Network models of genome-wide association studies uncover the topological centrality of protein interactions in complex diseases

Common variants at MS4A4/MS4A6E, CD2AP, CD33 and EPHA1 are associated with late-onset Alzheimer's disease

(2011) Adam C Naj et al.   NATURE GENETICS

Pathways of Distinction Analysis: A New Technique for Multi–SNP Analysis of GWAS Data

(2011) Rosemary Braun et al.   PLoS Genetics

Network properties of human disease genes with pleiotropic effects

(2010) Sreenivas Chavali et al.   BMC Systems Biology

Protein interaction network underpins concordant prognosis among heterogeneous breast cancer signatures

(2010) James Chen et al.   JOURNAL OF BIOMEDICAL INFORMATICS

Network medicine: a network-based approach to human disease

(2010) Albert-László Barabási et al.   NATURE REVIEWS GENETICS

Reactome: a database of reactions, pathways and biological processes

(2010) D. Croft et al.   NUCLEIC ACIDS RESEARCH

Rare Variants Create Synthetic Genome-Wide Associations

(2010) Samuel P. Dickson et al.   PLOS BIOLOGY

Network Modeling Identifies Molecular Functions Targeted by miR-204 to Suppress Head and Neck Tumor Metastasis

(2010) Younghee Lee et al.   PLoS Computational Biology

Trait-Associated SNPs Are More Likely to Be eQTLs: Annotation to Enhance Discovery from GWAS

(2010) Dan L. Nicolae et al.   PLoS Genetics

SNPit: A federated data integration system for the purpose of functional SNP annotation

(2009) Terry H. Shen et al.   COMPUTER METHODS AND PROGRAMS IN BIOMEDICINE

Pathway and network-based analysis of genome-wide association studies in multiple sclerosis

(2009) S. E. Baranzini et al.   HUMAN MOLECULAR GENETICS

Edgetic perturbation models of human inherited disorders

(2009) Quan Zhong et al.   Molecular Systems Biology

Finding the missing heritability of complex diseases

(2009) Teri A. Manolio et al.   NATURE

Modularity and interactions in the genetics of gene expression

(2009) O. Litvin et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Potential etiologic and functional implications of genome-wide association loci for human diseases and traits

(2009) L. A. Hindorff et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Understanding biological functions through molecular networks

(2008) Jing-Dong Jackie Han   CELL RESEARCH

Pathway analysis of seven common diseases assessed by genome-wide association

(2008) Ali Torkamani et al.   GENOMICS

eQED: an efficient method for interpreting eQTL associations using protein networks

(2008) Silpa Suthram et al.   Molecular Systems Biology

STRING 8--a global view on proteins and their functional interactions in 630 organisms

(2008) L. J. Jensen et al.   NUCLEIC ACIDS RESEARCH

Low duplicability and network fragility of cancer genes

(2008) Davide Rambaldi et al.   TRENDS IN GENETICS

Distinct Roles for Arp2/3 Regulators in Actin Assembly and Endocytosis

(2007) Brian J Galletta et al.   PLOS BIOLOGY