Amorfrutins: A Promising Class of Natural Products that Are Beneficial to Health

Discovery and Characterization of Protein-Modifying Natural Products by MALDI Mass Spectrometry Reveal Potent SIRT1 and p300 Inhibitors

(2013) Susanne Holzhauser et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Target Identification for Small Bioactive Molecules: Finding the Needle in the Haystack

(2013) Slava Ziegler et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Amorfrutin B is an efficient natural peroxisome proliferator-activated receptor gamma (PPARγ) agonist with potent glucose-lowering properties

(2013) C. Weidner et al.   DIABETOLOGIA

Protein set analyses: how could this impact the clinic?

(2013) Sascha Saueru   Expert Review of Proteomics

Emerging roles of the corepressors NCoR1 and SMRT in homeostasis

(2013) A. Mottis et al.   GENES & DEVELOPMENT

Structural Characterization of Amorfrutins Bound to the Peroxisome Proliferator-Activated Receptor γ

(2013) Jens C. de Groot et al.   JOURNAL OF MEDICINAL CHEMISTRY

Protein Sets Define Disease States and PredictIn VivoEffects of Drug Treatment

(2013) David Meierhofer et al.   MOLECULAR & CELLULAR PROTEOMICS

Lemon balm extract causes potent antihyperglycemic and antihyperlipidemic effects in insulin-resistant obese mice

(2013) Christopher Weidner et al.   MOLECULAR NUTRITION & FOOD RESEARCH

Genome-wide analysis of LXRα activation reveals new transcriptional networks in human atherosclerotic foam cells

(2013) Radmila Feldmann et al.   NUCLEIC ACIDS RESEARCH

Foam Cell Specific LXRα Ligand

(2013) Radmila Feldmann et al.   PLoS One

Antidiabetic Effects of Chamomile Flowers Extract in Obese Mice through Transcriptional Stimulation of Nutrient Sensors of the Peroxisome Proliferator-Activated Receptor (PPAR) Family

(2013) Christopher Weidner et al.   PLoS One

Comprehensive proteomic datasets for studying adipocyte-macrophage cell-cell communication

(2013) Anja Freiwald et al.   PROTEOMICS

A facile total synthesis of amorfrutin A

(2013) Yao Yao Song et al.   TETRAHEDRON LETTERS

Total synthesis and dual PPARα/γ agonist effects of Amorphastilbol and its synthetic derivatives

(2012) Taejung Kim et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Caloric Restriction Induces Changes in Insulin and Body Weight Measurements That Are Inversely Associated with Subsequent Weight Regain

(2012) Monica H. T. Wong et al.   PLoS One

Amorfrutins are potent antidiabetic dietary natural products

(2012) C. Weidner et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Can Noncommunicable Diseases Be Prevented? Lessons from Studies of Populations and Individuals

(2012) M. Ezzati et al.   SCIENCE

PPARγ is an E3 ligase that induces the degradation of NFκB/p65

(2012) Yongzhong Hou et al.   Nature Communications

Biology-Oriented Synthesis

(2011) Stefan Wetzel et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Plant Polyphenols: Chemical Properties, Biological Activities, and Synthesis

(2011) Stéphane Quideau et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Inflammatory Mechanisms in Obesity

(2011) Margaret F. Gregor et al.   Annual Review of Immunology

Adipocyte NCoR Knockout Decreases PPARγ Phosphorylation and Enhances PPARγ Activity and Insulin Sensitivity

(2011) Pingping Li et al.   CELL

PPAR-γ action: it's all in your head

(2011) Martin G Myers et al.   NATURE MEDICINE

Biomimetic Total Synthesis of Angelicoin A and B via a Palladium-Catalyzed Decarboxylative Prenylation-Aromatization Sequence

(2011) Katie Anderson et al.   ORGANIC LETTERS

Total synthesis of amorfrutin A via a palladium-catalyzed migratory prenylation–aromatization sequence

(2011) Sylvain Laclef et al.   TETRAHEDRON LETTERS

Synergy research: Approaching a new generation of phytopharmaceuticals

(2010) Hildebert Wagner   FITOTERAPIA

New life for antidiabetic drugs

(2010) Riekelt H. Houtkooper et al.   NATURE

Anti-diabetic drugs inhibit obesity-linked phosphorylation of PPARγ by Cdk5

(2010) Jang Hyun Choi et al.   NATURE

Potential remains for PPAR-targeted drugs

(2010) Dan Jones   NATURE REVIEWS DRUG DISCOVERY

Rosiglitazone, PPARγ, and Type 2 Diabetes

(2010) Barbara B. Kahn et al.   NEW ENGLAND JOURNAL OF MEDICINE

Diets with High or Low Protein Content and Glycemic Index for Weight-Loss Maintenance

(2010) Thomas Meinert Larsen et al.   NEW ENGLAND JOURNAL OF MEDICINE

Synthesis of Natural Product Inspired Compound Collections

(2009) Kamal Kumar et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Prenylation of aromatic compounds, a key diversification of plant secondary metabolites

(2009) Kazufumi Yazaki et al.   PHYTOCHEMISTRY

De-Novo Identification of PPARγ/RXR Binding Sites and Direct Targets during Adipogenesis

(2009) Mohamed Sabry Hamza et al.   PLoS One

PPAR  and C/EBP factors orchestrate adipocyte biology via adjacent binding on a genome-wide scale

(2008) M. I. Lefterova et al.   GENES & DEVELOPMENT

Phenolic Constituents ofAmorpha fruticosaThat Inhibit NF-κB Activation and Related Gene Expression

(2008) Nguyen Tien Dat et al.   JOURNAL OF NATURAL PRODUCTS

Integration of metabolism and inflammation by lipid-activated nuclear receptors

(2008) Steven J. Bensinger et al.   NATURE

Structure of the intact PPAR-γ–RXR-α nuclear receptor complex on DNA

(2008) Vikas Chandra et al.   NATURE

Plant Polyketide Synthases: A fascinating group of enzymes

(2008) Isvett J. Flores-Sanchez et al.   PLANT PHYSIOLOGY AND BIOCHEMISTRY

Scaffold-based discovery of indeglitazar, a PPAR pan-active anti-diabetic agent

(2008) D. R. Artis et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA