A Chemical-Biological Evaluation of Rhodium(I)N-Heterocyclic Carbene Complexes as Prospective Anticancer Drugs

A potential rhodium cancer therapy: Studies of a cytotoxic organorhodium(I) complex that binds DNA

(2013) Jeanette R. McConnell et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Luminescent organoplatinum(ii) complexes containing bis(N-heterocyclic carbene) ligands selectively target the endoplasmic reticulum and induce potent photo-toxicity

(2013) Taotao Zou et al.   CHEMICAL COMMUNICATIONS

A comparative chemical–biological evaluation of titanium(iv) complexes with a salan or cyclopentadienyl ligand

(2013) Julia Schur et al.   CHEMICAL COMMUNICATIONS

Properties and biological activity of [Rh(COD)(N–N)]BF4 and [IrCl2(COD)(N–N)]BF4 polypyridyl complexes

(2013) Urszula Śliwińska-Hill et al.   INORGANICA CHIMICA ACTA

Neutral and cationic multinuclear half-sandwich rhodium and iridium complexes coordinated to poly(propyleneimine) dendritic scaffolds: Synthesis and cytotoxicity

(2013) Richard Payne et al.   JOURNAL OF ORGANOMETALLIC CHEMISTRY

Synthesis, Characterization, and Pharmacological Evaluation of Silicon-Containing Aminoquinoline Organometallic Complexes As Antiplasmodial, Antitumor, and Antimycobacterial Agents

(2013) Yiqun Li et al.   ORGANOMETALLICS

Biological effects of simple changes in functionality on rhodium metalloinsertors

(2013) A. G. Weidmann et al.   PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY A-MATHEMATICAL PHYSICAL AND ENGINEERING SCIENCES

Rhodium(Cp*) Compounds with Flavone-derived Ligand Systems: Synthesis and Characterization

(2013) Martina B. Schwarz et al.   ZEITSCHRIFT FUR ANORGANISCHE UND ALLGEMEINE CHEMIE

TrxR inhibition and antiproliferative activities of structurally diverse gold N-heterocyclic carbene complexes

(2013) Riccardo Rubbiani et al.   MedChemComm

Organometallic Compounds: An Opportunity for Chemical Biology?

(2012) Malay Patra et al.   CHEMBIOCHEM

Designing organometallic compounds for catalysis and therapy

(2012) Anna Louisa Noffke et al.   CHEMICAL COMMUNICATIONS

Metal N-heterocyclic carbene complexes as potential antitumor metallodrugs

(2012) Wukun Liu et al.   CHEMICAL SOCIETY REVIEWS

Expanding the Chemistry of CationicN-Heterocyclic Carbenes: Alternative Synthesis, Reactivity, and Coordination Chemistry

(2012) Björn Hildebrandt et al.   CHEMISTRY-A EUROPEAN JOURNAL

Butyltin(IV) Benzoates: Inhibition of Thioredoxin Reductase, Tumor Cell Growth Inhibition, and Interactions with Proteins

(2012) Kely Navakoski de Oliveira et al.   ChemMedChem

Evaluation of arene ruthenium(ii) N-heterocyclic carbene complexes as organometallics interacting with thiol and selenol containing biomolecules

(2012) Luciano Oehninger et al.   DALTON TRANSACTIONS

N-Heterocyclic carbene metal complexes in medicinal chemistry

(2012) Luciano Oehninger et al.   DALTON TRANSACTIONS

Synthesis and Biological Activity of Ester- and Amide-Functionalized Imidazolium Salts and Related Water-Soluble Coinage Metal N-Heterocyclic Carbene Complexes

(2012) Maura Pellei et al.   INORGANIC CHEMISTRY

Rhodium(III) and iridium(III) complexes as anticancer agents

(2012) Yvonne Geldmacher et al.   INORGANICA CHIMICA ACTA

Synthesis and biological evaluation of N-heterocyclic carbene–silver(I) acetate complexes derived from 4,5-ditolyl-imidazole

(2012) Frauke Hackenberg et al.   INORGANICA CHIMICA ACTA

Gold(I) Carbene Complexes Causing Thioredoxin 1 and Thioredoxin 2 Oxidation as Potential Anticancer Agents

(2012) Esther Schuh et al.   JOURNAL OF MEDICINAL CHEMISTRY

Au(i)- and Pt(ii)-N-heterocyclic carbene complexes with picoline functionalized benzimidazolin-2-ylidene ligands; synthesis, structures, electrochemistry and cytotoxicity studies

(2012) Sirsendu Das Adhikary et al.   NEW JOURNAL OF CHEMISTRY

Challenges and Opportunities in the Development of Organometallic Anticancer Drugs

(2012) Christian G. Hartinger et al.   ORGANOMETALLICS

Selective Cytotoxicity of Rhodium Metalloinsertors in Mismatch Repair-Deficient Cells

(2011) Russell J. Ernst et al.   BIOCHEMISTRY

A platinum Chugaev carbene complex as a potent anticancer agent

(2011) Georges Alves et al.   CHEMICAL COMMUNICATIONS

Cellular Selectivity and Biological Impact of Cytotoxic Rhodium(III) and Iridium(III) Complexes Containing Methyl-Substituted Phenanthroline Ligands

(2011) Yvonne Geldmacher et al.   ChemMedChem

From Catalysts to Bioactive Organometallics: Do Grubbs Catalysts Trigger Biological Effects?

(2011) Luciano Oehninger et al.   ChemMedChem

Evaluation of reproductive toxicity in male rats treated with novel synthesized ruthenium(II) and gold(I)-NHC complexes

(2011) Osman Ciftci et al.   DRUG DEVELOPMENT AND INDUSTRIAL PHARMACY

Small molecule inhibitors of mammalian thioredoxin reductase

(2011) Wenqing Cai et al.   FREE RADICAL BIOLOGY AND MEDICINE

Novel Benzyl- or 4-Cyanobenzyl-Substituted N-Heterocyclic (Bromo)(carbene)silver(I) and (Carbene)(chloro)gold(I) Complexes: Synthesis and Preliminary Cytotoxicity Studies

(2011) Siddappa Patil et al.   HELVETICA CHIMICA ACTA

In vitro antimicrobial studies of silver carbene complexes: activity of free and nanoparticle carbene formulations against clinical isolates of pathogenic bacteria

(2011) J. G. Leid et al.   JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY

Highly cytotoxic substitutionally inert rhodium(III) tris(chelate) complexes: DNA binding modes and biological impact on human cancer cells

(2011) Frauke Hackenberg et al.   JOURNAL OF INORGANIC BIOCHEMISTRY

Preparation and Characterization of Amino-Linked Heterocyclic Carbene Palladium, Gold, and Silver Complexes and Their Use as Anticancer Agents That Act by Triggering Apoptotic Cell Death

(2011) Chie-Hong Wang et al.   JOURNAL OF MEDICINAL CHEMISTRY

Comparative in Vitro Evaluation of N-Heterocyclic Carbene Gold(I) Complexes of the Benzimidazolylidene Type

(2011) Riccardo Rubbiani et al.   JOURNAL OF MEDICINAL CHEMISTRY

Cellular uptake and subcellular distribution of ruthenium-based metallodrugs under clinical investigation versus cisplatin

(2011) Michael Groessl et al.   Metallomics

Gold compounds as therapeutic agents for human diseases

(2011) Susan J. Berners-Price et al.   Metallomics

Advances in metal–carbene complexes as potent anti-cancer agents

(2011) Arnaud Gautier et al.   Metallomics

Synthesis, Cytotoxicity and Antibacterial Studies of Novel Symmetrically and Non-Symmetrically p-Nitrobenzyl-Substituted N-Heterocyclic Carbene-Silver(I) Acetate Complexes

(2011) Siddappa Patil et al.   ZEITSCHRIFT FUR ANORGANISCHE UND ALLGEMEINE CHEMIE

Luminescent cyclometalated platinum(ii) complexes containing N-heterocyclic carbene ligands with potent in vitro and in vivo anti-cancer properties accumulate in cytoplasmic structures of cancer cells

(2011) Raymond Wai-Yin Sun et al.   Chemical Science

[Cyclopentadienyl]metalcarbonyl complexes of acetylsalicylic acid as neo-anticancer agents

(2010) Gerhard Rubner et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Substrate and inhibitor specificities differ between human cytosolic and mitochondrial thioredoxin reductases: Implications for development of specific inhibitors

(2010) Oliver Rackham et al.   FREE RADICAL BIOLOGY AND MEDICINE

Synthesis, Cytotoxicity and Antibacterial Studies of Novel Symmetrically and Nonsymmetrically 4-(Methoxycarbonyl)benzyl-Substituted N-Heterocyclic Carbene-Silver Acetate Complexes

(2010) Siddappa Patil et al.   HELVETICA CHIMICA ACTA

Benzimidazol-2-ylidene Gold(I) Complexes Are Thioredoxin Reductase Inhibitors with Multiple Antitumor Properties

(2010) Riccardo Rubbiani et al.   JOURNAL OF MEDICINAL CHEMISTRY

N-Heterocyclic Carbene-Amine Pt(II) Complexes, a New Chemical Space for the Development of Platinum-Based Anticancer Drugs

(2010) Myriem Skander et al.   JOURNAL OF MEDICINAL CHEMISTRY

Organometallic Anticancer Compounds

(2010) Gilles Gasser et al.   JOURNAL OF MEDICINAL CHEMISTRY

Novel benzyl-substituted N-heterocyclic carbene–silver acetate complexes: synthesis, cytotoxicity and antibacterial studies

(2010) Siddappa Patil et al.   Metallomics

Gold(I) Complexes of N-Heterocyclic Carbene Ligands Containing Benzimidazole: Synthesis and Antimicrobial Activity

(2010) İlknur Özdemir et al.   MOLECULES

Thioredoxin reductase, an emerging target for anticancer metallodrugs. Enzyme inhibition by cytotoxic gold(iii) compounds studied with combined mass spectrometry and biochemical assays

(2010) Chiara Gabbiani et al.   MedChemComm

Thioredoxin reductase: A target for gold compounds acting as potential anticancer drugs

(2009) Alberto Bindoli et al.   COORDINATION CHEMISTRY REVIEWS

Synthesis and Study of 5,5′-Bibenzimidazolylidenes and Their Bimetallic Complexes

(2009) Joyce A. V. Er et al.   EUROPEAN JOURNAL OF INORGANIC CHEMISTRY

Rhodium(I), a Carbene-Transfer Transition-Metal Ion and a Synthetic Route to Symmetrical and Asymmetrical Substitutedtrans-RhCl(CO)(NHC)(NHC) Complexes

(2009) Agnes Bittermann et al.   ORGANOMETALLICS

Cytotoxic Rhodium(III) and Iridium(III) Polypyridyl Complexes: Structure-Activity Relationships, Antileukemic Activity, and Apoptosis Induction

(2008) Mara Dobroschke et al.   ChemMedChem

Synthesis, Biological Activity, and Structure−Activity Relationships for Potent Cytotoxic Rhodium(III) Polypyridyl Complexes

(2008) Melanie Harlos et al.   JOURNAL OF MEDICINAL CHEMISTRY

Emerging Protein Targets for Anticancer Metallodrugs: Inhibition of Thioredoxin Reductase and Cathepsin B by Antitumor Ruthenium(II)−Arene Compounds

(2008) Angela Casini et al.   JOURNAL OF MEDICINAL CHEMISTRY

Cytotoxic half-sandwich rhodium(III) complexes: Polypyridyl ligand influence on their DNA binding properties and cellular uptake

(2008) Michael A. Scharwitz et al.   JOURNAL OF ORGANOMETALLIC CHEMISTRY

Mitochondria-Targeted Chemotherapeutics: The Rational Design of Gold(I)N-Heterocyclic Carbene Complexes That Are Selectively Toxic to Cancer Cells and Target Protein Selenols in Preference to Thiols

(2008) James L. Hickey et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY