Experimental and computational evidence for an essential role of NaV1.6 in spike initiation at stretch-sensitive colorectal afferent endings

The Bile Acid Receptor TGR5 Activates the TRPA1 Channel to Induce Itch in Mice

(2014) TinaMarie Lieu et al.   GASTROENTEROLOGY

Multiple roles for NaV1.9 in the activation of visceral afferents by noxious inflammatory, mechanical, and human disease–derived stimuli

(2014) James R.F. Hockley et al.   PAIN

Combined genetic and pharmacological inhibition of TRPV1 and P2X3 attenuates colorectal hypersensitivity and afferent sensitization

(2013) Michael E. Kiyatkin et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

Modeling activity-dependent changes of axonal spike conduction in primary afferent C-nociceptors

(2013) Jenny Tigerholm et al.   JOURNAL OF NEUROPHYSIOLOGY

Activation of Guanylate Cyclase-C Attenuates Stretch Responses and Sensitization of Mouse Colorectal Afferents

(2013) B. Feng et al.   JOURNAL OF NEUROSCIENCE

Small-Fiber Neuropathy Nav1.8 Mutation Shifts Activation to Hyperpolarized Potentials and Increases Excitability of Dorsal Root Ganglion Neurons

(2013) J. Huang et al.   JOURNAL OF NEUROSCIENCE

Knockdown of sodium channel NaV1.6 blocks mechanical pain and abnormal bursting activity of afferent neurons in inflamed sensory ganglia

(2013) Wenrui Xie et al.   PAIN

Spatial mismatch between the Na+ flux and spike initiation in axon initial segment

(2013) G. Baranauskas et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Connection between Oligomeric State and Gating Characteristics of Mechanosensitive Ion Channels

(2013) Christoph A. Haselwandter et al.   PLoS Computational Biology

Linaclotide for Irritable Bowel Syndrome With Constipation: A 26-Week, Randomized, Double-blind, Placebo-Controlled Trial to Evaluate Efficacy and Safety

(2012) William D Chey et al.   AMERICAN JOURNAL OF GASTROENTEROLOGY

A 12-Week, Randomized, Controlled Trial With a 4-Week Randomized Withdrawal Period to Evaluate the Efficacy and Safety of Linaclotide in Irritable Bowel Syndrome With Constipation

(2012) Satish Rao et al.   AMERICAN JOURNAL OF GASTROENTEROLOGY

Altered colorectal afferent function associated with TNBS-induced visceral hypersensitivity in mice

(2012) Bin Feng et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

Luminal hypertonicity and acidity modulate colorectal afferents and induce persistent visceral hypersensitivity

(2012) Jun-Ho La et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

Long-term sensitization of mechanosensitive and -insensitive afferents in mice with persistent colorectal hypersensitivity

(2012) Bin Feng et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

Irritable Bowel Syndrome: Methods, Mechanisms, and Pathophysiology. Neural and neuro-immune mechanisms of visceral hypersensitivity in irritable bowel syndrome

(2012) Bin Feng et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

A novel mechanism for gut barrier dysfunction by dietary fat: epithelial disruption by hydrophobic bile acids

(2012) Lotta K. Stenman et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

The Physiology of the Axon Initial Segment

(2012) Kevin J. Bender et al.   Annual Review of Neuroscience

Membrane properties and electrogenesis in the distal axons of small dorsal root ganglion neurons in vitro

(2012) Dmytro V. Vasylyev et al.   JOURNAL OF NEUROPHYSIOLOGY

Intestinal barrier function in health and gastrointestinal disease

(2012) M. Camilleri et al.   NEUROGASTROENTEROLOGY AND MOTILITY

Persistent inflammation increases GABA-induced depolarization of rat cutaneous dorsal root ganglion neurons in vitro

(2012) Y. Zhu et al.   NEUROSCIENCE

Conotoxins Targeting Neuronal Voltage-Gated Sodium Channel Subtypes: Potential Analgesics?

(2012) Oliver Knapp et al.   Toxins

Kinetic modeling of Nav1.7 provides insight into erythromelalgia-associated F1449V mutation

(2011) Meron Gurkiewicz et al.   JOURNAL OF NEUROPHYSIOLOGY

Physiological interactions between Nav1.7 and Nav1.8 sodium channels: a computer simulation study

(2011) Jin-Sung Choi et al.   JOURNAL OF NEUROPHYSIOLOGY

Differences in the expression of transient receptor potential channel V1, transient receptor potential channel A1 and mechanosensitive two pore-domain K+ channels between the lumbar splanchnic and pelvic nerve innervations of mouse urinary bladder and colon

(2011) J.H. La et al.   NEUROSCIENCE

 -Conotoxins that differentially block sodium channels NaV1.1 through 1.8 identify those responsible for action potentials in sciatic nerve

(2011) M. J. Wilson et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Differential roles of stretch-sensitive pelvic nerve afferents innervating mouse distal colon and rectum

(2010) Bin Feng et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

Characterization of silent afferents in the pelvic and splanchnic innervations of the mouse colorectum

(2010) Bin Feng et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

Altered Purinergic Signaling in Colorectal Dorsal Root Ganglion Neurons Contributes to Colorectal Hypersensitivity

(2010) Masamichi Shinoda et al.   JOURNAL OF NEUROPHYSIOLOGY

Multiple Desensitization Mechanisms of Mechanotransducer Channels Shape Firing of Mechanosensory Neurons

(2010) J. Hao et al.   JOURNAL OF NEUROSCIENCE

Na+ imaging reveals little difference in action potential–evoked Na+ influx between axon and soma

(2010) Ilya A Fleidervish et al.   NATURE NEUROSCIENCE

Simulation in Sensory Neurons Reveals a Key Role for Delayed Na+ Current in Subthreshold Oscillations and Ectopic Discharge: Implications for Neuropathic Pain

(2009) Yifat Kovalsky et al.   JOURNAL OF NEUROPHYSIOLOGY

Kinetic properties of mechanically activated currents in spinal sensory neurons

(2009) François Rugiero et al.   JOURNAL OF PHYSIOLOGY-LONDON

Distinct contributions of Nav1.6 and Nav1.2 in action potential initiation and backpropagation

(2009) Wenqin Hu et al.   NATURE NEUROSCIENCE

Direct excitation of spinal GABAergic interneurons by noradrenaline

(2009) Matthias Gassner et al.   PAIN

ProTx-II, a Selective Inhibitor of NaV1.7 Sodium Channels, Blocks Action Potential Propagation in Nociceptors

(2008) W. A. Schmalhofer et al.   MOLECULAR PHARMACOLOGY

Action potential generation requires a high sodium channel density in the axon initial segment

(2008) Maarten H P Kole et al.   NATURE NEUROSCIENCE