Review
Biochemistry & Molecular Biology
Xavier R. Chapa-Dubocq, Keishla M. Rodriguez-Graciani, Nelson Escobales, Sabzali Javadov
Summary: Mitochondria, known as the powerhouse of the cell, regulate various cellular processes including ion homeostasis, energy production, and cell death. The inner mitochondrial membrane (IMM) plays a critical role in controlling mitochondrial metabolism and function. The volume of the mitochondrial matrix, regulated by ion transport mechanisms, influences IMM remodeling and can affect mitochondrial respiration and cell survival. Despite extensive research, the mechanisms underlying changes in matrix volume and IMM remodeling in response to energy and oxidative stressors remain poorly understood. This review summarizes previous studies and discusses the interplay between matrix volume regulation and IMM remodeling.
Review
Pharmacology & Pharmacy
Shaoyun Zhou, Qinwei Yu, Luyong Zhang, Zhenzhou Jiang
Summary: Mitochondria play multiple roles in cellular processes, acting as energy producers and biosynthetic centers. The opening of the mitochondrial permeability transition pore (mPTP) is a major contributor to mitochondrial dysfunction, leading to cellular damage or death. Cyclophilin D (CypD), a mitochondrial chaperone, has been identified as a key mediator of mPTP. Inhibiting CypD activity has shown to protect against diseases such as ischemia/reperfusion injury and neurodegenerative disorders.
CURRENT PHARMACEUTICAL DESIGN
(2023)
Article
Biochemistry & Molecular Biology
Jing Zhao, Xinyue Liu, Alan Blayney, Yumeng Zhang, Lauren Gandy, Paige Olivia Mirsky, Nathan Smith, Fuming Zhang, Robert J. Linhardt, Jianhan Chen, Christopher Baines, Stewart N. Loh, Chunyu Wang
Summary: The mitochondrial permeability transition pore (mPTP) plays crucial roles in various diseases. Cyclophilin D is confirmed as the only component of mPTP. Previous studies have reported that p53 interacts with CypD through its DNA-binding domain (DBD). However, this study found that the N-terminal domain (NTD) of p53 is the major binding site for CypD. The study provides insights into the dynamic interface between NTD and CypD.
JOURNAL OF MOLECULAR BIOLOGY
(2022)
Review
Cell Biology
Ibrahim Damilare Boyenle, Abdulquddus Kehinde Oyedele, Abdeen Tunde Ogunlana, Aishat Folashade Adeyemo, Faith Sunday Oyelere, Olateju Balikis Akinola, Temitope Isaac Adelusi, Leonard Ona Ehigie, Adeola Folasade Ehigie
Summary: The mitochondrial permeability transition pore (MPTP) is a pore formed on the inner mitochondrial membrane under calcium overload and oxidative stress, which can cause cell death and has physiological significance. Various models of MPTP have been proposed, with F1Fo ATPase being the most debated candidate protein. Cyclophilin D (CyPD) is widely accepted as the positive regulator of MPTP, but no drug candidate as its inhibitor has emerged.
Article
Plant Sciences
Ping Huang, Si-Peng Wu, Ning Wang, Saiwang Seto, Dennis Chang
Summary: This study evaluated the protective effects of HSYA on cerebral I/R injury by inhibiting the opening of mPTP through the MEK/ERK/CypD pathway, reducing the release of CytC from mitochondria to protect cells and alleviate damage.
Article
Biochemistry & Molecular Biology
Miguel Olivas-Aguirre, Liliana Torres-Lopez, Zeferino Gomez-Sandoval, Kathya Villatoro-Gomez, Igor Pottosin, Oxana Dobrovinskaya
Summary: The study demonstrated a synergistic cytotoxic effect of TAM and CBD against T-ALL cells. TAM targets CypD to inhibit mPTP formation, sensitizing T-ALL to CBD by altering mitochondrial Ca2+ homeostasis.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Biochemistry & Molecular Biology
Maxime Schleef, Margaux Rozes, Bruno Pillot, Gabriel Bidaux, Fitsum Guebre-Egziabher, Laurent Juillard, Delphine Baetz, Sandrine Lemoine
Summary: This study aimed to investigate the effect of CsA preconditioning on kidney and mitochondrial functions. The results showed that CsA significantly improved renal function and mitochondrial functions, while the use of Hsp70 inhibitor abolished the protection afforded by CsA. In vitro experiments demonstrated that Hsp70 modulation could protect kidneys from ischemia reperfusion injury by regulating mitochondrial functions. This pathway may be targeted by drugs to provide new therapeutics for improving renal function.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Cardiac & Cardiovascular Systems
Hector Chapoy Villanueva, Jae Hwi Sung, Jackie A. Stevens, Michael J. Zhang, Peyton M. Nelson, Lalitha S. Denduluri, Feng Feng, Timothy D. O'Connell, DeWayne Townsend, Julia C. Liu
Summary: Transport of Ca2+ into mitochondria through the mitochondrial Ca2+ uniporter complex is essential for ATP production, but excessive Ca2+ can be detrimental. Short-term deletion of the regulatory protein EMRE in the heart resulted in impaired Ca2+ uptake, attenuated ATP production, and improved cardiac function in an I/R model. However, long-term EMRE loss led to similar impairment in Ca2+ handling and function, but loss of protection against I/R injury. These findings suggest that long-term absence of EMRE restores susceptibility to I/R, despite impaired bioenergetic response.
JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Maria Jose Perez, Rodrigo Ibarra-Garcia-Padilla, Maoping Tang, George A. Porter Jr, Gail V. W. Johnson, Rodrigo A. Quintanilla
Summary: The cleavage of tau protein by Caspase-3 negatively affects mitochondrial bioenergetics through the activation of mitochondrial permeability transition pore (mPTP), emphasizing the importance of this channel and its regulatory protein, cyclophilin D (CypD), in neuronal damage induced by tau pathology in Alzheimer's disease.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE
(2024)
Review
Chemistry, Medicinal
Annamaria Haleckova, Ondrej Benek, Lucie Zemanova, Rafael Dolezal, Kamil Musilek
Summary: This review provides an overview of current knowledge on CypD inhibitors, with a focus on the in vitro activity of small-molecule compounds, their selectivity for CypD, and their binding mode within the enzyme's active site. Approaches for improving the molecular design of CypD inhibitors are also discussed.
MEDICINAL RESEARCH REVIEWS
(2022)
Article
Endocrinology & Metabolism
Astrid L. Basse, Marianne Agerholm, Jean Farup, Emilie Dalbram, Joachim Nielsen, Niels Ortenblad, Ali Altintas, Amy M. Ehrlich, Thomas Krag, Santina Bruzzone, Morten Dall, Roldan M. de Guia, Jonas B. Jensen, Andreas B. Moller, Anders Karlsen, Michael Kjaer, Romain Barres, John Vissing, Steen Larsen, Niels Jessen, Jonas T. Treebak
Summary: The study showed that NAMPT is crucial for maintaining cellular Ca2+ homeostasis and skeletal muscle development, which is vital for juvenile survival. Through analysis of skeletal muscle-specific Nampt KO mice, it was found that NAMPT plays a critical role in these processes.
MOLECULAR METABOLISM
(2021)
Article
Biochemistry & Molecular Biology
Balazs Koszegi, Gabor Balogh, Zoltan Berente, Anett Vranesics, Edit Pollak, Laszlo Molnar, Aniko Takatsy, Viktoria Poor, Matyas Wahr, Csenge Antus, Krisztian Eros, Laszlo Vigh, Ferenc Gallyas, Maria Peter, Balazs Veres
Summary: Recent studies have shown that the absence of cyclophilin D (CypD) affects glucose and lipid metabolism, resulting in lipid-specific alterations. Our analysis of CypD-/- mice compared to wild-type mice revealed significant changes in lipid species in liver and plasma samples. This study highlights the potential long-term therapeutic implications of CypD inhibition for various diseases.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Xiaomin Zhao, Jianxiong Guo, Xinyue Wang, Jiadi Lin, Zhihao Liu, Chunmei Xu, Di Zhang, Dewen Tong
Summary: TGEV infection reduces circBIRC6-2 levels, leading to a decrease in mitochondrial calcium, membrane potential, and mPTP opening. Furthermore, we identified an interaction between the novel protein BIRC6-236aa encoded by circBIRC6-2 and VDAC1, suggesting that BIRC6-236aa destabilizes the VDAC1-CypD complex and inhibits mPTP opening.
JOURNAL OF BIOLOGICAL CHEMISTRY
(2022)
Article
Multidisciplinary Sciences
Noemi Daradics, Gergo Horvath, Laszlo Tretter, Agnes Paal, Andras Fulop, Andras Budai, Attila Szijarto
Summary: Depletion of CypD improves mitochondrial function following ALPPS and enhances liver growth.
