Colitis-associated neoplasia: molecular basis and clinical translation

In vivo imaging using fluorescent antibodies to tumor necrosis factor predicts therapeutic response in Crohn's disease

(2014) Raja Atreya et al.   NATURE MEDICINE

Mutant p53 Prolongs NF-κB Activation and Promotes Chronic Inflammation and Inflammation-Associated Colorectal Cancer

(2013) Tomer Cooks et al.   CANCER CELL

Interleukin-11 Is the Dominant IL-6 Family Cytokine during Gastrointestinal Tumorigenesis and Can Be Targeted Therapeutically

(2013) Tracy L. Putoczki et al.   CANCER CELL

Label-Free Imaging of Inflammatory Bowel Disease Using Multiphoton Microscopy

(2013) Sebastian Schürmann et al.   GASTROENTEROLOGY

Beyond Gene Discovery in Inflammatory Bowel Disease: The Emerging Role of Epigenetics

(2013) Nicholas T. Ventham et al.   GASTROENTEROLOGY

Tumor fibroblast–derived epiregulin promotes growth of colitis-associated neoplasms through ERK

(2013) Clemens Neufert et al.   JOURNAL OF CLINICAL INVESTIGATION

Gut microbiota accelerate tumor growth via c-jun and STAT3 phosphorylation in APC Min/+ mice

(2012) Yinghui Li et al.   CARCINOGENESIS

Intestinal Tumorigenesis Initiated by Dedifferentiation and Acquisition of Stem-Cell-like Properties

(2012) Sarah Schwitalla et al.   CELL

Therapeutic Blockade of Interleukin-6 in Chronic Inflammatory Disease

(2012) K Yamamoto et al.   CLINICAL PHARMACOLOGY & THERAPEUTICS

The Role of Chemoprevention of Colorectal Cancer with 5-Aminosalicylates in Ulcerative Colitis

(2012) Hans Herfarth   DIGESTIVE DISEASES

Colitis and Colorectal Cancer

(2012) Sebastian Foersch et al.   DIGESTIVE DISEASES

Interleukin-6 - A Key Regulator of Colorectal Cancer Development

(2012) Maximilian J. Waldner et al.   International Journal of Biological Sciences

Chronic epithelial NF- B activation accelerates APC loss and intestinal tumor initiation through iNOS up-regulation

(2012) H. Shaked et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Intestinal Inflammation Targets Cancer-Inducing Activity of the Microbiota

(2012) J. C. Arthur et al.   SCIENCE

Interactions Between Commensal Fungi and the C-Type Lectin Receptor Dectin-1 Influence Colitis

(2012) I. D. Iliev et al.   SCIENCE

Regulatory T cells in inflammatory bowel diseases and colorectal cancer

(2012) Györgyi Műzes   WORLD JOURNAL OF GASTROENTEROLOGY

Stat3: linking inflammation to epithelial cancer - more than a "gut" feeling?

(2012) Andrew Jarnicki et al.   Cell Division

High-Dose Ursodeoxycholic Acid Is Associated With the Development of Colorectal Neoplasia in Patients With Ulcerative Colitis and Primary Sclerosing Cholangitis

(2011) John E Eaton et al.   AMERICAN JOURNAL OF GASTROENTEROLOGY

Therapeutic Targeting of the Interleukin-6 Receptor

(2011) Toshio Tanaka et al.   Annual Review of Pharmacology and Toxicology

IL-6 signaling in autoimmunity, chronic inflammation and inflammation-associated cancer

(2011) Markus F. Neurath et al.   CYTOKINE & GROWTH FACTOR REVIEWS

Intestinal Inflammation and Cancer

(2011) Thomas A. Ullman et al.   GASTROENTEROLOGY

New therapies for inflammatory bowel disease: from the bench to the bedside

(2011) Silvio Danese   GUT

DNA methylation of colon mucosa in ulcerative colitis patients: Correlation with inflammatory status

(2011) Shunsuke Saito et al.   INFLAMMATORY BOWEL DISEASES

STAT6 activation in ulcerative colitis: A new target for prevention of IL-13-induced colon epithelial cell dysfunction

(2011) Michael J. Rosen et al.   INFLAMMATORY BOWEL DISEASES

Role of miR-150-targeting c-Myb in colonic epithelial disruption during dextran sulphate sodium-induced murine experimental colitis and human ulcerative colitis

(2011) Zhen Bian et al.   JOURNAL OF PATHOLOGY

Advanced Endoscopic Imaging for Diagnosis of Crohn's Disease

(2011) Helmut Neumann et al.   Gastroenterology Research and Practice

Prevention of Colitis-Associated Carcinogenesis with Infliximab

(2010) Y. J. Kim et al.   Cancer Prevention Research

Tumor formation in a mouse model of colitis-associated colon cancer does not require COX-1 or COX-2 expression

(2010) T. o. Ishikawa et al.   CARCINOGENESIS

The diagnostic accuracy of chromoendoscopy for dysplasia in ulcerative colitis: meta-analysis of six randomized controlled trials

(2010) L. Wu et al.   Colorectal Disease

Inflammatory Bowel Disease as a Risk Factor for Colorectal Cancer

(2010) Milan Lukas   DIGESTIVE DISEASES

Phosphoinositide 3-Kinase Signaling Mediates β-Catenin Activation in Intestinal Epithelial Stem and Progenitor Cells in Colitis

