Article
Biochemistry & Molecular Biology
Joana Hipolito, Ana M. Martins, Luis G. Alves
Summary: Complexes [(H2N2O2)TiCl2] and [(H2N2O2)Ti((OPr)-Pr-i)(2)] were synthesized and used as efficient catalysts for the reduction of benzaldehyde, phenylacetaldehyde, and hydrocinnamaldehyde into corresponding alkanes.
Article
Chemistry, Multidisciplinary
Yubin M. Kwon, Yuri Lee, Anna K. Schmautz, Timothy A. Jackson, Dong Wang
Summary: The recent focus on developing high-valent non-oxo-metal complexes has proven effective in studying their rich chemistry. In this study, a formal mononuclear Ni(IV)-nitrate complex was obtained and its geometric and electronic structures, bonding interactions, and spectroscopic properties were analyzed.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
(2022)
Review
Chemistry, Inorganic & Nuclear
Yujie Zhang, Francisco de Azambuja, Tatjana N. Parac-Vogt
Summary: Group (IV) metal oxo clusters are a diverse class of compounds with unique structural stability, reactivity and electronic properties. Despite their potential applications in catalysis, materials chemistry, electronics and optics, gaps in fundamental understanding about their structure, intrinsic features, and nuances in their synthesis hinder their full exploration. Through a critical overview of the chemistry of discrete zirconium, hafnium, and titanium metal oxo clusters reported in the literature, important insights on their properties, reactivity, and potential applications have been provided.
COORDINATION CHEMISTRY REVIEWS
(2021)
Article
Chemistry, Inorganic & Nuclear
Anna Dall'Anese, Pavel S. Kulyabin, Dmitry V. Uborsky, Antonio Vittoria, Christian Ehm, Roberta Cipullo, Peter H. M. Budzelaar, Alexander Z. Voskoboynikov, Vincenzo Busico, Leonardo Tensi, Alceo Macchioni, Cristiano Zuccaccia
Summary: Group 4 metal-Salan olefin polymerization catalysts have low activity due to a pre-equilibrium favoring a non-polymerization active state. Catalysts with large, flat substituents show high activity, possibly due to stabilization of a more favorable active isomer. The choice of ligand and solvent can affect the isomer structure and activity of the catalyst.
INORGANIC CHEMISTRY
(2023)
Article
Chemistry, Inorganic & Nuclear
Florian Nahrig, Sergej Lauk, Yu Sun, Helmut Sitzmann, Werner R. Thiel
Summary: In this study, trisdimethylamido complexes of the Group IV elements titanium, zirconium, and hafnium, with the chiral Cp-type ligand (Cp-C)(-1), were synthesized and characterized using NMR spectroscopy, elemental analysis, and single crystal X-ray diffraction.
ZEITSCHRIFT FUR ANORGANISCHE UND ALLGEMEINE CHEMIE
(2021)
Article
Chemistry, Inorganic & Nuclear
Alexander A. Vinogradov, Pavel D. Komarov, Lada N. Puntus, Ilya Taydakov, Konstantin A. Lyssenko, Ilya E. Nifant'ev, Evgenia A. Varaksina, Dmitrii M. Roitershtein
Summary: In this study, a series of tetranuclear complexes were synthesized and characterized, with the Tb complex showing a high degree of π-system stacking interaction. Additionally, the luminescent properties of the Nd ion were observed for the first time, and the energy levels of the Cp-Ant ligand were estimated.
INORGANICA CHIMICA ACTA
(2022)
Article
Chemistry, Inorganic & Nuclear
Mohammad Taha, Edit Y. Y. Tshuva
Summary: A new series of titanium(iv) complexes based on diaminobis(phenolato)-bis(alkoxo) ligands were synthesized and characterized. The complexes showed enhanced solubility in aqueous media and high hydrolytic stability. They also exhibited cytotoxicity against human cancer cell lines, with the halogenated compounds showing the best combination of stability and activity.
DALTON TRANSACTIONS
(2023)
Article
Polymer Science
Hirotaka Aoki, Kotohiro Nomura
Summary: Copolymerization of ethylene with 2-vinylnaphthalene and 4-vinylbiphenyl using various catalyst systems yielded high-molecular-weight copolymers with different thermal properties, including amorphous and semicrystalline polymers. The thermal properties of the copolymers were found to be influenced by the comonomer content and structure.
