Rhodium-catalysed asymmetric hydrogenation as a valuable synthetic tool for the preparation of chiral drugs

Modular POP Ligands in Rhodium-Mediated Asymmetric Hydrogenation: A Comparative Catalysis Study

(2012) José L. Núñez-Rico et al.   ADVANCED SYNTHESIS & CATALYSIS

Brønsted Acid Activation Strategy in Transition-Metal Catalyzed Asymmetric Hydrogenation of N-Unprotected Imines, Enamines, and N-Heteroaromatic Compounds

(2012) Zhengkun Yu et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Asymmetric homogeneous hydrogenations at scale

(2012) David J. Ager et al.   CHEMICAL SOCIETY REVIEWS

Recent advances in transition metal-catalyzed enantioselective hydrogenation of unprotected enamines

(2012) Jian-Hua Xie et al.   CHEMICAL SOCIETY REVIEWS

Development of iridium-catalyzed asymmetric hydrogenation: New catalysts, new substrate scope

(2012) Alban Cadu et al.   JOURNAL OF ORGANOMETALLIC CHEMISTRY

Rhodium-Catalyzed and Zinc(II)-Triflate-Promoted Asymmetric Hydrogenation of Tetrasubstituted α,β-Unsaturated Ketones

(2012) Joel R. Calvin et al.   ORGANIC LETTERS

Development of an Enantioselective Hydrogenation Based Synthesis of a Glucokinase Activator

(2012) Nicholas A. Magnus et al.   ORGANIC PROCESS RESEARCH & DEVELOPMENT

Development and Scale-Up of a Continuous, High-Pressure, Asymmetric Hydrogenation Reaction, Workup, and Isolation

(2012) Martin D. Johnson et al.   ORGANIC PROCESS RESEARCH & DEVELOPMENT

Large-Scale Carbonyl Reductions in the Pharmaceutical Industry

(2012) Javier Magano et al.   ORGANIC PROCESS RESEARCH & DEVELOPMENT

New Synthetic Strategy for High-Enantiopurity N-Protected α-Amino Ketones and their Derivatives by Asymmetric Hydrogenation

(2011) Tian Sun et al.   ADVANCED SYNTHESIS & CATALYSIS

Highly Enantioselective Hydrogenation of β-Acyloxy and β-Acylamino α,β-Unsaturated Phosphonates Catalyzed by Rhodium Phosphane-Phosphite Complexes

(2011) M. Ángeles Chávez et al.   ADVANCED SYNTHESIS & CATALYSIS

The Growing Impact of Catalysis in the Pharmaceutical Industry

(2011) Carl A. Busacca et al.   ADVANCED SYNTHESIS & CATALYSIS

Sitagliptin Manufacture: A Compelling Tale of Green Chemistry, Process Intensification, and Industrial Asymmetric Catalysis

(2011) Aman A. Desai   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

The Synthesis of Chiral Phosphorus Ligands for use in Homogeneous Metal Catalysis

(2011) Susan Lühr et al.   ChemCatChem

Asymmetric hydrogenation of alkenes lacking coordinating groups

(2011) David H. Woodmansee et al.   CHEMICAL COMMUNICATIONS

Design of molecular catalysts for achievement of high turnover number in homogeneous hydrogenation

(2011) Noriyoshi Arai et al.   CHEMICAL RECORD

Phosphine−Phosphinite and Phosphine−Phosphite Ligands: Preparation and Applications in Asymmetric Catalysis

(2011) Héctor Fernández-Pérez et al.   CHEMICAL REVIEWS

Use of Nonfunctionalized Enamides and Enecarbamates in Asymmetric Synthesis

(2011) Kovuru Gopalaiah et al.   CHEMICAL REVIEWS

Asymmetric Hydrogenation of Heteroarenes and Arenes

(2011) Duo-Sheng Wang et al.   CHEMICAL REVIEWS

BINEPINES: chiral binaphthalene-core monophosphepine ligands for multipurpose asymmetric catalysis

(2011) Serafino Gladiali et al.   CHEMICAL SOCIETY REVIEWS

Enantioselective Access to Chiral Drugs by using Asymmetric Hydrogenation Catalyzed by Rh(POP) Complexes

(2011) Pablo Etayo et al.   CHEMISTRY-A EUROPEAN JOURNAL

Supramolecular ligand–ligand and ligand–substrate interactions for highly selective transition metal catalysis

(2011) Stefano Carboni et al.   DALTON TRANSACTIONS

Catalytic Asymmetric Synthesis of a Tertiary Benzylic Carbon Center via Phenol-Directed Alkene Hydrogenation

