Endogenous recovery after brain damage: molecular mechanisms that balance neuronal life/death fate

Neuronal NLRP1 inflammasome activation of Caspase-1 coordinately regulates inflammatory interleukin-1-beta production and axonal degeneration-associated Caspase-6 activation

(2015) V Kaushal et al.   CELL DEATH AND DIFFERENTIATION

Inhibition of Caspase-1 Activation in Endothelial Cells Improves Angiogenesis

(2015) Jahaira Lopez-Pastrana et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

MiR-27a ameliorates inflammatory damage to the blood-spinal cord barrier after spinal cord ischemia: reperfusion injury in rats by downregulating TICAM-2 of the TLR4 signaling pathway

(2015) Xiao-Qian Li et al.   Journal of Neuroinflammation

Intravenous immunoglobulin (IVIg) dampens neuronal toll-like receptor-mediated responses in ischemia

(2015) Ker Zhing Lok et al.   Journal of Neuroinflammation

Brain-Derived Neurotrophic Factor Inhibits Calcium Channel Activation, Exocytosis, and Endocytosis at a Central Nerve Terminal

(2015) M. Baydyuk et al.   JOURNAL OF NEUROSCIENCE

Bruton’s tyrosine kinase is essential for NLRP3 inflammasome activation and contributes to ischaemic brain injury

(2015) Minako Ito et al.   Nature Communications

Apoptosis-Associated Speck-like Protein Containing a CARD Forms Specks but Does Not Activate Caspase-1 in the Absence of NLRP3 during Macrophage Swelling

(2015) Vincent Compan et al.   JOURNAL OF IMMUNOLOGY

Involvement of autophagy in hypoxic-excitotoxic neuronal death

(2014) Vanessa Ginet et al.   Autophagy

Voluntary forced use of the impaired limb following stroke facilitates functional recovery in the rat

(2014) Jessica M. Livingston-Thomas et al.   BEHAVIOURAL BRAIN RESEARCH

SOD1G93A transgenic mouse CD4+ T cells mediate neuroprotection after facial nerve axotomy when removed from a suppressive peripheral microenvironment

(2014) Nichole A. Mesnard-Hoaglin et al.   BRAIN BEHAVIOR AND IMMUNITY

Testosterone enhances functional recovery after stroke through promotion of antioxidant defenses, BDNF levels and neurogenesis in male rats

(2014) Hamed Fanaei et al.   BRAIN RESEARCH

Bidirectional crosstalk between periventricular endothelial cells and neural progenitor cells promotes the formation of a neurovascular unit

(2014) Ravi Vissapragada et al.   BRAIN RESEARCH

BDNF Polymorphism and Differential rTMS Effects on Motor Recovery of Stroke Patients

(2014) Won Hyuk Chang et al.   Brain Stimulation

Unified Polymerization Mechanism for the Assembly of ASC-Dependent Inflammasomes

(2014) Alvin Lu et al.   CELL

Distinct roles of RIP1–RIP3 hetero- and RIP3–RIP3 homo-interaction in mediating necroptosis

(2014) X-N Wu et al.   CELL DEATH AND DIFFERENTIATION

RIPK1- and RIPK3-induced cell death mode is determined by target availability

(2014) W D Cook et al.   CELL DEATH AND DIFFERENTIATION

Dysregulation of Neurotrophic and Haematopoietic Growth Factors in Alzheimer’s Disease: From Pathophysiology to Novel Treatment Strategies

(2014) Kateryna Sopova et al.   Current Alzheimer Research

Spinal cord pathology is ameliorated by P2X7 antagonism in a SOD1-mutant mouse model of amyotrophic lateral sclerosis

(2014) S. Apolloni et al.   Disease Models & Mechanisms

Inhibition of mitogen-activated protein kinase phosphatase-1 (MKP-1) increases experimental stroke injury

(2014) Lin Liu et al.   EXPERIMENTAL NEUROLOGY

Disruption of the brain-derived neurotrophic factor (BDNF) immunoreactivity in the human Kölliker-Fuse nucleus in victims of unexplained fetal and infant death