Article
Chemistry, Multidisciplinary
Tadewos Damena, Digafie Zeleke, Tegene Desalegn, Taye B. Demissie, Rajalakshmanan Eswaramoorthy
Summary: In this study, novel cobalt and vanadium complexes were synthesized from an (E)-2-(((2-((2-hydroxyethyl) amino) quinolin-3-yl) methylene) amino)ethan-1-ol ligand (L), cobalt(II) chloride hexahydrate, and vanadyl(IV) sulfate in methanolic solutions. The ligand and complexes were characterized using various spectroscopic and physical techniques, and their antibacterial and antioxidant activities were evaluated. The results showed that the complexes exhibited better activities than the free ligand.
Article
Biochemistry & Molecular Biology
Tiankun Zhao, Peng Wang, Nan Liu, Wenzhuo Zhao, Mingjun Yang, Shanjia Li, Zhongduo Yang, Bolu Sun, Thomas Huhn
Summary: Four novel Hf(IV) complexes stabilized by 2,6-dipicolinic acid (Dipic) were synthesized and characterized. These complexes demonstrated good stability in aqueous media and on silica gel. Among them, [L1-2Hf(IV)Dipic4-Cl] showed excellent anti-tumoral activity comparable to cisplatin.
JOURNAL OF INORGANIC BIOCHEMISTRY
(2023)
Article
Chemistry, Physical
G. Spiekermann, Ch. J. Sahle, J. Niskanen, K. Gilmore, S. Petitgirard, C. Sternemann, J. S. Tse, M. Murakami
Summary: Based on ab initio spectral calculations on amorphous and crystalline structures, we find that the hard X-ray K beta'' emission line is sensitive to a wide range of cation-ligand coordination. In compressed amorphous GeO2, the relationship between K beta'' shift and coordination is approximately linear between 4-fold and 7-fold coordination. A similar sensitivity of the K beta'' emission line exists in the coordination range between six and nine of crystalline high-pressure TiO2 polymorphs. Our results demonstrate the potential of the K beta'' emission line in research on the structure of amorphous oxide material.
JOURNAL OF PHYSICAL CHEMISTRY LETTERS
(2023)
Article
Chemistry, Inorganic & Nuclear
Fen You, Suting Xu, Jixing Wang, Jingjing Zhai, Fei Wang, Li Pan, Yat-Ming So, Xiaochao Shi
Summary: A simple method for accessing new derivatizable bulky-demanding OHF ligands has been developed, leading to the synthesis of a series of half-sandwich rare-earth metal complexes bearing the OHF ancillary ligands, which exhibit high catalytic activity for styrene (co)polymerization.
INORGANIC CHEMISTRY
(2022)
Article
Chemistry, Inorganic & Nuclear
Gilad Nahari, Edit Y. Tshuva
Summary: Fine-tuning of complex properties by different substitutions on the two aromatic rings resulted in enhanced solubility, high anticancer activity (IC50 < 4 mu M), and significant hydrolytic stability.
DALTON TRANSACTIONS
(2021)
Article
Chemistry, Inorganic & Nuclear
Anastasia Pedko, Eden Rubanovich, Edit Y. Tshuva, Avital Shurki
Summary: A new family of titanium(IV) complexes based on [ONON] diaminobis(phenolato) ligands with different substitutions was synthesized and characterized. These complexes showed cytotoxic activity comparable to or higher than that of cisplatin towards cancer cell lines. The preference of an L2Ti complex was determined by entropic effects. The chlorinated derivative exhibited the best combination of stability, cytotoxicity, and bioavailability.
INORGANIC CHEMISTRY
(2022)
Article
Chemistry, Physical
Yeolib Jeong, Min Ki Cho, Sanghyup Seo, Heyjin Cho, Kyung-sun Son, Hyunwoo Kim
Summary: A new titanium (IV) complex coordinated with iminophenolate ligands was developed as an efficient catalyst for alternating ring-opening copolymerization (ROCOP). The crystal structures showed that iminophenolate titanium (IV) complexes had octahedral geometries due to geometrical constraints. Electronic tuning of iminophenolate ligands revealed that chloro-substituted ligands were more efficient in stabilizing the transition state for the epoxide opening step.
Article
Biochemistry & Molecular Biology
Guy Mayer, Zohar Shpilt, Hadar Kowalski, Edit Y. Tshuva, Assaf Friedler
Summary: The main challenge in inhibiting protein-protein interactions (PPI) is designing molecules that bind specifically to the hotspots of these interactions. This study presents a strategy using chimeric peptides containing both structured and disordered parts to inhibit PPI. The effectiveness of this strategy is demonstrated through the development of peptide inhibitors for the interactions of the antiapoptotic iASPP protein.
ACS CHEMICAL BIOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Zohar Shpilt, Edit Y. Tshuva
Summary: Titanium (IV) anticancer complexes interact with serum proteins albumin and transferrin. Albumin serves as a carrier for the complexes through its known drug binding sites. Albumin and transferrin have negligible impact on cytotoxicity.
JOURNAL OF INORGANIC BIOCHEMISTRY
(2022)
Article
Behavioral Sciences
Nina Lindemann, Leon Kalix, Jasmin Possiel, Richard Stasch, Tamia Kusian, Reinhard Wolfgang Koester, Jakob William von Trotha
Summary: Danionella cerebrum, a small vertebrate species, holds promise for studying higher cognitive functions. Comparative analysis reveals both similarities and differences in locomotor activity between Danionella cerebrum and zebrafish, possibly due to their different natural habitats.
FRONTIERS IN BEHAVIORAL NEUROSCIENCE
(2022)
Article
Chemistry, Inorganic & Nuclear
Anastasia Pedko, Eden Rubanovich, Edit Y. Tshuva, Avital Shurki
Summary: A new family of titanium(IV) complexes based on [ONON] diaminobis(phenolato) ligands with different substitutions was synthesized and characterized. These complexes showed cytotoxic activity comparable to or higher than that of cisplatin towards cancer cell lines. The preference of an L2Ti complex was determined by entropic effects. The chlorinated derivative exhibited the best combination of stability, cytotoxicity, and bioavailability.
INORGANIC CHEMISTRY
(2022)
Article
Chemistry, Multidisciplinary
Ohad Solomon, Zohar Shpilt, Hannah Sapir, Shir Marom, Shai Bibas, Yu-Ju Chen, Edit Y. Tshuva, Shlomo Yitzchaik, Assaf Friedler
Summary: Abnormal kinase activity, especially in cancer, is closely associated with disease. The common approach of inhibiting kinases using small molecules that target the ATP-binding site lacks selectivity. This study proposes an alternative method of targeting protein-protein interactions to achieve selectivity in kinase inhibition. The researchers successfully demonstrated the effectiveness of this approach by designing peptides that inhibit the docking D-recruitment site (DRS) of the kinase ERK2, which showed potential for developing selective peptide-based kinase inhibitors.
ISRAEL JOURNAL OF CHEMISTRY
(2022)
Article
Virology
Marcel Jaron, Michael Lehky, Marta Zara, Chris Nicole Zaydowicz, Aidin Lak, Rico Ballmann, Philip Alexander Heine, Esther Veronika Wenzel, Kai-Thomas Schneider, Federico Bertoglio, Susanne Kempter, Reinhard Wolfgang Koester, Silvia Stella Barbieri, Joop van den Heuvel, Michael Hust, Stefan Duebel, Maren Schubert
Summary: This study presents a fast and powerful method for producing SARS-CoV-2 VLPs in insect cells and evaluating their ability to inhibit monoclonal antibodies and sera from vaccinated donors. The method involves direct plasmid transfection to co-express specific viral proteins, resulting in the self-assembly of VLPs. The VLPs obtained were confirmed to have a diameter of approximately 145 nm and exhibited characteristic features by nanoparticle tracking analysis and transmission electron microscopy. The fusion of membrane protein with GFP allowed for quantification of binding inhibition to ACE2 without the need for purification or labeling.
Article
Chemistry, Multidisciplinary
Tomer Babu, Hiba Ghareeb, Uttara Basu, Hemma Schueffl, Sarah Theiner, Petra Heffeter, Gunda Koellensperger, Norman Metanis, Valentina Gandin, Ingo Ott, Claudia Schmidt, Dan Gibson
Summary: Au-I-carbene and Pt-IV-Au-I-carbene prodrugs exhibit low to sub-mu M activity against various cancer cell lines and overcome cisplatin resistance. The most potent prodrug is achieved by linking a cisplatin-derived Pt-IV(phenylbutyrate) complex to an Au-I-phenylimidazolylidene complex 2. In vivo tests on Lewis Lung Carcinoma demonstrate that the prodrug Pt-IV(phenylbutyrate)-Au-I-carbene (7) and the co-administration of cisplatin:phenylbutyrate:2 efficiently inhibit tumor growth (approximately 95%), surpassing the effectiveness of 2 (75%) or cisplatin (84%), while only causing 5% body weight loss compared to 14% for 2, 20% for cisplatin, and >30% for the co-administration.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2023)
Article
Biochemistry & Molecular Biology
Khadija Hassan, Blondelle Matio Kemkuignou, Marco Kirchenwitz, Kathrin Wittstein, Monique Rascher-Albaghdadi, Clara Chepkirui, Josphat C. Matasyoh, Cony Decock, Reinhard W. Koster, Theresia E. B. Stradal, Marc Stadler
Summary: This study investigated the neurotrophic properties of compounds isolated from two types of mushrooms. The results showed that some of these compounds can stimulate the expression of neurotrophic factors and enhance neurite outgrowth. These findings suggest that these compounds have potential as therapeutic agents for neurodegenerative diseases.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Chemistry, Multidisciplinary
Tan Hu, Michaela Kaganovich, Zohar Shpilt, Apurba Pramanik, Omer Agazani, Siyi Pan, Edit Tshuva, Meital Reches
Summary: In this study, two extremely short peptides, DOPA-Phe-NH2 and DOPA-Phe(4F)-NH2, were found to self-assemble into spherical nanoparticles with antiviral activity. When applied on a glass substrate, these peptide assemblies effectively deactivated viruses and showed low toxicity towards mammalian cells. These findings provide a new strategy for the design and development of antiviral coatings.
ADVANCED MATERIALS INTERFACES
(2023)
Article
Biochemistry & Molecular Biology
Zohar Shpilt, Naomi Melamed-Book, Edit Y. Tshuva
Summary: The cellular mechanism of PhenolaTi, a promising Ti(IV) anticancer complex, was investigated and found to be related to ER stress, leading to the formation of mitochondrial ROS and hypoxia. Unlike cisplatin, PhenolaTi has a distinct mechanism of action, stability, and favorable anticancer properties, making it a strong candidate for chemotherapy.
JOURNAL OF INORGANIC BIOCHEMISTRY
(2023)
Article
Chemistry, Inorganic & Nuclear
Reinhard Thaler, Holger Kopacka, Klaus Wurst, Thomas Mueller, Florian R. Neururer, Stephan Hohloch, Petra Lippmann, Ingo Ott, Benno Bildstein
Summary: New clathrochelate complexes of manganese, iron, and cobalt containing organometallic manganese moieties cymantrene or tromancenium were synthesized via self-assembly from dioximes, metal templates, and boronic acid pinacol esters. These complexes are air-stable, highly colored, oligometallic assemblies with complicated magnetic and electrochemical properties. The tetrametallic complexes with tromanceniumyl substituents exhibit promising anticancer activity against different tumor cell lines.
EUROPEAN JOURNAL OF INORGANIC CHEMISTRY
(2023)
Article
Biochemical Research Methods
Hanbin Zhang, Stavrini Papadaki, Xiaoting Sun, Xinyue Wang, Mikhail Drobizhev, Luxia Yao, Michel Rehbock, Reinhard W. Koester, Lianfeng Wu, Kazuhiko Namikawa, Kiryl D. Piatkevich
Summary: Recent progress in the development of fluorescent proteins has led to the creation of a wide range of near-infrared fluorescent proteins (NIR FPs), which are increasingly being used in various imaging applications. However, the diversity of NIR FPs presents a challenge for end-users in selecting the most suitable one for a specific application. In this study, we conducted a systematic and quantitative assessment of 22 NIR FPs in cultured mammalian cells and primary mouse neurons, and identified a set of top-performing FPs that can cover a majority of imaging applications.
Article
Biochemistry & Molecular Biology
Maria Gil-Moles, Cillian O'Beirne, Igor V. V. Esarev, Petra Lippmann, Matthias Tacke, Jindrich Cinatl, Denisa Bojkova, Ingo Ott
Summary: The ongoing SARS-CoV-2 pandemic has led to a high demand for innovative antiviral drugs. In this study, silver NHC complexes with chloride or iodide ligands were found to be potent inhibitors of the SARS-CoV-2 papain-like protease (PLpro), but inactive against another SARS-CoV-2 protease, 3C-like protease (3CL(pro)). Mechanistic studies showed that the complexes could remove zinc from the zinc binding domain of PLpro, which was a relevant factor for their activity. In addition, enzyme kinetic experiments revealed that the complexes were uncompetitive inhibitors, offering advantages in selectivity. The silver NHC complexes with iodide ligands showed low or no host cell toxicity and showed strong effects on viral replication in SARS-CoV-2-infected cells, making them promising candidates for future antiviral drugs.
RSC MEDICINAL CHEMISTRY
(2023)
Article
Chemistry, Inorganic & Nuclear
Mohammad Taha, Edit Y. Y. Tshuva
Summary: A new series of titanium(iv) complexes based on diaminobis(phenolato)-bis(alkoxo) ligands were synthesized and characterized. The complexes showed enhanced solubility in aqueous media and high hydrolytic stability. They also exhibited cytotoxicity against human cancer cell lines, with the halogenated compounds showing the best combination of stability and activity.
DALTON TRANSACTIONS
(2023)
Article
Chemistry, Multidisciplinary
Mihyun Park, Claudia Schmidt, Sebastian Tuerck, Franziska Hanusch, Simone V. Hirmer, Ingo Ott, Angela Casini, Shigeyoshi Inoue
Summary: A dinuclear gold(I) complex with a strongly donating bis-N-heterocyclic imine ligand was synthesized and characterized. It showed highly selective anticancer effects against non-small cell lung cancer cells, particularly A549 cells. The anticancer effects were not correlated with the amount of gold uptake by the cells but correlated with its selective inhibition of cancer cells overexpressing a specific enzyme.
Review
Chemistry, Multidisciplinary
Dan He, Yawen Li, Fuwen Zhao, Yuze Lin
Summary: High trap density in organic solar cells leads to localized charge carriers and reduced carrier lifetime, limiting device efficiency. This feature article summarizes the recent advances of trap suppression by material design and device engineering.
CHEMICAL COMMUNICATIONS
(2024)
Review
Chemistry, Multidisciplinary
Olivier Monfort, Arshitha Madhusudhan, Martin Motola
Summary: This article presents the advantages of coupling photocatalysis and Fenton-based processes for environmental remediation and discusses their synergy. It critically examines the simultaneous triggering of these two processes and provides insights into research approaches. The study aims to enhance understanding of this complex process and highlight the potential integration of new catalysts in current wastewater treatment technology.
CHEMICAL COMMUNICATIONS
(2024)
Article
Chemistry, Multidisciplinary
Manideepa Dhar, Chittaranjan Mishra, Avijit Das, Uttam Manna
Summary: An approach of 'polymerization of monomers in its aggregated form' has been introduced to tailor the water wettability of fibrous and porous substrates, achieving hydrophobicity to superhydrophobicity transition, as well as patterned wettability. This facile chemical method provides a durable coating with adjustable and patterned wettability for various potential applications.
CHEMICAL COMMUNICATIONS
(2024)
Article
Chemistry, Multidisciplinary
Saswat Ranjan Bhoi, Chhanda Debnath, Shikha Gandhi
Summary: In this article, a novel catalytic reaction using Pd(0) and Bronsted acid is reported for the synthesis of biologically important imidazolidinone-fused N-heterocycles through redox-neutral intramolecular N-allylation of indoles and pyrroles with alkynes. This atom-economical method is applicable to a wide range of substrates and eliminates the need for leaving groups or oxidizing agents commonly used in traditional allylation reactions.
