Perispinal Etanercept for Post-Stroke Neurological and Cognitive Dysfunction: Scientific Rationale and Current Evidence
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Title
Perispinal Etanercept for Post-Stroke Neurological and Cognitive Dysfunction: Scientific Rationale and Current Evidence
Authors
Keywords
Tumor Necrosis Factor, Traumatic Brain Injury, Etanercept, Microglial Activation, Tumor Necrosis Factor Inhibitor
Journal
CNS DRUGS
Volume 28, Issue 8, Pages 679-697
Publisher
Springer Nature
Online
2014-05-26
DOI
10.1007/s40263-014-0174-2
References
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Note: Only part of the references are listed.- Venous drainage of the spine and spinal cord: A comprehensive review of its history, embryology, anatomy, physiology, and pathology
- (2014) Christoph J. Griessenauer et al. CLINICAL ANATOMY
- Immediate Neurological Recovery Following Perispinal Etanercept Years After Brain Injury
- (2014) Edward Tobinick et al. CLINICAL DRUG INVESTIGATION
- Etanercept reduces thermal and mechanical orofacial hyperalgesia following inflammation and neuropathic injury
- (2014) S.C. Coelho et al. EUROPEAN JOURNAL OF PAIN
- Peripheral administration of an anti-TNF-α receptor fusion protein counteracts the amyloid induced elevation of hippocampal TNF-α levels and memory deficits in mice
- (2014) E.R. Detrait et al. NEUROCHEMISTRY INTERNATIONAL
- Off-Label Use of Drugs in Children
- (2014) et al. PEDIATRICS
- Long-Term Functional Consequences and Ongoing Cerebral Inflammation after Subarachnoid Hemorrhage in the Rat
- (2014) Elke Kooijman et al. PLoS One
- Beneficial Neurological Effects Observed in a Patient with Psoriasis Treated with Etanercept
- (2013) Elisa Bassi et al. AMERICAN JOURNAL OF CLINICAL DERMATOLOGY
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- (2013) Ian A. Clark et al. BIOCHEMICAL PHARMACOLOGY
- Etanercept attenuates traumatic brain injury in rats by reducing early microglial expression of tumor necrosis factor-α
- (2013) Chung-Ching Chio et al. BMC NEUROSCIENCE
- Inflammation and white matter degeneration persist for years after a single traumatic brain injury
- (2013) Victoria E. Johnson et al. BRAIN
- Soluble TNF Receptor 1-Secreting ex Vivo-Derived Dendritic Cells Reduce Injury After Stroke
- (2013) Melissa G Works et al. JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM
- Surgical treatment options and management strategies of metastatic renal cell carcinoma to the lumbar spinal nerve roots
- (2013) Christian Strong et al. JOURNAL OF CLINICAL NEUROSCIENCE
- Tumor necrosis factor alpha antagonism improves neurological recovery in murine intracerebral hemorrhage
- (2013) Beilei Lei et al. Journal of Neuroinflammation
- Analysis of venous drainage in three patients with extradural spinal arteriovenous fistulae at the craniovertebral junction with potentially benign implication
- (2013) Ajit S Puri et al. Journal of NeuroInterventional Surgery
- TDP-43 frontotemporal lobar degeneration and autoimmune disease
- (2013) Z. A. Miller et al. JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY
- 3,6′-dithiothalidomide improves experimental stroke outcome by suppressing neuroinflammation
- (2013) Jeong Seon Yoon et al. JOURNAL OF NEUROSCIENCE RESEARCH
- Etanercept Attenuates Traumatic Brain Injury in Rats by Reducing Brain TNF-αContents and by Stimulating Newly Formed Neurogenesis
- (2013) Chong-Un Cheong et al. MEDIATORS OF INFLAMMATION
- The liver–brain axis in liver failure: neuroinflammation and encephalopathy
- (2013) Roger F. Butterworth Nature Reviews Gastroenterology & Hepatology
- TNF-alpha receptor antagonist, R-7050, improves neurological outcomes following intracerebral hemorrhage in mice
