Immunoglobulin light chain amyloid aggregation

A Peptide-Fc Opsonin with Pan-Amyloid Reactivity

(2017) James S. Foster et al.   Frontiers in Immunology

Differential recruitment efficacy of patient-derived amyloidogenic and myeloma light chain proteins by synthetic fibrils—A metric for predicting amyloid propensity

(2017) Emily B. Martin et al.   PLoS One

Concurrent structural and biophysical traits link with immunoglobulin light chains amyloid propensity

(2017) Luca Oberti et al.   Scientific Reports

Recruitment of Light Chains by Homologous and Heterologous Fibrils Shows Distinctive Kinetic and Conformational Specificity

(2016) Luis M. Blancas-Mejía et al.   BIOCHEMISTRY

Solid-state NMR chemical shift assignments for AL-09 VL immunoglobulin light chain fibrils

(2016) Dennis W. Piehl et al.   Biomolecular NMR Assignments

Clarifying immunoglobulin gene usage in systemic and localized immunoglobulin light-chain amyloidosis by mass spectrometry

(2016) Taxiarchis V. Kourelis et al.   BLOOD

Aggregation of Full-length Immunoglobulin Light Chains from Systemic Light Chain Amyloidosis (AL) Patients Is Remodeled by Epigallocatechin-3-gallate

(2016) Kathrin Andrich et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Cell Damage in Light Chain Amyloidosis

(2016) Marta Marin-Argany et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Solid-state NMR structure of a pathogenic fibril of full-length human α-synuclein

(2016) Marcus D Tuttle et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Solid-state NMR structure of a pathogenic fibril of full-length human α-synuclein

(2016) Marcus D Tuttle et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Thermodynamic and fibril formation studies of full length immunoglobulin light chain AL-09 and its germline protein using scan rate dependent thermal unfolding

(2015) Luis M. Blancas-Mejía et al.   BIOPHYSICAL CHEMISTRY

Novel mitochondrial protein interactors of immunoglobulin light chains causing heart amyloidosis

(2015) Francesca Lavatelli et al.   FASEB JOURNAL

The Antibody Light-Chain Linker Is Important for Domain Stability and Amyloid Formation

(2015) Cardine N. Nokwe et al.   JOURNAL OF MOLECULAR BIOLOGY

Light Chain Amyloid Fibrils Cause Metabolic Dysfunction in Human Cardiomyocytes

(2015) Helen P. McWilliams-Koeppen et al.   PLoS One

Mutations can cause light chains to be too stable or too unstable to form amyloid fibrils

(2015) Marta Marin-Argany et al.   PROTEIN SCIENCE

Decreased Amyloidogenicity Caused by Mutational Modulation of Surface Properties of the Immunoglobulin Light Chain BRE Variable Domain

(2014) Yuta Kobayashi et al.   BIOCHEMISTRY

A Caenorhabditis elegans-based assay recognizes immunoglobulin light chains causing heart amyloidosis

(2014) L. Diomede et al.   BLOOD

Lysosomal dysfunction and impaired autophagy underlie the pathogenesis of amyloidogenic light chain-mediated cardiotoxicity

(2014) J. Guan et al.   EMBO Molecular Medicine

Differential Effects on Light Chain Amyloid Formation Depend on Mutations and Type of Glycosaminoglycans

(2014) Luis M. Blancas-Mejía et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

An animal model of glomerular light-chain-associated amyloidogenesis depicts the crucial role of lysosomes

(2014) Jiamin Teng et al.   KIDNEY INTERNATIONAL

Human amyloidogenic light chain proteins result in cardiac dysfunction, cell death, and early mortality in zebrafish

(2013) Shikha Mishra et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

Stanniocalcin1 is a key mediator of amyloidogenic light chain induced cardiotoxicity

(2013) Jian Guan et al.   BASIC RESEARCH IN CARDIOLOGY

The N-terminal strand modulates immunoglobulin light chain fibrillogenesis

(2013) Luis del Pozo-Yauner et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Amyloid Formation in Light Chain Amyloidosis

(2013) Marina Ramirez-Alvarado   CURRENT TOPICS IN MEDICINAL CHEMISTRY

Thermal Stability Threshold for Amyloid Formation in Light Chain Amyloidosis

(2013) Tanya Poshusta et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Kinetic Control in Protein Folding for Light Chain Amyloidosis and the Differential Effects of Somatic Mutations

(2013) Luis.M. Blancas-Mejía et al.   JOURNAL OF MOLECULAR BIOLOGY

A molten globule intermediate of the Von Willebrand factor A1 domain firmly tethers platelets under shear flow

(2013) Alexander Tischer et al.   PROTEINS-STRUCTURE FUNCTION AND BIOINFORMATICS

Role of mutations in the cellular internalization of amyloidogenic light chains into cardiomyocytes

(2013) Rebecca T. Levinson et al.   Scientific Reports

Differences in Immunoglobulin Light Chain Species Found in Urinary Exosomes in Light Chain Amyloidosis (AL)

(2012) Marina Ramirez-Alvarado et al.   PLoS One

Glycosaminoglycans promote fibril formation by amyloidogenic immunoglobulin light chains through a transient interaction

(2011) Douglas J. Martin et al.   BIOPHYSICAL CHEMISTRY

Doxycycline reduces fibril formation in a transgenic mouse model of AL amyloidosis

(2011) J. E. Ward et al.   BLOOD

A Reappraisal of Immunoglobulin Variable Gene Primers and Its Impact on Assessing Clonal Relationships Between PB B Cells and BM Plasma Cells in AL Amyloidosis

(2011) Nagaaki Katoh et al.   JOURNAL OF CLINICAL IMMUNOLOGY

In vivo molecular imaging of peripheral amyloidosis using heparin-binding peptides

(2011) J. S. Wall et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Comparison of amyloid fibril formation by two closely related immunoglobulin light chain variable domains

(2010) Douglas J. Martin et al.   AMYLOID-JOURNAL OF PROTEIN FOLDING DISORDERS

The Critical Role of the Constant Region in Thermal Stability and Aggregation of Amyloidogenic Immunoglobulin Light Chain

(2010) Elena S. Klimtchuk et al.   BIOCHEMISTRY

The amyloid fibrils of the constant domain of immunoglobulin light chain

(2010) Kaori Yamamoto et al.   FEBS LETTERS

Role of Glycosaminoglycan Sulfation in the Formation of Immunoglobulin Light Chain Amyloid Oligomers and Fibrils

(2010) Ruiyi Ren et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Amyloidogenic light chains induce cardiomyocyte contractile dysfunction and apoptosis via a non-canonical p38  MAPK pathway

(2010) J. Shi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A Single Mutation Promotes Amyloidogenicity through a Highly Promiscuous Dimer Interface

(2010) Francis C. Peterson et al.   STRUCTURE

Cytotoxicity of amyloidogenic immunoglobulin light chains in cell culture

(2010) L A Sikkink et al.   Cell Death & Disease

Classification of amyloidosis by laser microdissection and mass spectrometry-based proteomic analysis in clinical biopsy specimens

(2009) J. A. Vrana et al.   BLOOD

Animal models of human amyloidoses: Are transgenic mice worth the time and trouble?

(2009) Joel N. Buxbaum   FEBS LETTERS

Structural Alterations within Native Amyloidogenic Immunoglobulin Light Chains

(2009) Edward G. Randles et al.   JOURNAL OF MOLECULAR BIOLOGY

A Single Mutation at the Sheet Switch Region Results in Conformational Changes Favoring λ6 Light-Chain Fibrillogenesis

(2009) Alejandra Hernández-Santoyo et al.   JOURNAL OF MOLECULAR BIOLOGY

Fibril protein fragmentation pattern in systemic AL-amyloidosis

(2009) Stina Enqvist et al.   JOURNAL OF PATHOLOGY

Mutations in Specific Structural Regions of Immunoglobulin Light Chains Are Associated with Free Light Chain Levels in Patients with AL Amyloidosis

(2009) Tanya L. Poshusta et al.   PLoS One

Biochemical and aggregation analysis of Bence Jones proteins from different light chain diseases

(2008) Laura A. Sikkink et al.   AMYLOID-JOURNAL OF PROTEIN FOLDING DISORDERS

Salts enhance both protein stability and amyloid formation of an immunoglobulin light chain

(2008) Laura A. Sikkink et al.   BIOPHYSICAL CHEMISTRY

Biologic and genetic characterization of the novel amyloidogenic lambda light chain-secreting human cell lines, ALMC-1 and ALMC-2

(2008) B. K. Arendt et al.   BLOOD

Altered Dimer Interface Decreases Stability in an Amyloidogenic Protein

(2008) Elizabeth M. Baden et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Structural Insights into the Role of Mutations in Amyloidogenesis

(2008) Elizabeth M. Baden et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Amyloidogenic and Associated Proteins in Systemic Amyloidosis Proteome of Adipose Tissue

(2008) Francesca Lavatelli et al.   MOLECULAR & CELLULAR PROTEOMICS

Amyloid formation by globular proteins under native conditions

(2008) Fabrizio Chiti et al.   Nature Chemical Biology

Influence of the germline sequence on the thermodynamic stability and fibrillogenicity of human lambda 6 light chains

(2008) Luis del Pozo Yauner et al.   PROTEINS-STRUCTURE FUNCTION AND BIOINFORMATICS