Carnosine: can understanding its actions on energy metabolism and protein homeostasis inform its therapeutic potential?

Autophagy and ageing: Insights from invertebrate model organisms

(2012) Eirini Lionaki et al.   AGEING RESEARCH REVIEWS

Carnosine and cancer: a perspective

(2012) Frank Gaunitz et al.   AMINO ACIDS

Yeast and cancer cells – common principles in lipid metabolism

(2012) Klaus Natter et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS

Parkinson's disease, insulin resistance and novel agents of neuroprotection

(2012) Iciar Aviles-Olmos et al.   BRAIN

Is cancer a metabolic rebellion against host aging? In the quest for immortality, tumor cells try to save themselves by boosting mitochondrial metabolism

(2012) Adam Ertel et al.   CELL CYCLE

Excitotoxic stimulus stabilizes PFKFB3 causing pentose-phosphate pathway to glycolysis switch and neurodegeneration

(2012) P Rodriguez-Rodriguez et al.   CELL DEATH AND DIFFERENTIATION

Anticancer Agents That Counteract Tumor Glycolysis

(2012) Carlotta Granchi et al.   ChemMedChem

Carnosine has antinociceptive properties in the inflammation-induced nociceptive response in mice

(2012) Masahiro Ohsawa et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Links between metabolism and cancer

(2012) C. V. Dang   GENES & DEVELOPMENT

parkin-induced defects in neurophysiology and locomotion are generated by metabolic dysfunction and not oxidative stress

(2012) A. Vincent et al.   HUMAN MOLECULAR GENETICS

Methylglyoxal Activates Nociceptors through Transient Receptor Potential Channel A1 (TRPA1)

(2012) Mirjam J. Eberhardt et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Proteomic profiling of the substantia nigra demonstrates CNDP2 overexpression in Parkinson's disease

(2012) Virginie Licker et al.   Journal of Proteomics

Metabolic differentiation in the embryonic retina

(2012) Michalis Agathocleous et al.   NATURE CELL BIOLOGY

Methylglyoxal modification of Nav1.8 facilitates nociceptive neuron firing and causes hyperalgesia in diabetic neuropathy

(2012) Angelika Bierhaus et al.   NATURE MEDICINE

Amyloid precursor protein accumulates in aggresomes in response to proteasome inhibitor

(2012) Nodi Dehvari et al.   NEUROCHEMISTRY INTERNATIONAL

Metformin-inclusive sulfonylurea therapy reduces the risk of Parkinson's disease occurring with Type 2 diabetes in a Taiwanese population cohort

(2012) Mark L. Wahlqvist et al.   PARKINSONISM & RELATED DISORDERS

NMR Structure of Hsp12, a Protein Induced by and Required for Dietary Restriction-Induced Lifespan Extension in Yeast

(2012) Andrew P. Herbert et al.   PLoS One

L-Carnosine Affects the Growth of Saccharomyces cerevisiae in a Metabolism-Dependent Manner

(2012) Stephanie P. Cartwright et al.   PLoS One

A preliminary, randomized, double-blind, placebo-controlled trial of l-carnosine to improve cognition in schizophrenia

(2012) K.N. Roy Chengappa et al.   SCHIZOPHRENIA RESEARCH

Glycation-altered proteolysis as a pathobiologic mechanism that links dietary glycemic index, aging, and age-related disease (in nondiabetics)

(2011) Tomoaki Uchiki et al.   AGING CELL

Carnosine protects neurons against oxidative stress and modulates the time profile of MAPK cascade signaling

(2011) Konstantin Kulebyakin et al.   AMINO ACIDS

The influence of sex, age and heritability on human skeletal muscle carnosine content

(2011) Audrey Baguet et al.   AMINO ACIDS

Upregulation of aldolase B and overproduction of methylglyoxal in vascular tissues from rats with metabolic syndrome

(2011) Jianghai Liu et al.   CARDIOVASCULAR RESEARCH

High-dose rapamycin induces apoptosis in human cancer cells by dissociating mTOR complex 1 and suppressing phosphorylation of 4E-BP1

(2011) Paige Yellen et al.   CELL CYCLE

Recruitment of APPL1 to ubiquitin-rich aggresomes in response to proteasomal impairment

(2011) Iwona Pilecka et al.   EXPERIMENTAL CELL RESEARCH

Occurrence and distribution of salsolinol-like compound, 1-acetyl-6,7-dihydroxy-1,2,3,4-tetrahydroisoquinoline (ADTIQ) in Parkinsonian brains

