Polyphenols and Human Health: A Prospectus

Mitochondria and vascular pathology

(2014) Fabio Di Lisa et al.   Pharmacological Reports

Development of Mitochondria-targeted Aromatic-cationic Peptides for Neurodegenerative Diseases

(2010) Hazel H. Szeto   Annals of the New York Academy of Sciences

Preventing NAD+ Depletion Protects Neurons against Excitotoxicity

(2010) Dong Liu et al.   Annals of the New York Academy of Sciences

Human absorption of a supplement containing purified hydroxytyrosol, a natural antioxidant from olive oil, and evidence for its transient association with low-density lipoproteins

(2010) Maria González-Santiago et al.   PHARMACOLOGICAL RESEARCH

The MEtabolomics to characterise Dietary Exposure (MEDE) Study: kinetics of metabolite responses to a test breakfast

(2010) G. Fave et al.   PROCEEDINGS OF THE NUTRITION SOCIETY

Curcumin and Cancer Cells: How Many Ways Can Curry Kill Tumor Cells Selectively?

(2009) Jayaraj Ravindran et al.   AAPS Journal

Mitochondrial targeting of electron scavenging antioxidants: Regulation of selective oxidation vs random chain reactions☆

(2009) Valerian E. Kagan et al.   ADVANCED DRUG DELIVERY REVIEWS

Resveratrol induces mitochondrial biogenesis in endothelial cells

(2009) Anna Csiszar et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

Resveratrol attenuates mitochondrial oxidative stress in coronary arterial endothelial cells

(2009) Zoltan Ungvari et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

MitoQ administration prevents endotoxin-induced cardiac dysfunction

(2009) G. S. Supinski et al.   AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY

Resveratrol: Its Biologic Targets and Functional Activity

(2009) Shazib Pervaiz et al.   ANTIOXIDANTS & REDOX SIGNALING

Mitochondrial pathways for ROS formation and myocardial injury: the relevance of p66Shc and monoamine oxidase

(2009) Fabio Di Lisa et al.   BASIC RESEARCH IN CARDIOLOGY

Microglia-aging: Roles of microglial lysosome- and mitochondria-derived reactive oxygen species in brain aging

(2009) Hiroshi Nakanishi et al.   BEHAVIOURAL BRAIN RESEARCH

Mitochondria-targeted plastoquinone derivatives as tools to interrupt execution of the aging program. 2. Treatment of some ROS- and Age-related diseases (heart arrhythmia, heart infarctions, kidney ischemia, and stroke)

(2009) L. E. Bakeeva et al.   BIOCHEMISTRY-MOSCOW

Mitochondria-targeted plastoquinone derivatives as tools to interrupt execution of the aging program. 4. Age-related eye disease. SkQ1 returns vision to blind animals

(2009) V. V. Neroev et al.   BIOCHEMISTRY-MOSCOW

Mitochondria-targeted plastoquinone derivatives as tools to interrupt execution of the aging program. 3. Inhibitory effect of SkQ1 on tumor development from p53-deficient cells

(2009) L. S. Agapova et al.   BIOCHEMISTRY-MOSCOW

Mitochondria-targeted plastoquinone derivatives as tools to interrupt execution of the aging program. 5. SkQ1 prolongs lifespan and prevents development of traits of senescence

(2009) V. N. Anisimov et al.   BIOCHEMISTRY-MOSCOW

Mitochondria-targeted plastoquinone derivatives as tools to interrupt execution of the aging program. 1. Cationic plastoquinone derivatives: Synthesis and in vitro studies

(2009) Y. N. Antonenko et al.   BIOCHEMISTRY-MOSCOW

Switch from inhibition to activation of the mitochondrial permeability transition during hematoporphyrin-mediated photooxidative stress.