(2011) Seb Caille et al.   JOURNAL OF ORGANIC CHEMISTRY

Rigid P-Chiral Phosphine Ligands with tert-Butylmethylphosphino Groups for Rhodium-Catalyzed Asymmetric Hydrogenation of Functionalized Alkenes

(2011) Tsuneo Imamoto et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Hybrid bidentate phosphorus ligands in asymmetric catalysis: Privileged ligand approach vs. combinatorial strategies

(2011) Jeroen Wassenaar et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

Protecting-group-free synthesis of a dual CCK1/CCK2 receptor antagonist

(2011) Jing Liu et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

Highly Enantioselective Hydrogenation of Styrenes Directed by 2′-Hydroxyl Groups

(2011) Xiang Wang et al.   ORGANIC LETTERS

Development of an Asymmetric Hydrogenation Route to (S)-N-Boc-2,6-dimethyltyrosine

(2011) Céline F. B. Praquin et al.   ORGANIC PROCESS RESEARCH & DEVELOPMENT

The Development of a Practical Multikilogram Synthesis of the Chiral β-Amino Acid Imagabalin Hydrochloride (PD-0332334) via Asymmetric Hydrogenation

(2011) Melissa Birch et al.   ORGANIC PROCESS RESEARCH & DEVELOPMENT

Chiral Rhodium Complexes Derived From Electron-Rich Phosphine-Phosphites as Asymmetric Hydrogenation Catalysts

(2011) Pablo Etayo et al.   ORGANOMETALLICS

Application of [BoPhoz Rh] catalysts in the asymmetric hydrogenation of a pyridyl benzothiophene alkene

(2011) Timothy Gross et al.   TETRAHEDRON LETTERS

Chiral Amine Synthesis - Recent Developments and Trends for Enamide Reduction, Reductive Amination, and Imine Reduction

(2010) Thomas C. Nugent et al.   ADVANCED SYNTHESIS & CATALYSIS

Phosphoramidites: Privileged Ligands in Asymmetric Catalysis

(2010) Johannes F. Teichert et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Achiral bis-imine in combination with CoCl2: A remarkable effect on enantioselectivity of lipase-mediated acetylation of racemic secondary alcohol

(2010) K Arunkumar et al.   Beilstein Journal of Organic Chemistry

Highlights of Transition Metal-Catalyzed Asymmetric Hydrogenation of Imines

(2010) Nicolas Fleury-Brégeot et al.   ChemCatChem

Phosphite-Containing Ligands for Asymmetric Catalysis

(2010) Piet W. N. M. van Leeuwen et al.   CHEMICAL REVIEWS

Transition Metal-Catalyzed Enantioselective Hydrogenation of Enamines and Imines

(2010) Jian-Hua Xie et al.   CHEMICAL REVIEWS

Recent advances in the catalytic asymmetric synthesis of β-amino acids

(2010) Barbara Weiner et al.   CHEMICAL SOCIETY REVIEWS

Asymmetric Hydrogenation of Minimally Functionalised Terminal Olefins: An Alternative Sustainable and Direct Strategy for Preparing Enantioenriched Hydrocarbons

(2010) Oscar Pàmies et al.   CHEMISTRY-A EUROPEAN JOURNAL

Discovery of 5-Chloro-N2-[(1S)-1-(5-fluoropyrimidin-2-yl)ethyl]-N4-(5-methyl-1H-pyrazol-3-yl)pyrimidine-2,4-diamine (AZD1480) as a Novel Inhibitor of the Jak/Stat Pathway

(2010) Stephanos Ioannidis et al.   JOURNAL OF MEDICINAL CHEMISTRY

Large-Scale Asymmetric Synthesis of a Cathepsin S Inhibitor

(2010) Jon C. Lorenz et al.   JOURNAL OF ORGANIC CHEMISTRY

Enantioselective Rh-Catalyzed Hydrogenation of 3-Aryl-4-phosphonobutenoates with aP-Stereogenic BoPhoz-Type Ligand

(2010) Zheng-Chao Duan et al.   JOURNAL OF ORGANIC CHEMISTRY

Phosphine-free chiral metal catalysts for highly effective asymmetric catalytic hydrogenation

(2010) Yan-Mei He et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

Rapid Identification of a Scalable Catalyst for the Asymmetric Hydrogenation of a Sterically Demanding Aryl Enamide

(2010) Laurent Lefort et al.   ORGANIC PROCESS RESEARCH & DEVELOPMENT

Asymmetric Hydrogenation of Heteroaromatic Compounds Mediated by Iridium−(P-OP) Complexes

(2010) José L. Núñez-Rico et al.   ORGANOMETALLICS

Asymmetric hydrogenation of ketones: Tactics to achieve high reactivity, enantioselectivity, and wide scope

(2010) Takeshi OHKUMA   PROCEEDINGS OF THE JAPAN ACADEMY SERIES B-PHYSICAL AND BIOLOGICAL SCIENCES

Highly modular P-OP ligands in asymmetric allylic substitution

(2010) Armen Panossian et al.   TETRAHEDRON-ASYMMETRY

Anthranilic sulfonamide CCK1/CCK2 dual receptor antagonists II: Tuning of receptor selectivity and in vivo efficacy

(2009) Marna Pippel et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Mechanistic analysis of the transition metal-catalyzed hydrogenation of imines and functionalized enamines

(2009) Amandine Fabrello et al.   COORDINATION CHEMISTRY REVIEWS

Practical Synthesis of a Potent Bradykinin B1Antagonist via Enantioselective Hydrogenation of a PyridylN-Acyl Enamide

(2009) Paul D. O’Shea et al.   JOURNAL OF ORGANIC CHEMISTRY

Highly Efficient Asymmetric Synthesis of Sitagliptin

(2009) Karl B. Hansen et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Identification and preclinical characterization of AZ-23, a novel, selective, and orally bioavailable inhibitor of the Trk kinase pathway

(2009) K. Thress et al.   MOLECULAR CANCER THERAPEUTICS

New Efficient Asymmetric Synthesis of Taranabant, a CB1R Inverse Agonist for the Treatment of Obesity

(2009) Debra J. Wallace et al.   ORGANIC PROCESS RESEARCH & DEVELOPMENT

Diastereoselective, large scale synthesis of β-amino acids via asymmetric enamide hydrogenation as α2δ ligands for the treatment of generalized anxiety disorder and insomnia

(2009) Javier Magano et al.   TETRAHEDRON LETTERS

Highly ModularP-O-PLigands for Asymmetric Hydrogenation

(2008) Héctor Fernández-Pérez et al.   ADVANCED SYNTHESIS & CATALYSIS

Efficient Synthesis of Chiral β-Arylisopropylamines by Using Catalytic Asymmetric Hydrogenation

(2008) Jian Chen et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Highly Enantioselective Hydrogenation of Enol Ester Phosphonates: A Versatile Procedure for the Preparation of Chiral β-Hydroxyphosphonates

(2008) Sergio Vargas et al.   CHEMISTRY-A EUROPEAN JOURNAL

Identification of 4-Aminopyrazolylpyrimidines as Potent Inhibitors of Trk Kinases

(2008) Tao Wang et al.   JOURNAL OF MEDICINAL CHEMISTRY

Catalytic Asymmetric Syntheses of Tyrosine Surrogates

(2008) Xiaojun Han et al.   JOURNAL OF ORGANIC CHEMISTRY

Lacosamide

(2008) Emilio Perucca et al.   NATURE REVIEWS DRUG DISCOVERY

Chemical Development of NBI-75043. Use of a Flow Reactor to Circumvent a Batch-Limited Metal−Halogen Exchange Reaction

(2008) Timothy D. Gross et al.   ORGANIC PROCESS RESEARCH & DEVELOPMENT

Development of a Practical Synthesis of DPP IV Inhibitor LY2497282†

(2008) Hannah Yu et al.   ORGANIC PROCESS RESEARCH & DEVELOPMENT

Synthesis of enantiopure (R)-2-(4-methoxy-3-(3-methoxypropoxy)-benzyl)-3-methylbutanoic acid—a key intermediate for the preparation of Aliskiren

(2008) Natalia Andrushko et al.   TETRAHEDRON LETTERS

A new class of bradykinin B1 receptor antagonists with high oral bioavailability and minimal PXR activity

(2007) Dong-Mei Feng et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Synthesis of β-aminoacid derivatives via enantioselective hydrogenation of β-substituted-β-(acylamino)acrylates

(2007) Christian Bruneau et al.   COORDINATION CHEMISTRY REVIEWS

Iridium catalysts for the asymmetric hydrogenation of olefins with nontraditional functional substituents

(2007) Tamara L. Church et al.   COORDINATION CHEMISTRY REVIEWS

Asymmetric Hydrogenation of Unsaturated Ureas with the BIPI Ligands

(2007) Carl A. Busacca et al.   ORGANIC LETTERS

An efficient chiral synthesis of fluoro-containing amino acids: N-benzyloxycarbonyl-2-amino-4,4-difluorobutyric acid methyl ester and its analogs

(2007) Zilun Hu et al.   TETRAHEDRON LETTERS