(2014) Anna M. Lavezzi et al.   Frontiers in Human Neuroscience

Calpain 5 Is Highly Expressed in the Central Nervous System (CNS), Carries Dual Nuclear Localization Signals, and Is Associated with Nuclear Promyelocytic Leukemia Protein Bodies

(2014) Ranjana Singh et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Heat Shock Protein 70.1 (Hsp70.1) Affects Neuronal Cell Fate by Regulating Lysosomal Acid Sphingomyelinase

(2014) Hong Zhu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The Essential Role of p53-up-regulated Modulator of Apoptosis (Puma) and Its Regulation by FoxO3a Transcription Factor in β-Amyloid-induced Neuron Death

(2014) Rumana Akhter et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

IGF-1 Alleviates NMDA-Induced Excitotoxicity in Cultured Hippocampal Neurons Against Autophagy via the NR2B/PI3K-AKT-mTOR Pathway

(2014) Yansong Wang et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Ischemia–Reperfusion Injury Induces Occludin Phosphorylation/Ubiquitination and Retinal Vascular Permeability in a VEGFR-2-Dependent Manner

(2014) Arivalagan Muthusamy et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Pyroptotic Neuronal Cell Death Mediated by the AIM2 Inflammasome

(2014) Stephanie E Adamczak et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Role of the TLR4 pathway in blood-spinal cord barrier dysfunction during the bimodal stage after ischemia/reperfusion injury in rats

(2014) Xiao-Qian Li et al.   Journal of Neuroinflammation

Spinal Cord Injury Causes Brain Inflammation Associated with Cognitive and Affective Changes: Role of Cell Cycle Pathways

(2014) J. Wu et al.   JOURNAL OF NEUROSCIENCE

An Adaptive Role for BDNF Val66Met Polymorphism in Motor Recovery in Chronic Stroke

(2014) L. Qin et al.   JOURNAL OF NEUROSCIENCE

Ischemic Stroke Injury Is Mediated by Aberrant Cdk5

(2014) D. A. Meyer et al.   JOURNAL OF NEUROSCIENCE

Neurodegeneration by Activation of the Microglial Complement-Phagosome Pathway

(2014) L.-G. Bodea et al.   JOURNAL OF NEUROSCIENCE

DAPK1-p53 Interaction Converges Necrotic and Apoptotic Pathways of Ischemic Neuronal Death

(2014) L. Pei et al.   JOURNAL OF NEUROSCIENCE

Mixed Lineage Kinase Domain-like Protein MLKL Causes Necrotic Membrane Disruption upon Phosphorylation by RIP3

(2014) Huayi Wang et al.   MOLECULAR CELL

Remote Neurodegeneration: Multiple Actors for One Play

(2014) Maria Teresa Viscomi et al.   MOLECULAR NEUROBIOLOGY

The adaptor ASC has extracellular and 'prionoid' activities that propagate inflammation

(2014) Bernardo S Franklin et al.   NATURE IMMUNOLOGY

Nuclear and cytosolic JNK signalling in neurons

(2014) Eleanor T. Coffey   NATURE REVIEWS NEUROSCIENCE

Ischemic insults induce necroptotic cell death in hippocampal neurons through the up-regulation of endogenous RIP3

(2014) M. Vieira et al.   NEUROBIOLOGY OF DISEASE

Rodent models of ischemic stroke lack translational relevance… are baboon models the answer?