- (2013) Melanie D. King et al. NEUROSCIENCE LETTERS
- Astrocyte signaling and neurodegeneration
- (2013) Liliana Brambilla et al. Prion
- TNF-α and its receptors modulate complex behaviours and neurotrophins in transgenic mice
- (2013) Marie Lou Camara et al. PSYCHONEUROENDOCRINOLOGY
- Randomized, Double-blind, Placebo-Controlled, Trial of Transforaminal Epidural Etanercept for the Treatment of Symptomatic Lumbar Disc Herniation
- (2013) Brian J. C. Freeman et al. SPINE
- Understanding Stroke Survivorship
- (2013) Lesli E. Skolarus et al. STROKE
- Balancing Burdens and Benefits: Ethical Issues of Off-Label Prescription Pharmaceutical Use
- (2013) Ford Vox et al. PM&R
- Evidence Needs to Be Translated, Whether or Not It Is Complete
- (2013) Penny A. Dacks et al. JAMA Neurology
- New Hope for Survivors of Stroke and Traumatic Brain Injury
- (2012) Ian Clark CNS DRUGS
- Selective TNF Inhibition for Chronic Stroke and Traumatic Brain Injury
- (2012) Edward Tobinick et al. CNS DRUGS
- Editorial [Hot Topic: Progressive and Unconventional Pharmacotherapeutic Approaches to Alzheimers Disease Therapy (Guest Editors: Stuart Maudsley & Wayne Chadwick)]
- (2012) Stuart Maudsley et al. Current Alzheimer Research
- Deciphering the Physiology Underlying the Rapid Clinical Effects of Perispinal Etanercept in Alzheimers Disease
- (2012) Edward Tobinick Current Alzheimer Research
- Stroke Disability and Rehabilitation of Stroke: World Health Organization Perspective
- (2012) Shanthi Mendis International Journal of Stroke
- Brain Protection from Stroke with Intravenous TNFα Decoy Receptor-Trojan Horse Fusion Protein
- (2012) Rachita K Sumbria et al. JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM
- Early intervention with a small molecule inhibitor for tumor nefosis factor-α prevents cognitive deficits in a triple transgenic mouse model of Alzheimer’s disease
- (2012) S Prasad Gabbita et al. Journal of Neuroinflammation
- TNF-α protein synthesis inhibitor restores neuronal function and reverses cognitive deficits induced by chronic neuroinflammation
- (2012) Karim Belarbi et al. Journal of Neuroinflammation
- Increasing TNF levels solely in the rat hippocampus produces persistent pain-like symptoms
- (2012) Regina T. Martuscello et al. PAIN
- Etanercept, a Widely Used Inhibitor of Tumor Necrosis Factor-α (TNF- α), Prevents Retinal Ganglion Cell Loss in a Rat Model of Glaucoma
- (2012) Miin Roh et al. PLoS One
- Inflammatory Cascades Driven by Tumor Necrosis Factor-Alpha Play a Major Role in the Progression of Acute Liver Failure and Its Neurological Complications
- (2012) Anne Chastre et al. PLoS One
- TNFα in synaptic function: switching gears
- (2012) Mirko Santello et al. TRENDS IN NEUROSCIENCES
- Inflammation after trauma: Microglial activation and traumatic brain injury
- (2011) Anil F. Ramlackhansingh et al. ANNALS OF NEUROLOGY
- IMiD immunomodulatory compounds block C/EBP translation through eIF4E down-regulation resulting in inhibition of MM
- (2011) S. Li et al. BLOOD
- Evaluating treatments in health care: The instability of a one-legged stool
- (2011) Bonnie J Kaplan et al. BMC Medical Research Methodology
- Targeting TNF-Alpha to Elucidate and Ameliorate Neuroinflammation in Neurodegenerative Diseases
- (2011) Kathryn A. Frankola et al. CNS & Neurological Disorders-Drug Targets
- Rapid Improvement of Chronic Stroke Deficits after Perispinal Etanercept
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- Implications of Gliotransmission for the Pharmacotherapy of CNS Disorders
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- (2011) Renana Baratz et al. JOURNAL OF NEUROCHEMISTRY
- Alzheimer's disease - a neurospirochetosis. Analysis of the evidence following Koch's and Hill's criteria