Article
Biology
Giampaolo Morciano, Natalia Naumova, Piotr Koprowski, Sara Valente, Vilma A. Sardao, Yaiza Potes, Alessandro Rimessi, Mariusz R. Wieckowski, Paulo J. Oliveira
Summary: This review summarizes the intriguing phenomenon of the mitochondrial permeability transition pore (mPTP) in cell biology. Despite almost 50 years of research, the mechanisms of mPTP are still not definitively understood. From initially being considered an in vitro artifact to now being recognized for its physiological and pathological implications, the journey of mPTP research has been long and complex.
BIOLOGICAL REVIEWS
(2021)
Article
Neuroimaging
Alexandre Bani-Sadr, Tae-Hee Cho, Matteo Cappucci, Marc Hermier, Roxana Ameli, Andrea Filip, Roberto Riva, Laurent Derex, Charles De Bourguignon, Laura Mechtouff, Omer F. Eker, Norbert Nighoghossian, Yves Berthezene
Summary: Automated MRI perfusion software packages show high variability in predicting final infarct volume. Routine expert evaluation and correction are needed for appropriate patient management.
JOURNAL OF NEUROINTERVENTIONAL SURGERY
(2023)
Editorial Material
Gastroenterology & Hepatology
Mariana Milashka-Brihay, Mariana Figueiredo, Miguel Pantaleon Sanchez, Clara Yzet, Sophie Collardeau-Frachon, Jerome Rivory, Mathieu Pioche
Article
Neurosciences
Susanna Diamanti, Jacopo Mariani, Alessandro Versace, Matteo Riva, Elisa Cuccione, Ruiyao Cai, Laura Monza, Martina Vigano, Radu Bolbos, Fabien Chauveau, Tae-Hee Cho, Davide Carone, Carlo Ferrarese, Simone Beretta
Summary: The neurological outcome after ischemic stroke is influenced by the amount of salvageable brain tissue when blood flow is restored. Head down tilt 15 degrees (HDT15) has been found to reduce infarct size and improve functional outcome in rats with transient middle cerebral artery occlusion (t-MCAO) by increasing cerebral perfusion within the ischemic penumbra. In this study, data from three experimental series involving 104 t-MCAO rats were analyzed. The results showed that HDT15 led to smaller infarct size and better functional outcome at 24 hours compared to the flat position group. Additionally, HDT15 increased cerebral perfusion in the ischemic hemisphere without affecting hemodynamics in non-ischemic areas.
EUROPEAN JOURNAL OF NEUROSCIENCE
(2023)
Article
Anesthesiology
Martin Ruste, Charlotte Chabanol, Jean-Luc Fellahi, Matthias Jacquet-Lagreze
Summary: Bioelectrical impedance analysis (BIA) is used to evaluate the body composition of critically-ill patients. This study aimed to assess the value of BIA as a fluid management monitoring tool. The results showed that BIA-derived hydration variables were significantly correlated with cumulative fluid balance, but there were limitations in the agreement between the measurements, indicating they cannot be used interchangeably.
JOURNAL OF CLINICAL MONITORING AND COMPUTING
(2023)
Article
Cardiac & Cardiovascular Systems
Clemence Delhomme, Marina Urena, Oualid Zouaghi, Francisco Campelo-Parada, Patrick Ohlmann, Gilles Rioufol, Eric Van Belle, Frederic Pinaud, Nicolas Meneveau, Patrick Staat, Olivier Morel, Francois Derimay, Flavien Vincent, Frederic Rouleau, Eric Brochet, Caroline Chong-Nguyen, Dominique Himbert
Summary: This study evaluated the effectiveness of transcatheter aortic valve implantation using the SAPIEN 3 transcatheter heart valve in patients with pure aortic regurgitation. The results showed a device success rate of 94.6%, a 30-day all-cause mortality rate of 8.1%, and a one-year all-cause mortality rate of 16.2%. This method appears promising for treating high-risk patients with pure aortic regurgitation, but further research is needed.
ARCHIVES OF CARDIOVASCULAR DISEASES
(2023)
Letter
Cardiac & Cardiovascular Systems
Clement Karsenty, Camelia Djeddai, Ariel Cohen, Guillaume Bonnet, Iris Ma, Paul Vignaud, Jean-Benoit Thambo, Sylvie Di Filippo, Philippe Acar, Magalie Ladouceur
ARCHIVES OF CARDIOVASCULAR DISEASES
(2023)
Review
Geriatrics & Gerontology
Lodovico Balducci, Claire Falandry, Alan List
Summary: Age is associated with the decline of multiple organ systems. Two molecules, trilaciclib and ALRN-6924, have emerged as novel strategies to prevent chemotherapy toxicity by inducing cell-cycle arrest. Trilaciclib inhibits CDK 4/6 to cause cell-cycle arrest, while ALRN-6924 activates p53. These drugs have shown promising results in preventing hematological toxicities in patients with small cell lung cancer and may also preserve the stem cell reserve of other tissues with high turnover.
Editorial Material
Transplantation
Rajiv Agarwal, Denis Fouque
NEPHROLOGY DIALYSIS TRANSPLANTATION
(2023)
Article
Multidisciplinary Sciences
Adrien Mirouse, Alice Friol, Anne-Sophie Moreau, Boris Jung, Edouard Jullien, Come Bureau, Michel Djibre, Nicolas de Prost, Lara Zafrani, Laurent Argaud, Danielle Reuter, Laure Calvet, Etienne de Montmollin, Sarah Benghanem, Claire Pichereau, Tai Pham, Patrice Cacoub, Lucie Biard, David Saadoun
Summary: Vaccination reduces the risk of severe illness and death from SARS-Cov2, but vaccinated patients may still experience severe disease. This study examined the clinical features of vaccinated patients admitted to the ICU due to SARS-Cov2 infection and compared them to unvaccinated patients.
SCIENTIFIC REPORTS
(2023)
Article
Infectious Diseases
Amine Benadji, Thomas Debroucker, Guillaume Martin-Blondel, Laurent Argaud, Virginie Vitrat, Charlotte Biron, Michel Wolff, Bruno Hoen, Xavier Duval, Sarah Tubiana
Summary: This study aimed to assess the prevalence of cerebrovascular complications (CVC) in patients with community-acquired bacterial meningitis and identify the factors associated with CVC in the first 48 hours. It was found that CVC occurred frequently in these patients and were independently associated with advanced age, altered mental status at admission, and seizures within 48 hours from admission, but not with adjunctive corticosteroids.
BMC INFECTIOUS DISEASES
(2023)
Article
Geriatrics & Gerontology
Emilie Bres, Julia Bouvier, Aymeric Courtay, Leo Delaire, Joannes Humblot, Charlotte Cuerq, Stephanie Tripoz-Dit-Masson, Mathieu Fauvernier, Thomas Gilbert, Marc Bonnefoy
Summary: This study aimed to determine the correlation between serum fibroblast growth factor 19 (FGF19) levels and functional muscle tests and muscle ultrasound parameters. The results showed significant correlations between FGF19 levels and muscle ultrasound parameters, suggesting that FGF19 may promote the development of large muscle fibers. However, high FGF19 levels were unexpectedly associated with a low SPPB score. Further studies are needed to validate and further elucidate these exploratory findings.
EXPERIMENTAL GERONTOLOGY
(2023)
Article
Multidisciplinary Sciences
Louis Marie Galerneau, Sebastien Bailly, Nicolas Terzi, Stephane Ruckly, Maite Garrouste-Orgeas, Yves Cohen, Vivien Hong Tuan Ha, Marc Gainnier, Shidasp Siami, Claire Dupuis, Michael Darmon, Elie Azoulay, Jean-Marie Forel, Florian Sigaud, Christophe Adrie, Dany Goldgran-Toledano, Alexis Ferre, Etienne de Montmollin, Laurent Argaud, Jean Reignier, Jean-Louis Pepin, Jean-Francois Timsit, OUTCOMEREA network
Summary: The study aimed to evaluate the impact of systemic corticosteroids on the occurrence of death or need for continuous invasive mechanical ventilation at day 28 after ICU admission in patients with acute exacerbation of COPD. The results showed that corticosteroids improved the main composite endpoint, but had no significant effect on the most severe COPD patients. Additionally, corticosteroids did not affect non-invasive ventilation failure, ICU or hospital stay, mortality, or the duration of mechanical ventilation, but increased the risk of glycaemic disorders.
Article
Anesthesiology
Matthias Jacquet-Lagreze, Christophe Saint-Jean, Thierry Bouet, Sebastien Reynaud, Martin Ruste, Jean-Luc Fellahi
Summary: Capillary refill time (CRT) is an important indicator of peripheral perfusion. DiCARTECH has developed a device to assess CRT. In the bench and in-silico studies, the device demonstrated robustness and the algorithm showed good reproducibility, confirming its ability for clinical assessment.
JOURNAL OF CLINICAL MONITORING AND COMPUTING
(2023)
Article
Cardiac & Cardiovascular Systems
Elena De Angelis, Thomas Bochaton, Enrico Ammirati, Andrea Tedeschi, Maria Vincenza Polito, Maurizio Pieroni, Marco Merlo, Piero Gentile, Caroline M. Van De Heyning, Thalia Bekelaar, Alberto Cipriani, Massimiliano Camilli, Tommaso Sanna, Martina Perazzolo Marra, Aderville Cabassi, Massimo F. Piepoli, Gianfranco Sinagra, Nathan Mewton, Eric Bonnefoy-Cudraz, Amelia Ravera, Ahmad Hayek
Summary: This study aims to investigate the clinical presentation, management, and outcome of patients with pheochromocytoma-induced cardiogenic shock (PICS). Data of 18 patients without previously known pheochromocytoma were collected retrospectively from 8 European hospitals. The main clinical features at presentation were pulmonary congestion and cyclic fluctuation of blood pressure. All patients underwent surgical removal of the pheochromocytoma and most patients showed stable condition.
INTERNATIONAL JOURNAL OF CARDIOLOGY
(2023)
Article
Urology & Nephrology
Matthias Jacquet-Lagreze, Martin Ruste, William Fornier, Pierre-Louis Jacquemet, Remi Schweizer, Jean-Luc Fellahi
Summary: This study aimed to investigate the ability of plasma protein concentration variations to detect a decrease in cardiac index (CI) during mechanical fluid removal and to assess other predictive factors of CI change. The results showed that haemoconcentration and passive leg raising failed to accurately predict a decrease in CI.
JOURNAL OF NEPHROLOGY
(2023)
Article
Cardiac & Cardiovascular Systems
Andrew B. Harvey, Renelyn A. Woltes, Raymond N. Deepe, Hannah G. Tarolli, Jenna R. Drummond, Allison Trouten, Auva Zandi, Jeremy L. Barth, Rupak Mukherjee, Martin J. Romeo, Silvia G. Vaena, Ge Tao, Robin Muise-Helmericks, Paula S. Ramos, Russell A. Norris, Andy Wessels
Summary: This study highlights the importance of SOX9 in the regulation of epicardial cell invasion and emphasizes the role of EPDCs in regulating atrioventricular valve development and homeostasis. It also reports a novel expression profile of Cd109, a gene with previously unknown relevance in heart development.
JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY
(2024)
Review
Cardiac & Cardiovascular Systems
MariaSanta C. Mangione, Jinhua Wen, Dian J. Cao
Summary: mTOR, a mechanistic target of rapamycin, is an evolutionarily conserved pathway that plays a fundamental role in nutrient sensing, growth, metabolism, lifespan, and aging. Recent studies have highlighted the regulatory role of mTOR in innate immune responses and its involvement in the pathogenesis of cardiovascular diseases, especially in acute inflammation and atherosclerotic cardiovascular disease. This review also discusses mTOR's role in trained immunity, immune senescence, and clonal hematopoiesis, as well as its architecture and regulatory complexes.
JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY
(2024)
Article
Cardiac & Cardiovascular Systems
Junlin Li, Yajun Gong, Yiren Wang, Huihui Huang, Huan Du, Lianying Cheng, Cui Ma, Yongxiang Cai, Hukui Han, Jianhong Tao, Gang Li, Panke Cheng
Summary: Myocardial ischemia-reperfusion injury is closely related to the final infarct size in acute myocardial infarction. Regulatory T cells play an important role in the inflammatory response after AMI, but different subtypes of Tregs have different effects on the injury.
JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY
(2024)
Article
Cardiac & Cardiovascular Systems
Yuxin Chu, Yutao Hua, Lihao He, Jin He, Yunxi Chen, Jing Yang, Ismail Mahmoud, Fanfang Zeng, Xiaochang Zeng, Gloria A. Benavides, Victor M. Darley-Usmar, Martin E. Young, Scott W. Ballinger, Sumanth D. Prabhu, Cheng Zhang, Min Xie
Summary: This study demonstrates that administering beta-hydroxybutyrate (beta-OHB) at the time of reperfusion can reduce infarct size and preserve cardiac function by activating autophagy and preserving mitochondrial homeostasis, potentially through mTOR inhibition.
JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY
(2024)