(2014) Timothy D. Kwiecien et al.   NEUROLOGICAL RESEARCH

TrkB is involved in the mechanism by which BDNF accelerates the glutamate-induced death of rat neuroblastoma B35 cells

(2014) Takehiro Maki et al.   NEUROLOGICAL RESEARCH

Hypoxia Induces Autophagic Cell Death through Hypoxia-Inducible Factor 1α in Microglia

(2014) Zhao Yang et al.   PLoS One

The miR-17/106-p38 axis is a key regulator of the neurogenic-to-gliogenic transition in developing neural stem/progenitor cells

(2014) H. Naka-Kaneda et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Delayed Hyperbaric Oxygen Therapy Promotes Neurogenesis Through Reactive Oxygen Species/Hypoxia-Inducible Factor-1α/β-Catenin Pathway in Middle Cerebral Artery Occlusion Rats

(2014) Qin Hu et al.   STROKE

Protection after stroke: cellular effectors of neurovascular unit integrity

(2014) Rafael Andres Posada-Duque et al.   Frontiers in Cellular Neuroscience

Trophic factors as modulators of motor neuron physiology and survival: implications for ALS therapy

(2014) Luis B. Tovar-y-Romo et al.   Frontiers in Cellular Neuroscience

Amyloid-β induces NLRP1-dependent neuronal pyroptosis in models of Alzheimer’s disease

(2014) M-S Tan et al.   Cell Death & Disease

Akt and mTOR mediate programmed necrosis in neurons

(2014) Q Liu et al.   Cell Death & Disease

Toll-Like Receptors 2, -3 and -4 Prime Microglia but not Astrocytes Across Central Nervous System Regions for ATP-Dependent Interleukin-1β Release

(2014) Laura Facci et al.   Scientific Reports

MLKL Compromises Plasma Membrane Integrity by Binding to Phosphatidylinositol Phosphates

(2014) Yves Dondelinger et al.   Cell Reports

Inflammasomes in neuroinflammation and changes in brain function: a focused review

(2014) Gaurav Singhal et al.   Frontiers in Neuroscience

Neurovascular Recovery via Cotransplanted Neural and Vascular Progenitors Leads to Improved Functional Restoration after Ischemic Stroke in Rats

(2014) Jia Li et al.   Stem Cell Reports

Aβ and tau toxicities in Alzheimer’s are linked via oxidative stress-induced p38 activation: Protective role of vitamin E

(2014) E. Giraldo et al.   Redox Biology

Pathogenesis of acute stroke and the role of inflammasomes

(2013) David Yang-Wei Fann et al.   AGEING RESEARCH REVIEWS

A Recombinant Inhibitory Isoform of Vascular Endothelial Growth Factor164/165 Aggravates Ischemic Brain Damage in a Mouse Model of Focal Cerebral Ischemia

(2013) Ganta V. Chaitanya et al.   AMERICAN JOURNAL OF PATHOLOGY

Temporal Profile of Matrix Metalloproteinases and Their Inhibitors in a Human Endothelial Cell Culture Model of Cerebral Ischemia

(2013) Björn Reuter et al.   CEREBROVASCULAR DISEASES

Toll-Like Receptor 4-Dependent Microglial Activation Mediates Spinal Cord Ischemia-Reperfusion Injury

(2013) M. T. Bell et al.   CIRCULATION

Toll-Like Receptors: Sensor Molecules for Detecting Damage to the Nervous System

(2013) Hyunkyoung Lee et al.   CURRENT PROTEIN & PEPTIDE SCIENCE

Celecoxib increases SMN and survival in a severe spinal muscular atrophy mouse model via p38 pathway activation

(2013) Faraz Farooq et al.   HUMAN MOLECULAR GENETICS

Calpain activation induced by glucose deprivation is mediated by oxidative stress and contributes to neuronal damage

(2013) Blanca Páramo et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

Caspase Inhibitors Protect Neurons by Enabling Selective Necroptosis of Inflamed Microglia

(2013) Michael Fricker et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Death of developing neurons: New insights and implications for connectivity

(2013) Martijn P.J. Dekkers et al.   JOURNAL OF CELL BIOLOGY

Phagocytic Removal of Neuronal Debris by Olfactory Ensheathing Cells Enhances Neuronal Survival and Neurite Outgrowth via p38MAPK Activity

(2013) Bao-Rong He et al.   MOLECULAR NEUROBIOLOGY

Dose-dependent Neuroprotection of VEGF165 in Huntington's Disease Striatum

(2013) Stuart M Ellison et al.   MOLECULAR THERAPY

Proximal inhibition of p38 MAPK stress signaling prevents distal axonopathy

(2013) Jason D. Dapper et al.   NEUROBIOLOGY OF DISEASE

Evidence that collaboration between HIF-1α and Notch-1 promotes neuronal cell death in ischemic stroke

(2013) Yi-Lin Cheng et al.   NEUROBIOLOGY OF DISEASE

Lymphocyte-mediated neuroprotection in in vitro models of excitotoxicity involves astrocytic activation and the inhibition of MAP kinase signalling pathways

(2013) Rajeev Shrestha et al.   NEUROPHARMACOLOGY

An ASK1-p38 signalling pathway mediates hydrogen peroxide-induced toxicity in NG108-15 neuronal cells

(2013) Koji Nomura et al.   NEUROSCIENCE LETTERS

Brain-Derived Neurotrophic Factor Promotes Vasculature-Associated Migration of Neuronal Precursors toward the Ischemic Striatum

(2013) Sofia Grade et al.   PLoS One

Deficiency in p38β MAPK Fails to Inhibit Cytokine Production or Protect Neurons against Inflammatory Insult in In Vitro and In Vivo Mouse Models

(2013) Bin Xing et al.   PLoS One

Inhibition of Fast Axonal Transport by Pathogenic SOD1 Involves Activation of p38 MAP Kinase

(2013) Gerardo A. Morfini et al.   PLoS One

Local Administration of AAV-BDNF to Subventricular Zone Induces Functional Recovery in Stroke Rats

(2013) Seong-Jin Yu et al.   PLoS One

Serum Brain–Derived Neurotrophic Factor and Vascular Endothelial Growth Factor Levels Are Associated With Risk of Stroke and Vascular Brain Injury

(2013) Aleksandra Pikula et al.   STROKE

Thyroxin Treatment Protects Against White Matter Injury in The Immature Brain via Brain-Derived Neurotrophic Factor

(2013) P.-L. Hung et al.   STROKE

Arsenic induces the expressions of angiogenesis-related factors through PI3K and MAPK pathways in SV-HUC-1 human uroepithelial cells

(2013) Fei Wang et al.   TOXICOLOGY LETTERS

Janus-faced microglia: beneficial and detrimental consequences of microglial phagocytosis

(2013) Amanda Sierra et al.   Frontiers in Cellular Neuroscience

Role of Inflammation and Its Mediators in Acute Ischemic Stroke

(2013) Rong Jin et al.   Journal of Cardiovascular Translational Research

TRAF1 is a critical regulator of cerebral ischaemia–reperfusion injury and neuronal death

(2013) Yan-Yun Lu et al.   Nature Communications

VEGF significantly restores impaired memory behavior in Alzheimer's mice by improvement of vascular survival

(2013) Piotr Religa et al.   Scientific Reports

Unravelling the enigma of selective vulnerability in neurodegeneration: motor neurons resistant to degeneration in ALS show distinct gene expression characteristics and decreased susceptibility to excitotoxicity

(2012) Alice Brockington et al.   ACTA NEUROPATHOLOGICA

Delayed Administration of VEGF Rescues Spinal Motor Neurons from Death with a Short Effective Time Frame in Excitotoxic Experimental Models in Vivo

(2012) Luis B Tovar-y-Romo et al.   ASN Neuro

The CARD plays a critical role in ASC foci formation and inflammasome signalling

(2012) Martina Proell et al.   BIOCHEMICAL JOURNAL

The novel proteasome inhibitor BSc2118 protects against cerebral ischaemia through HIF1A accumulation and enhanced angioneurogenesis

(2012) Thorsten R. Doeppner et al.   BRAIN

Systemic anti-vascular endothelial growth factor therapies induce a painful sensory neuropathy

(2012) An Verheyen et al.   BRAIN

Loss of substance P and inflammation precede delayed neurodegeneration in the substantia nigra after cerebral ischemia