- (2011) Judith Miklossy Journal of Neuroinflammation
- Widespread and Prolonged Increase in (R)-11C-PK11195 Binding After Traumatic Brain Injury
- (2011) H. Folkersma et al. JOURNAL OF NUCLEAR MEDICINE
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- (2010) Xingshun Xu et al. BRAIN RESEARCH
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- (2010) Jian-Quan Shi et al. BRAIN RESEARCH
- AMPA-receptor trafficking and injury-induced cell death
- (2010) Michael S. Beattie et al. EUROPEAN JOURNAL OF NEUROSCIENCE
- Perispinal etanercept: a new therapeutic paradigm in neurology
- (2010) Edward Tobinick Expert Review of Neurotherapeutics
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- (2010) Yi-Ming Chen et al. JOINT BONE SPINE
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- (2010) Chung-Ching Chio et al. JOURNAL OF NEUROCHEMISTRY
- The roles of TNF in brain dysfunction and disease
- (2010) Ian A. Clark et al. PHARMACOLOGY & THERAPEUTICS
- Tumor necrosis factor- triggers a cytokine cascade yielding postoperative cognitive decline
- (2010) N. Terrando et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Everyday Cognitive Failure in Sarcoidosis: The Prevalence and the Effect of Anti-TNF-α Treatment
- (2010) Marjon D. Elfferich et al. RESPIRATION
- Venous Air Embolism: An Unusual Complication of Atlantoaxial Arthrodesis
- (2010) Travis M. Dumont et al. SPINE
- Stroke: Working Toward a Prioritized World Agenda
- (2010) Vladimir Hachinski et al. STROKE
- Anti-TNF therapy in the injured spinal cord
- (2010) Emanuela Esposito et al. TRENDS IN PHARMACOLOGICAL SCIENCES
- Randomized, Double-blind, Placebo-controlled, Dose-response, and Preclinical Safety Study of Transforaminal Epidural Etanercept for the Treatment of Sciatica
- (2009) Steven P. Cohen et al. ANESTHESIOLOGY
- Decreased behavioral impairments in an Alzheimer mice model by interfering with TNF-alpha metabolism
- (2009) Fabienne Giuliani et al. BRAIN RESEARCH BULLETIN
- Systematic review by meta-analyses on the possible role of TNF-α polymorphisms in association with Alzheimer's disease
- (2009) Danilo Di Bona et al. BRAIN RESEARCH REVIEWS
- Tumour Necrosis Factor Modulation for Treatment of Alzheimerʼs Disease
- (2009) Edward Tobinick CNS DRUGS
- Inflammation and Anti-Inflammatory Strategies for Alzheimer’s Disease – A Mini-Review
- (2009) Benjamin Brian Alexander McNaull et al. GERONTOLOGY
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- (2009) Wenlei Jiang et al. JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM
- Cerebral inflammation contributes to encephalopathy and brain edema in acute liver failure: protective effect of minocycline
- (2009) Wenlei Jiang et al. JOURNAL OF NEUROCHEMISTRY
- Tumor necrosis factor-α-induced neutral sphingomyelinase-2 modulates synaptic plasticity by controlling the membrane insertion of NMDA receptors
- (2009) David Wheeler et al. JOURNAL OF NEUROCHEMISTRY
- Cerebral Microglia Recruit Monocytes into the Brain in Response to Tumor Necrosis Factor Signaling during Peripheral Organ Inflammation
- (2009) C. D'Mello et al. JOURNAL OF NEUROSCIENCE
- J&J's billion dollar punt on anti-amyloid antibody
- (2009) Cormac Sheridan NATURE BIOTECHNOLOGY
- IL-1 or TNF receptor gene deletion delays onset of encephalopathy and attenuates brain edema in experimental acute liver failure
- (2009) Chantal Bémeur et al. NEUROCHEMISTRY INTERNATIONAL
- Mapping selective neuronal loss and microglial activation in the salvaged neocortical penumbra in the rat
- (2009) J.L. Hughes et al. NEUROIMAGE
- Orbital and anterior visual pathway infection and inflammation
- (2009) Roel De Wyngaert et al. NEURORADIOLOGY
- Rapid nitric oxide-dependent effects of tumor necrosis factor-α on suprachiasmatic nuclei neuronal activity
- (2009) Mikael Nygård et al. NEUROREPORT
- Distribution and tumor necrosis factor-alpha isoform binding specificity of locally administered etanercept into injured and uninjured rat sciatic nerve
- (2009) K. Kato et al. NEUROSCIENCE
- Along a TNF-paved road from dead parasites in red cells to cerebral malaria, and beyond
- (2009) I. A. CLARK PARASITOLOGY
- Dissemination of Prostate Adenocarcinoma to the Skull Base Mimicking Giant Trigeminal Schwannoma: Anatomic Relevance of the Extradural Neural Axis Component
- (2009) Jaime Gasco et al. SKULL BASE-AN INTERDISCIPLINARY APPROACH
- Effect of Etanercept, a Tumor Necrosis Factor-Alpha Inhibitor, on Neuropathic Pain in the Rat Chronic Constriction Injury Model
- (2009) John M. Zanella et al. SPINE
- Rapid improvement in verbal fluency and aphasia following perispinal etanercept in Alzheimer's disease
- (2008) Edward L Tobinick et al. BMC Neurology
- Necroptosis: A Specialized Pathway of Programmed Necrosis
- (2008) Lorenzo Galluzzi et al. CELL
- Identification of a Molecular Signaling Network that Regulates a Cellular Necrotic Cell Death Pathway
- (2008) Junichi Hitomi et al. CELL
- Classification of cell death: recommendations of the Nomenclature Committee on Cell Death 2009
- (2008) G Kroemer et al. CELL DEATH AND DIFFERENTIATION
- Perispinal etanercept for neuroinflammatory disorders
- (2008) Edward Tobinick DRUG DISCOVERY TODAY
- Paths to acceptance. The advancement of scientific knowledge is an uphill struggle against ‘accepted wisdom’
- (2008) Howard Wolinsky EMBO REPORTS
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- (2008) Fabien Marchand et al. EUROPEAN JOURNAL OF PAIN
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- (2008) Melissa D. Laird et al. FREE RADICAL BIOLOGY AND MEDICINE
- Necrostatin-1 Reduces Histopathology and Improves Functional Outcome after Controlled Cortical Impact in Mice
- (2008) Zerong You et al. JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM
- Perispinal etanercept: Potential as an Alzheimer therapeutic
- (2008) W Sue T Griffin Journal of Neuroinflammation
- Rapid cognitive improvement in Alzheimer's disease following perispinal etanercept administration
- (2008) Edward L Tobinick et al. Journal of Neuroinflammation
- Mechanisms of Microglia-Mediated Neurotoxicity in a New Model of the Stroke Penumbra
- (2008) V. Kaushal et al. JOURNAL OF NEUROSCIENCE
- Paraplegia after extensive thoracic and thoracoabdominal aortic aneurysm repair: Does critical spinal cord ischemia occur postoperatively?
- (2008) Christian D. Etz et al. JOURNAL OF THORACIC AND CARDIOVASCULAR SURGERY
- Guidance for off-label use of drugs
- (2008) The Lancet Neurology LANCET NEUROLOGY
- Assessment of cervical venous blood flow and the craniocervical venus valve using ultrasound sonography
- (2008) Akira Morimoto et al. Legal Medicine
- Identification of RIP1 kinase as a specific cellular target of necrostatins
- (2008) Alexei Degterev et al. Nature Chemical Biology
- Soluble TNF receptors are associated with Aβ metabolism and conversion to dementia in subjects with mild cognitive impairment
- (2008) Peder Buchhave et al. NEUROBIOLOGY OF AGING
- Evidence for a cytokine model of cognitive function
- (2008) J. McAfoose et al. NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS
- Peripheral and central biodistribution of 111In-labeled anti-beta-amyloid autoantibodies in a transgenic mouse model of Alzheimer's disease
- (2008) Michael Bacher et al. NEUROSCIENCE LETTERS
- Tumor necrosis factor antagonist mechanisms of action: A comprehensive review
- (2007) Daniel Tracey et al. PHARMACOLOGY & THERAPEUTICS
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