Redox stress unbalances the inflammatory cytokine network: role in autoinflammatory patients and healthy subjects

Cell stress increases ATP release in NLRP3 inflammasome-mediated autoinflammatory diseases, resulting in cytokine imbalance

(2015) Sonia Carta et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Autoinflammatory diseases

(2014) Anna Rubartelli   IMMUNOLOGY LETTERS

Redox balance in Cystic Fibrosis

(2014) Assem G. Ziady et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

TLR dependent XBP-1 activation induces an autocrine loop in rheumatoid arthritis synoviocytes

(2014) Sinisa Savic et al.   JOURNAL OF AUTOIMMUNITY

Selective Antibody Intervention of Toll-like Receptor 4 Activation through Fc γ Receptor Tethering

(2014) Limin Shang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

TLR Costimulation Causes Oxidative Stress with Unbalance of Proinflammatory and Anti-Inflammatory Cytokine Production

(2014) R. Lavieri et al.   JOURNAL OF IMMUNOLOGY

Nonmetal Haptens Induce ATP Release from Keratinocytes through Opening of Pannexin Hemichannels by Reactive Oxygen Species

(2014) Kaoru Onami et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

Stress, Inflammation, and Defense of Homeostasis

(2014) Raj Chovatiya et al.   MOLECULAR CELL

Inflammasomes and Metabolic Disorders: Old Genes in Modern Diseases

(2014) Gregory R. Robbins et al.   MOLECULAR CELL

Emerging functions of the unfolded protein response in immunity

(2014) Sophie Janssens et al.   NATURE IMMUNOLOGY

Extracellular ATP drives systemic inflammation, tissue damage and mortality

(2014) A Cauwels et al.   Cell Death & Disease

Increased NLRP3-dependent interleukin 1β secretion in patients with familial Mediterranean fever: correlation withMEFVgenotype

(2013) Alessia Omenetti et al.   ANNALS OF THE RHEUMATIC DISEASES

Toll-like receptor-mediated IRE1α activation as a therapeutic target for inflammatory arthritis

(2013) Quan Qiu et al.   EMBO JOURNAL

Oxidative stress and pathology in muscular dystrophies: focus on protein thiol oxidation and dysferlinopathies

(2013) Jessica R. Terrill et al.   FEBS Journal

The Interleukin-1 Family: Back to the Future

(2013) Cecilia Garlanda et al.   IMMUNITY

Cellular stress response and innate immune signaling: integrating pathways in host defense and inflammation

(2013) Sujatha Muralidharan et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Paneth cells as a site of origin for intestinal inflammation

(2013) Timon E. Adolph et al.   NATURE

The UPR and lung disease

(2013) Fabiola Osorio et al.   Seminars in Immunopathology

CD39 and CD73 in immunity and inflammation

(2013) Luca Antonioli et al.   TRENDS IN MOLECULAR MEDICINE

Different Members of the IL-1 Family Come Out in Different Ways: DAMPs vs. Cytokines?

(2013) Sonia Carta et al.   Frontiers in Immunology

Deficient production of IL-1 receptor antagonist and IL-6 coupled to oxidative stress in cryopyrin-associated periodic syndrome monocytes

(2012) Sonia Carta et al.   ANNALS OF THE RHEUMATIC DISEASES

Autoinflammatory syndromes and cellular responses to stress: pathophysiology, diagnosis and new treatment perspectives

(2012) Sinisa Savic et al.   BEST PRACTICE & RESEARCH IN CLINICAL RHEUMATOLOGY

Dysregulated Toll-Like Receptor-Induced Interleukin-1  and Interleukin-6 Responses in Subjects at Risk for the Development of Type 1 Diabetes

(2012) A. K. Alkanani et al.   DIABETES

Inflammasome Activators Induce Interleukin-1α Secretion via Distinct Pathways with Differential Requirement for the Protease Function of Caspase-1

(2012) Olaf Groß et al.   IMMUNITY

Regulation of inflammasome signaling

(2012) Vijay A K Rathinam et al.   NATURE IMMUNOLOGY

The pro- and anti-inflammatory properties of the cytokine interleukin-6

(2011) Jürgen Scheller et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Interleukin-1 in the pathogenesis and treatment of inflammatory diseases

(2011) C. A. Dinarello   BLOOD

Anti-interleukin-6 receptor antibody, tocilizumab, for the treatment of autoimmune diseases

(2011) Toshio Tanaka et al.   FEBS LETTERS

The Rate of Interleukin-1β Secretion in Different Myeloid Cells Varies with the Extent of Redox Response to Toll-like Receptor Triggering

(2011) Sonia Carta et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Pannexin-1 Is Required for ATP Release during Apoptosis but Not for Inflammasome Activation

(2011) Y. Qu et al.   JOURNAL OF IMMUNOLOGY

Role of IL-1 Beta in the Development of Human TH17 Cells: Lesson from NLPR3 Mutated Patients

(2011) Denise Lasigliè et al.   PLoS One

Interplay between redox status and inflammasome activation

(2011) Anna Rubartelli et al.   TRENDS IN IMMUNOLOGY

Clinical presentation and pathogenesis of cold-induced autoinflammatory disease in a family with recurrence of an NLRP12 mutation

(2010) S. Borghini et al.   ARTHRITIS AND RHEUMATISM

Pattern Recognition Receptors and Inflammation

(2010) Osamu Takeuchi et al.   CELL

Endoplasmic Reticulum Stress and the Inflammatory Basis of Metabolic Disease

(2010) Gökhan S. Hotamisligil   CELL

Inflammasomes: current understanding and open questions

(2010) Franz Bauernfeind et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

IL-1: Discoveries, controversies and future directions

(2010) Charles A. Dinarello   EUROPEAN JOURNAL OF IMMUNOLOGY

NLRP3 inflammasomes are required for atherogenesis and activated by cholesterol crystals

(2010) Peter Duewell et al.   NATURE

TLR activation of the transcription factor XBP1 regulates innate immune responses in macrophages

(2010) Fabio Martinon et al.   NATURE IMMUNOLOGY

Concerted action of wild-type and mutant TNF receptors enhances inflammation in TNF receptor 1-associated periodic fever syndrome

(2010) A. Simon et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Altered redox state of monocytes from cryopyrin-associated periodic syndromes causes accelerated IL-1  secretion

(2010) S. Tassi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Horror Autoinflammaticus: The Molecular Pathophysiology of Autoinflammatory Disease

(2009) Seth L. Masters et al.   Annual Review of Immunology

The Inflammasomes: Guardians of the Body

(2009) Fabio Martinon et al.   Annual Review of Immunology

Stress as an Intercellular Signal: The Emergence of Stress-Associated Molecular Patterns (SAMP)

(2009) Anna Rubartelli et al.   ANTIOXIDANTS & REDOX SIGNALING

An Autoinflammatory Disease with Deficiency of the Interleukin-1–Receptor Antagonist

(2009) Ivona Aksentijevich et al.   NEW ENGLAND JOURNAL OF MEDICINE

ATP release from non-excitable cells

(2009) Helle A. Praetorius et al.   Purinergic Signalling

Differential requirement for the activation of the inflammasome for processing and release of IL-1  in monocytes and macrophages

(2008) M. G. Netea et al.   BLOOD

The NALP3 inflammasome is involved in the innate immune response to amyloid-β

(2008) Annett Halle et al.   NATURE IMMUNOLOGY

ATP is released by monocytes stimulated with pathogen-sensing receptor ligands and induces IL-1  and IL-18 secretion in an autocrine way

(2008) A. Piccini et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Innate Immune Activation Through Nalp3 Inflammasome Sensing of Asbestos and Silica

(2008) C. Dostert et al.   SCIENCE