Regulation of lipogenesis by cyclin-dependent kinase 8–mediated control of SREBP-1

Dysregulation of CDK8 and Cyclin C in tumorigenesis

(2011) Wu Xu et al.   Journal of Genetics and Genomics

Insulin Resistance: the Link Between Obesity and Cardiovascular Disease

(2011) Gerald M. Reaven   MEDICAL CLINICS OF NORTH AMERICA

A genome-scale shRNA resource for transgenic RNAi in Drosophila

(2011) Jian-Quan Ni et al.   NATURE METHODS

Origins and activity of the Mediator complex

(2011) Ronald C. Conaway et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

SREBPs: metabolic integrators in physiology and metabolism

(2011) Tae-Il Jeon et al.   TRENDS IN ENDOCRINOLOGY AND METABOLISM

Time of Day and Nutrients in Feeding Govern Daily Expression Rhythms of the Gene for Sterol Regulatory Element-binding Protein (SREBP)-1 in the Mouse Liver

(2010) Eriko Matsumoto et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The histone variant macroH2A suppresses melanoma progression through regulation of CDK8

(2010) Avnish Kapoor et al.   NATURE

The metazoan Mediator co-activator complex as an integrative hub for transcriptional regulation

(2010) Sohail Malik et al.   NATURE REVIEWS GENETICS

The human Mediator complex: a versatile, genome-wide regulator of transcription

(2010) Dylan J. Taatjes   TRENDS IN BIOCHEMICAL SCIENCES

Nuclear CDKs Drive Smad Transcriptional Activation and Turnover in BMP and TGF-β Pathways

(2009) Claudio Alarcón et al.   CELL

An Emerging Role of mTOR in Lipid Biosynthesis

(2009) Mathieu Laplante et al.   CURRENT BIOLOGY

The role of the lipogenic pathway in the development of hepatic steatosis

(2009) C. Postic et al.   DIABETES & METABOLISM

SREBP-1c in nonalcoholic fatty liver disease induced by Western-type high-fat diet plus fructose in rats

(2009) Manuela Aragno et al.   FREE RADICAL BIOLOGY AND MEDICINE

Evolutionary conservation and adaptation in the mechanism that regulates SREBP action: what a long, strange tRIP it's been

(2009) Timothy F. Osborne et al.   GENES & DEVELOPMENT

A Phosphorylation Cascade Controls the Degradation of Active SREBP1

(2009) Maria T. Bengoechea-Alonso et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Insulin Enhances the Biogenesis of Nuclear Sterol Regulatory Element-binding Protein (SREBP)-1c by Posttranscriptional Down-regulation of Insig-2A and Its Dissociation from SREBP Cleavage-activating Protein (SCAP)·SREBP-1c Complex

(2009) Chandrahasa R. Yellaturu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The Human CDK8 Subcomplex Is a Histone Kinase That Requires Med12 for Activity and Can Function Independently of Mediator

(2008) M. T. Knuesel et al.   MOLECULAR AND CELLULAR BIOLOGY

E2F1 represses β-catenin transcription and is antagonized by both pRB and CDK8

(2008) Erick J. Morris et al.   NATURE

CDK8 is a colorectal cancer oncogene that regulates β-catenin activity

(2008) Ron Firestein et al.   NATURE

Microarray analyses of SREBP-1a and SREBP-1c target genes identify new regulatory pathways in muscle

(2008) Sophie Rome et al.   PHYSIOLOGICAL GENOMICS

Abnormalities of Lipid Metabolism in Nonalcoholic Fatty Liver Disease

(2008) Onpan Cheung et al.   SEMINARS IN LIVER DISEASE

Lipid accumulation in non-adipose tissue and lipotoxicity

(2007) N.A. van Herpen et al.   PHYSIOLOGY & BEHAVIOR