(2011) Yulin Deng et al.   JOURNAL OF NEURAL TRANSMISSION

Higher levels of heat shock proteins in longer-lived mammals and birds

(2011) Kurtis D. Salway et al.   MECHANISMS OF AGEING AND DEVELOPMENT

Energy metabolism, proteotoxic stress and age-related dysfunction – Protection by carnosine

(2011) Alan R. Hipkiss   MOLECULAR ASPECTS OF MEDICINE

Neuroprotective features of carnosine in oxidative driven diseases

(2011) Francesco Bellia et al.   MOLECULAR ASPECTS OF MEDICINE

Vimentin intermediate filaments modulate the motility of mitochondria

(2011) Oxana E. Nekrasova et al.   MOLECULAR BIOLOGY OF THE CELL

Effects of Dietary Supplementation of Carnosine on Mitochondrial Dysfunction, Amyloid Pathology, and Cognitive Deficits in 3xTg-AD Mice

(2011) Carlo Corona et al.   PLoS One

Resveratrol Inhibits Protein Translation in Hepatic Cells

(2011) Eugenia Villa-Cuesta et al.   PLoS One

Glycation of the Muscle-Specific Enolase by Reactive Carbonyls: Effect of Temperature and the Protection Role of Carnosine, Pirydoxamine and Phosphatidylserine

(2011) Jadwiga Pietkiewicz et al.   PROTEIN JOURNAL

Methylglyoxal, glyoxalase 1 and the dicarbonyl proteome

(2010) Naila Rabbani et al.   AMINO ACIDS

Oxidative stress and aging: Is methylglyoxal the hidden enemy?This review is one of a selection of papers published in a Special Issue on Oxidative Stress in Health and Disease.

(2010) Kaushik M. Desai et al.   CANADIAN JOURNAL OF PHYSIOLOGY AND PHARMACOLOGY

Salsolinol, a catechol neurotoxin, induces modification of ferritin: Protection by histidine dipeptide

(2010) Jung Hoon Kang   ENVIRONMENTAL TOXICOLOGY AND PHARMACOLOGY

The carbonyl scavenger carnosine ameliorates dyslipidaemia and renal function in Zucker obese rats

(2010) Giancarlo Aldini et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Renal Podocyte Apoptosis in Zucker Diabetic Fatty Rats: Involvement of Methylglyoxal-Induced Oxidative DNA Damage

(2010) J. Kim et al.   JOURNAL OF COMPARATIVE PATHOLOGY

Molecular and biochemical analysis of the α class carbonic anhydrases in Caenorhabditis elegans

(2010) Michael K. Fasseas et al.   MOLECULAR BIOLOGY REPORTS

Carnosine retards tumor growth in vivo in an NIH3T3-HER2/neu mouse model

(2010) Christof Renner et al.   Molecular Cancer

Muscle Carnosine Metabolism and β-Alanine Supplementation in Relation to Exercise and Training

(2010) Wim Derave et al.   SPORTS MEDICINE

Hyperglycemia and Glycation in Diabetic Complications

(2009) Anne Negre-Salvayre et al.   ANTIOXIDANTS & REDOX SIGNALING

Design, Synthesis, and Evaluation of Carnosine Derivatives as Selective and Efficient Sequestering Agents of Cytotoxic Reactive Carbonyl Species

(2009) Giulio Vistoli et al.   ChemMedChem

Metabolic links between diabetes and Alzheimer’s disease

(2009) Pamela A Maher et al.   Expert Review of Neurotherapeutics

The bioenergetic and antioxidant status of neurons is controlled by continuous degradation of a key glycolytic enzyme by APC/C–Cdh1

(2009) Angel Herrero-Mendez et al.   NATURE CELL BIOLOGY

E3 ubiquitin ligase APC/C-Cdh1 accounts for the Warburg effect by linking glycolysis to cell proliferation

(2009) A. Almeida et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Carnosine As a Natural Antioxidant and Geroprotector: From Molecular Mechanisms to Clinical Trials

(2009) A.A. Boldyrev et al.   REJUVENATION RESEARCH

AGE-RAGE System and Carcinogenesis

(2008) Riichiro Abe et al.   CURRENT PHARMACEUTICAL DESIGN

Inhibitory effect of carnosine on interleukin-8 production in intestinal epithelial cells through translational regulation

(2008) Dong Ok Son et al.   CYTOKINE

Preventive effect of l-carnosine on changes in the thermal nociceptive threshold in streptozotocin-induced diabetic mice

(2008) Junzo Kamei et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Carnisone Increases Efficiency of DOPA Therapy of Parkinson's Disease: A Pilot Study

(2008) Alexander Boldyrev et al.   REJUVENATION RESEARCH