CHEMICAL COMMUNICATIONS
(2024)
Article
Chemistry, Multidisciplinary
Longkun Chen, Mingshuai Zhang, Meichen Liu, Zhuoyuan Liu, Yuetong Qiu, Zhilai Zhang, Fuchao Yu, Jiuzhong Huang
Summary: In this study, an efficient Rh(III)-catalyzed selective mono- and dual-C-H bond functionalization/cyclization with iodonium ylide as the sole coupling partner was demonstrated. Fused benzodiazepine skeletons were obtained in excellent yields, providing an improved approach to dual C-H unsymmetrical functionalization.
CHEMICAL COMMUNICATIONS
(2024)
Article
Chemistry, Multidisciplinary
Alice Kennett, Sven Epple, Gabriella van der Valk, Irene Georgiou, Evelyne Gout, Romain R. Vives, Angela J. Russell
Summary: This study presents the design and synthesis of sulfated disaccharide inhibitors based on IdoA(2S)-GlcNS(6S), which showed potent inhibition of Sulf-2. The results suggest that IdoA(2S)-GlcNS(6S) is the shortest fragment size required for effective inhibition of Sulfs, and a trisulfated disaccharide is identified as the minimal fragment size of heparan sulfate for effective endosulfatase inhibition.
CHEMICAL COMMUNICATIONS
(2024)
Article
Chemistry, Multidisciplinary
Mauro Garbini, Andrea Brunetti, Riccardo Pedrazzani, Magda Monari, Massimo Marcaccio, Giulio Bertuzzi, Marco Bandini
Summary: The self-adaptability of galvanostatic electrolysis was found to be helpful in a multistage chemo- and diastereoselective electrochemically promoted cyclodimerization of chalcones. Through a series of reductive events, densely functionalized cyclopentanes with five contiguous stereocenters were obtained (25 examples, yields up to 95%, dr values up to >20:1). Further experimental and electrochemical investigations indicated the crucial role of dynamic kinetic resolution of the aldol intermediate in the reaction mechanism.
CHEMICAL COMMUNICATIONS
(2024)
Article
Chemistry, Multidisciplinary
Dhananjay S. Nipate, Neha Meena, Prakash N. Swami, Krishnan Rangan, Anil Kumar
Summary: In this study, the synthesis of functionalized benzo[a]phenazines and indazolo[2,3-a]quinolines was achieved through Rh(III)-catalyzed oxidative annulation of 2-arylquinoxalines and 2-aryl-2H-indazoles with allyl alcohols. The method showed a wide substrate scope, excellent functional group tolerance, good to high yields of annulated products, and the capability for scaled-up synthesis. A tentative mechanism of the annulation reaction was proposed based on a preliminary mechanistic investigation.
CHEMICAL COMMUNICATIONS
(2024)
Article
Chemistry, Multidisciplinary
Ruonan Zhang, Abudukadi Tudi, Xia Yang, Xuping Wang, Zhihua Yang, Shujuan Han, Shilie Pan
Summary: A new lead tellurium borate material with a unique fundamental building block [B4O10] was synthesized and found to exhibit high birefringence. The structure-property relationship was discussed using first-principles calculations.
CHEMICAL COMMUNICATIONS
(2024)
Article
Chemistry, Multidisciplinary
Amresh Kumar Singh, Baishali Thakurta, Anupam Giri, Monalisa Pal
Summary: This study introduces three key concepts for the quick synthesis of large-scale high-quality 2D materials films and their utilization in device fabrication.
CHEMICAL COMMUNICATIONS
(2024)
Article
Chemistry, Multidisciplinary
Reina Hagiwara, Shun Nishimura, Kosuke Okeyoshi
Summary: A copolymer-conjugated nanocatalytic system has been developed to improve electron transfer and enhance photoinduced H2 generation.
CHEMICAL COMMUNICATIONS
(2024)
