Astrocytes play a key role in EAE pathophysiology by orchestrating in the CNS the inflammatory response of resident and peripheral immune cells and by suppressing remyelination

The astrocyte in multiple sclerosis revisited

(2013) Celia F. Brosnan et al.   GLIA

Circulating Fibrocytes Prepare the Lung for Cancer Metastasis by Recruiting Ly-6C+ Monocytes Via CCL2

(2013) H. W. van Deventer et al.   JOURNAL OF IMMUNOLOGY

Neurological Diseases as Primary Gliopathies: A Reassessment of Neurocentrism

(2012) Alexei Verkhratsky et al.   ASN Neuro

Endothelial Nuclear Factor-κB–Dependent Regulation of Arteriogenesis and Branching

(2012) Daniela Tirziu et al.   CIRCULATION

Nuclear factor-κB activation in schwann cells regulates regeneration and remyelination

(2012) Paul D. Morton et al.   GLIA

Mechanisms regulating regional localization of inflammation during CNS autoimmunity

(2012) Emily Pierson et al.   IMMUNOLOGICAL REVIEWS

Stimulation of the neurotrophin receptor TrkB on astrocytes drives nitric oxide production and neurodegeneration

(2012) Emanuela Colombo et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Canonical Type I IFN Signaling in Simian Immunodeficiency Virus-Infected Macrophages Is Disrupted by Astrocyte-Secreted CCL2

(2012) L. A. Zaritsky et al.   JOURNAL OF IMMUNOLOGY

Glial cells in (patho)physiology

(2012) Vladimir Parpura et al.   JOURNAL OF NEUROCHEMISTRY

Transgenic inhibition of astroglial NF-κB protects from optic nerve damage and retinal ganglion cell loss in experimental optic neuritis

(2012) Roberta Brambilla et al.   Journal of Neuroinflammation

CNS-specific Therapy for Ongoing EAE by Silencing IL-17 Pathway in Astrocytes

(2012) Yaping Yan et al.   MOLECULAR THERAPY

CCL2-Expressing Astrocytes Mediate the Extravasation of T Lymphocytes in the Brain. Evidence from Patients with Glioma and Experimental Models In Vivo

(2012) Maria Angeles Carrillo-de Sauvage et al.   PLoS One

Interferon regulatory factor 1 regulation of oligodendrocyte injury and inflammatory demyelination

(2012) Eileah Loda et al.   REVIEWS IN THE NEUROSCIENCES

IκB kinase 2 determines oligodendrocyte loss by non-cell-autonomous activation of NF-κB in the central nervous system

(2011) Jenni Raasch et al.   BRAIN

Glial NF-kappa B inhibition alters neuropeptide expression after sciatic nerve injury in mice

(2011) Yan Ping Zhang et al.   BRAIN RESEARCH

Aloe emodin inhibits colon cancer cell migration/angiogenesis by downregulating MMP-2/9, RhoB and VEGF via reduced DNA binding activity of NF-κB

(2011) Priya Suboj et al.   EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES

Contrasting effects of TNF and anti-TNF on the activation of effector T cells and regulatory T cells in autoimmunity

(2011) Xin Chen et al.   FEBS LETTERS

Astrocytic P2Y1 receptor is involved in the regulation of cytokine/chemokine transcription and cerebral damage in a rat model of cerebral ischemia

(2011) Kazuya Kuboyama et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

An Evolutionarily Conserved TNF- -Responsive Enhancer in the Far Upstream Region of Human CCL2 Locus Influences Its Gene Expression

(2011) G. B. Bonello et al.   JOURNAL OF IMMUNOLOGY

IRF-1 signaling in central nervous system glial cells regulates inflammatory demyelination

(2011) Zhihua Ren et al.   JOURNAL OF NEUROIMMUNOLOGY

Differences in Origin of Reactive Microglia in Bone Marrow Chimeric Mouse and Rat After Transient Global Ischemia

(2011) Kate L. Lambertsen et al.   JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY

IL-17 receptor signaling and T helper 17-mediated autoimmune demyelinating disease

(2011) Jarod Zepp et al.   TRENDS IN IMMUNOLOGY

T cells in multiple sclerosis and experimental autoimmune encephalomyelitis

(2010) J. M. Fletcher et al.   CLINICAL AND EXPERIMENTAL IMMUNOLOGY

Antigen presentation in EAE: role of microglia, macrophages and dendritic cells

(2010) Beatriz Almolda   Frontiers in Bioscience-Landmark

Astrocyte-Restricted Ablation of Interleukin-17-Induced Act1-Mediated Signaling Ameliorates Autoimmune Encephalomyelitis

(2010) Zizhen Kang et al.   IMMUNITY

Neuromyelitis optica: a demyelinating disease characterized by acute destruction and regeneration of perivascular astrocytes

(2010) John DE Parratt et al.   Multiple Sclerosis Journal

Astrocytes in Alzheimer’s disease

(2010) Alexei Verkhratsky et al.   Neurotherapeutics

Astrocytes and therapeutics for Parkinson’s disease

(2010) Phillip M. Rappold et al.   Neurotherapeutics

Transgenic inhibition of glial NF-kappa B reduces pain behavior and inflammation after peripheral nerve injury

(2010) Eugene S. Fu et al.   PAIN

Estradiol inhibits ongoing autoimmune neuroinflammation and NF B-dependent CCL2 expression in reactive astrocytes

(2010) S. N. Giraud et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Inactivation of astroglial NF-κB promotes survival of retinal neurons following ischemic injury

(2009) Galina Dvoriantchikova et al.   EUROPEAN JOURNAL OF NEUROSCIENCE

Transgenic Inhibition of Astroglial NF- B Improves Functional Outcome in Experimental Autoimmune Encephalomyelitis by Suppressing Chronic Central Nervous System Inflammation

(2009) R. Brambilla et al.   JOURNAL OF IMMUNOLOGY

Degeneration in Different Parkinsonian Syndromes Relates to Astrocyte Type and Astrocyte Protein Expression

(2009) Yun Ju C. Song et al.   JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY

Regulation of hypoxia-inducible factor-1α by NF-κB

(2008) Patrick van Uden et al.   BIOCHEMICAL JOURNAL

Interleukin-1beta and tumor necrosis factor-alpha are expressed by different subsets of microglia and macrophages after ischemic stroke in mice

(2008) Bettina H Clausen et al.   Journal of Neuroinflammation

Kinin B2 receptor regulates chemokines CCL2 and CCL5 expression and modulates leukocyte recruitment and pathology in experimental autoimmune encephalomyelitis (EAE) in mice

(2008) Adriana C Dos Santos et al.   Journal of Neuroinflammation

The Blood-Brain Barrier in Health and Chronic Neurodegenerative Disorders

(2008) Berislav V. Zlokovic   NEURON