The liver–brain axis in liver failure: neuroinflammation and encephalopathy

Secondary Prophylaxis of Hepatic Encephalopathy in Cirrhosis: An Open-Label, Randomized Controlled Trial of Lactulose, Probiotics and No Therapy

(2012) Amit Agrawal et al.   AMERICAN JOURNAL OF GASTROENTEROLOGY

Real-time analysis of microglial activation and motility in hepatic and hyperammonemic encephalopathy

(2012) V. RANGROO THRANE et al.   NEUROSCIENCE

Inflammatory Cascades Driven by Tumor Necrosis Factor-Alpha Play a Major Role in the Progression of Acute Liver Failure and Its Neurological Complications

(2012) Anne Chastre et al.   PLoS One

Microglia activation in hepatic encephalopathy in rats and humans

(2011) Irina Zemtsova et al.   HEPATOLOGY

Hepatic encephalopathy: A central neuroinflammatory disorder?

(2011) Roger F. Butterworth   HEPATOLOGY

Occludin is regulated by epidermal growth factor receptor activation in brain endothelial cells and brains of mice with acute liver failure

(2011) Feng Chen et al.   HEPATOLOGY

Manganese potentiates LPS-induced heme-oxygenase 1 in microglia but not dopaminergic cells: Role in controlling microglial hydrogen peroxide and inflammatory cytokine output

(2011) Celia A. Dodd et al.   NEUROTOXICOLOGY

Hyperammonemia Induces Neuroinflammation That Contributes to Cognitive Impairment in Rats With Hepatic Encephalopathy

(2010) Regina Rodrigo et al.   GASTROENTEROLOGY

Matrix metalloproteinase-9 in fulminant hepatic failure

(2010) Lluis Palenzuela et al.   HEPATOLOGY

Locomotor impairment and cerebrocortical oxidative stress in portal vein ligated rats in vivo

(2010) Jonathan Brück et al.   JOURNAL OF HEPATOLOGY

Infection and systemic inflammation, not ammonia, are associated with Grade 3/4 hepatic encephalopathy, but not mortality in cirrhosis

(2010) D.L. Shawcross et al.   JOURNAL OF HEPATOLOGY

Translocator Protein PET Imaging for Glial Activation in Multiple Sclerosis

(2010) Unsong Oh et al.   Journal of Neuroimmune Pharmacology

N-Acetylcysteine attenuates cerebral complications of non-acetaminophen-induced acute liver failure in mice: antioxidant and anti-inflammatory mechanisms

(2010) Chantal Bémeur et al.   METABOLIC BRAIN DISEASE

Ammonia and proinflammatory cytokines modify expression of genes coding for astrocytic proteins implicated in brain edema in acute liver failure

(2010) Anne Chastre et al.   METABOLIC BRAIN DISEASE

Translocator protein (18 kDa) (TSPO) as a therapeutic target for neurological and psychiatric disorders

(2010) Rainer Rupprecht et al.   NATURE REVIEWS DRUG DISCOVERY

Rifaximin Treatment in Hepatic Encephalopathy

(2010) Nathan M. Bass et al.   NEW ENGLAND JOURNAL OF MEDICINE

Efficacy of L-Ornithine L-Aspartate in Acute Liver Failure: A Double-Blind, Randomized, Placebo-Controlled Study

(2009) Subrat Kumar Acharya et al.   GASTROENTEROLOGY

Direct Evidence for Central Proinflammatory Mechanisms in Rats with Experimental Acute Liver Failure: Protective Effect of Hypothermia

(2009) Wenlei Jiang et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Cerebral inflammation contributes to encephalopathy and brain edema in acute liver failure: protective effect of minocycline

(2009) Wenlei Jiang et al.   JOURNAL OF NEUROCHEMISTRY

Synergistic dopaminergic neurotoxicity of manganese and lipopolysaccharide: differential involvement of microglia and astroglia

(2009) Ping Zhang et al.   JOURNAL OF NEUROCHEMISTRY

Cerebral Microglia Recruit Monocytes into the Brain in Response to Tumor Necrosis Factor  Signaling during Peripheral Organ Inflammation

(2009) C. D'Mello et al.   JOURNAL OF NEUROSCIENCE

Alterations in expression of genes coding for proteins of the neurovascular unit in ischemic liver failure

(2009) Kei Sawara et al.   NEUROCHEMISTRY INTERNATIONAL

Minocycline attenuates oxidative/nitrosative stress and cerebral complications of acute liver failure in rats

(2009) Wenlei Jiang et al.   NEUROCHEMISTRY INTERNATIONAL

No changes in expression of tight junction proteins or blood–brain barrier permeability in azoxymethane-induced experimental acute liver failure

(2009) Chantal Bémeur et al.   NEUROCHEMISTRY INTERNATIONAL

Subtle BBB alterations in brain edema associated with acute liver failure

(2009) Justin H. Nguyen   NEUROCHEMISTRY INTERNATIONAL

IL-1 or TNF receptor gene deletion delays onset of encephalopathy and attenuates brain edema in experimental acute liver failure

(2009) Chantal Bémeur et al.   NEUROCHEMISTRY INTERNATIONAL

Peripheral lipopolysaccharide (LPS) challenge promotes microglial hyperactivity in aged mice that is associated with exaggerated induction of both pro-inflammatory IL-1β and anti-inflammatory IL-10 cytokines

(2008) Christopher J. Henry et al.   BRAIN BEHAVIOR AND IMMUNITY

Altered Expression of Zonula Occludens-2 Precedes Increased Blood–Brain Barrier Permeability in a Murine Model of Fulminant Hepatic Failure

(2008) Naoki Shimojima et al.   JOURNAL OF INVESTIGATIVE SURGERY

Neuroinflammation contributes to hypokinesia in rats with hepatic encephalopathy: Ibuprofen restores its motor activity

(2008) Omar Cauli et al.   JOURNAL OF NEUROSCIENCE RESEARCH

Inhibitory Effect on Cerebral Inflammatory Response following Traumatic Brain Injury in Rats: A Potential Neuroprotective Mechanism of N-Acetylcysteine

(2008) Gang Chen et al.   MEDIATORS OF INFLAMMATION

Lactate Contributes to Ammonia-Mediated Astroglial Dysfunction During Hyperammonemia

(2008) Anna K. Andersson et al.   NEUROCHEMICAL RESEARCH