A Caenorhabditis elegans-based assay recognizes immunoglobulin light chains causing heart amyloidosis

Human amyloidogenic light chain proteins result in cardiac dysfunction, cell death, and early mortality in zebrafish

(2013) Shikha Mishra et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

Stanniocalcin1 is a key mediator of amyloidogenic light chain induced cardiotoxicity

(2013) Jian Guan et al.   BASIC RESEARCH IN CARDIOLOGY

Novel approaches for studying amyloidogenic peptides/proteins

(2013) Marten Beeg et al.   CURRENT OPINION IN PHARMACOLOGY

A New Face for Old Antibiotics: Tetracyclines in Treatment of Amyloidoses

(2013) Tatiana Stoilova et al.   JOURNAL OF MEDICINAL CHEMISTRY

Effects of the antibiotic tetracycline on the reproduction, growth and population growth rate of the nematode Caenorhabditis elegans

(2013) Matthew Vangheel et al.   NEMATOLOGY

A Strategy for Synthesis of Pathogenic Human Immunoglobulin Free Light Chains in E. coli

(2013) Paola Rognoni et al.   PLoS One

Worms under stress: C. elegans stress response and its relevance to complex human disease and aging

(2013) Miriam Rodriguez et al.   TRENDS IN GENETICS

Overexpression of human amyloidogenic light chains causes heart failure in embryonic zebrafish: a preliminary report

(2012) Jordan T. Shin et al.   AMYLOID-JOURNAL OF PROTEIN FOLDING DISORDERS

Specific Recognition of Biologically Active Amyloid-β Oligomers by a New Surface Plasmon Resonance-based Immunoassay and anin VivoAssay inCaenorhabditis elegans

(2012) Matteo Stravalaci et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

New Criteria for Response to Treatment in Immunoglobulin Light Chain Amyloidosis Based on Free Light Chain Measurement and Cardiac Biomarkers: Impact on Survival Outcomes

(2012) Giovanni Palladini et al.   JOURNAL OF CLINICAL ONCOLOGY

Role of mitochondrial homeostasis and dynamics in Alzheimer's disease

(2012) J. Eva Selfridge et al.   NEUROBIOLOGY OF DISEASE

C. elegans Expressing Human β2-Microglobulin: A Novel Model for Studying the Relationship between the Molecular Assembly and the Toxic Phenotype

(2012) Luisa Diomede et al.   PLoS One

A novel approach for the purification and proteomic analysis of pathogenic immunoglobulin free light chains from serum

(2011) Francesca Lavatelli et al.   BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS

Doxycycline reduces fibril formation in a transgenic mouse model of AL amyloidosis

(2011) J. E. Ward et al.   BLOOD

The repertoire of   light chains causing predominant amyloid heart involvement and identification of a preferentially involved germline gene, IGLV1-44

(2011) V. Perfetti et al.   BLOOD

Natural polyphenols inhibit different steps of the process of transthyretin (TTR) amyloid fibril formation

(2011) Nelson Ferreira et al.   FEBS LETTERS

Impaired mitochondrial dynamics and abnormal interaction of amyloid beta with mitochondrial protein Drp1 in neurons from patients with Alzheimer's disease: implications for neuronal damage

(2011) Maria Manczak et al.   HUMAN MOLECULAR GENETICS

Amyloidosis: Pathogenesis and New Therapeutic Options

(2011) Giampaolo Merlini et al.   JOURNAL OF CLINICAL ONCOLOGY

Effects of the main green tea polyphenol epigallocatechin-3-gallate on cardiac involvement in patients with AL amyloidosis

(2010) Derliz Mereles et al.   Clinical Research in Cardiology

β-Amyloid peptide increases levels of iron content and oxidative stress in human cell and Caenorhabditis elegans models of Alzheimer disease

(2010) Li Wan et al.   FREE RADICAL BIOLOGY AND MEDICINE

Tetracycline and its analogues protect Caenorhabditis elegans from β amyloid-induced toxicity by targeting oligomers

(2010) Luisa Diomede et al.   NEUROBIOLOGY OF DISEASE

Tetracycline compounds with non-antimicrobial organ protective properties: Possible mechanisms of action

(2010) Michael O. Griffin et al.   PHARMACOLOGICAL RESEARCH

Amyloidogenic light chains induce cardiomyocyte contractile dysfunction and apoptosis via a non-canonical p38  MAPK pathway

(2010) J. Shi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

EGCG remodels mature α-synuclein and amyloid-β fibrils and reduces cellular toxicity

(2010) Jan Bieschke et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Mitochondrial respiratory chain dysfunction variably increases oxidant stress in Caenorhabditis elegans

(2009) Stephen Dingley et al.   MITOCHONDRION

Amyloidosis: is a cure possible?

(2008) G. Merlini et al.   ANNALS OF ONCOLOGY

Potential anthelmintics: polyphenols from the tea plant Camellia sinensis L. are lethally toxic to Caenorhabditis elegans

(2008) Daisuke Mukai et al.   Journal of Natural Medicines

The selective detection of mitochondrial superoxide by live cell imaging

(2008) Kristine M Robinson et al.   Nature Protocols

EGCG redirects amyloidogenic polypeptides into unstructured, off-pathway oligomers

(2008) Dagmar E Ehrnhoefer et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

The Efficacy of Tetracyclines in Peripheral and Intracerebral Prion Infection

(2008) Ada De Luigi et al.   PLoS One

Detection of 2-hydroxyethidium in cellular systems: a unique marker product of superoxide and hydroethidine

(2007) Jacek Zielonka et al.   Nature Protocols