Epicardial deletion of Sox9 leads to myxomatous valve degeneration and identifies Cd109 as a novel gene associated with valve development

Single-cell RNA sequencing reveals the diversity and biology of valve cells in cardiac valve disease

(2022) Mengxia Fu et al.   Journal of Cardiology

The Role of Transforming Growth Factor-β Signaling in Myxomatous Mitral Valve Degeneration

(2022) Qiyu Tang et al.   Frontiers in Cardiovascular Medicine

A cross-population atlas of genetic associations for 220 human phenotypes

(2021) Saori Sakaue et al.   NATURE GENETICS

The Role of the Epicardium During Heart Development and Repair

(2020) Pearl Quijada et al.   CIRCULATION RESEARCH

Comparative pathology of human and canine myxomatous mitral valve degeneration: 5HT and TGF-β mechanisms

(2020) Mark A. Oyama et al.   CARDIOVASCULAR PATHOLOGY

Disease Severity-Associated Gene Expression in Canine Myxomatous Mitral Valve Disease Is Dominated by TGFβ Signaling

(2020) Greg R. Markby et al.   Frontiers in Genetics

The prevalent I686T human variant and loss of function mutations in the cardiomyocyte-specific kinase gene TNNI3K cause adverse contractility and concentric remodeling in mice

(2020) Peiheng Gan et al.   HUMAN MOLECULAR GENETICS

Population-specific and trans-ancestry genome-wide analyses identify distinct and shared genetic risk loci for coronary artery disease

(2020) Satoshi Koyama et al.   NATURE GENETICS

SOX9 drives the epithelial–mesenchymal transition in non-small-cell lung cancer through the Wnt/β-catenin pathway

(2019) Jing-Qiang Huang et al.   Journal of Translational Medicine

Epicardium in Heart Development

(2019) Yingxi Cao et al.   Cold Spring Harbor Perspectives in Biology

SOX9 promotes nasopharyngeal carcinoma cell proliferation, migration and invasion through BMP2 and mTOR signaling

(2019) Bin Xiao et al.   GENE

SOX9 in cartilage development and disease

(2019) Véronique Lefebvre et al.   CURRENT OPINION IN CELL BIOLOGY

Hippo Signaling Plays an Essential Role in Cell State Transitions during Cardiac Fibroblast Development

(2018) Yang Xiao et al.   DEVELOPMENTAL CELL

Myocardial β-Catenin-BMP2 signaling promotes mesenchymal cell proliferation during endocardial cushion formation

(2018) Yidong Wang et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Identification of Novel Natural Substrates of Fibroblast Activation Protein-alpha by Differential Degradomics and Proteomics

(2018) Hui Emma Zhang et al.   MOLECULAR & CELLULAR PROTEOMICS

Overexpression of CD109 in the Epidermis Differentially Regulates ALK1 Versus ALK5 Signaling and Modulates Extracellular Matrix Synthesis in the Skin

(2017) Joshua Vorstenbosch et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

Unravelling the immunological roles of dipeptidyl peptidase 4 (DPP4) activity and/or structure homologue (DASH) proteins

(2016) L. Wagner et al.   CLINICAL AND EXPERIMENTAL IMMUNOLOGY

CD109 attenuates TGF-β1 signaling and enhances EGF signaling in SK-MG-1 human glioblastoma cells

(2015) Jing-Min Zhang et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Role of Sox9 in Growth Factor Regulation of Articular Chondrocytes

(2015) Shuiliang Shi et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

Myocardin-related transcription factors control the motility of epicardium-derived cells and the maturation of coronary vessels

(2014) M. A. Trembley et al.   DEVELOPMENT

Alk3 mediated Bmp signaling controls the contribution of epicardially derived cells to the tissues of the atrioventricular junction

(2014) Marie M. Lockhart et al.   DEVELOPMENTAL BIOLOGY

CD109, a novel TGF-βantagonist, decreases fibrotic responses in a hypoxic wound model

(2014) Sebastian Winocour et al.   EXPERIMENTAL DERMATOLOGY

Tbx18 regulates development of the epicardium and coronary vessels

(2013) San-Pin Wu et al.   DEVELOPMENTAL BIOLOGY

STAR: ultrafast universal RNA-seq aligner

(2012) Alexander Dobin et al.   BIOINFORMATICS

Developmental basis for filamin-A-associated myxomatous mitral valve disease

(2012) Kimberly Sauls et al.   CARDIOVASCULAR RESEARCH

The bHLH transcription factor Tcf21 is required for lineage-specific EMT of cardiac fibroblast progenitors

(2012) A. Acharya et al.   DEVELOPMENT

Epicardially derived fibroblasts preferentially contribute to the parietal leaflets of the atrioventricular valves in the murine heart

(2012) Andy Wessels et al.   DEVELOPMENTAL BIOLOGY

Atrioventricular valve development: New perspectives on an old theme

(2012) Annemarieke de Vlaming et al.   DIFFERENTIATION

CD109, a TGF-β co-receptor, attenuates extracellular matrix production in scleroderma skin fibroblasts

(2012) Xiao-Yong Man et al.   ARTHRITIS RESEARCH & THERAPY

Heart Valve Structure and Function in Development and Disease

(2011) Robert B. Hinton et al.   Annual Review of Physiology

Epicardial-Derived Cell Epithelial-to-Mesenchymal Transition and Fate Specification Require PDGF Receptor Signaling

(2011) Christopher L. Smith et al.   CIRCULATION RESEARCH

IGF signaling directs ventricular cardiomyocyte proliferation during embryonic heart development

(2011) P. Li et al.   DEVELOPMENT

Defective Tbx2-dependent patterning of the atrioventricular canal myocardium causes accessory pathway formation in mice

(2011) Wim T.J. Aanhaanen et al.   JOURNAL OF CLINICAL INVESTIGATION

Epicardial–Myocardial Signaling Directing Coronary Vasculogenesis

(2010) Harold E. Olivey et al.   CIRCULATION RESEARCH

Genetic fate mapping demonstrates contribution of epicardium-derived cells to the annulus fibrosis of the mammalian heart

(2009) Bin Zhou et al.   DEVELOPMENTAL BIOLOGY

Abundance and location of proteoglycans and hyaluronan within normal and myxomatous mitral valves

(2008) Vishal Gupta et al.   CARDIOVASCULAR PATHOLOGY

Epicardium-Derived Cells in Development of Annulus Fibrosis and Persistence of Accessory Pathways

(2008) Denise P. Kolditz et al.   CIRCULATION

Platelet-Derived Growth Factor Receptor β Signaling Is Required for Efficient Epicardial Cell Migration and Development of Two Distinct Coronary Vascular Smooth Muscle Cell Populations

(2008) Amy M. Mellgren et al.   CIRCULATION RESEARCH

Sox9, a key transcription factor of bone morphogenetic protein-2-induced chondrogenesis, is activated through BMP pathway and a CCAAT box in the proximal promoter

(2008) Qiuhui Pan et al.   JOURNAL OF CELLULAR PHYSIOLOGY