(2010) Goo Lee et al.   GASTROENTEROLOGY

AGA Technical Review on the Diagnosis and Management of Colorectal Neoplasia in Inflammatory Bowel Disease

(2010) Francis A. Farraye et al.   GASTROENTEROLOGY

Molecular imaging of VEGF in gastrointestinal cancer in vivo using confocal laser endomicroscopy

(2010) S. Foersch et al.   GUT

VEGF receptor signaling links inflammation and tumorigenesis in colitis-associated cancer

(2010) Maximilian J. Waldner et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Chronic inflammation and mutagenesis

(2010) Lynnette R. Ferguson   MUTATION RESEARCH-FUNDAMENTAL AND MOLECULAR MECHANISMS OF MUTAGENESIS

Innate lymphoid cells drive interleukin-23-dependent innate intestinal pathology

(2010) Sofia Buonocore et al.   NATURE

IL-6 and Stat3 Are Required for Survival of Intestinal Epithelial Cells and Development of Colitis-Associated Cancer

(2009) Sergei Grivennikov et al.   CANCER CELL

Intestinal Mucosal Inflammation Leads to Systemic Genotoxicity in Mice

(2009) A. M. Westbrook et al.   CANCER RESEARCH

In Vivo Molecular Imaging of Colorectal Cancer With Confocal Endomicroscopy by Targeting Epidermal Growth Factor Receptor

(2009) Martin Goetz et al.   GASTROENTEROLOGY

Mesalamine Inhibits Epithelial β-Catenin Activation in Chronic Ulcerative Colitis

(2009) Jeffrey B. Brown et al.   GASTROENTEROLOGY

Long-term safety of Infliximab for the treatment of inflammatory bowel disease: does blocking TNF  reduce colitis-associated colorectal carcinogenesis?

(2009) L. Biancone et al.   GUT

Translating Inflammatory Bowel Disease Research into Clinical Medicine

(2009) Markus F. Neurath et al.   IMMUNITY

Analysis of mutations in TP53, APC, K-ras, and DCC genes in the non-dysplastic mucosa of patients with inflammatory bowel disease

(2009) Davy Carlos Mendes Rapozo et al.   INTERNATIONAL JOURNAL OF COLORECTAL DISEASE

Tyrosine dephosphorylation of H2AX modulates apoptosis and survival decisions

(2009) Peter J. Cook et al.   NATURE

Single Lgr5 stem cells build crypt-villus structures in vitro without a mesenchymal niche

(2009) Toshiro Sato et al.   NATURE

A human colonic commensal promotes colon tumorigenesis via activation of T helper type 17 T cell responses

(2009) Shaoguang Wu et al.   NATURE MEDICINE

The Clinical Benefit of Bevacizumab in Metastatic Colorectal Cancer Is Independent of K-ras Mutation Status: Analysis of a Phase III Study of Bevacizumab with Chemotherapy in Previously Untreated Metastatic Colorectal Cancer

(2009) H. I. Hurwitz et al.   ONCOLOGIST

Nitric oxide and TNF-  trigger colonic inflammation and carcinogenesis in Helicobacter hepaticus-infected, Rag2-deficient mice

(2009) S. E. Erdman et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Colitis-associated cancer: the role of T cells in tumor development

(2009) Maximilian J. Waldner et al.   Seminars in Immunopathology

Roles for Inflammation and Regulatory T Cells in Colon Cancer

(2009) Susan E. Erdman et al.   TOXICOLOGIC PATHOLOGY

Autocrine IL-6 Signaling: A Key Event in Tumorigenesis?

(2008) Sergei Grivennikov et al.   CANCER CELL

Infliximab for Inflammatory Bowel Disease in Denmark 1999–2005: Clinical Outcome and Follow-Up Evaluation of Malignancy and Mortality

(2008) Sarah Caspersen et al.   Clinical Gastroenterology and Hepatology

Ulcerative Colitis Is a Disease of Accelerated Colon Aging: Evidence From Telomere Attrition and DNA Damage

(2008) Rosa Ana Risques et al.   GASTROENTEROLOGY

Confocal chromoscopic endomicroscopy is superior to chromoscopy alone for the detection and characterisation of intraepithelial neoplasia in chronic ulcerative colitis

(2008) D P Hurlstone et al.   GUT

Long-term safety of infliximab for the treatment of inflammatory bowel disease: a single-centre cohort study

(2008) H Fidder et al.   GUT

Epigenetic Regulation of WNT Signaling Pathway Genes in Inflammatory Bowel Disease (IBD) Associated Neoplasia

(2008) Mashaal Dhir et al.   JOURNAL OF GASTROINTESTINAL SURGERY

Crypt stem cells as the cells-of-origin of intestinal cancer

(2008) Nick Barker et al.   NATURE

Sequence variants in IL10, ARPC2 and multiple other loci contribute to ulcerative colitis susceptibility

(2008) Andre Franke et al.   NATURE GENETICS

Colorectal cancer prevention in inflammatory bowel disease and the role of 5-aminosalicylic acid: A clinical review and update

(2007) David T. Rubin et al.   INFLAMMATORY BOWEL DISEASES