Perispinal etanercept: a new therapeutic paradigm in neurology

The role of TNF-α signaling pathway on COX-2 upregulation and cognitive decline induced by β-amyloid peptide

(2010) Rodrigo Medeiros et al.   BEHAVIOURAL BRAIN RESEARCH

Tumor necrosis factor-alpha mediated signaling in neuronal homeostasis and dysfunction

(2010) Keigan M. Park et al.   CELLULAR SIGNALLING

Tarenflurbil for Alzheimer's disease: a “shot on goal” that missed

(2010) Bruno Vellas   LANCET NEUROLOGY

Bapineuzumab in Alzheimer's disease: where now?

(2010) Gordon K Wilcock   LANCET NEUROLOGY

Wishing Away Inflammation? New Links between Serotonin and TNF Signaling

(2010) M. Pelletier et al.   MOLECULAR INTERVENTIONS

Alzheimer's Disease

(2010) Henry W. Querfurth et al.   NEW ENGLAND JOURNAL OF MEDICINE

A Critique of Intradiscal Administration for Treatment of Radiculopathy

(2009) Edward L. Tobinick   ANESTHESIOLOGY

Randomized, Double-blind, Placebo-controlled, Dose-response, and Preclinical Safety Study of Transforaminal Epidural Etanercept for the Treatment of Sciatica

(2009) Steven P. Cohen et al.   ANESTHESIOLOGY

Updated consensus statement on biological agents for the treatment of rheumatic diseases, 2009

(2009) D E Furst et al.   ANNALS OF THE RHEUMATIC DISEASES

Vascular Factors and Markers of Inflammation in Offspring With a Parental History of Late-Onset Alzheimer Disease

(2009) Eric van Exel et al.   ARCHIVES OF GENERAL PSYCHIATRY

A Meta-Analysis of Cytokines in Major Depression

(2009) Yekta Dowlati et al.   BIOLOGICAL PSYCHIATRY

Recent developments in Alzheimer's disease therapeutics

(2009) Michael S Rafii et al.   BMC Medicine

Decreased behavioral impairments in an Alzheimer mice model by interfering with TNF-alpha metabolism

(2009) Fabienne Giuliani et al.   BRAIN RESEARCH BULLETIN

Systematic review by meta-analyses on the possible role of TNF-α polymorphisms in association with Alzheimer's disease

(2009) Danilo Di Bona et al.   BRAIN RESEARCH REVIEWS

Perineural Injection of Etanercept as a Treatment for Postamputation Pain

(2009) Erik Dahl et al.   CLINICAL JOURNAL OF PAIN

Tumour Necrosis Factor Modulation for Treatment of Alzheimerʼs Disease

(2009) Edward Tobinick   CNS DRUGS

Biomarkers for Alzheimer’s disease and other forms of dementia: Clinical needs, limitations and future aspects

(2009) Angel Cedazo-Minguez et al.   EXPERIMENTAL GERONTOLOGY

Accumulation of tau induced in neurites by microglial proinflammatory mediators

(2009) Philipp Gorlovoy et al.   FASEB JOURNAL

Inflammation and Anti-Inflammatory Strategies for Alzheimer’s Disease – A Mini-Review

(2009) Benjamin Brian Alexander McNaull et al.   GERONTOLOGY

Tumor necrosis factor-α-induced neutral sphingomyelinase-2 modulates synaptic plasticity by controlling the membrane insertion of NMDA receptors

(2009) David Wheeler et al.   JOURNAL OF NEUROCHEMISTRY

Immediate anti-tumor necrosis factor-α (etanercept) therapy enhances axonal regeneration after sciatic nerve crush

(2009) Kinshi Kato et al.   JOURNAL OF NEUROSCIENCE RESEARCH

Imipramine, in Part through Tumor Necrosis Factor   Inhibition, Prevents Cognitive Decline and  -Amyloid Accumulation in a Mouse Model of Alzheimer's Disease

(2009) F. Chavant et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

Significant recovery of motor function in a patient with complete T7 paraplegia receiving etanercept

(2009) M Dinomais et al.   JOURNAL OF REHABILITATION MEDICINE

Regulatory T cells are key cerebroprotective immunomodulators in acute experimental stroke

(2009) Arthur Liesz et al.   NATURE MEDICINE

Chronic expression of low levels of tumor necrosis factor-α in the substantia nigra elicits progressive neurodegeneration, delayed motor symptoms and microglia/macrophage activation

(2009) Ana Laura De Lella Ezcurra et al.   NEUROBIOLOGY OF DISEASE

Systemic inflammation and disease progression in Alzheimer disease

(2009) C. Holmes et al.   NEUROLOGY

A phase 2 multiple ascending dose trial of bapineuzumab in mild to moderate Alzheimer disease

(2009) S. Salloway et al.   NEUROLOGY

Rapid nitric oxide-dependent effects of tumor necrosis factor-α on suprachiasmatic nuclei neuronal activity

(2009) Mikael Nygård et al.   NEUROREPORT

Distribution and tumor necrosis factor-alpha isoform binding specificity of locally administered etanercept into injured and uninjured rat sciatic nerve

(2009) K. Kato et al.   NEUROSCIENCE

GluN2B subunit-containing NMDA receptor antagonists prevent A -mediated synaptic plasticity disruption in vivo

(2009) N.-W. Hu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Blood–brain barrier permeability in Alzheimer's disease: a case–control MRI study

(2009) John M. Starr et al.   PSYCHIATRY RESEARCH-NEUROIMAGING

Rapid improvement in verbal fluency and aphasia following perispinal etanercept in Alzheimer's disease

(2008) Edward L Tobinick et al.   BMC Neurology

Perispinal etanercept for neuroinflammatory disorders

(2008) Edward Tobinick   DRUG DISCOVERY TODAY

Paths to acceptance. The advancement of scientific knowledge is an uphill struggle against ‘accepted wisdom’

(2008) Howard Wolinsky   EMBO REPORTS

Effects of Etanercept and Minocycline in a rat model of spinal cord injury

(2008) Fabien Marchand et al.   EUROPEAN JOURNAL OF PAIN

In vitro neuronal and glial differentiation from embryonic or adult neural precursor cells are differently affected by chronic or acute activation of microglia

(2008) Emanuele Cacci et al.   GLIA

Perispinal etanercept: Potential as an Alzheimer therapeutic

(2008) W Sue T Griffin   Journal of Neuroinflammation

Rapid cognitive improvement in Alzheimer's disease following perispinal etanercept administration

(2008) Edward L Tobinick et al.   Journal of Neuroinflammation

TNF signaling inhibition in the CNS: implications for normal brain function and neurodegenerative disease

(2008) Melissa K McCoy et al.   Journal of Neuroinflammation

Cell Death after Spinal Cord Injury Is Exacerbated by Rapid TNF -Induced Trafficking of GluR2-Lacking AMPARs to the Plasma Membrane

(2008) A. R. Ferguson et al.   JOURNAL OF NEUROSCIENCE

Exogenous tumor necrosis factor-α rapidly alters synaptic and sensory transmission in the adult rat spinal cord dorsal horn

(2008) Dong-ho Youn et al.   JOURNAL OF NEUROSCIENCE RESEARCH

Histopathological and molecular heterogeneity among individuals with dementia associated with Presenilin mutations

(2008) Chera L Maarouf et al.   Molecular Neurodegeneration

Systemic infection and inflammation in acute CNS injury and chronic neurodegeneration: Underlying mechanisms

(2008) J.L. Teeling et al.   NEUROSCIENCE

The dual role of tumor necrosis factor-alpha in the pathophysiology of spinal cord injury

(2008) Ling-Yi Chi et al.   NEUROSCIENCE LETTERS

Cytokine regulation in animal models of neuropathic pain and in human diseases

(2008) Nurcan Üçeyler et al.   NEUROSCIENCE LETTERS

Biomarkers for evaluation of clinical efficacy of multipotential neuroprotective drugs for Alzheimer’s and Parkinson’s diseases

(2008) Ilan Halperin et al.   Neurotherapeutics

Neuroprotective effects of infliximab in experimental spinal cord injury

(2008) Gökhan Kurt et al.   SURGICAL NEUROLOGY

Loss-of-function mutations in the filaggrin gene: no contribution to disease susceptibility, but to autoantibody formation against citrullinated peptides in early rheumatoid arthritis

(2007) U Huffmeier et al.   ANNALS OF THE RHEUMATIC DISEASES

Restraining tumor necrosis factor-alpha by thalidomide prevents the Amyloid beta-induced impairment of recognition memory in mice

(2007) Tursun Alkam et al.   BEHAVIOURAL BRAIN RESEARCH

From inflammation to sickness and depression: when the immune system subjugates the brain

(2007) Robert Dantzer et al.   NATURE REVIEWS NEUROSCIENCE

Tumor necrosis factor antagonist mechanisms of action: A comprehensive review

(2007) Daniel Tracey et al.   PHARMACOLOGY & THERAPEUTICS