by VMP1-USP9x-p62, Prevents Pancreatic Cell Death

(2010) Daniel Grasso et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

A Randomized Controlled Trial of Valdecoxib and Glyceryl Trinitrate for the Prevention of Post-ERCP Pancreatitis

(2010) Vikram Bhatia et al.   JOURNAL OF CLINICAL GASTROENTEROLOGY

Montelukast, A Selective Cysteinyl Leukotriene Receptor 1 Antagonist, Reduces Cerulein-Induced Pancreatic Injury in Rats

(2010) Erkan Özkan et al.   PANCREAS

Vitamin K3 Attenuates Cerulein-Induced Acute Pancreatitis Through Inhibition of the Autophagic Pathway

(2010) Ryo Chinzei et al.   PANCREAS

Dominant Negative p38 Mitogen-Activated Protein Kinase Expression Inhibits NF-κB Activation in AR42J Cells

(2010) Erik Twait et al.   PANCREATOLOGY

Co-operative effects of angiotensin II and caerulein in NFκB activation in pancreatic acinar cells in vitro

(2010) Yuk Cheung Chan et al.   REGULATORY PEPTIDES

Curcumin Attenuates Airway Hyperreactivity Induced by Ischemia-Reperfusion of the Pancreas in Rats

(2010) K.H. Chen et al.   TRANSPLANTATION PROCEEDINGS

Protease activation during in vivo pancreatitis is dependent on calcineurin activation

(2009) Ahsan U. Shah et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

Chronic Pancreatitis: Genetics and Pathogenesis

(2009) Jian-Min Chen et al.   Annual Review of Genomics and Human Genetics

An endoplasmic reticulum/plasma membrane junction: STIM1/Orai1/TRPCs

(2009) Kyu Pil Lee et al.   FEBS LETTERS

Reducing Extracellular pH Sensitizes the Acinar Cell to Secretagogue-Induced Pancreatitis Responses in Rats

(2009) Madhavi Bhoomagoud et al.   GASTROENTEROLOGY

Biliary Acute Pancreatitis in Mice is Mediated by the G-Protein−Coupled Cell Surface Bile Acid Receptor Gpbar1

(2009) George Perides et al.   GASTROENTEROLOGY

Pancreatitis-associated chymotrypsinogen C (CTRC) mutant elicits endoplasmic reticulum stress in pancreatic acinar cells

(2009) R. Szmola et al.   GUT

Intracellular Autoactivation of Human Cationic Trypsinogen Mutants Causes Reduced Trypsinogen Secretion and Acinar Cell Death

(2009) Éva Kereszturi et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Intracellular Trypsin Induces Pancreatic Acinar Cell Death but Not NF-κB Activation

(2009) Baoan Ji et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Pentoxifylline Prevents Loss of PP2A Phosphatase Activity and Recruitment of Histone Acetyltransferases to Proinflammatory Genes in Acute Pancreatitis

(2009) J. Sandoval et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

NAADP mobilizes calcium from acidic organelles through two-pore channels

(2009) Peter J. Calcraft et al.   NATURE

Protein Kinase C δ-Mediated Processes in Cholecystokinin-8-Stimulated Pancreatic Acini

(2009) Edwin C. Thrower et al.   PANCREAS

Pancreatic protease activation by alcohol metabolite depends on Ca2+ release via acid store IP3 receptors

(2009) J. V. Gerasimenko et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Antioxidant therapy in the management of acute, chronic and post-ERCP pancreatitis: A systematic review

(2009) Seyed Sajad Mohseni Salehi Monfared et al.   WORLD JOURNAL OF GASTROENTEROLOGY

The novel protein kinase C isoforms -δ and -ε modulate caerulein-induced zymogen activation in pancreatic acinar cells

(2008) Edwin C. Thrower et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

Protein kinase D1 mediates NF-κB activation induced by cholecystokinin and cholinergic signaling in pancreatic acinar cells

(2008) Jingzhen Yuan et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

Effects of bile acids on pancreatic ductal bicarbonate secretion in guinea pig

(2008) V Venglovecz et al.   GUT

Involvement of autophagy in trypsinogen activation within the pancreatic acinar cells

(2008) Daisuke Hashimoto et al.   JOURNAL OF CELL BIOLOGY

Protein kinase C in the pancreatic acinar cell

(2008) Fred Gorelick et al.   JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY

Ca2+-induced pancreatic cell death: Roles of the endoplasmic reticulum, zymogen granules, lysosomes and endosomes

(2008) Ole H Petersen   JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY