Anticancer Agents That Counteract Tumor Glycolysis

No evidence for a shift in pyruvate kinase PKM1 to PKM2 expression during tumorigenesis

(2015) Katharina Bluemlein et al.   Oncotarget

Metabolic Targeting of Lactate Efflux by Malignant Glioma Inhibits Invasiveness and Induces Necrosis: An In Vivo Study

(2015) Chaim B Colen et al.   NEOPLASIA

Harnessing Impaired Energy Metabolism in Cancer Cell: Small Molecule- Mediated Ways to Regulate Tumorigenesis

(2012) Govardhan K. Shroff et al.   Anti-Cancer Agents in Medicinal Chemistry

Multiple Biological Activities of Lactic Acid in Cancer: Influences on Tumor Growth,Angiogenesis and Metastasis

(2012) Suveera Dhup et al.   CURRENT PHARMACEUTICAL DESIGN

Design and Synthesis of Novel Lactate Dehydrogenase A Inhibitors by Fragment-Based Lead Generation

(2012) Richard A. Ward et al.   JOURNAL OF MEDICINAL CHEMISTRY

Genome-wide RNA interference analysis of renal carcinoma survival regulators identifies MCT4 as a Warburg effect metabolic target

(2012) Marco Gerlinger et al.   JOURNAL OF PATHOLOGY

Mitaplatin Increases Sensitivity of Tumor Cells to Cisplatin by Inducing Mitochondrial Dysfunction

(2012) Xue Xue et al.   MOLECULAR PHARMACEUTICS

IDH mutation impairs histone demethylation and results in a block to cell differentiation

(2012) Chao Lu et al.   NATURE

Antiangiogenic agents increase breast cancer stem cells via the generation of tumor hypoxia

(2012) S. J. Conley et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Unraveling the Obesity-Cancer Connection

(2012) G. Taubes   SCIENCE

Effects of three modifiers of glycolysis on ATP, lactate, hypoxia, and growth in human tumor cell lines in vivo

(2012) A. Yaromina et al.   STRAHLENTHERAPIE UND ONKOLOGIE

Inhibitor-bound structures of human pyruvate dehydrogenase kinase 4

(2011) Mutsuko Kukimoto-Niino et al.   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

Sulforaphane induces apoptosis in human hepatic cancer cells through inhibition of 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase4, mediated by hypoxia inducible factor-1-dependent pathway

(2011) Young Keul Jeon et al.   BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS

Synthesis of sulfonamide-containing N-hydroxyindole-2-carboxylates as inhibitors of human lactate dehydrogenase-isoform 5

(2011) Carlotta Granchi et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

2-Oxo-N-aryl-1,2,3,4-tetrahydroquinoline-6-sulfonamides as activators of the tumor cell specific M2 isoform of pyruvate kinase

(2011) Martin J. Walsh et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

A New, Convenient Cell-Based Screening Method for Small-Molecule Glycolytic Inhibitors

(2011) Mitsuhiro KITAGAWA et al.   BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY

Differential utilization of ketone bodies by neurons and glioma cell lines: a rationale for ketogenic diet as experimental glioma therapy

(2011) Gabriele D Maurer et al.   BMC CANCER

LDH-A silencing suppresses breast cancer tumorigenicity through induction of oxidative stress mediated mitochondrial pathway apoptosis

(2011) Zhi-Yu Wang et al.   BREAST CANCER RESEARCH AND TREATMENT

D-amino acid oxidase gene therapy sensitizes glioma cells to the antiglycolytic effect of 3-bromopyruvate

(2011) S M El Sayed et al.   CANCER GENE THERAPY

Suppression of T-cell responses by tumor metabolites

(2011) Katrin Singer et al.   CANCER IMMUNOLOGY IMMUNOTHERAPY

Vitamin K3 and K5 are inhibitors of tumor pyruvate kinase M2

(2011) Jing Chen et al.   CANCER LETTERS

Overcoming Trastuzumab Resistance in Breast Cancer by Targeting Dysregulated Glucose Metabolism

(2011) Y. Zhao et al.   CANCER RESEARCH

A Low Carbohydrate, High Protein Diet Slows Tumor Growth and Prevents Cancer Initiation

(2011) V. W. Ho et al.   CANCER RESEARCH

Lactate: A Metabolic Key Player in Cancer

(2011) F. Hirschhaeuser et al.   CANCER RESEARCH

Monocarboxylate transporters 1 and 4 are involved in the invasion activity of human lung cancer cells

(2011) Hiroto Izumi et al.   CANCER SCIENCE

Pyruvate Kinase M2 Is a PHD3-Stimulated Coactivator for Hypoxia-Inducible Factor 1

(2011) Weibo Luo et al.   CELL

Hallmarks of Cancer: The Next Generation

(2011) Douglas Hanahan et al.   CELL

FLNA and PGK1 are Two Potential Markers for Progression in Hepatocellular Carcinoma

(2011) Jianzhong Ai et al.   CELLULAR PHYSIOLOGY AND BIOCHEMISTRY

A Pairwise Chemical Genetic Screen Identifies New Inhibitors of Glucose Transport

(2011) Olesya A. Ulanovskaya et al.   CHEMISTRY & BIOLOGY

Broadening Deoxysugar Glycodiversity: Natural and Engineered Transaldolases Unlock a Complementary Substrate Space

(2011) Madhura Rale et al.   CHEMISTRY-A EUROPEAN JOURNAL

Galloflavin (CAS 568-80-9): A Novel Inhibitor of Lactate Dehydrogenase

(2011) Marcella Manerba et al.   ChemMedChem

Prognostic and Predictive Role of Lactate Dehydrogenase 5 Expression in Colorectal Cancer Patients Treated with PTK787/ZK 222584 (Vatalanib) Antiangiogenic Therapy

(2011) M. I. Koukourakis et al.   CLINICAL CANCER RESEARCH

Lactate shuttles at a glance: from physiological paradigms to anti-cancer treatments

(2011) N. Draoui et al.   Disease Models & Mechanisms

Human pluripotent stem cells decouple respiration from energy production

(2011) Ng Shyh-Chang et al.   EMBO JOURNAL

N-Hydroxyindole-based inhibitors of lactate dehydrogenase against cancer cell proliferation

(2011) Carlotta Granchi et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

The monocarboxylate transporter family-Structure and functional characterization

(2011) Andrew P. Halestrap   IUBMB LIFE

Regulation of Glycolytic Enzyme Phosphoglycerate Mutase-1 by Sirt1 Protein-mediated Deacetylation

(2011) William C. Hallows et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Metabolic flux analysis gives an insight on verapamil induced changes in central metabolism of HL-1 cells

(2011) Alexander Strigun et al.   JOURNAL OF BIOTECHNOLOGY

Hexokinase 2 is a key mediator of aerobic glycolysis and promotes tumor growth in human glioblastoma multiforme

(2011) Amparo Wolf et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Discovery ofN-Hydroxyindole-Based Inhibitors of Human Lactate Dehydrogenase Isoform A (LDH-A) as Starvation Agents against Cancer Cells

(2011) Carlotta Granchi et al.   JOURNAL OF MEDICINAL CHEMISTRY

Use of Oral Dichloroacetate for Palliation of Leg Pain Arising from Metastatic Poorly Differentiated Carcinoma: A Case Report

(2011) Akbar Khan   JOURNAL OF PALLIATIVE MEDICINE

Metabolism unhinged: IDH mutations in cancer

(2011) John R Prensner et al.   NATURE MEDICINE

Interfering with pH regulation in tumours as a therapeutic strategy

(2011) Dario Neri et al.   NATURE REVIEWS DRUG DISCOVERY

Targeting cancer metabolism: a therapeutic window opens

(2011) Matthew G. Vander Heiden   NATURE REVIEWS DRUG DISCOVERY

Conserved features of cancer cells define their sensitivity to HAMLET-induced death; c-Myc and glycolysis

(2011) P Storm et al.   ONCOGENE

Fasting vs dietary restriction in cellular protection and cancer treatment: from model organisms to patients

(2011) C Lee et al.   ONCOGENE

Shikonin and its analogs inhibit cancer cell glycolysis by targeting tumor pyruvate kinase-M2

(2011) J Chen et al.   ONCOGENE

Structure-Based Development of Small Molecule PFKFB3 Inhibitors: A Framework for Potential Cancer Therapeutic Agents Targeting the Warburg Effect

(2011) Minsuh Seo et al.   PLoS One

Cellular Model of Warburg Effect Identifies Tumor Promoting Function of UCP2 in Breast Cancer and Its Suppression by Genipin

(2011) Vanniarajan Ayyasamy et al.   PLoS One

Prisoner's Dilemma in Cancer Metabolism

(2011) Irina Kareva   PLoS One

CD147 subunit of lactate/H+ symporters MCT1 and hypoxia-inducible MCT4 is critical for energetics and growth of glycolytic tumors

(2011) R. Le Floch et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Anti-VEGF treatment reduces blood supply and increases tumor cell invasion in glioblastoma

(2011) Olivier Keunen et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Glycation of the Muscle-Specific Enolase by Reactive Carbonyls: Effect of Temperature and the Protection Role of Carnosine, Pirydoxamine and Phosphatidylserine

(2011) Jadwiga Pietkiewicz et al.   PROTEIN JOURNAL

LDH-A influences hypoxia-inducible factor 1α (HIF1 α) and is critical for growth of HT29 colon carcinoma cells in vivo

(2011) Stefan Langhammer et al.   Targeted Oncology

Physical therapy-induced rhabdomyolysis and acute kidney injury associated with reduced activity of muscle lactate dehydrogenase A

(2011) Benjamin J. Lee et al.   ARTHRITIS CARE & RESEARCH

The importance of solvation in the design of ligands targeting membrane proteins

(2011) Angel González et al.   MedChemComm

Triazole-substituted N-hydroxyindol-2-carboxylates as inhibitors of isoform 5 of human lactate dehydrogenase (hLDH5)

(2011) Carlotta Granchi et al.   MedChemComm

Clinical report: A patient with primary peritoneal mesothelioma that has improved after taking citric acid orally

(2011) A.H. Bucay   Clinics and Research in Hepatology and Gastroenterology

Anticancer Targets in the Glycolytic Metabolism of Tumors: A Comprehensive Review

(2011) Paolo E. Porporato et al.   Frontiers in Pharmacology

The inhibition of monocarboxylate transporter 2 (MCT2) by AR-C155858 is modulated by the associated ancillary protein

(2010) Matthew J. Ovens et al.   BIOCHEMICAL JOURNAL

Evaluation of thieno[3,2-b]pyrrole[3,2-d]pyridazinones as activators of the tumor cell specific M2 isoform of pyruvate kinase

(2010) Jian-kang Jiang et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Characterization of Phosphoglycerate Kinase-1 Expression of Stromal Cells Derived from Tumor Microenvironment in Prostate Cancer Progression

(2010) J. Wang et al.   CANCER RESEARCH

Silencing of pkm2 increases the efficacy of docetaxel in human lung cancer xenografts in mice

(2010) Hua-shan Shi et al.   CANCER SCIENCE

Phosphoglycerate Kinase 1 Promoting Tumor Progression and Metastasis in Gastric Cancer - Detected in a Tumor Mouse Model Using Positron Emission Tomography/Magnetic Resonance Imaging

(2010) Derek Zieker et al.   CELLULAR PHYSIOLOGY AND BIOCHEMISTRY

Targeting glycolysis: a fragment based approach towards bifunctional inhibitors of hLDH-5

(2010) Adam D. Moorhouse et al.   CHEMICAL COMMUNICATIONS

Inhibitors of Lactate Dehydrogenase Isoforms and their Therapeutic Potentials

(2010) C. Granchi et al.   CURRENT MEDICINAL CHEMISTRY

3-Bromopyruvate: A New Targeted Antiglycolytic Agent and a Promise for Cancer Therapy

(2010) S. Ganapathy-Kanniappan et al.   CURRENT PHARMACEUTICAL BIOTECHNOLOGY

ENO1, a potential prognostic head and neck cancer marker, promotes transformation partly via chemokine CCL20 induction

(2010) Sen-Tien Tsai et al.   EUROPEAN JOURNAL OF CANCER

Emerging Metabolic Targets in Cancer Therapy

(2010) Yuhua Zhao   Frontiers in Bioscience-Landmark

Monocarboxylate transporter 1 is up-regulated in basal-like breast carcinoma

(2010) Céline Pinheiro et al.   HISTOPATHOLOGY

Pyruvate kinase type M2: A key regulator of the metabolic budget system in tumor cells

(2010) Sybille Mazurek   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

Anticancer drugs that target metabolism: Is dichloroacetate the new paradigm?

(2010) Ioanna Papandreou et al.   INTERNATIONAL JOURNAL OF CANCER

Efficacy of RNAi targeting of pyruvate kinase M2 combined with cisplatin in a lung cancer model

(2010) Wenhao Guo et al.   JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY

Tumour hypoxia induces a metabolic shift causing acidosis: a common feature in cancer

(2010) Johanna Chiche et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Silybin and dehydrosilybin decrease glucose uptake by inhibiting GLUT proteins

(2010) Tianzuo Zhan et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

Warburg effect in chemosensitivity: Targeting lactate dehydrogenase-A re-sensitizes Taxol-resistant cancer cells to Taxol

(2010) Ming Zhou et al.   Molecular Cancer

Metformin in Cancer Therapy: A New Perspective for an Old Antidiabetic Drug?

(2010) I. Ben Sahra et al.   MOLECULAR CANCER THERAPEUTICS

Cancer-associated IDH mutations: biomarker and therapeutic opportunities

(2010) K E Yen et al.   ONCOGENE

Impairment of Aerobic Glycolysis by Inhibitors of Lactic Dehydrogenase Hinders the Growth of Human Hepatocellular Carcinoma Cell Lines

(2010) Luigi Fiume et al.   PHARMACOLOGY

Inhibition of lactate dehydrogenase A induces oxidative stress and inhibits tumor progression

(2010) A. Le et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Targeting tumor metabolism with 2-deoxyglucose in patients with castrate-resistant prostate cancer and advanced malignancies

(2010) Mark Stein et al.   PROSTATE

Evidence for an Alternative Glycolytic Pathway in Rapidly Proliferating Cells

(2010) M. G. Vander Heiden et al.   SCIENCE

Fatty Acid Oxidation and Malonyl-CoA Decarboxylase in the Vascular Remodeling of Pulmonary Hypertension

(2010) G. Sutendra et al.   Science Translational Medicine

The Senescence-Related Mitochondrial/Oxidative Stress Pathway is Repressed in Human Induced Pluripotent Stem Cells

(2010) Alessandro Prigione et al.   STEM CELLS

Perspective beyond Cancer Genomics: Bioenergetics of Cancer Stem Cells

(2010) Hideshi Ishii et al.   YONSEI MEDICAL JOURNAL

AR-C155858 is a potent inhibitor of monocarboxylate transporters MCT1 and MCT2 that binds to an intracellular site involving transmembrane helices 7–10

(2009) Matthew J. Ovens et al.   BIOCHEMICAL JOURNAL

Identification of small molecule inhibitors of pyruvate kinase M2

(2009) Matthew G. Vander Heiden et al.   BIOCHEMICAL PHARMACOLOGY

Increased expression of enolase α in human breast cancer confers tamoxifen resistance in human breast cancer cells

(2009) Shih-Hsin Tu et al.   BREAST CANCER RESEARCH AND TREATMENT

Reversal of the glycolytic phenotype by dichloroacetate inhibits metastatic breast cancer cell growth in vitro and in vivo

(2009) Ramon C. Sun et al.   BREAST CANCER RESEARCH AND TREATMENT

d-Glucose- and d-mannose-based antimetabolites. Part 2. Facile synthesis of 2-deoxy-2-halo-d-glucoses and -d-mannoses

(2009) Izabela Fokt et al.   CARBOHYDRATE RESEARCH

Manipulation of Glycolysis in Malignant Tumors: Fantasy or Therapy?

(2009) U. Sattler et al.   CURRENT MEDICINAL CHEMISTRY

HIF-1: upstream and downstream of cancer metabolism

(2009) Gregg L Semenza   CURRENT OPINION IN GENETICS & DEVELOPMENT

Role of the hypoxic tumor microenvironment in the resistance to anti-angiogenic therapies

(2009) Annamaria Rapisarda et al.   DRUG RESISTANCE UPDATES

Regulation of glucose metabolism by 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatases in cancer

(2009) Abdullah Yalcin et al.   EXPERIMENTAL AND MOLECULAR PATHOLOGY

Pyruvate kinase isoenzyme M2 is a glycolytic sensor differentially regulating cell proliferation, cell size and apoptotic cell death dependent on glucose supply

(2009) Gilles A. Spoden et al.   EXPERIMENTAL CELL RESEARCH

Cardioprotective activity of a novel and potent competitive inhibitor of lactate dehydrogenase

(2009) Alexander B. Kotlyar et al.   FEBS LETTERS

Tumor metabolism of lactate: the influence and therapeutic potential for MCT and CD147 regulation

(2009) Kelly M Kennedy et al.   Future Oncology

Phosphoglucose isomerase enhances colorectal cancer metastasis

(2009) Tsutsumi   INTERNATIONAL JOURNAL OF ONCOLOGY

The anti-oxidant capacity of tumour glycolysis

(2009) Ulrike G. A. Sattler et al.   INTERNATIONAL JOURNAL OF RADIATION BIOLOGY

Evaluation of SubstitutedN,N′-Diarylsulfonamides as Activators of the Tumor Cell Specific M2 Isoform of Pyruvate Kinase

(2009) Matthew B. Boxer et al.   JOURNAL OF MEDICINAL CHEMISTRY

18F-FDG PET and PET/CT in the Evaluation of Cancer Treatment Response

(2009) S. Ben-Haim et al.   JOURNAL OF NUCLEAR MEDICINE

Can Game Theory Explain Invasive Tumor Metabolism?

(2009) Mike Martin   JNCI-Journal of the National Cancer Institute

The Antitumor Effect and Hepatotoxicity of a Hexokinase II Inhibitor 3-Bromopyruvate: In Vivo Investigation of Intraarterial Administration in a Rabbit VX2 Hepatoma Model

(2009) Hwan Jun Jae et al.   KOREAN JOURNAL OF RADIOLOGY

Hypothesis proved…citric acid (citrate) does improve cancer: A case of a patient suffering from medullary thyroid cancer

(2009) Alberto Halabe Bucay   MEDICAL HYPOTHESES

Targets of 3-Bromopyruvate, A New, Energy Depleting, Anticancer Agent

(2009) P. Dell'Antone   Medicinal Chemistry

Estrogen receptor β ligands: Recent advances and biomedical applications

(2009) Filippo Minutolo et al.   MEDICINAL RESEARCH REVIEWS

LDH-A inhibition, a therapeutic strategy for treatment of hereditary leiomyomatosis and renal cell cancer

(2009) H. Xie et al.   MOLECULAR CANCER THERAPEUTICS

Mitaplatin, a potent fusion of cisplatin and the orphan drug dichloroacetate

(2009) Shanta Dhar et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Probing the location and function of the conserved histidine residue of phosphoglucose isomerase by using an active site directed inhibitor N-bromoacetylethanolamine phosphate

(2009) Menghsiao Meng et al.   PROTEIN SCIENCE

Tyrosine Phosphorylation Inhibits PKM2 to Promote the Warburg Effect and Tumor Growth

(2009) T. Hitosugi et al.   Science Signaling

Overview of the Proton-coupled MCT (SLC16A) Family of Transporters: Characterization, Function and Role in the Transport of the Drug of Abuse γ-Hydroxybutyric Acid

(2008) Marilyn E. Morris et al.   AAPS Journal

Role of dichloroacetate in the treatment of genetic mitochondrial diseases☆

(2008) Peter W. Stacpoole et al.   ADVANCED DRUG DELIVERY REVIEWS

Lactate Dehydrogenase-5 (LDH-5) Expression in Human Gastric Cancer: Association with Hypoxia-Inducible Factor (HIF-1α) Pathway, Angiogenic Factors Production and Poor Prognosis

(2008) Yanislav Kolev et al.   ANNALS OF SURGICAL ONCOLOGY

Inhibition of energy-producing pathways of HepG2 cells by 3-bromopyruvate1

(2008) Ana Paula Pereira Da Silva et al.   BIOCHEMICAL JOURNAL

Acetylsalicylic acid and salicylic acid decrease tumor cell viability and glucose metabolism modulating 6-phosphofructo-1-kinase structure and activity

(2008) Guilherme A. Spitz et al.   BIOCHEMICAL PHARMACOLOGY

Specific Ion Influences on Self-Association of Pyruvate Dehydrogenase Kinase Isoform 2 (PDHK2), Binding of PDHK2 to the L2 Lipoyl Domain, and Effects of the Lipoyl Group-Binding Site Inhibitor, Nov3r†

(2008) Yasuaki Hiromasa et al.   BIOCHEMISTRY

Glycosyl and polyalcoholic prodrugs of lonidamine

(2008) G. Giorgioni et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Separate synthesis and evaluation of glucitol bis-phosphate and mannitol bis-phosphate, as competitive inhibitors of fructose bis-phosphate aldolases

(2008) Charles-Gabin Mabiala-Bassiloua et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Dichloroacetate (DCA) as a potential metabolic-targeting therapy for cancer

(2008) E D Michelakis et al.   BRITISH JOURNAL OF CANCER

2-Methoxyoestradiol-3,17-O,O-bis-sulphamate and 2-deoxy-D-glucose in combination: a potential treatment for breast and prostate cancer

(2008) S L C Tagg et al.   BRITISH JOURNAL OF CANCER

Can weight loss prevent cancer?

(2008) K Y Wolin et al.   BRITISH JOURNAL OF CANCER

PDK-1 regulates lactate production in hypoxia and is associated with poor prognosis in head and neck squamous cancer

(2008) S M Wigfield et al.   BRITISH JOURNAL OF CANCER

Tumor Cell Metabolism: Cancer's Achilles' Heel

(2008) Guido Kroemer et al.   CANCER CELL

AMF/PGI transactivates the MMP-3 gene through the activation of Src-RhoA-phosphatidylinositol 3-kinase signaling to induce hepatoma cell migration

(2008) Wen-Ling Shih et al.   CANCER LETTERS

Histone Deacetylase Inhibition and Blockade of the Glycolytic Pathway Synergistically Induce Glioblastoma Cell Death

(2008) V. Egler et al.   CLINICAL CANCER RESEARCH

Synergistic Antipancreatic Tumor Effect by Simultaneously Targeting Hypoxic Cancer Cells With HSP90 Inhibitor and Glycolysis Inhibitor

(2008) X. Cao et al.   CLINICAL CANCER RESEARCH

Metformin attenuates the stimulatory effect of a high-energy diet on in vivo LLC1 carcinoma growth

(2008) C. Algire et al.   ENDOCRINE-RELATED CANCER

Glycolytic enzyme inhibitors in cancer treatment

(2008) Roberto Scatena et al.   EXPERT OPINION ON INVESTIGATIONAL DRUGS

Dichloroacetate induces apoptosis in endometrial cancer cells

(2008) Jason Y.Y. Wong et al.   GYNECOLOGIC ONCOLOGY

Isotype-specific inhibitors of the glycolytic key regulator pyruvate kinase subtype M2 moderately decelerate tumor cell proliferation

(2008) Gilles A. Spoden et al.   INTERNATIONAL JOURNAL OF CANCER

Role of reactive oxygen species-mediated mitochondrial dysregulation in 3-bromopyruvate induced cell death in hepatoma cells

(2008) Ji Su Kim et al.   JOURNAL OF BIOENERGETICS AND BIOMEMBRANES

Pyruvate Dehydrogenase Complex Activity Controls Metabolic and Malignant Phenotype in Cancer Cells

(2008) Thomas McFate et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Inhibition of human muscle-specific enolase by methylglyoxal and irreversible formation of advanced glycation end products

(2008) Jadwiga Pietkiewicz et al.   JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY

A novel inhibitor of glucose uptake sensitizes cells to FAS-induced cell death

(2008) T. E. Wood et al.   MOLECULAR CANCER THERAPEUTICS

Small-molecule inhibition of 6-phosphofructo-2-kinase activity suppresses glycolytic flux and tumor growth

(2008) B. Clem et al.   MOLECULAR CANCER THERAPEUTICS

2-Deoxyglucose induces Akt phosphorylation via a mechanism independent of LKB1/AMP-activated protein kinase signaling activation or glycolysis inhibition

(2008) D. Zhong et al.   MOLECULAR CANCER THERAPEUTICS

3-Bromopyruvate as inhibitor of tumour cell energy metabolism and chemopotentiator of platinum drugs

(2008) Linda Strandberg Ihrlund et al.   Molecular Oncology

Pyruvate kinase M2 is a phosphotyrosine-binding protein

(2008) Heather R. Christofk et al.   NATURE

The M2 splice isoform of pyruvate kinase is important for cancer metabolism and tumour growth

(2008) Heather R. Christofk et al.   NATURE

Methyl jasmonate binds to and detaches mitochondria-bound hexokinase

(2008) N Goldin et al.   ONCOGENE

Hexokinase II Detachment from Mitochondria Triggers Apoptosis through the Permeability Transition Pore Independent of Voltage-Dependent Anion Channels

(2008) Federica Chiara et al.   PLoS One

Dichloroacetate (DCA) sensitizes both wild‐type and over expressingBcl‐2prostate cancer cells in vitro to radiation

(2008) Wengang Cao et al.   PROSTATE

Hexokinase-2 bound to mitochondria: Cancer's stygian link to the “Warburg effect” and a pivotal target for effective therapy

(2008) Saroj P. Mathupala et al.   SEMINARS IN CANCER BIOLOGY

Operational Tolerance in Nonvascularized Transplant Models Induced by AR-C117977, a Monocarboxylate Transporter Inhibitor

(2008) Clara Påhlman et al.   TRANSPLANTATION

Increased expression of monocarboxylate transporters 1, 2, and 4 in colorectal carcinomas

(2008) Céline Pinheiro et al.   VIRCHOWS ARCHIV

Glucose-dependent active ATP depletion by koningic acid kills high-glycolytic cells

(2007) Shohei Kumagai et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS