Structure-guided design affirms inhibitors of hepatitis C virus p7 as a viable class of antivirals targeting virion release

Unusual architecture of the p7 channel from hepatitis C virus

(2013) Bo OuYang et al.   NATURE

The p7 Protein of Hepatitis C Virus Forms Structurally Plastic, Minimalist Ion Channels

(2012) Danielle E. Chandler et al.   PLoS Computational Biology

Resistance mutations define specific antiviral effects for inhibitors of the hepatitis C virus p7 ion channel

(2011) Toshana L. Foster et al.   HEPATOLOGY

Development and Application of Hepatitis C Reporter Viruses with Genotype 1 to 7 Core-Nonstructural Protein 2 (NS2) Expressing Fluorescent Proteins or Luciferase in Modified JFH1 NS5A

(2011) J. M. Gottwein et al.   JOURNAL OF VIROLOGY

The influence of different lipid environments on the structure and function of the hepatitis C virus p7 ion channel protein

(2011) Thomas Whitfield et al.   MOLECULAR MEMBRANE BIOLOGY

Genetic and functional heterogeneity of the hepatitis C virus p7 ion channel during natural chronic infection

(2011) Hui Li et al.   VIROLOGY

A Concerted Action of Hepatitis C Virus P7 and Nonstructural Protein 2 Regulates Core Localization at the Endoplasmic Reticulum and Virus Assembly

(2011) Bertrand Boson et al.   PLoS Pathogens

NS2 Protein of Hepatitis C Virus Interacts with Structural and Non-Structural Proteins towards Virus Assembly

(2011) Costin-Ioan Popescu et al.   PLoS Pathogens

A novel Hepatitis C virus p7 ion channel inhibitor, BIT225, inhibits bovine viral diarrhea virus in vitro and shows synergism with recombinant interferon-α-2b and nucleoside analogues

(2010) Carolyn A. Luscombe et al.   ANTIVIRAL RESEARCH

Secondary structure, dynamics, and architecture of the p7 membrane protein from hepatitis C virus by NMR spectroscopy

(2010) Gabriel A. Cook et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES

Expression and purification of the membrane protein p7 from hepatitis C virus

(2010) Gabriel A. Cook et al.   BIOPOLYMERS

NMR Structure and Ion Channel Activity of the p7 Protein from Hepatitis C Virus

(2010) Roland Montserret et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The subcellular localization of the hepatitis C virus non-structural protein NS2 is regulated by an ion channel-independent function of the p7 protein

(2010) P. Tedbury et al.   JOURNAL OF GENERAL VIROLOGY

Hepatitis C Virus NS2 Coordinates Virus Particle Assembly through Physical Interactions with the E1-E2 Glycoprotein and NS3-NS4A Enzyme Complexes

(2010) K. A. Stapleford et al.   JOURNAL OF VIROLOGY

Intracellular Proton Conductance of the Hepatitis C Virus p7 Protein and Its Contribution to Infectious Virus Production

(2010) Ann L. Wozniak et al.   PLoS Pathogens

Structural and Functional Studies of Nonstructural Protein 2 of the Hepatitis C Virus Reveal Its Key Role as Organizer of Virion Assembly

(2010) Vlastimil Jirasko et al.   PLoS Pathogens

Determination of Pore-Lining Residues in the Hepatitis C Virus p7 Protein

(2009) Chee Foong Chew et al.   BIOPHYSICAL JOURNAL

NMR studies of p7 protein from hepatitis C virus

(2009) Gabriel A. Cook et al.   EUROPEAN BIOPHYSICS JOURNAL WITH BIOPHYSICS LETTERS

Determinants of Hepatitis C Virus p7 Ion Channel Function and Drug Sensitivity Identified In Vitro

(2009) C. StGelais et al.   JOURNAL OF VIROLOGY

Prediction of membrane protein structures with complex topologies using limited constraints

(2009) P. Barth et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Mechanism of drug inhibition and drug resistance of influenza A M2 channel

(2009) R. M. Pielak et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The 3-dimensional structure of a hepatitis C virus p7 ion channel by electron microscopy

(2009) P. Luik et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Genotype-dependent sensitivity of hepatitis C virus to inhibitors of the p7 ion channel

(2008) Stephen Griffin et al.   HEPATOLOGY

Structure and mechanism of the M2 proton channel of influenza A virus

(2008) Jason R. Schnell et al.   NATURE

HOLLOW: Generating Accurate Representations of Channel and Interior Surfaces in Molecular Structures

(2008) Bosco K Ho et al.   BMC STRUCTURAL BIOLOGY