(2012) Beatriz Rodriguez-Grande et al.   BRAIN BEHAVIOR AND IMMUNITY

p53 Opens the Mitochondrial Permeability Transition Pore to Trigger Necrosis

(2012) Angelina V. Vaseva et al.   CELL

Restoration of Intracortical and Thalamocortical Circuits after Transplantation of Bone Marrow Mesenchymal Stem Cells into the Ischemic Brain of Mice

(2012) Mingke Song et al.   CELL TRANSPLANTATION

Astrocyte-derived VEGF-A drives blood-brain barrier disruption in CNS inflammatory disease

(2012) Azeb Tadesse Argaw et al.   JOURNAL OF CLINICAL INVESTIGATION

Toll-like receptor 2 deficiency leads to delayed exacerbation of ischemic injury

(2012) Ivan Bohacek et al.   Journal of Neuroinflammation

Human Immunodeficiency Virus Type 1 Alters Brain-Derived Neurotrophic Factor Processing in Neurons

(2012) A. Bachis et al.   JOURNAL OF NEUROSCIENCE

An unconventional role for miRNA: let-7 activates Toll-like receptor 7 and causes neurodegeneration

(2012) Sabrina M Lehmann et al.   NATURE NEUROSCIENCE

Apoptotic and non-apoptotic roles of caspases in neuronal physiology and pathophysiology

(2012) Bradley T. Hyman et al.   NATURE REVIEWS NEUROSCIENCE

Combination treatment with progesterone and vitamin D hormone is more effective than monotherapy in ischemic stroke: The role of BDNF/TrkB/Erk1/2 signaling in neuroprotection

(2012) Fahim Atif et al.   NEUROPHARMACOLOGY

Protective effects of MCI-186 on transplantation of bone marrow stromal cells in rat ischemic stroke model

(2012) L.H. SHEN et al.   NEUROSCIENCE

Ipsilateral versus contralateral spontaneous post-stroke neuroplastic changes: Involvement of BDNF?

(2012) A. Madinier et al.   NEUROSCIENCE

Post-stroke infections exacerbate ischemic brain injury in middle-aged rats: Immunomodulation and neuroprotection by progesterone

(2012) S. Yousuf et al.   NEUROSCIENCE

Neuron-Specific Prolyl-4-Hydroxylase Domain 2 Knockout Reduces Brain Injury After Transient Cerebral Ischemia

(2012) Reiner Kunze et al.   STROKE

Brain-Derived Neurotrophic Factor Val66Met Polymorphism Predicts Worse Functional Outcome After Surgery in Patients With Unruptured Brain Arteriovenous Malformation

(2012) Erick M. Westbroek et al.   STROKE

The secretome of stem cells isolated from the adipose tissue and Wharton's jelly acts differently on central nervous system-derived cell populations

(2012) Carlos A Ribeiro et al.   Stem Cell Research & Therapy

Vascular endothelial growth factor is upregulated by l-dopa in the parkinsonian brain: implications for the development of dyskinesia

(2011) K. Elisabet Ohlin et al.   BRAIN

The systemic response to brain injury and disease

(2011) Daniel C. Anthony et al.   BRAIN BEHAVIOR AND IMMUNITY

Motoneuron programmed cell death in response to proBDNF

(2011) Anna R. Taylor et al.   Developmental Neurobiology

The Yin and Yang of Microglia

(2011) Melinda Czeh et al.   DEVELOPMENTAL NEUROSCIENCE

HIF-1α is neuroprotective during the early phases of mild hypoxia in rat cortical neurons

(2011) Beatriz López-Hernández et al.   EXPERIMENTAL NEUROLOGY

Toll-like receptors 2 and 4 in ischemic stroke: Outcome and therapeutic values

(2011) David Brea et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Coexpression of Angiopoietin-1 with VEGF Increases the Structural Integrity of the Blood–Brain Barrier and Reduces Atrophy Volume

(2011) Fanxia Shen et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Microglial p38α MAPK is a key regulator of proinflammatory cytokine up-regulation induced by toll-like receptor (TLR) ligands or beta-amyloid (Aβ)

(2011) Adam D Bachstetter et al.   Journal of Neuroinflammation

AMPA Receptor-Induced Local Brain-Derived Neurotrophic Factor Signaling Mediates Motor Recovery after Stroke

(2011) A. N. Clarkson et al.   JOURNAL OF NEUROSCIENCE

Controlled Cortical Impact Traumatic Brain Injury in 3xTg-AD Mice Causes Acute Intra-Axonal Amyloid-  Accumulation and Independently Accelerates the Development of Tau Abnormalities

(2011) H. T. Tran et al.   JOURNAL OF NEUROSCIENCE

HMGB1 Acts on Microglia Mac1 to Mediate Chronic Neuroinflammation That Drives Progressive Neurodegeneration

(2011) H.-M. Gao et al.   JOURNAL OF NEUROSCIENCE

The JNK inhibitor D-JNKI-1 blocks apoptotic JNK signaling in brain mitochondria

(2011) Yi Zhao et al.   MOLECULAR AND CELLULAR NEUROSCIENCE

Microglial p38α MAPK is critical for LPS-induced neuron degeneration, through a mechanism involving TNFα

(2011) Bin Xing et al.   Molecular Neurodegeneration

Antiangiogenic effect of silicate nanoparticle on retinal neovascularization induced by vascular endothelial growth factor

(2011) Dong Hyun Jo et al.   Nanomedicine-Nanotechnology Biology and Medicine

Inhibition of prolyl hydroxylases by dimethyloxaloylglycine after stroke reduces ischemic brain injury and requires hypoxia inducible factor-1α

(2011) Molly E. Ogle et al.   NEUROBIOLOGY OF DISEASE

PI3-K/Akt and ERK pathways activated by VEGF play opposite roles in MPP+-induced neuronal apoptosis

(2011) Wei Cui et al.   NEUROCHEMISTRY INTERNATIONAL

p38β MAPK affords cytoprotection against oxidative stress-induced astrocyte apoptosis via induction of αB-crystallin and its anti-apoptotic function

(2011) Joo-Hyun Shin et al.   NEUROSCIENCE LETTERS

Gene and protein analysis of brain derived neurotrophic factor expression in relation to neurological recovery induced by an enriched environment in a rat stroke model

(2011) Kenji Hirata et al.   NEUROSCIENCE LETTERS

Brain Regeneration in Physiology and Pathology: The Immune Signature Driving Therapeutic Plasticity of Neural Stem Cells

(2011) Gianvito Martino et al.   PHYSIOLOGICAL REVIEWS

Calpain-mediated Hsp70.1 cleavage in hippocampal CA1 neuronal death

(2010) Shunya Sahara et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Matrix Metalloproteinase-9 Mediates Hypoxia-Induced Vascular Leakage in the Brain via Tight Junction Rearrangement

(2010) Alexander T Bauer et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

VEGF protects spinal motor neurons against chronic excitotoxic degeneration in vivo by activation of PI3-K pathway and inhibition of p38MAPK

(2010) Luis B. Tovar-y-Romo et al.   JOURNAL OF NEUROCHEMISTRY

O2 regulates stem cells through Wnt/β-catenin signalling

(2010) Jolly Mazumdar et al.   NATURE CELL BIOLOGY

Intranasal brain-derived neurotrophic factor protects brain from ischemic insult via modulating local inflammation in rats

(2010) Y. Jiang et al.   NEUROSCIENCE

Neural Stem Cells Adopt Tumorigenic Properties by Constitutively Activated NF-κB and Subsequent VEGF Up-Regulation

(2010) Aljoscha Kaus et al.   STEM CELLS AND DEVELOPMENT

Vascular Endothelial Growth Factor Receptor-2 Inhibition Promotes Cell Death and Limits Endothelial Cell Proliferation in a Neonatal Rodent Model of Stroke

(2010) Janet Shimotake et al.   STROKE

Neuroprotective strategies targeting apoptotic and necrotic cell death for stroke

