β-cell metabolic alterations under chronic nutrient overload in rat and human islets

Ablation of TSC2 Enhances Insulin Secretion by Increasing the Number of Mitochondria through Activation of mTORC1

(2011) Maki Koyanagi et al.   PLoS One

Glucolipotoxicity age-dependently impairs beta cell function in rats despite a marked increase in beta cell mass

(2010) G. Fontés et al.   DIABETOLOGIA

Loss of Lkb1 in Adult β Cells Increases β Cell Mass and Enhances Glucose Tolerance in Mice

(2009) Accalia Fu et al.   Cell Metabolism

Islet beta cell failure in the 60% pancreatectomised obese hyperlipidaemic Zucker fatty rat: severe dysfunction with altered glycerolipid metabolism without steatosis or a falling beta cell mass

(2009) V. Delghingaro-Augusto et al.   DIABETOLOGIA

Perilipin Is Present in Islets of Langerhans and Protects against Lipotoxicity When Overexpressed in the β-Cell Line INS-1

(2009) Jörgen Borg et al.   ENDOCRINOLOGY

mTORC1 Activation Regulates β-Cell Mass and Proliferation by Modulation of Cyclin D2 Synthesis and Stability

(2009) Norman Balcazar et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Glycogen Synthase Kinase-3 and Mammalian Target of Rapamycin Pathways Contribute to DNA Synthesis, Cell Cycle Progression, and Proliferation in Human Islets

(2008) H. Liu et al.   DIABETES

Anatomicalversusfunctional β-cell mass in experimental diabetes

(2008) C. Kargar et al.   DIABETES OBESITY & METABOLISM

Initiation and execution of lipotoxic ER stress in pancreatic  -cells

(2008) D. A. Cunha et al.   JOURNAL OF CELL SCIENCE

Disruption of Tsc2 in pancreatic   cells induces   cell mass expansion and improved glucose tolerance in a TORC1-dependent manner

(2008) L. Rachdi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA