Conotoxins Targeting Neuronal Voltage-Gated Sodium Channel Subtypes: Potential Analgesics?

Structurally Diverse μ-Conotoxin PIIIA Isomers Block Sodium Channel NaV1.4

(2012) Alesia A. Tietze et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Isolation, characterization and total regioselective synthesis of the novel μO-conotoxin MfVIA from Conus magnificus that targets voltage-gated sodium channels

(2012) Irina Vetter et al.   BIOCHEMICAL PHARMACOLOGY

N- and c-terminal extensions of μ-conotoxins increase potency and selectivity for neuronal sodium channels

(2012) Christina I. Schroeder et al.   BIOPOLYMERS

Biophysical properties of Nav1.8/Nav1.2 chimeras and inhibition by µO-conotoxin MrVIB

(2012) O Knapp et al.   BRITISH JOURNAL OF PHARMACOLOGY

Mechanism and molecular basis for the sodium channel subtype specificity of µ-conopeptide CnIIIC

(2012) René Markgraf et al.   BRITISH JOURNAL OF PHARMACOLOGY

A novel µ-conopeptide, CnIIIC, exerts potent and preferential inhibition of NaV1.2/1.4 channels and blocks neuronal nicotinic acetylcholine receptors

(2012) Philippe Favreau et al.   BRITISH JOURNAL OF PHARMACOLOGY

Localization of Nav1.7 in the normal and injured rodent olfactory system indicates a critical role in olfaction, pheromone sensing and immune function

(2012) Darshani B. Rupasinghe et al.   Channels

Design of Bioactive Peptides from Naturally Occurring μ-Conotoxin Structures

(2012) Marijke Stevens et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Crystal structure of an orthologue of the NaChBac voltage-gated sodium channel

(2012) Xu Zhang et al.   NATURE

Crystal structure of a voltage-gated sodium channel in two potentially inactivated states

(2012) Jian Payandeh et al.   NATURE

Partial nerve injury induces electrophysiological changes in conducting (uninjured) nociceptive and nonnociceptive DRG neurons: Possible relationships to aspects of peripheral neuropathic pain and paresthesias

(2012) Laiche Djouhri et al.   PAIN

Animal Toxins Can Alter the Function of Nav1.8 and Nav1.9

(2012) John Gilchrist et al.   Toxins

Total Synthesis of the Analgesic Conotoxin MrVIB through Selenocysteine-Assisted Folding

(2011) Aline Dantas de Araujo et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Functional properties and toxin pharmacology of a dorsal root ganglion sodium channel viewed through its voltage sensors

(2011) Frank Bosmans et al.   JOURNAL OF GENERAL PHYSIOLOGY

Lactam-Stabilized Helical Analogues of the Analgesic μ-Conotoxin KIIIA

(2011) Keith K. Khoo et al.   JOURNAL OF MEDICINAL CHEMISTRY

NaV  Subunits Modulate the Inhibition of NaV1.8 by the Analgesic Gating Modifier  O-Conotoxin MrVIB

(2011) M. J. Wilson et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

Nav1.7 is the Predominant Sodium Channel in Rodent Olfactory Sensory Neurons

(2011) Hye-Sook Ahn et al.   Molecular Pain

Interactions of Key Charged Residues Contributing to Selective Block of Neuronal Sodium Channels by  -Conotoxin KIIIA

(2011) J. R. McArthur et al.   MOLECULAR PHARMACOLOGY

Orientation of  -Conotoxin PIIIA in a Sodium Channel Vestibule, Based on Voltage Dependence of Its Binding

(2011) J. R. McArthur et al.   MOLECULAR PHARMACOLOGY

Loss-of-function mutations in sodium channel Nav1.7 cause anosmia

(2011) Jan Weiss et al.   NATURE

The crystal structure of a voltage-gated sodium channel

(2011) Jian Payandeh et al.   NATURE

Molecular determinants for the subtype specificity of μ-conotoxin SIIIA targeting neuronal voltage-gated sodium channels

(2011) Enrico Leipold et al.   NEUROPHARMACOLOGY

Antisense-Mediated Knockdown of NaV1.8, but Not NaV1.9, Generates Inhibitory Effects on Complete Freund's Adjuvant-Induced Inflammatory Pain in Rat

(2011) Yao-Qing Yu et al.   PLoS One

 -Conotoxins that differentially block sodium channels NaV1.1 through 1.8 identify those responsible for action potentials in sciatic nerve

(2011) M. J. Wilson et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Recent Developments Regarding Voltage-Gated Sodium Channel Blockers for the Treatment of Inherited and Acquired Neuropathic Pain Syndromes

(2011) Jonathan W. Theile et al.   Frontiers in Pharmacology

The Engineering of an Orally Active Conotoxin for the Treatment of Neuropathic Pain

(2010) Richard J. Clark et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

μ-Conotoxin KIIIA Derivatives with Divergent Affinities versus Efficacies in Blocking Voltage-Gated Sodium Channels

(2010) Min-Min Zhang et al.   BIOCHEMISTRY

Multiple, Distributed Interactions of μ-Conotoxin PIIIA Associated with Broad Targeting among Voltage-Gated Sodium Channels

(2010) Jeff R. McArthur et al.   BIOCHEMISTRY

Interaction between voltage-gated sodium channels and the neurotoxin, tetrodotoxin

(2010) Chong Hyun Lee et al.   Channels

A diverse family of novel peptide toxins from an unusual cone snail, Conus californicus

(2010) W. F. Gilly et al.   JOURNAL OF EXPERIMENTAL BIOLOGY

RAPID REPORT: Anin vivotethered toxin approach for the cell-autonomous inactivation of voltage-gated sodium channel currents in nociceptors

(2010) Annika S. Stürzebecher et al.   JOURNAL OF PHYSIOLOGY-LONDON

µ-Conotoxins as Leads in the Development of New Analgesics

(2010) Raymond S. Norton   MOLECULES

TNF-α contributes to up-regulation of Nav1.3 and Nav1.8 in DRG neurons following motor fiber injury

(2010) Xin-Hua He et al.   PAIN

Sodium channelopathies and pain

(2010) Angelika Lampert et al.   PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY

Inhibition of the activation pathway of the T-type calcium channel CaV3.1 by ProTxII

(2010) Gabrielle B. Edgerton et al.   TOXICON

Targeting voltage sensors in sodium channels with spider toxins

(2010) Frank Bosmans et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

A Peripherally Acting Nav1.7 Sodium Channel Blocker Reverses Hyperalgesia and Allodynia on Rat Models of Inflammatory and Neuropathic Pain

(2009) Erin McGowan et al.   ANESTHESIA AND ANALGESIA

Integrated Oxidative Folding of Cysteine/Selenocysteine Containing Peptides: Improving Chemical Synthesis of Conotoxins

(2009) Aleksandra Walewska et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Identification of a novel M-superfamily conotoxin with the ability to enhance tetrodotoxin sensitive sodium currents

(2009) Lei Wang et al.   ARCHIVES OF TOXICOLOGY

Exploring the role of nociceptor-specific sodium channels in pain transmission using Nav1.8 and Nav1.9 knockout mice

(2009) Sandra Leo et al.   BEHAVIOURAL BRAIN RESEARCH

Structure of the Analgesic μ-Conotoxin KIIIA and Effects on the Structure and Function of Disulfide Deletion†‡

(2009) Keith K. Khoo et al.   BIOCHEMISTRY

Impact of Postherpetic Neuralgia and Painful Diabetic Peripheral Neuropathy on Health Care Costs

(2009) Robert H. Dworkin et al.   JOURNAL OF PAIN

Abnormal expression of voltage-gated sodium channels Nav1.7, Nav1.3 and Nav1.8 in trigeminal neuralgia

(2009) S.R.D.T. Siqueira et al.   NEUROSCIENCE

Remarkable inter- and intra-species complexity of conotoxins revealed by LC/MS

(2009) Jasmine Davis et al.   PEPTIDES

Specificity, affinity and efficacy of iota-conotoxin RXIA, an agonist of voltage-gated sodium channels NaV1.2, 1.6 and 1.7

(2008) Brian Fiedler et al.   BIOCHEMICAL PHARMACOLOGY

Structure, Dynamics, and Selectivity of the Sodium Channel Blocker μ-Conotoxin SIIIA†‡

(2008) Shenggen Yao et al.   BIOCHEMISTRY

Structurally Minimized μ-Conotoxin Analogues as Sodium Channel Blockers: Implications for Designing Conopeptide-Based Therapeutics

(2008) Tiffany S. Han et al.   ChemMedChem

Sensory neuron voltage-gated sodium channels as analgesic drug targets

(2008) Aliakmal Momin et al.   CURRENT OPINION IN NEUROBIOLOGY

Conus Venoms - A Rich Source of Peptide-Based Therapeutics

(2008) Tiffany Han et al.   CURRENT PHARMACEUTICAL DESIGN

Identification and characterization of a novel O-superfamily conotoxin fromConus litteratus

(2008) Lei Wang et al.   JOURNAL OF PEPTIDE SCIENCE

Deconstructing voltage sensor function and pharmacology in sodium channels

(2008) Frank Bosmans et al.   NATURE

Prevalence of chronic pain with neuropathic characteristics in the general population

(2007) Didier Bouhassira et al.   PAIN