(2009) Junying Yuan   APOPTOSIS

N-Myc down regulation induced differentiation, early cell cycle exit, and apoptosis in human malignant neuroblastoma cells having wild type or mutant p53

(2009) Rajiv Janardhanan et al.   BIOCHEMICAL PHARMACOLOGY

Multi-targeted neuroprotection by the HSV-2 gene ICP10PK includes robust bystander activity through PI3-K/Akt and/or MEK/ERK-dependent neuronal release of vascular endothelial growth factor and fractalkine

(2009) Jennifer M. Laing et al.   JOURNAL OF NEUROCHEMISTRY

Cerebral ischemia provokes a profound exchange of activated JNK isoforms in brain mitochondria

(2009) Yi Zhao et al.   MOLECULAR AND CELLULAR NEUROSCIENCE

CD36 ligands promote sterile inflammation through assembly of a Toll-like receptor 4 and 6 heterodimer

(2009) Cameron R Stewart et al.   NATURE IMMUNOLOGY

Dynamics and diversity in autophagy mechanisms: lessons from yeast

(2009) Hitoshi Nakatogawa et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

The bright side of the glial scar in CNS repair

(2009) Asya Rolls et al.   NATURE REVIEWS NEUROSCIENCE

Differential regulation of toll-like receptor mRNAs in amyloid plaque-associated brain tissue of aged APP23 transgenic mice

(2009) Stefanie Frank et al.   NEUROSCIENCE LETTERS

Ablation of cholesterol biosynthesis in neural stem cells increases their VEGF expression and angiogenesis but causes neuron apoptosis

(2009) K. Saito et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Temporal and Spatial Dynamics of Cerebral Immune Cell Accumulation in Stroke

(2009) Mathias Gelderblom et al.   STROKE

Inhibition of Autophagy Prevents Hippocampal Pyramidal Neuron Death after Hypoxic-Ischemic Injury

(2008) Masato Koike et al.   AMERICAN JOURNAL OF PATHOLOGY

Identification of a Molecular Signaling Network that Regulates a Cellular Necrotic Cell Death Pathway

(2008) Junichi Hitomi et al.   CELL

Neurotrophic Factors in Neurodegenerative Disorders

(2008) Fabio Fumagalli et al.   CNS DRUGS

All JNKs Can Kill, but Nuclear Localization Is Critical for Neuronal Death

(2008) Benny Björkblom et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Tissue Inhibitor of Metalloproteinases Protect Blood—Brain Barrier Disruption in Focal Cerebral Ischemia

(2008) Motoaki Fujimoto et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

The Good, the Bad, and the Cell Type-Specific Roles of Hypoxia Inducible Factor-1  in Neurons and Astrocytes

(2008) G. Vangeison et al.   JOURNAL OF NEUROSCIENCE

Early increase of Nox4 NADPH oxidase and superoxide generation following endothelin-1-induced stroke in conscious rats

(2008) Sarah K. McCann et al.   JOURNAL OF NEUROSCIENCE RESEARCH

Neuronal Death by Oxidative Stress Involves Activation of FOXO3 through a Two-Arm Pathway That Activates Stress Kinases and Attenuates Insulin-like Growth Factor I Signaling

(2008) David Dávila et al.   MOLECULAR BIOLOGY OF THE CELL

Identification of RIP1 kinase as a specific cellular target of necrostatins

(2008) Alexei Degterev et al.   Nature Chemical Biology

Status epilepticus induces a TrkB to p75 neurotrophin receptor switch and increases brain-derived neurotrophic factor interaction with p75 neurotrophin receptor: An initial event in neuronal injury induction

(2008) N. Unsain et al.   NEUROSCIENCE

Brain-Derived Neurotrophic Factor But Not Forced Arm Use Improves Long-Term Outcome After Photothrombotic Stroke and Transiently Upregulates Binding Densities of Excitatory Glutamate Receptors in the Rat Brain

(2008) Harald D. Müller et al.   STROKE