Journal
ADVANCED SYNTHESIS & CATALYSIS
Volume 353, Issue 2-3, Pages 253-256Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/adsc.201000680
Keywords
alpha-amino ketones; amphetamines; enantioselectivity; hydrogenation; rhodium
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Funding
- National Institutes of Health [GM58832]
- Merck Co., Inc.
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Asymmetric hydrogenation of alpha-dehydroamino ketones catalyzed by a rhodium-chiral phosphorus ligand complex (up to 99% ee, 1000 TON), represents an efficient approach to chiral alpha-amino ketones. The reduction of alpha-amino ketones catalyzed by palladium on carbon (Pd/C) leads to amphetamine precursors with quantitative yield and no significant enantioselectivity loss.
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