(2009) Valeria Petronilli et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS

Quercetin can act either as an inhibitor or an inducer of the mitochondrial permeability transition pore: A demonstration of the ambivalent redox character of polyphenols

(2009) Umberto De Marchi et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS

Mitochondrial calcium in health and disease

(2009) Andrew P. Halestrap   BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS

Impact of mitochondriotropic quercetin derivatives on mitochondria

(2009) Lucia Biasutto et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS

Cause and consequence: Mitochondrial dysfunction initiates and propagates neuronal dysfunction, neuronal death and behavioral abnormalities in age-associated neurodegenerative diseases

(2009) Gary E. Gibson et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Effect of quercetin on oxidative nuclear and mitochondrial DNA damage

(2009) Lucia Potenza et al.   BIOFACTORS

A Review of the Antioxidant Mechanisms of Polyphenol Compounds Related to Iron Binding

(2009) Nathan R. Perron et al.   CELL BIOCHEMISTRY AND BIOPHYSICS

Chocolate, Lifestyle, and Health

(2009) Francesco Visioli et al.   CRITICAL REVIEWS IN FOOD SCIENCE AND NUTRITION

Oxidative Stress and Mitochondrial Dysfunction in Atherosclerosis: Mitochondria-Targeted Antioxidants as Potential Therapy

(2009) V. Victor et al.   CURRENT MEDICINAL CHEMISTRY

The role of diet and nutritional supplements in preventing and treating cardiovascular disease

(2009) Alison M Hill et al.   CURRENT OPINION IN CARDIOLOGY

Neuroinflammation in Alzheimer's disease: different molecular targets and potential therapeutic agents including curcumin

(2009) Balmiki Ray et al.   CURRENT OPINION IN PHARMACOLOGY

Mitochondria-targeted antioxidant SkQR1 selectively protects MDR (Pgp 170)-negative cells against oxidative stress

(2009) Elena K. Fetisova et al.   FEBS LETTERS

Interaction of dietary resveratrol with animal-associated bacteria

(2009) Carina M. Jung et al.   FEMS MICROBIOLOGY LETTERS

Towards an updated methodology for measurement of dietary fiber, including associated polyphenols, in food and beverages

(2009) Isabel Goñi et al.   FOOD RESEARCH INTERNATIONAL

Resveratrol metabolites in urine as a biomarker of wine intake in free-living subjects: The PREDIMED Study

(2009) Raul Zamora-Ros et al.   FREE RADICAL BIOLOGY AND MEDICINE

Mitochondria and reactive oxygen species

(2009) Alicia J. Kowaltowski et al.   FREE RADICAL BIOLOGY AND MEDICINE

Consequences of long-term oral administration of the mitochondria-targeted antioxidant MitoQ to wild-type mice

(2009) Sergio Rodriguez-Cuenca et al.   FREE RADICAL BIOLOGY AND MEDICINE

Vitagenes, dietary antioxidants and neuroprotection in neurodegenerative diseases

(2009) Vittorio Calabrese   Frontiers in Bioscience-Landmark

Measurement of dietary exposure: a challenging problem which may be overcome thanks to metabolomics?

(2009) Gaëlle Favé et al.   Genes and Nutrition

Improving the oral bioavailability of beneficial polyphenols through designed synergies

(2009) Arjan Scheepens et al.   Genes and Nutrition

Mitochondria-Targeted Antioxidant MitoQ 10 Improves Endothelial Function and Attenuates Cardiac Hypertrophy

(2009) Delyth Graham et al.   HYPERTENSION

Effect of Fat Content on the Digestibility and Bioaccessibility of Cocoa Polyphenol by an in Vitro Digestion Model

(2009) Nàdia Ortega et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

Metabolism of Berry Anthocyanins to Phenolic Acids in Humans

(2009) Tarja Nurmi et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

High Contents of Nonextractable Polyphenols in Fruits Suggest That Polyphenol Contents of Plant Foods Have Been Underestimated

(2009) Sara Arranz et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

Pharmacokinetics ofTrans-resveratrol Following Repeated Administration in Healthy Elderly and Young Subjects

(2009) Teresa Nunes et al.   JOURNAL OF CLINICAL PHARMACOLOGY

A CaPful of mechanisms regulating the mitochondrial permeability transition

(2009) Fabio Di Lisa et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

An LC-MS-Based Metabolomics Approach for Exploring Urinary Metabolome Modifications after Cocoa Consumption

(2009) Rafael Llorach et al.   JOURNAL OF PROTEOME RESEARCH

Tumor cell redox state and mitochondria at the center of the non-canonical activity of telomerase reverse transcriptase

(2009) Inthrani Raja Indran et al.   MOLECULAR ASPECTS OF MEDICINE

Pharmacokinetic and safety profile of trans-resveratrol in a rising multiple-dose study in healthy volunteers

(2009) Luis Almeida et al.   MOLECULAR NUTRITION & FOOD RESEARCH

Resveratrol Protects Mitochondria against Oxidative Stress through AMP-Activated Protein Kinase-Mediated Glycogen Synthase Kinase-3  Inhibition Downstream of Poly(ADP-ribose)polymerase-LKB1 Pathway

(2009) S. M. Shin et al.   MOLECULAR PHARMACOLOGY

Dietary phenolics: chemistry, bioavailability and effects on health

(2009) Alan Crozier et al.   NATURAL PRODUCT REPORTS

Resveratrol pretreatment protects rat brain from cerebral ischemic damage via a sirtuin 1–uncoupling protein 2 pathway

(2009) D. Della-Morte et al.   NEUROSCIENCE

Metabolomics, a novel tool for studies of nutrition, metabolism and lipid dysfunction

(2009) M. Orešič   NUTRITION METABOLISM AND CARDIOVASCULAR DISEASES

Altered profiles of gene expression in curcumin-treated rats with experimentally induced myocardial infarction

(2009) Dongsheng Hong et al.   PHARMACOLOGICAL RESEARCH

Theobroma cacao L., the Food of the Gods: A scientific approach beyond myths and claims

(2009) M. Rusconi et al.   PHARMACOLOGICAL RESEARCH

Bioavailability of Phenolic Antioxidants Associated with Dietary Fiber: Plasma Antioxidant Capacity After Acute and Long-Term Intake in Humans

(2009) Jara Pérez-Jiménez et al.   PLANT FOODS FOR HUMAN NUTRITION

A mitochondria-targeted S-nitrosothiol modulates respiration, nitrosates thiols, and protects against ischemia-reperfusion injury

(2009) T. A. Prime et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Synthesis of a mitochondria-targeted spin trap using a novel Parham-type cyclization

(2009) Caroline Quin et al.   TETRAHEDRON

Mitochondrial generation of free radicals and hypoxic signaling

(2009) Robert O. Poyton et al.   TRENDS IN ENDOCRINOLOGY AND METABOLISM

Direct measurement of the total antioxidant capacity of foods: the ‘QUENCHER’ approach

(2009) Vural Gökmen et al.   TRENDS IN FOOD SCIENCE & TECHNOLOGY

Phenolic compounds in olive oil: antioxidant, health and organoleptic activities according to their chemical structure

(2009) M. Servili et al.   INFLAMMOPHARMACOLOGY

Targeting Mitochondria

(2008) Adam T. Hoye et al.   ACCOUNTS OF CHEMICAL RESEARCH

Mild mitochondrial uncoupling in mice affects energy metabolism, redox balance and longevity

(2008) Camille C. Caldeira da Silva et al.   AGING CELL

Are polyphenols antioxidants or pro-oxidants? What do we learn from cell culture and in vivo studies?

(2008) Barry Halliwell   ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS

Rapid and extensive uptake and activation of hydrophobic triphenylphosphonium cations within cells

(2008) Meredith F. Ross et al.   BIOCHEMICAL JOURNAL

How mitochondria produce reactive oxygen species

(2008) Michael P. Murphy   BIOCHEMICAL JOURNAL

Modulation of anti-apoptotic and survival pathways by curcumin as a strategy to induce apoptosis in cancer cells

(2008) Simone Reuter et al.   BIOCHEMICAL PHARMACOLOGY

An attempt to prevent senescence: A mitochondrial approach

(2008) Vladimir P. Skulachev et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS

Development of mitochondria-targeted derivatives of resveratrol

(2008) Lucia Biasutto et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Resveratrol exerts its neuroprotective effect by modulating mitochondrial dysfunctions and associated cell death during cerebral ischemia

(2008) Seema Yousuf et al.   BRAIN RESEARCH

Stress-Response Hormesis and Aging: “That which Does Not Kill Us Makes Us Stronger”

(2008) David Gems et al.   Cell Metabolism

Curcumin: From ancient medicine to current clinical trials

(2008) H. Hatcher et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

A Mitochondriotropic Derivative of Quercetin: A Strategy to Increase the Effectiveness of Polyphenols

