Aggregation of Full-length Immunoglobulin Light Chains from Systemic Light Chain Amyloidosis (AL) Patients Is Remodeled by Epigallocatechin-3-gallate

Recruitment of Light Chains by Homologous and Heterologous Fibrils Shows Distinctive Kinetic and Conformational Specificity

(2016) Luis M. Blancas-Mejía et al.   BIOCHEMISTRY

Inhibition of Light Chain 6aJL2-R24G Amyloid Fiber Formation Associated with Light Chain Amyloidosis

(2015) Angel E. Pelaez-Aguilar et al.   BIOCHEMISTRY

Thermodynamic and fibril formation studies of full length immunoglobulin light chain AL-09 and its germline protein using scan rate dependent thermal unfolding

(2015) Luis M. Blancas-Mejía et al.   BIOPHYSICAL CHEMISTRY

Clonotypic Light Chain Peptides Identified for Monitoring Minimal Residual Disease in Multiple Myeloma without Bone Marrow Aspiration

(2015) H. R. Bergen et al.   CLINICAL CHEMISTRY

Mutations can cause light chains to be too stable or too unstable to form amyloid fibrils

(2015) Marta Marin-Argany et al.   PROTEIN SCIENCE

Salt mediated unusual switching in the aggregation kinetic profile of human carbonic anhydrase

(2015) Preeti Gupta et al.   RSC Advances

Inhibition by small-molecule ligands of formation of amyloid fibrils of an immunoglobulin light chain variable domain

(2015) Boris Brumshtein et al.   eLife

The green tea polyphenol (−)-epigallocatechin gallate prevents the aggregation of tau protein into toxic oligomers at substoichiometric ratios

(2014) Heike J. Wobst et al.   FEBS LETTERS

Hybrid Nanocomposites of Gold Single-Crystal Platelets and Amyloid Fibrils with Tunable Fluorescence, Conductivity, and Sensing Properties

(2013) Chaoxu Li et al.   ADVANCED MATERIALS

Thermal Stability Threshold for Amyloid Formation in Light Chain Amyloidosis

(2013) Tanya Poshusta et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Kinetic Control in Protein Folding for Light Chain Amyloidosis and the Differential Effects of Somatic Mutations

(2013) Luis.M. Blancas-Mejía et al.   JOURNAL OF MOLECULAR BIOLOGY

Toward the Molecular Mechanism(s) by Which EGCG Treatment Remodels Mature Amyloid Fibrils

(2013) Fernando L. Palhano et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

The interplay between carbon nanomaterials and amyloid fibrils in bio-nanotechnology

(2013) Chaoxu Li et al.   Nanoscale

Quantitative analysis of the time course of Aβ oligomerization and subsequent growth steps using tetramethylrhodamine-labeled Aβ

(2013) Kanchan Garai et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Proliferation of amyloid- 42 aggregates occurs through a secondary nucleation mechanism

(2013) S. I. A. Cohen et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Mechanism for retardation of amyloid fibril formation by sugars in Vλ6 protein

(2013) Masahiro Abe et al.   PROTEIN SCIENCE

Comparison of Three Amyloid Assembly Inhibitors: The Sugar scyllo-Inositol, the Polyphenol Epigallocatechin Gallate, and the Molecular Tweezer CLR01

(2012) Sharmistha Sinha et al.   ACS Chemical Neuroscience

Tyrosine Residues Mediate Fibril Formation in a Dynamic Light Chain Dimer Interface

(2012) Ara Celi DiCostanzo et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Structural Properties of EGCG-Induced, Nontoxic Alzheimer's Disease Aβ Oligomers

(2012) Juan Miguel Lopez del Amo et al.   JOURNAL OF MOLECULAR BIOLOGY

Thermodynamic Analysis of the Molecular Interactions between Amyloid β-Protein Fragments and (−)-Epigallocatechin-3-gallate

(2012) Shi-Hui Wang et al.   JOURNAL OF PHYSICAL CHEMISTRY B

AL Amyloidosis

(2012) Estelle Desport et al.   Orphanet Journal of Rare Diseases

In Vitro Aggregation Behavior of a Non-Amyloidogenic λ Light Chain Dimer Deriving from U266 Multiple Myeloma Cells

(2012) Paolo Arosio et al.   PLoS One

EGCG disaggregates amyloid-like fibrils formed by Plasmodium falciparum merozoite surface protein 2

(2011) Indu R. Chandrashekaran et al.   ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS

Black Tea Theaflavins Inhibit Formation of Toxic Amyloid-β and α-Synuclein Fibrils

(2011) Gerlinde Grelle et al.   BIOCHEMISTRY

Glycosaminoglycans promote fibril formation by amyloidogenic immunoglobulin light chains through a transient interaction

(2011) Douglas J. Martin et al.   BIOPHYSICAL CHEMISTRY

Inhibition and disaggregation of α-synuclein oligomers by natural polyphenolic compounds

(2011) Mario Caruana et al.   FEBS LETTERS

Amyloid-β forms fibrils by nucleated conformational conversion of oligomers

(2011) Jiyong Lee et al.   Nature Chemical Biology

Small-molecule conversion of toxic oligomers to nontoxic β-sheet–rich amyloid fibrils

(2011) Jan Bieschke et al.   Nature Chemical Biology

Comparison of amyloid fibril formation by two closely related immunoglobulin light chain variable domains

(2010) Douglas J. Martin et al.   AMYLOID-JOURNAL OF PROTEIN FOLDING DISORDERS

Inhibition by Flavonoids of Amyloid-like Fibril Formation byPlasmodium falciparumMerozoite Surface Protein 2

(2010) Indu R. Chandrashekaran et al.   BIOCHEMISTRY

The Critical Role of the Constant Region in Thermal Stability and Aggregation of Amyloidogenic Immunoglobulin Light Chain

(2010) Elena S. Klimtchuk et al.   BIOCHEMISTRY

Effect of lysine modification on the stability and cellular binding of human amyloidogenic light chains

(2010) S. Davern et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Effects of the main green tea polyphenol epigallocatechin-3-gallate on cardiac involvement in patients with AL amyloidosis

(2010) Derliz Mereles et al.   Clinical Research in Cardiology

Thermodynamic Analysis of the Molecular Interactions between Amyloid β-Peptide 42 and (−)-Epigallocatechin-3-gallate

(2010) Shi-Hui Wang et al.   JOURNAL OF PHYSICAL CHEMISTRY B

Exploring the sequence determinants of amyloid structure using position-specific scoring matrices

(2010) Sebastian Maurer-Stroh et al.   NATURE METHODS

EGCG remodels mature α-synuclein and amyloid-β fibrils and reduces cellular toxicity

(2010) Jan Bieschke et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Recombinant immunoglobulin variable domains generated from synthetic genes provide a system for in vitro characterization of light-chain amyloid proteins

(2010) Priscilla Wilkins Stevens et al.   PROTEIN SCIENCE

Thermodynamic and Kinetic Characterization of a Germ Line Human λ6 Light-Chain Protein: The Relation between Unfolding and Fibrillogenesis

(2009) Luis M. Blancas-Mejia et al.   JOURNAL OF MOLECULAR BIOLOGY

IMGT/3Dstructure-DB and IMGT/DomainGapAlign: a database and a tool for immunoglobulins or antibodies, T cell receptors, MHC, IgSF and MhcSF

(2009) François Ehrenmann et al.   NUCLEIC ACIDS RESEARCH

Biochemical and aggregation analysis of Bence Jones proteins from different light chain diseases

(2008) Laura A. Sikkink et al.   AMYLOID-JOURNAL OF PROTEIN FOLDING DISORDERS

(−)-Epigallocatechin-3-gallate prevents lipopolysaccharide-induced elevation of beta-amyloid generation and memory deficiency

(2008) Young Kyoung Lee et al.   BRAIN RESEARCH

Therapy effects of green tea in a patient with systemic light-chain amyloidosis

(2008) Derliz Mereles et al.   Clinical Research in Cardiology

Altered Dimer Interface Decreases Stability in an Amyloidogenic Protein

(2008) Elizabeth M. Baden et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Structural Insights into the Role of Mutations in Amyloidogenesis

(2008) Elizabeth M. Baden et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

EGCG redirects amyloidogenic polypeptides into unstructured, off-pathway oligomers

(2008) Dagmar E Ehrnhoefer et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Adapting Proteostasis for Disease Intervention

(2008) William E. Balch et al.   SCIENCE