(2008) Andrea Mattarei et al.   CHEMBIOCHEM

Paraoxonase and Coronary Heart Disease Risk

(2008) Joseph Loscalzo   Circulation-Cardiovascular Genetics

Intervention with cloudy apple juice results in altered biological activities of ileostomy samples collected from individual volunteers

(2008) Selvaraju Veeriah et al.   EUROPEAN JOURNAL OF NUTRITION

Mechanism for resveratrol-induced cardioprotection against reperfusion injury involves glycogen synthase kinase 3β and mitochondrial permeability transition pore

(2008) Jinkun Xi et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

The mitochondria-targeted antioxidant MitoQ protects against organ damage in a lipopolysaccharide–peptidoglycan model of sepsis

(2008) Damon A. Lowes et al.   FREE RADICAL BIOLOGY AND MEDICINE

Regulation of cellular signals from nutritional molecules: a specific role for phytochemicals, beyond antioxidant activity

(2008) F VIRGILI et al.   FREE RADICAL BIOLOGY AND MEDICINE

A mitochondria-targeted nitroxide is reduced to its hydroxylamine by ubiquinol in mitochondria

(2008) Jan Trnka et al.   FREE RADICAL BIOLOGY AND MEDICINE

Potential therapeutic effects of curcumin, the anti-inflammatory agent, against neurodegenerative, cardiovascular, pulmonary, metabolic, autoimmune and neoplastic diseases

(2008) Bharat B. Aggarwal et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

Associations between dietary methods and biomarkers, and between fruits and vegetables and risk of ischaemic heart disease, in the EPIC Norfolk Cohort Study

(2008) S. Bingham et al.   INTERNATIONAL JOURNAL OF EPIDEMIOLOGY

GC–MS methods for metabolic profiling of microbial fermentation products of dietary polyphenols in human and in vitro intervention studies

(2008) Christian H. Grün et al.   JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES

Curcumin: A Promising Spice for Therapeutics

(2008) Catalina Alarcón de la Lastra   MOLECULAR NUTRITION & FOOD RESEARCH

Quantification of free and protein-boundtrans-resveratrol metabolites and identification oftrans-resveratrol-C/O-conjugated diglucuronides – Two novel resveratrol metabolites in human plasma

(2008) Alexander Burkon et al.   MOLECULAR NUTRITION & FOOD RESEARCH

New mechanisms and therapeutic potential of curcumin for colorectal cancer

(2008) Isabel Villegas et al.   MOLECULAR NUTRITION & FOOD RESEARCH

Curcumin and the cellular stress response in free radical-related diseases

(2008) Vittorio Calabrese et al.   MOLECULAR NUTRITION & FOOD RESEARCH

Carotenoids: Actual knowledge on food sources, intakes, stability and bioavailability and their protective role in humans

(2008) Giuseppe Maiani et al.   MOLECULAR NUTRITION & FOOD RESEARCH

Resveratrol addiction: To die or not to die

(2008) Mehdi Shakibaei et al.   MOLECULAR NUTRITION & FOOD RESEARCH

Cancer chemoprevention and mitochondria: Targeting apoptosis in transformed cellsviathe disruption of mitochondrial bioenergetics/redox state

(2008) Numsen Hail et al.   MOLECULAR NUTRITION & FOOD RESEARCH

Factors influencing the bioavailability of antioxidants in foods: A critical appraisal

(2008) Marisa Porrini et al.   NUTRITION METABOLISM AND CARDIOVASCULAR DISEASES

Cereal dietary fibre: a natural functional ingredient to deliver phenolic compounds into the gut

(2008) Paola Vitaglione et al.   TRENDS IN FOOD SCIENCE & TECHNOLOGY

The challenge of developing green tea polyphenols as therapeutic agents

(2008) C. Huo et al.   INFLAMMOPHARMACOLOGY

Mitochondria-Targeted Cytoprotective Peptides for Ischemia–Reperfusion Injury

(2007) Hazel H. Szeto   ANTIOXIDANTS & REDOX SIGNALING

Curcumin as “Curecumin”: From kitchen to clinic

(2007) Ajay Goel et al.   BIOCHEMICAL PHARMACOLOGY

Effects of Different Cooking Methods on Nutritional and Physicochemical Characteristics of Selected Vegetables

(2007) Cristiana Miglio et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY